Abstract:
:A comparison of bone scintigrams and roentgenographic skeletal surveys, obtained on 170 patients with breast carcinoma, was made to evaluate the diagnostic efficacy of these techniques in detecting metastatic bone lesions. The bone scans were abnormal in 81 patients, while the roentgenograms were abnormal in only 51. In 34 of the 81 (42%) patients with abnormal bone scans, there was no radiographic evidence of a benign lesion to account for the increased ratiotracer uptake; and the abnormalities noted on the bone scans were proven to be bony metastases on follow-up examinations. In the remaining 47 patients with positive bone scintigrams, both the scans and the roentgenograms were abnormal; however, in 23 patients the bone scan demonstrated significantly more lesions than what the roentgenograms had revealed. This study confirms that bone scan is superior to roentgen surveys in detecting skeletal metastases in patients with breast carcinoma. It was noted that the metastatic lesions can be visualized on the scans earlier than they are apparent on the X-rays by a mean interval of 4 months.
journal_name
Oncologyjournal_title
Oncologyauthors
Joo KG,Parthasarathy KL,Bakshi SP,Rosner Ddoi
10.1159/000225325subject
Has Abstractpub_date
1979-01-01 00:00:00pages
94-8issue
2eissn
0030-2414issn
1423-0232journal_volume
36pub_type
杂志文章相关文献
ONCOLOGY文献大全abstract:OBJECTIVE:The aim of this study was to assess the use of 5-fluorouracil (5-FU), leucovorin and oxaliplatin (FOLFOX) regimens in clinical practice according to their efficacy and toxicity. METHODS:Patients who received oxaliplatin-containing regimens after curative resection for colorectal carcinoma from 10 different o...
journal_title:Oncology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1159/000336902
更新日期:2013-01-01 00:00:00
abstract::Objective tumor responses and survival rates with standard chemotherapy options for small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC) have been disappointing. However, several promising new classes of agents have emerged in recent years, including the taxanes, mitotic spindle inhibitors, antimetabol...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000055387
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:The RUNX proteins are a family of transcriptional factors that have essential functions during embryogenesis and development, whereas deregulation in expression of RUNXs is often linked to tumor formation. To date, there has been no study describing the precise expression, prognostic impact and methylation s...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000135350
更新日期:2007-01-01 00:00:00
abstract::To evaluate the influence of delay between first symptom and first treatment upon survival the medical records of 596 patients with breast cancer were reviewed. The following intervals were considered: less than 3 months; 3-6 months and greater than 6 months. Patients in the less than 3 months delay group had a better...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226689
更新日期:1989-01-01 00:00:00
abstract::As TS-1 and docetaxel (TXT) have different mechanisms of antitumor activity, the combination therapy is expected to have a higher response. Human gastric cancer xenografts SC-2, St-40, and SC-4 inoculated into nude rats were treated with TS-1 alone (TS-1 12 mg/kg/day, day 1-14), TXT alone (TXT 2 mg/kg/day, day 1 or da...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000086767
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:This phase II study examined the efficacy and safety of alternating regimens of mFOLFOX6 and FOLFIRI as a first-line treatment for unresectable or metastatic colorectal cancer. PATIENTS AND METHODS:Forty-eight patients were enrolled in this study. Patients received an alternating regimen of 4 cycles of mFOLF...
journal_title:Oncology
pub_type: 杂志文章,多中心研究
doi:10.1159/000346690
更新日期:2013-01-01 00:00:00
abstract::While central ports are located at the chest, peripheral ports (PP) are inserted at the patients' forearms. Two new PPs (Healthport miniMax((R)) and Bard Titan Low Profile Port) and two well-established types (Port-A-Cath((R)) P.A.S. Port and PeriPort(TM) peripheral access system) were tested. 125 patients were given ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000012059
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:Identification of high-risk stage II colorectal cancer (CRC) patients, potential candidates for adjuvant chemotherapy, is challenging. Current clinical guidelines rely mainly on histopathological markers with relatively weak prognostic value. This motivates further search for prognostic markers. METHODS:Thi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000507118
更新日期:2020-01-01 00:00:00
abstract::Autoantibodies (AAb) directed against the nuclear phosphoprotein p53 can be detected in patients with various forms of cancer. The objective was to determine the prevalence of p53 AAb at the time of diagnosis in ovarian cancer patients and to correlate the presence of p53 AAb with clinicopathological parameters. Sera ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000012069
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVE:Keratin (K) 19 positivity has been reported to be a useful predictive marker for recurrence in patients with hepatocellular carcinoma (HCC) who have undergone hepatic resection. We investigated the clinical usefulness of K19 positivity in patients who had received curative radiofrequency ablation (RFA). METH...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000328448
更新日期:2011-01-01 00:00:00
abstract:UNLABELLED:The outlook for patients with testicular germ cell cancer was dramatically improved by the introduction of cisplatin. Well-known side effects of cisplatin (nausea, vomiting, nephrotoxicity, myelosuppression) can be managed with preventive methods. The long life expectancy after this therapy draws attention t...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227724
更新日期:1997-09-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) has been shown to be highly responsive to chemotherapy. The major limiting toxicity was myelotoxicity. Recently, the role of granulocyte colony-stimulating factor (G-CSF) in reducing chemotherapy-induced neutropenic sepsis has been well established. In this study, we tested whether recom...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227658
更新日期:1997-01-01 00:00:00
abstract::The activity and toxicity of UFT (Tegafur and Uracil) in a 4:1 molar concentration, plus leucovorin (LV), were evaluated in the treatment of 45 patients with advanced, bidimensionally measurable metastatic colorectal carcinoma. Initially 350 and later 300 mg/m2/day, plus 150 mg LV, as administered in divided doses eve...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227741
更新日期:1997-01-01 00:00:00
abstract:PURPOSE:There is no standard second-line therapy for patients with oesophagogastric cancer who progress following first-line chemotherapy for advanced disease or relapse following radical multi-modality therapy. The aim of this retrospective study was to evaluate survival following rechallenge with platinum plus fluoro...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000322114
更新日期:2010-01-01 00:00:00
abstract::The purpose of this study was to evaluate in a dog model whether intrapericardial instillation of tetracycline is superior to the effect of drainage alone in causing pericardial adhesions and cavity obliteration. Twelve mongrel dogs were randomly divided into two experimental groups. All dogs received a pericardial dr...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227232
更新日期:1993-11-01 00:00:00
abstract:OBJECTIVE:The herpes simplex virus thymidine kinase (HSVtk)/ganciclovir suicide gene therapy system has been considered as one of the most promising therapeutic strategies for malignant gliomas. We have been using HSVtk gene-transduced neural stem cells (NSCtk) that possess an ability to migrate toward a tumor mass for...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000091032
更新日期:2005-01-01 00:00:00
abstract::Many patients on cytotoxic chemotherapy show reduced frequency of menstrual bleeding due to a reduction in ovarian follicular activity. The endocrine perturbations related to these changed menstrual patterns were studied in detail. Nineteen regularly menstruating patients with primary breast cancer were given either c...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226930
更新日期:1991-01-01 00:00:00
abstract:PURPOSE:Nucleoside and nucleobase derivatives are currently used in the treatment of a variety of solid tumors; however, the role of plasma membrane transporters as biomarkers of drug metabolism has not been fully addressed. Thus, the purpose of this study was to determine whether the concentrative nucleoside transport...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000094541
更新日期:2006-01-01 00:00:00
abstract::An in vitro system was used to study the uptake of 5-fluorouracil by LSA ascites tumor cells. Changes in drug uptake with cell age and following a 1,000-rad radiation perturbation of the cell population were studied. DNA synthesis and drug uptake were highest during early rapid tumor growth and decreased with tumor ag...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225540
更新日期:1981-01-01 00:00:00
abstract::To clarify the inhibitory effect of telomere-mimic oligonucleotides on human cancer cell lines, we synthesized 18-mers (18T; n = 3), 24-mers (24T; n = 4) and 30-mers (30T; n = 5) of telomere-mimic phosphorothioate oligodeoxy nucleotides [5'-d(TTA GGG)n-3'] and examined their effects on the proliferation of human tumor...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000055272
更新日期:1999-10-01 00:00:00
abstract::Sorafenib, an oral multikinase inhibitor, has demonstrated clinical efficacy in patients with advanced hepatocellular carcinoma (HCC). However, in the SHARP trial (Sorafenib HCC Assessment Randomized Protocol trial) and the Asia-Pacific trial (conducted in the Asia-Pacific region), no cases of complete response (CR) w...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000333279
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to establish a new formula predicting liver metastasis in patients with colorectal cancer (CRC). METHODS:Nine previously reported predictive markers for liver metastasis and/or prognosis (COX-2, dysadherin, E-cadherin, beta-catenin, Ki-67, p53, laminin5gamma2, matrilysin and MUC...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000151667
更新日期:2008-01-01 00:00:00
abstract::The methodology of future antiemetic studies will reflect the need to address the problems identified in current studies. New preclinical information on the mechanisms of emesis and antiemetic action will allow more rational clinical study design. Prior to large randomized studies, phase I and II trials should define ...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000227648
更新日期:1996-06-01 00:00:00
abstract::The prognosis of brain glioblastoma is still very poor and the median survival time is generally less than 6 months. At present, no chemotherapy has appeared to influence its prognosis. On the other hand, recent advances in brain tumor biology have suggested that brain tumor growth is at least in part under a neuroend...
journal_title:Oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000227533
更新日期:1996-01-01 00:00:00
abstract::To determine the relationship between neoplastic transformation and increased genetic instability, spontaneous and induced mutation rates were compared in a nontumorigenic, immortalized human bronchial epithelial cell line (NL20) and a tumorigenic cell line (NL20T) spontaneously derived from the NL20 line. Using the h...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227713
更新日期:1997-07-01 00:00:00
abstract::A large number of targeted anticancer drugs are currently under development and most of them will have a companion diagnostic linked to their use. If a diagnostic assay is developed in conjunction with a targeted anticancer drug, such an assay will later end up determining the conditions for the use of the drug after ...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000353454
更新日期:2013-01-01 00:00:00
abstract::6 cases of endodermal sinus tumor of the ovary are presented. In 4 patients pure endodermal sinus tumor was found microscopically. 1 patient had endodermal sinus tumor in one ovary and gonadoblastoma in the contralateral one. In another case endodermal sinus tumor was accompanied by an embryonal teratoma. Histological...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225338
更新日期:1979-01-01 00:00:00
abstract::Breast tumorigenesis is a continuum from preinvasive lesions to early breast cancer and advanced disease. In this article the data supporting the use of the aromatase inhibitor anastrozole in postmenopausal women across this continuum are reviewed. In advanced disease, anastrozole has a significant survival benefit an...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000091180
更新日期:2006-01-01 00:00:00
abstract::Previous studies have demonstrated a rise in serum alpha-1-antitrypsin at advanced stages of malignancy. These, together with results of animal experiments with another anti-proteinase, aprotinin, have prompted studies of the plasma alpha-1-antitrypsin in the early stages of malignancy, using cervical carcinoma as a m...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225093
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND:Previous data showed that distant metastatic breast cancer (MBC) might be curable in up to 3% of the cases in selected patients, mostly young, with good performance status and with low-volume metastatic disease, mainly by an aggressive multidisciplinary approach including aggressive combination chemotherapy ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000500298
更新日期:2019-01-01 00:00:00