Abstract:
OBJECTIVE:The purpose of this study was to establish a new formula predicting liver metastasis in patients with colorectal cancer (CRC). METHODS:Nine previously reported predictive markers for liver metastasis and/or prognosis (COX-2, dysadherin, E-cadherin, beta-catenin, Ki-67, p53, laminin5gamma2, matrilysin and MUC-1) were immunohistochemically investigated in 439 consecutive patients with CRC. We tried to determine the combination of molecules which best predicted liver metastasis. A formula for predicting liver metastasis was constructed using a training cohort comprising 150 cases, and applied to a validation cohort comprising 190 cases and another comprising 99 cases from an outside hospital. RESULTS:A combination of dysadherin, E-cadherin and matrilysin was identified to be best for predicting liver metastasis (area under the curve value, 0.807). The predictive formula: 3x dysadherin score [0 for low expression (=50% of tumor cells positive) or 1 for high expression (>50%)] + 4x E-cadherin score [0 for preserved (>80% of tumor cells positive) or 1 for reduced (=80%)] + 2x matrilysin score [0 for low expression (=30% of tumor cells positive) or 1 for high expression (>30%)] was able to discriminate patients with liver metastasis in the training cohort with a sensitivity of 85.7% and a specificity of 58.9%. The discriminative capacity of the formula was validated in the first cohort with a sensitivity of 87.0% and a specificity of 66.5%, and in the second cohort with a sensitivity of 80% and a specificity of 60.0%. CONCLUSIONS:We have established a formula for predicting liver metastasis in patients with CRC, and confirmed that it has a high sensitivity potentially useful for clinical application.
journal_name
Oncologyjournal_title
Oncologyauthors
Ochiai H,Nakanishi Y,Fukasawa Y,Sato Y,Yoshimura K,Moriya Y,Kanai Y,Watanabe M,Hasegawa H,Kitagawa Y,Kitajima M,Hirohashi Sdoi
10.1159/000151667subject
Has Abstractpub_date
2008-01-01 00:00:00pages
32-41issue
1-2eissn
0030-2414issn
1423-0232pii
000151667journal_volume
75pub_type
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