Expression of the high-affinity fluoropyrimidine-preferring nucleoside transporter hCNT1 correlates with decreased disease-free survival in breast cancer.

abstract：OBJECTIVES:The impact of ethnicity and the socioeconomic status (SES) among Caucasians is not well studied. Here, we examine the impact of income on melanoma presentation and prognosis within a Caucasian cohort, accounting for ethnicity, as some reports suggest increased melanoma incidence in Ashkenazi Jewish (AJ) BRCA...

journal_title：Oncology

authors： Salvaggio C,Han SW,Martires K,Robinson E,Madankumar R,Gumaste P,Polsky D,Stein J,Berman R,Shapiro R,Zhong J,Osman I

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:Syndecan-1 is a cell surface heparan sulphate proteoglycan which participates in cell proliferation, cell migration and cell-matrix interactions. Epithelial syndecan-1 expression is reduced in several malignant tumours, but in breast and pancreatic cancer, increased expression has also been described. Loss of...

journal_title：Oncology

authors： Leivonen M,Lundin J,Nordling S,von Boguslawski K,Haglund C

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:This phase I study (EudraCT No. 2006-001177-25) investigated aflibercept, a vascular endothelial growth factor decoy receptor protein (VEGF Trap), in combination with docetaxel, cisplatin, and 5-fluorouracil in patients with advanced solid tumors. PATIENTS AND METHODS:Patients received 2, 4, or 6 mg/kg of intr...

journal_title：Oncology

authors： Bahleda R,Baker J,Massard C,Gadgeel SM,Rogers JE,Izzedine H,Deutsch E,Garris JL,Khan A,Boelle E,Assadourian S,Soria JC,Ajani JA

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Mutations in the human telomerase reverse transcriptase (hTERT) gene promoter have been reported in hepatocellular carcinoma (HCC); however, analyses of these mutations in liquid biopsies have been technically difficult because of the high GC content of the regions of interest within this promoter. We evalua...

journal_title：Oncology

authors： Ako S,Nouso K,Kinugasa H,Matsushita H,Terasawa H,Adachi T,Wada N,Takeuchi Y,Mandai M,Onishi H,Ikeda F,Shiraha H,Takaki A,Fujioka S,Mimura T,Okada H

更新日期：2020-01-01 00:00:00

abstract：:Thirteen samples of gastric tumors that had developed in the remnant stomach (remnant gastric cancer) were compared with 63 samples of primary gastric tumors located in the upper third of the stomach (primary gastric cancer) by both clinicopathologic and flow cytometric analysis. The depths of invasion of all these tu...

journal_title：Oncology

authors： Ikeguchi M,Kondou A,Oka A,Tsujitani S,Maeta M,Kaibara N

更新日期：1995-03-01 00:00:00

abstract：:Thirty-eight patients with metastatic renal-cell carcinoma (RCC) and 1 patient with a second primary RCC were treated with coumarin and cimetidine. Patients received 400 mg cimetidine p.o. daily and after 1 week 100 mg coumarin p.o. daily in addition until tumour progression. Two complete remission (30 and 50+ months)...

journal_title：Oncology

authors： Kokron O,Maca S,Gasser G,Schmidt PR

更新日期：1991-01-01 00:00:00

abstract：:In 86 children with acute lymphocytic leukemia (ALL) and in 6 children with medulloblastoma 253 24-hour methotrexate (MTX) infusions with 150, 500, and 700 mg/m2 were performed. MTX concentrations in plasma and cerebrospinal fluid (CSF) were measured with a specific radioimmunoassay. In 131 infusions with 500 mg/m2 gi...

journal_title：Oncology

authors： Janka GE,Mack R,Helmig M,Haas RJ,Bidlingmaier F

更新日期：1984-01-01 00:00:00

abstract：:Originally referred to as 'lymphoepithelioma', undifferentiated and poorly differentiated nasopharyngeal carcinoma (NPC) tissues showed intense lymphoinfiltration. In a study of cryosections from 15 NPC tissues, we found that infiltrating lymphoid elements were comprised predominantly of lymphocytes, but plasma cells,...

journal_title：Oncology

authors： Zong YS,Lin H,Choy DT,Sham JS,Wei W,Chan KH,Ng MH

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:The present study evaluated the clinical relevance of an integrative preoperative assessment of inflammation-, nutrition-, and muscle-based markers for patients with muscle-invasive bladder cancer (MIBC) undergoing curative radical cystectomy (RC). METHODS:The analysis enrolled 117 patients and the variables...

journal_title：Oncology

authors： Miyake M,Morizawa Y,Hori S,Marugami N,Iida K,Ohnishi K,Gotoh D,Tatsumi Y,Nakai Y,Inoue T,Anai S,Torimoto K,Aoki K,Tanaka N,Shimada K,Konishi N,Fujimoto K

更新日期：2017-01-01 00:00:00

abstract：:This is a case report of hyperpyrexia, shock and death following initial injection of low-dose bleomycin (7.5 units) for a poorly differentiated metastatic carcinoma. Premedication with high-dose dexamethasone and acetaminophen did not abort the reaction. A review of the literature uncovered one nearly fatal reaction ...

journal_title：Oncology

authors： Levy RL,Chiarillo S

更新日期：1980-01-01 00:00:00

abstract：:HER2 amplification/overexpression is a marker of poor prognosis in breast cancer. The prognostic impact of HER2 positivity is lower in node-negative compared with node-positive women. The only significant, independent prognostic factors in breast cancer are node status, HER2 status and menopausal status. HER2-positive...

journal_title：Oncology

authors： Ménard S,Fortis S,Castiglioni F,Agresti R,Balsari A

更新日期：2001-01-01 00:00:00

abstract：:A comparison of bone scintigrams and roentgenographic skeletal surveys, obtained on 170 patients with breast carcinoma, was made to evaluate the diagnostic efficacy of these techniques in detecting metastatic bone lesions. The bone scans were abnormal in 81 patients, while the roentgenograms were abnormal in only 51. ...

journal_title：Oncology

authors： Joo KG,Parthasarathy KL,Bakshi SP,Rosner D

更新日期：1979-01-01 00:00:00

abstract：:During the period 1965-1980, 84 patients with Wilms' tumor, neuroblastoma and Ewing's sarcoma were treated at the University of Rochester Medical Center. All patients were evaluated for the presence of congenital abnormalities. Ten of 34 (29%) patients with Wilms' tumor, 3 of 32 (9%) patients with neuroblastoma, and 0...

journal_title：Oncology

authors： Nakissa N,Constine LS,Rubin P,Strohl R

更新日期：1985-01-01 00:00:00

abstract：:We studied the chemo-radiotherapy of testicular tumors in clinical stage III. Our study involved 54 patients with lung metastases of seminoma and nonseminoma, treated with a combination of radiotherapy and chemotherapy. The results obtained have not satisfied our expectations. While in the 16 seminoma patients only 43...

journal_title：Oncology

authors： Mechl Z,Malír A

更新日期：1980-01-01 00:00:00

abstract：:Twenty-five patients with cutaneous melanoma were imaged with F(ab')2 fragments of antimelanoma monoclonal antibody (MoAb) 225.28S labeled with 99mTc and 131I or 111In. Out of 16 patients without evidence of metastatic lesions, 6 false-positive cases were observed. Only 4 out of 9 patients with known lesions showed po...

journal_title：Oncology

authors： Repetto L,Scopinaro G,Michelotti A,Claudiani F,Fusco V,Grimaldi A,Sertoli MR,Rosso R

更新日期：1988-01-01 00:00:00

abstract：:Information technology (IT) can enhance or change many scenarios in cancer research for the better. In this paper, we introduce several examples, starting with clinical data reuse and collaboration including data sharing in research networks. Key challenges are semantic interoperability and data access (including data...

journal_title：Oncology

authors： Ahlbrandt J,Lablans M,Glocker K,Stahl-Toyota S,Maier-Hein K,Maier-Hein L,Ückert F

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:Superficially spreading early gastric cancer is characterized by wide horizontal extension without deep vertical invasion. This study aimed to clarify the clinicopathological characteristics and prognosis of this rare disease. METHODS:We defined superficially spreading early gastric cancer as any tumor inva...

journal_title：Oncology

authors： Kunisaki C,Akiyama H,Nomura M,Matsuda G,Otsuka Y,Ono H,Shimada H

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:It is unclear for whom new anti-human epidermal growth factor receptor 2 (anti-HER2) agents, such as pertuzumab and T-DM1, should be considered. We investigated prognostic factors before neoadjuvant chemotherapy (NAC) among HER2-positive invasive breast cancer patients and those after NAC among patients who ...

journal_title：Oncology

authors： Fujita N,Enomoto Y,Inakami K,Yanagisawa T,Iguchi C,Aono T,Nomura T,Yamamoto H,Kasugai T,Shiba E

更新日期：2020-01-01 00:00:00

abstract：:The cytochrome P450 CYP2D6 is a polymorphic drug-metabolizing enzyme that is involved in the metabolism of several drugs and xenobiotics. Several independent studies indicate that the CYP2D6 metabolic status is a secondary factor in the risk of developing lung cancer, with individuals with high activity being at incre...

journal_title：Oncology

authors： Agúndez JA,Gallardo L,Ledesma MC,Lozano L,Rodriguez-Lescure A,Pontes JC,Iglesias-Moreno MC,Poch J,Ladero JM,Benítez J

更新日期：2001-01-01 00:00:00

abstract：:Oral cancer is the eleventh most common cancer globally, with well-established major risk factors of tobacco, areca nut, alcohol, and high-risk human papillomavirus (HR-HPV) types 16 and 18. HR-HPV16/18 are the etiologic agents of cervical cancers and a proportion of oropharyngeal cancers. HPV-associated oropharyngeal...

journal_title：Oncology

authors： Yete S,D'Souza W,Saranath D

更新日期：2018-01-01 00:00:00

abstract：:The effects of mesna (sodium 2-mercaptoethane-sulfonate) on the frequency of sister chromatid exchange (SCE) and chromosomal aberrations were studied in PHA-stimulated lymphocytes in vitro. Our data give no evidence for either an increase of SCE or chromosomal aberrations and, thus, do not suggest a mutagenic or cance...

journal_title：Oncology

authors： Becher R,Kakati S,Gibas Z,Sandberg AA

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:Ovarian cancer is the most lethal gynecological malignancy, but information relevant to prognosis and outcomes remain unknown. Here, we used statistical methods to focus specifically on interactions between candidate prognostic variables. METHODS AND RESULTS:Univariate, multivariate, and elastic net modeling...

journal_title：Oncology

authors： Jatoi A,Vierkant RA,Hawthorne KM,Block MS,Ramus SJ,Larson NB,Fridley BL,Goode EL

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:In most guidelines, no other interventional therapy but liver transplantation is recommended for the treatment of hepatocellular carcinoma (HCC) with Child-Pugh C cirrhosis (CP-C). However, in Japan, patients were sometimes treated with expectation of benefit. SUMMARY:A workshop was conducted to explore the...

journal_title：Oncology

authors： Nouso K,Kokudo N,Tanaka M,Kuromatsu R,Nishikawa H,Toyoda H,Oishi N,Kuwaki K,Kusanaga M,Sakaguchi T,Morise Z,Kitai S,Kudo M

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:This study was performed to investigate the activity and safety of high dose 5-fluorouracil (5-FU) given as a weekly 24-hour infusion in combination with folinic acid plus mitomycin C in patients with advanced gastric cancer. PATIENTS AND METHODS:Chemonaive patients with locally advanced inoperable, recurrent ...

journal_title：Oncology

authors： Kretzschmar A,Reichardt P,Thuss-Patience PC,Hohenberger P,Benter T,Dörken B,Köhne CH

更新日期：2000-06-01 00:00:00

abstract：AIMS:We investigated the relationship between serum leptin concentrations and polymorphism of the leptin receptor gene and breast cancer. METHODS:Serum leptin concentrations were measured by enzyme-linked immunosorbent assay in 47 women with invasive breast cancer compared with 41 age-matched controls without cancer. ...

journal_title：Oncology

authors： Liu CL,Chang YC,Cheng SP,Chern SR,Yang TL,Lee JJ,Guo IC,Chen CP

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:The phosphatidylinositol 3-kinase (PI3K) pathway plays a critical role in ovarian cancer cell survival and proliferation. The aim of this study was to determine whether the suppression of the PI3K catalytic subunit p110alphainhibits the growth of ovarian cancer cells in vitro and in vivo. METHODS:The short h...

journal_title：Oncology

authors： Zhang X,Deng HX,Zhao X,Su D,Chen XC,Chen LJ,Wei YQ,Zhong Q,Li ZY,He X,Yi T

更新日期：2009-01-01 00:00:00

abstract：:A unique case of multiple keratoacanthomas is described, with involvement of the face and lower extremities with persistent lesions clinically and histologically diagnostic of keratoacanthomas. The lower extremity lesions appear as giant keratoacanthomas, with evolution into a distinctive confluent plaque. This import...

journal_title：Oncology

authors： Schwartz RA

更新日期：1979-01-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy and safety of neoadjuvant treatment comprising weekly high-dose 5-fluorouracil (5-FU) as a 24-hour infusion, folinic acid (FA) and biweekly oxaliplatin (L-OHP), followed by metastatic resection in patients with primarily resectable liver metastases of colorectal cancer (CRC). PATIENTS ...

journal_title：Oncology

authors： Wein A,Riedel C,Brückl W,Merkel S,Ott R,Hanke B,Baum U,Fuchs F,Günther K,Reck T,Papadopoulos T,Hahn EG,Hohenberger W

更新日期：2003-01-01 00:00:00

abstract：:The authors have reviewed the medical records of 421 sessions of hyperthermia treatments in 73 patients treated between 1987 and 1992 at the University Heights Cancer Center and the Indiana University Medical Center in Indianapolis, Ind. Temperatures attained during the course of therapy on each patient have been aver...

journal_title：Oncology

authors： Shidnia H,Hornback N,Ford G,Shen RN

更新日期：1993-09-01 00:00:00

abstract：:The best treatment for primary gastric lymphomas (PGL) has not yet been defined. Eighty-three patients with stage I/II PGL are documented, focusing on prognostic factors, treatment-related morbidity and mortality, and therapeutic outcome. Chemotherapy improved survival in comparison to local treatments, i.e. gastrecto...

journal_title：Oncology

authors： Ferreri AJ,Cordio S,Paro S,Ponzoni M,Freschi M,Veglia F,Villa E

更新日期：1999-01-01 00:00:00