Abstract:
:A cultured cell line (SHIN-3) derived from a human ovarian serous cystadenocarcinoma which consistently produces two tumor markers, CA-125 and tissue polypeptide antigen (TPA) was established. After 1 week of culture of 1 x 10(5) cells, high levels of tumor marker were observed (the total CA-125 release was 1,500 U and the total TPA release was 37.5 U). Expression of CA-125 and TPA was also demonstrated in cultured cells immunohistochemically. The volume of CA-125 release per cell was highest just before the start of the logarithmic growth phase. TPA production was increased in the logarithmic growth phase, but its relationship to the total number of cells was not clear.
journal_name
Oncologyjournal_title
Oncologyauthors
Imai S,Kiyozuka Y,Maeda H,Noda T,Hosick HLdoi
10.1159/000226813subject
Has Abstractpub_date
1990-01-01 00:00:00pages
177-84issue
2eissn
0030-2414issn
1423-0232journal_volume
47pub_type
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