Cells from normal and malignant human colon mucosa differentially inhibit embryonic cell aggregation.

Abstract:

:A model system for studying some aspects of the interaction of cancer cells in tumors and their surrounding nonmalignant tissue is the co-culture of cancer cells and embryonic chick neural retinal cells in gyratory shakers. Neural retina cell aggregation, under these conditions, has been shown to be differentially inhibited by small numbers of cultured mouse and human cancer cells. We extend here these observations to co-cultures of retinal cells with small numbers (60:1 ratio) of human cells isolated from normal colon mucosa or colonic adenocarcinoma tissue. The cells from the malignant tissue samples inhibited aggregation to a significantly greater extent than the cells from normal mucosa, even when both were from the same individual. Cells derived from nonmalignant tumors were more inhibitory than those from normal individuals, which is consistent with described differences in this 'transitional' region. Thus, the aggregation inhibition assay appears applicable to freshly isolated human tissues.

journal_name

Oncology

journal_title

Oncology

authors

Maslow DE,Mayhew E,Mittleman A

doi

10.1159/000225573

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

292-4

issue

5

eissn

0030-2414

issn

1423-0232

journal_volume

38

pub_type

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