Abstract:
:Lymphomas, which are frequently subdivided into Hodgkin's disease and non-Hodgkin's lymphoma, represent one of the more curable cancers that present as a solid tumor. Unfortunately, most patients cannot be cured with conventional chemotherapy, therefore new techniques have been developed including high-dose chemotherapy and autotransplantation. Non-Hodgkin's lymphoma was one of the first illnesses to be tested using the new methods and initial encouraging results in relapsed lymphoma led to the testing of high-dose chemotherapy with autotransplantation as a primary therapy for patients with lymphomas. Encouraging results have been obtained in several randomized trials. Studies of the treatment of lymphoma have identified several principles related to the application of autotransplantation, which may be relevant to other solid tumors. Autotransplantation is likely to be of benefit only when using active chemotherapeutic agents that can be escalated in dose and when myelosuppression is the dose-limiting toxicity. Chemotherapy-responsive tumors are obvious targets for autotransplantation, whereas chemotherapy-resistant tumors are unlikely to benefit. Other factors that should be taken into account when selecting patients for high-dose chemotherapy regimens include the extent of disease, preceding therapy and the performance status of the patient.
journal_name
Oncologyjournal_title
Oncologyauthors
Armitage JOdoi
10.1159/000012100subject
Has Abstractpub_date
2000-04-01 00:00:00pages
198-206issue
3eissn
0030-2414issn
1423-0232pii
12100journal_volume
58pub_type
杂志文章,评审相关文献
ONCOLOGY文献大全abstract:OBJECTIVE:To compare chemotherapy-related and total medical costs among patients with colorectal cancer (CRC) receiving capecitabine or 5-fluorouracil (5-FU) monotherapy after surgical resection. METHODS:This retrospective, claim-based study utilized the Thomson Reuters Market Scan(R) databases to identify 1,396 CRC p...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000236048
更新日期:2009-01-01 00:00:00
abstract::In patients affected with different tumours, disorders concerning clotting are frequently observed. The biological processes leading to coagulation are probably involved in the mechanisms of metastasis. We studied plasma levels of thrombin-antithrombin III complexes (TAT) in 90 patients affected with lung tumours subg...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227620
更新日期:1996-11-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate the antitumor, survival, and adverse effects of hepatic arterial infusion chemotherapy using epirubicin in patients with advanced hepatocellular carcinoma and portal vein tumor thrombosis. METHODS:The study population comprised 45 consecutive patients with advanced...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000112805
更新日期:2007-01-01 00:00:00
abstract::To establish appropriate indications for endoscopic treatment of submucosal invasive gastric carcinoma, we investigated clinicopathologic features and proliferating cell nuclear antigen (PCNA) expression at the deepest invasive portion of 192 differentiated submucosal invasive gastric carcinomas that had been surgical...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227486
更新日期:1995-07-01 00:00:00
abstract:BACKGROUND:There has been no clinically useful diagnostic or prognostic biomarker for renal cell carcinoma (RCC). Serum γ-glutamyltransferase (GGT) activity has been reported to be a prognostic marker for several types of cancer including RCC. Exosomes or small extracellular vesicles present in body fluids have potenti...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000508688
更新日期:2020-01-01 00:00:00
abstract::ACNU was highly effective for Sato lung carcinoma transplanted intravenously or intramuscularly by using a large single dose, and the cytotoxic action of ACNU for SLC showed clear dependence upon tumor size. Nonspecific activation of host-defence mechanism by Propionibacterium acnes contributed to the suppression for ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225309
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVES:A phase II study was performed to investigate the safety and efficacy of concurrent chemoradiotherapy (CCRT) combined with an orally active fluoropyrimidine, S-1, plus cisplatin for locally advanced esophageal cancer (LAEC). METHODS:CCRT comprised 2 courses, a 30-Gy radiotherapy over 3 weeks plus daily oral...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000348383
更新日期:2013-01-01 00:00:00
abstract::In this study an attempt is made to propose a working clinical classification and staging of adult non-Hodgkin's lymphoma (NHL) which brings out both primary site and extent of disease. Unlike childhood NHL, where histopathology is uniformly of unfavourable type, this clinical staging system seems to have a prognostic...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226843
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:Anti-p53 levels detected by different methods were compared in a predefined group of patients with breast cancer and correlated with p53 antigen expression in the corresponding tumors. METHODS:P53 autoantibodies were investigated in 165 patients with primary breast cancer using ELISAs with recombinant or nat...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000065472
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:Tyrosine kinase B (TrkB) is associated with aggressive behavior and poor prognosis in various cancers. Here we examined the association between TrkB expression and distant metastases/prognosis in gastric carcinoma (GC). PATIENTS AND METHODS:We analyzed TrkB expression in 161 GC patients by immunohistochemist...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000151615
更新日期:2008-01-01 00:00:00
abstract::We started a treatment trial for malignant pericardial tamponade with intracavitary oxytetracycline, 500-1,000 mg/day, administered via an indwelling pericardial cannula after extraction of as much pericardial fluid as possible. This procedure was repeated every 24 h for 6 consecutive days or until no more fluid could...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227098
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:The current study aimed to compare the therapeutic outcomes of surgery with those of chemoradiation for patients with advanced oropharyngeal cancer (OPC). METHODS:The data for 523 patients with previously untreated OPC were obtained from 12 institutions belonging to the Head and Neck Cancer Study Group in th...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000346908
更新日期:2013-01-01 00:00:00
abstract::72 patients with advanced malignant lymphoma resistant to standard chemotherapy were treated with 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea (CCNU) at 130 mg/m2 orally every six weeks. Objective responses were noted in 13 of 39 evaluable patients with Hodgkin's disease, three of 15 patients with lymphocytic lymphoma...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225162
更新日期:1976-01-01 00:00:00
abstract::Methyl-CCNU (NSC-95441) was administered to patients with malignant melanoma in a split dose schedule. Nausea and vomiting were eliminated as clinical problems during therapy. Response rate to the drug seemed somewhat lower than the average of three previously reported disease-oriented phase II trials, though the diff...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225178
更新日期:1977-01-01 00:00:00
abstract:OBJECTIVE:Uveal melanoma primarily metastasizes hematogenously with metastases often confined to the liver. The aim of this study was to investigate the presence of circulating tumor cells (CTC) in patients with metastatic disease as a marker for systemic disease and to determine their prognostic relevance. METHODS:Bl...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000328283
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:Transarterial chemoembolization (TACE) is recommended as a first-line therapy for hepatocellular carcinoma (HCC) patients ineligible for curative therapy and without portal invasion. The Assessment for Retreatment with TACE (ART) scoring system was recently proposed for identifying patients who would not show...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000440625
更新日期:2015-01-01 00:00:00
abstract::A loss of heterozygosity (LOH) at the DCC gene locus was detected in colorectal tumors, and this LOH might be related to metastasis. The aim of this study was to determine DCC protein expression in colorectal cancer and to evaluate its prognostic value. Allelic loss of the DCC locus was observed in 16 of the 23 patien...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011954
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:Clear cell renal cell carcinoma (CCRCC) is a malignant neoplasm frequently associated with an increase in circulating immune complexes (CIC). Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is a disease involving the chorioretinal structures of the eye, and it is commonly observe...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000079505
更新日期:2004-01-01 00:00:00
abstract::Further biochemical characterization of the Albert hepatoma has been performed. The following results were obtained: In spite of often repeated transplantations and a medium growth rate, the Albert hepatoma does still contain organ-characteristic enzymes. We have found significant activities of glucokinase, glucose-6-...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225357
更新日期:1979-01-01 00:00:00
abstract::The effects of the gamma-amino-n-butyric acid (GABA)A receptor agonist muscimol, and the GABAB receptor agonist baclofen, on colon carcinogenesis induced by azoxymethane in Wistar rats were tested. Administration of either muscimol or baclofen had no influence on the incidence of colon tumors at week 30. However, almo...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227048
更新日期:1992-01-01 00:00:00
abstract::Sixteen patients with histologically confirmed inoperable hepatocellular carcinoma were treated with vindesine 3 mg/m2 i.v. weekly. Anemia, leukopenia and neuritis were documented but no severe or life-threatening toxicity was seen. There were no objective responses among the 14 evaluable patients. Eight had a no chan...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227434
更新日期:1995-01-01 00:00:00
abstract::This is a case report of hyperpyrexia, shock and death following initial injection of low-dose bleomycin (7.5 units) for a poorly differentiated metastatic carcinoma. Premedication with high-dose dexamethasone and acetaminophen did not abort the reaction. A review of the literature uncovered one nearly fatal reaction ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225462
更新日期:1980-01-01 00:00:00
abstract::The encouraging results that have been reported for cisplatin combination chemotherapy in a minority of patients with cancer of unknown primary (CUP) together with the previously shown equal activity of carboplatin in this setting, prompted us to investigate the effectiveness of a carboplatin-containing regimen in a p...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000011890
更新日期:1998-09-01 00:00:00
abstract::Persistent infection with hepatitis C virus (HCV) is a major risk toward development of hepatocellular carcinoma. A number of transgenic mouse lines carrying the cDNA of HCV genome have been established and evaluated in the study of HCV pathogenesis. Among those, the studies using transgenic mouse lines that carry the...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000315226
更新日期:2010-07-01 00:00:00
abstract:INTRODUCTION:Breast cancer is one of the leading causes of death worldwide and is the result of dysregulation of various signaling pathways in mammary epithelial cells. The mortality rate in patients suffering from breast cancer is high because the tumor cells have a prominent invasive capacity towards the surrounding ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000501802
更新日期:2019-01-01 00:00:00
abstract::A comparison of bone scintigrams and roentgenographic skeletal surveys, obtained on 170 patients with breast carcinoma, was made to evaluate the diagnostic efficacy of these techniques in detecting metastatic bone lesions. The bone scans were abnormal in 81 patients, while the roentgenograms were abnormal in only 51. ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225325
更新日期:1979-01-01 00:00:00
abstract::Reported frequencies for microsatellite instability (MSI) in oesophageal cancer differ widely in the literature, perhaps due to the high incidence of loss of heterozygosity (LOH) in this cancer. Using high-resolution fluorescent microsatellite analysis (HRFMA), we analysed microsatellite alterations in detail in 50 Ja...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000081002
更新日期:2004-01-01 00:00:00
abstract::In a registry of 24,105 cancers, 15 patients were found to have three primary cancers in different organs. Decreasing time intervals between sequential diagnoses and then death were noted. Occurrence and sequence of cancer sites appeared to be random. Stage of second and third cancers tended, on the average, to be mor...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225051
更新日期:1975-01-01 00:00:00
abstract::The purpose of the present study was to determine with two-dimensional electrophoresis whether two sublines (high and low metastatic potential to lymph nodes) of rat fibrosarcoma induced by methylcholanthrene have differences in cellular proteins. The high metastatic potential subline had a specific protein in the pro...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227028
更新日期:1992-01-01 00:00:00
abstract::Thirty-five patients with metastatic breast cancer who had received one or two prior chemotherapeutic regimens were treated with elliptinium acetate at a dose of 80 mg/m2 for 3 days every 3 weeks. Of the 33 patients evaluable for response, 1 patient achieved complete remission, 4 achieved partial responses (15% overal...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226797
更新日期:1990-01-01 00:00:00