Abstract:
:The effects of the gamma-amino-n-butyric acid (GABA)A receptor agonist muscimol, and the GABAB receptor agonist baclofen, on colon carcinogenesis induced by azoxymethane in Wistar rats were tested. Administration of either muscimol or baclofen had no influence on the incidence of colon tumors at week 30. However, almost all the colon tumors that developed in rats treated with baclofen were adenomas, whereas in the control group the tumors were mainly adenocarcinomas. In contrast, administration of muscimol did not affect the histological types of the colon tumors. These findings indicate that baclofen inhibits the growth of colon tumors via the GABAB receptor.
journal_name
Oncologyjournal_title
Oncologyauthors
Tatsuta M,Iishi H,Baba M,Taniguchi Hdoi
10.1159/000227048subject
Has Abstractpub_date
1992-01-01 00:00:00pages
241-5issue
3eissn
0030-2414issn
1423-0232journal_volume
49pub_type
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