Abstract:
:The activities of established and experimental antitumor drugs were tested against the BRO and MeWo human melanomas transplanted in the subrenal capsule of phenotypically immunocompetent (CBA x C57BL/6)F1 mice. Immunosuppression was achieved with preliminary whole-body radiation, and cytological examination showed that the tumors of untreated mice consisted largely of viable tumor cells. Several drugs tested showed moderate activity against one or both tumors. The system described provides a basis for testing anticancer agents against a panel of human melanomas implanted in immunocompetent mice.
journal_name
Oncologyjournal_title
Oncologyauthors
Ryabkova VI,Lockshin A,Strukov IG,Sokolova VKdoi
10.1159/000227400subject
Has Abstractpub_date
1994-11-01 00:00:00pages
540-3issue
6eissn
0030-2414issn
1423-0232journal_volume
51pub_type
杂志文章相关文献
ONCOLOGY文献大全abstract::We started a treatment trial for malignant pericardial tamponade with intracavitary oxytetracycline, 500-1,000 mg/day, administered via an indwelling pericardial cannula after extraction of as much pericardial fluid as possible. This procedure was repeated every 24 h for 6 consecutive days or until no more fluid could...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227098
更新日期:1992-01-01 00:00:00
abstract::We examined the expression of p16, the CDKN2A gene product, in EBV-associated gastric carcinomas (EBV-GCs). EBV-GCs were identified by detecting EBV-encoded small RNA (EBER) using an in situ hybridization assay of paraffin-embedded tissue. Two non-EBV-GC cases for each EBV-GC case were selected, matched for age, sex, ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000080290
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy and safety of neoadjuvant treatment comprising weekly high-dose 5-fluorouracil (5-FU) as a 24-hour infusion, folinic acid (FA) and biweekly oxaliplatin (L-OHP), followed by metastatic resection in patients with primarily resectable liver metastases of colorectal cancer (CRC). PATIENTS ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000067772
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:To compare chemotherapy-related and total medical costs among patients with colorectal cancer (CRC) receiving capecitabine or 5-fluorouracil (5-FU) monotherapy after surgical resection. METHODS:This retrospective, claim-based study utilized the Thomson Reuters Market Scan(R) databases to identify 1,396 CRC p...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000236048
更新日期:2009-01-01 00:00:00
abstract::The present communication reports data on the lipid biosynthesis of Ehrlich ascites tumor cells grown in culture media supplemented with modified sera. Whereas the metabolisms of [14C]pyruvate and [14C]mevalonate are identical in all media tested, the incorporation of [14C] acetate is higher in medium with dialyzed se...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225321
更新日期:1979-01-01 00:00:00
abstract::The best treatment for primary gastric lymphomas (PGL) has not yet been defined. Eighty-three patients with stage I/II PGL are documented, focusing on prognostic factors, treatment-related morbidity and mortality, and therapeutic outcome. Chemotherapy improved survival in comparison to local treatments, i.e. gastrecto...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011978
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:We retrospectively investigated the treatment outcomes of second-line treatment with pazopanib or gemcitabine/docetaxel in patients with advanced soft tissue sarcoma (STS). METHODS:Ninety-one patients who were treated with pazopanib or gemcitabine/docetaxel for advanced STS between 1995 and 2015 were analyz...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000492597
更新日期:2019-01-01 00:00:00
abstract::C-reactive protein (CRP) has been found to be ubiquitous in sera when determined by a highly sensitive methods such as radioimmunoassay. Patients with some tumors appear to have much higher serum levels of CRP than others; in these, CRP seems to reflect the tumor burden. There is a positive correlation with TNM stagin...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225572
更新日期:1981-01-01 00:00:00
abstract:OBJECTIVE:It was the aim of our study to evaluate the efficacy and safety of weekly topotecan in patients with advanced or recurrent cervical disease. METHODS:Topotecan was administered intravenously as a weekly infusion at a dose of 3.5 mg/m(2) on days 1, 8 and 15 of a 28-day cycle. After the second cycle, the dose w...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000330537
更新日期:2011-01-01 00:00:00
abstract::High-dose megestrol acetate (800 mg/day) was administered to 34 patients as third-line endocrine therapy for metastatic breast cancer after progression on standard-dose megestrol acetate (160 mg/day). Among the 32 evaluable patients, no complete or partial response occurred. Ten patients remained stable and 22 progres...
journal_title:Oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000227119
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision surgery is a standard treatment for locally advanced rectal cancer (LARC). Tumor-infiltrating lymphocytes (TILs) have been reported to be associated with tumor response; however, this remains to be established. We previously reported ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000508922
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:In order to broaden the possibility for anti-MAGE-3 immune targeting, it is important to identify HLA-A24-restricted epitopes derived from MAGE-3, since HLA-A24 is one of the most common alleles in Japanese and Asian people. In the present study, we defined a new MAGE-3 derived, HLA-A24-binding peptide presente...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000091185
更新日期:2006-01-01 00:00:00
abstract::Adenocarcinoma of the stomach remains a significant cause of mortality worldwide. The majority of patients present with stage III or IV disease, negating surgery as a curative option. Numerous drugs have been tested over the past 2 decades in single-agent and combination chemotherapy trials. Given by intravenous bolus...
journal_title:Oncology
pub_type: 临床试验,杂志文章,评审
doi:10.1159/000227249
更新日期:1993-04-01 00:00:00
abstract::An antiserum to human melanoma antigens was obtained from a melanoma patient after immunization with autologous irradiated cultured melanoma cells and bacillus Calmette-Guerin. Using the microcomplement fixation assay, the antiserum, at a titer of 1/1,800, was noted to bind strongly with 7 of 10 allogeneic cultured hu...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225702
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVE:An increasing number of patients with advanced pancreatic or biliary tract cancer who progress after a gemcitabine-containing regimen are candidates for further chemotherapy. We therefore evaluated a fully oral regimen of capecitabine and celecoxib (CapCel) as second-line treatment in these patients. METHODS...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000205388
更新日期:2009-01-01 00:00:00
abstract::The expression of cyclin-dependent kinase 1 (cdc2), cyclin A and cyclin B1 was immunohistochemically studied in 101 hepatocellular carcinomas (HCC). cdc2 overexpression was directly related to advanced stage, portal invasion, intrahepatic metastasis, poor differentiation, high alpha-fetoprotein level, large size, high...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000012140
更新日期:2000-06-01 00:00:00
abstract::A cost-effectiveness analysis is one form of full economic evaluation where drug acquisition costs and the costs that are incurred as a result of using a particular treatment are assessed together with clinical efficacy. This paper reviews two such studies. One of the studies was a prospective randomised cost-effectiv...
journal_title:Oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000227175
更新日期:1993-05-01 00:00:00
abstract::In 323 of 1,620 patients with gastric cancer, the lesion was > or = 10 cm in maximum diameter. Studies were done with respect to clinicopathologic features and the prognosis. Patients with tumors > or = 10 cm were younger and women patients were more numerous compared to those with tumors < 10 cm. Tumors were more adv...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227424
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:To report the outcomes of surgical resection of borderline resectable (BL) and locally advanced (LA) 'unresectable' pancreatic cancer after neoadjuvant chemotherapy. METHODS:A review of a prospectively maintained database for pancreatic resections was undertaken to identify patients undergoing resection for ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000371745
更新日期:2015-01-01 00:00:00
abstract::The Abelson-virus-induced murine lymphosarcoma cell line RAW117-P and its in vivo selected highly malignant and metastatic variant RAW117-H10 have been studied for their growth in vivo, in vitro and in semi-solid agar. The highly malignant metastatic variant RAW117-H10 cells killed syngeneic Balb/c mice rapidly and fo...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226473
更新日期:1987-01-01 00:00:00
abstract::The priming action of estradiol and the antiestrogen tamoxifen (TMX) on progesterone receptor (PgR) synthesis has been investigated in the 7,12-dimethylbenz(a)anthracene-induced rat mammary tumor model testing different priming times. Rats received either TMX or estradiol benzoate (E2B) for 3 or 7 days. Tumors were as...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226488
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate the antitumor, survival, and adverse effects of hepatic arterial infusion chemotherapy using epirubicin in patients with advanced hepatocellular carcinoma and portal vein tumor thrombosis. METHODS:The study population comprised 45 consecutive patients with advanced...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000112805
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:Anti-p53 levels detected by different methods were compared in a predefined group of patients with breast cancer and correlated with p53 antigen expression in the corresponding tumors. METHODS:P53 autoantibodies were investigated in 165 patients with primary breast cancer using ELISAs with recombinant or nat...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000065472
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:In order to determine whether infection with Helicobacter pylori might be associated with pancreatic adenocarcinoma, we performed a study to compare the H. pylori seroprevalence rate between patients with pancreatic carcinoma and matched control subjects. PATIENTS AND METHODS:Blood samples from 92 patients wit...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011830
更新日期:1998-01-01 00:00:00
abstract::We examined the effects of cycloheximide on the amount of chromatin-bound and -unbound PCNA subpopulations in HeLa cells. The chromatin-bound PCNA content decreased rapidly in the presence of cycloheximide, whereas the reduction of the total amount of PCNA was minimal even 24 h after the treatment with cycloheximide. ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227500
更新日期:1995-09-01 00:00:00
abstract::Patients with polycythemia vera (PV) experience shortened survival, increased risk of thromboembolic and hemorrhagic events, and burdensome symptoms. For all patients with PV, treatment with aspirin and hematocrit control with phlebotomy are recommended. In addition, patients with high-risk status or poor hematocrit c...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000454953
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:It was the aim of this study to report on the role of laparoscopic staging in a large series of locally advanced cervical cancer (LACC) patients and its impact on prognosis. METHODS:Consecutive patients with LACC were considered for surgical staging: gynecological examination, cystoscopy and laparoscopy with...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000351995
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:A germline BIM deletion polymorphism has been proposed to predict a poor treatment efficacy of certain kinase inhibitors. The current study aimed to explore whether the BIM deletion polymorphism predicts the treatment efficacy of sorafenib for advanced hepatocellular carcinoma (HCC). METHODS:All patients wh...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000356019
更新日期:2013-01-01 00:00:00
abstract::The purpose of this study was to evaluate in a dog model whether intrapericardial instillation of tetracycline is superior to the effect of drainage alone in causing pericardial adhesions and cavity obliteration. Twelve mongrel dogs were randomly divided into two experimental groups. All dogs received a pericardial dr...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227232
更新日期:1993-11-01 00:00:00
abstract::Developmental pathways (e.g., Notch, Hippo, Hedgehog, Wnt, and TGF-β/BMP/FGF) are networks of genes that act co-ordinately to establish the body plan, and disruptions of genes in one pathway can have effects in related pathways and may result in serious dysmorphogenesis or cancer. Interestingly, all developmental path...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000478703
更新日期:2017-01-01 00:00:00