Abstract:
:The mucinous-like carcinoma-associated antigen (MCA), a new tumour marker, was dosed in 150 serous effusions. The levels of MCA were measured by means of an enzyme immunoassay (EIA). Ninety-seven were pleural effusions, 49 were peritoneal effusions and 4 were pericardial effusions. Thirty-five effusions were caused by breast carcinoma, 19 by ovarian carcinoma, 17 by pulmonary carcinoma, 19 by various cancers, while 60 effusions turned out to be of non-neoplastic origin. The results were considered in comparison with the cytologic examination, and the data obtained were also elaborated in terms of sensitivity, specificity, predictive value and test efficiency. The EIA showed satisfactory statistical parameters principally regarding ovarian metastatic cancer. On the other hand, less satisfactory results were extrapolated on breast and lung cancers. Even if further studies are necessary, for example to compare MCA with other seric tumour markers, this experience suggests that MCA could be a satisfactory tumour marker in the diagnosis of metastatic ovarian effusions.
journal_name
Oncologyjournal_title
Oncologyauthors
Cappellari A,Bagarella M,Olivati S,Corradi Gdoi
10.1159/000227072subject
Has Abstractpub_date
1992-01-01 00:00:00pages
354-7issue
5eissn
0030-2414issn
1423-0232journal_volume
49pub_type
杂志文章相关文献
ONCOLOGY文献大全abstract:OBJECTIVE:In order to improve the prognosis of pancreatic cancer patients, it is crucial to explore novel tools for its early diagnosis. Here, we attempted to screen serum biomarkers to distinguish pancreatic cancer from non-cancer individuals. METHODS:47 serum samples from pancreatic cancer patients, 39 of whom had s...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000084824
更新日期:2005-01-01 00:00:00
abstract::The antiemetic effect of oral medium-dosed metoclopramide (MCL, 3.5 mg/kg b.w./cycle) and placebo for chemotherapy-induced emesis of a noncisplatin regimen was assessed for inpatients and outpatients in two double-blind placebo-controlled sequential analyses according to Bross (1952). MCL was given in 5 single doses o...
journal_title:Oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000227153
更新日期:1993-03-01 00:00:00
abstract:AIMS:We investigated the relationship between serum leptin concentrations and polymorphism of the leptin receptor gene and breast cancer. METHODS:Serum leptin concentrations were measured by enzyme-linked immunosorbent assay in 47 women with invasive breast cancer compared with 41 age-matched controls without cancer. ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000111097
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:Esophagogastric cancer occurs more frequently in older patients, but these are underrepresented in clinical studies establishing the current treatment standards for perioperative chemotherapy in locally advanced disease. This leads to uncertainty regarding the treatment of older patients with potentially toxi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000458531
更新日期:2017-01-01 00:00:00
abstract::Fifteen patients, median age 64 years, presenting with advanced gastrointestinal adenocarcinomas, were included in this study. The treatment combination consisted of folinic acid (200 mg/m2, IV bolus injection) followed by 5-fluorouracil (5-FU; 400 mg/m2, 30-min infusion) for 5 consecutive days and mitomycin C (10 mg/...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226620
更新日期:1988-01-01 00:00:00
abstract::An in vitro system was used to study the uptake of 5-fluorouracil by LSA ascites tumor cells. Changes in drug uptake with cell age and following a 1,000-rad radiation perturbation of the cell population were studied. DNA synthesis and drug uptake were highest during early rapid tumor growth and decreased with tumor ag...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225540
更新日期:1981-01-01 00:00:00
abstract::The effects on gastric and duodenal mucosa induced by cisplatin plus etoposide (PE) chemotherapy were investigated in 32 patients with lung cancer. They were submitted to gastroduodenoscopy before receiving cisplatin 100 mg/m2 (day 1) plus etoposide at a mean dose of 107 mg/m2 (days 1, 3 and 5). Endoscopic examination...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226958
更新日期:1991-01-01 00:00:00
abstract::Systemic chemotherapy for advanced gastric cancer is frequently associated with significant treatment-related toxicity, which is particularly serve in patients presenting with a poor general condition. A search for effective and low-toxic regimens for this group of patients is mandatory. A weekly 24-hour infusion of h...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227702
更新日期:1997-07-01 00:00:00
abstract::Abundant expression of thymidine phosphorylase (TP) mRNA and protein was observed in human carcinoma tissues relative to the corresponding normal tissues. However, the distribution of cells that express TP has not yet been determined. In this study, we examined enzyme activity of TP in 24 primary colorectal carcinoma ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000065064
更新日期:2002-01-01 00:00:00
abstract::The treatment of metastatic renal cell carcinoma (MRCC) has evolved from being predominantly cytokine-based to being grounded in the use of drugs targeting vascular endothelial growth factor, platelet-derived growth factor and mammalian target of rapamycin (mTOR) pathways. New agents including the small-molecule targe...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000258504
更新日期:2009-01-01 00:00:00
abstract::Little is known about the expression and antioxidant function of manganese superoxide dismutase (Mn-SOD) in esophageal squamous cell carcinoma. To determine the significance of Mn-SOD in esophageal squamous cell carcinomas, Mn-SOD mRNA expression was examined in 45 esophageal squamous cell carcinomas and the correspon...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000012165
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVES:The neutrophil-to-lymphocyte ratio (NLR) has been proposed as an indicator of cancer-related inflammation. The aim of our study was to examine the prognostic value of the NLR for patients with advanced gastric cancer receiving second-line chemotherapy. METHODS:The association of overall survival (OS) in sec...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000493427
更新日期:2019-01-01 00:00:00
abstract::Capecitabine is converted to 5-fluorouracil by thymidine phosphorylase, and mitomycin C is capable of upregulating the expression of thymidine phosphorylase suggesting a synergistic effect. Fifty-three patients (median age 62 years) with anthracycline- and taxane-resistant, metastatic breast cancer received mitomycin ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000096250
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Recent data suggest that capecitabine may have little efficacy in women with metastatic triple negative breast cancer (TNT). We have therefore retrospectively analysed capecitabine outcome in the TN subgroup of patients with locally advanced or metastatic breast cancer treated in our unit. PATIENTS AND METH...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000323175
更新日期:2010-01-01 00:00:00
abstract::Endoscopic ultrasound-guided pancreatic drainage (EUS-PD) was performed in a patient with unresectable pancreatic cancer who developed pancreatitis. In this case, EUS-PD was useful as salvage therapy for pancreatitis as the transpapillary approach was difficult. ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000481238
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:Primary chemoradiotherapy for locally advanced pancreatic cancer (LAPC) may improve local control, curative resection rate and long-term survival. We performed a phase II study to evaluate toxicity and activity of primary radiation therapy and concurrent chemotherapy with gemcitabine (GEM) twice weekly in pa...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000086993
更新日期:2005-01-01 00:00:00
abstract::The mode of growth of tumour cells from primary breast carcinoma in the axillary nodes is shown to be related to the oestrogen receptor (ER) status of the primary tumour. ER-positive primaries are described as tending to show sinophilic growth, the tumour cells spreading along the nodal sinuses; while the ER-negative ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225735
更新日期:1983-01-01 00:00:00
abstract::Twenty-seven patients with advanced measurable colorectal carcinoma were treated with a combination protocol consisting of folinic acid (FA) 200 mg/m2 i.v. bolus followed by 5-fluorouracil (5-FU) 550 mg/m2, and cisplatin (CIS) 20 mg/m2 each administered as a 2-hour i.v. infusion. Treatment was given on 4 consecutive d...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226719
更新日期:1989-01-01 00:00:00
abstract::The expression of pro-gastrin-releasing peptide (proGRP) in medullary thyroid carcinoma (MTC) and other histological types of thyroid carcinoma was studied by an immunohistochemical technique, using polyclonal anti-proGRP antiserum. Immunoreactivity for proGRP was detected exclusively in MTC (n = 7); other histologica...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000012148
更新日期:2000-08-01 00:00:00
abstract::The local immunologic phenomena in the thyroid gland of 16 patients with chronic lymphocytic thyroiditis (CLTH) were investigated; 5 of these cases were associated with thyroid non-Hodgkin's lymphomas (NHL). All patients were admitted because of struma, growing slowly in patients with CLTH alone and rapidly in those w...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226897
更新日期:1991-01-01 00:00:00
abstract::Three polycyclic hydrocarbons: benzo(a)pyrene; dibenz(a,h)-anthracene and dibenz(a,c)anthracene, differing in their carcinogenicity, were administered to female rats. The comparative intracellular localization of these compounds was studied by fluorescence microscopy. The two carcinogenic molecules were localized both...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225395
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Neoadjuvant chemotherapy (NAC) has become prevalent in esophageal squamous cell carcinoma (ESCC), but its long-term prognostic advantages remain unclear. The latest prognostic outcomes in clinical Stage (cStage) II/III ESCC with NAC were herein elucidated. PATIENTS AND METHODS:NAC prior to curative treatmen...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000455128
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:The herpes simplex virus thymidine kinase (HSVtk)/ganciclovir suicide gene therapy system has been considered as one of the most promising therapeutic strategies for malignant gliomas. We have been using HSVtk gene-transduced neural stem cells (NSCtk) that possess an ability to migrate toward a tumor mass for...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000091032
更新日期:2005-01-01 00:00:00
abstract::A transplantable transitional cell murine bladder tumor induced by N-[4-(5-nitro-2-furyl)-thiazolyl] formamide (FANFT) was characterized by tumor growth, survival time and response to chemotherapy drugs, cis-dichloro-trans-dihydroxy-bis-iso-propylamine platinum IV (CHIP), cis- diaminedichloro platinum II (DDP), cyclop...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225822
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVES:Surgery has traditionally been the treatment of choice for patients with potentially resectable esophageal carcinoma. Recently, however, definitive chemoradiotherapy (CRT) has been suggested as a preferred treatment modality. In this study, CRT results with or without surgery are compared. METHODS:A total o...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000333448
更新日期:2011-01-01 00:00:00
abstract::The purpose of this study was to evaluate in a dog model whether intrapericardial instillation of tetracycline is superior to the effect of drainage alone in causing pericardial adhesions and cavity obliteration. Twelve mongrel dogs were randomly divided into two experimental groups. All dogs received a pericardial dr...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227232
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:Cisplatin-pemetrexed combination chemotherapy is the current standard primary treatment for malignant pleural mesothelioma (MPM). It was first approved for untreated and unresectable MPM in the 2003 National Comprehensive Cancer Network (NCCN) guidelines. However, to date, standard treatments for patients wi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000510691
更新日期:2020-10-14 00:00:00
abstract::Male and female mice of strains C3H/eB and C57BL/6 were injected subcutaneously with methylcholanthrene (MCA) dissolved in olive oil; mice injected with olive oil served as controls. After intervals of from 2 to 13 weeks, experimental and control mice were injected intraperitoneally with 51Cr-labeled rat red cells (RR...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225871
更新日期:1984-01-01 00:00:00
abstract::Information technology (IT) can enhance or change many scenarios in cancer research for the better. In this paper, we introduce several examples, starting with clinical data reuse and collaboration including data sharing in research networks. Key challenges are semantic interoperability and data access (including data...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000493638
更新日期:2020-01-01 00:00:00
abstract::Although the incidence of gastric cancer has been declining in Western countries, it is still a major health problem and a leading cause of cancer mortality. Surgery is the mainstay of treatment for gastric adenocarcinoma. However, even among patients undergoing gastrectomy with curative intent, 5-year survival rates ...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000258494
更新日期:2009-01-01 00:00:00