Abstract:
:Capecitabine is converted to 5-fluorouracil by thymidine phosphorylase, and mitomycin C is capable of upregulating the expression of thymidine phosphorylase suggesting a synergistic effect. Fifty-three patients (median age 62 years) with anthracycline- and taxane-resistant, metastatic breast cancer received mitomycin C 6 mg/m(2) on day 1, and capecitabine (Xeloda) 2,000 mg/m(2)/day from day 1 to day 14 with cycles repeated every 4 weeks. Overall, 77.4% had visceral metastases and 33 were pretreated with >/=3 chemotherapy lines. A median of 6 cycles were given (range 1-19) with a complete response observed in 2 patients (3.9%), partial response in 17 (33.3%) and stable disease in 19 (37.2%). Overall response rate was 37.2% (95% CI, 24.0-50.5%), with a median duration of 10.4 months. Median time to progression was 8.1 months and median survival was 17.4 months (1- and 2-year survival rates of 60 and 28%, respectively). Toxicity was mild. The most frequent grade 3/4 events were neutropenia (5.7% of patients), diarrhea (3.8%), and deep venous thrombosis (3.8%). Capecitabine plus mitomycin C may represent an effective and manageable treatment option for advanced breast cancer patients resistant to anthracyclines and taxanes. This approach provides an alternative for pretreated patients with advanced breast cancer.
journal_name
Oncologyjournal_title
Oncologyauthors
Massacesi C,La Cesa A,Marcucci F,Pilone A,Rocchi MB,Zepponi L,Santini D,Tonini G,Burattini Ldoi
10.1159/000096250subject
Has Abstractpub_date
2006-01-01 00:00:00pages
294-300issue
4eissn
0030-2414issn
1423-0232pii
96250journal_volume
70pub_type
杂志文章相关文献
ONCOLOGY文献大全abstract::Immunoperoxidase methods permit the demonstration of a variety of antigens in routinely processed tissues. The morphological detail obtained by this procedure is comparable to orthodox haematoxylin and eosin stained sections, and so offers the diagnostic pathologist the opportunity of simultaneously identifying normal...
journal_title:Oncology
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract:OBJECTIVE:Esophagogastric cancer occurs more frequently in older patients, but these are underrepresented in clinical studies establishing the current treatment standards for perioperative chemotherapy in locally advanced disease. This leads to uncertainty regarding the treatment of older patients with potentially toxi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000458531
更新日期:2017-01-01 00:00:00
abstract::Loss of heterozygosity (LOH) on chromosomes 13q, 16q and 17p has been associated with the progression of hepatocellular carcinoma (HCC). To investigate the prognostic impact of such LOH, we examined the metastasis-free survival of curatively resected HCC cases, in whom these LOHs were analyzed. Among the 49 HCC patien...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000048260
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:Ovarian cancer is the most lethal gynecological malignancy, but information relevant to prognosis and outcomes remain unknown. Here, we used statistical methods to focus specifically on interactions between candidate prognostic variables. METHODS AND RESULTS:Univariate, multivariate, and elastic net modeling...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000442710
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Transarterial chemoembolization (TACE) is recommended as a first-line therapy for hepatocellular carcinoma (HCC) patients ineligible for curative therapy and without portal invasion. The Assessment for Retreatment with TACE (ART) scoring system was recently proposed for identifying patients who would not show...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000440625
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the use of 5-fluorouracil (5-FU), leucovorin and oxaliplatin (FOLFOX) regimens in clinical practice according to their efficacy and toxicity. METHODS:Patients who received oxaliplatin-containing regimens after curative resection for colorectal carcinoma from 10 different o...
journal_title:Oncology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1159/000336902
更新日期:2013-01-01 00:00:00
abstract::Persistent infection with hepatitis C virus (HCV) is a major risk toward development of hepatocellular carcinoma. A number of transgenic mouse lines carrying the cDNA of HCV genome have been established and evaluated in the study of HCV pathogenesis. Among those, the studies using transgenic mouse lines that carry the...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000315226
更新日期:2010-07-01 00:00:00
abstract:INTRODUCTION:Carcinoma of the biliary system is a rare tumor entity, and patients with advanced disease face a dismal prognosis. Because of the absence of standard chemotherapy for advanced biliary carcinoma, we have performed two consecutive studies to evaluate the clinical potential of 5-fluorouracil, leucovorin and ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000011961
更新日期:1999-04-01 00:00:00
abstract::Three lung tumor-associated markers (LTAM), previously identified as a Cohn Fraction IV alpha-globulin (LTAM-1), ferritin (LTAM-2) and lactoferrin (LTAM-3) were separated by a combination of ion exchange, dye-affinity and molecular sieve chromatography. They were further purified by polyacrylamide gel electrophoresis ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225542
更新日期:1981-01-01 00:00:00
abstract::This is a phase II study to evaluate the efficacy and toxicity of short-course carboplatin in advanced-stage nasopharyngeal carcinoma (NPC). Thirty-three previously untreated stage III-IV NPC patients were studied. Carboplatin was given as a rapid intravenous injection every 3 weeks. The dose of carboplatin was calcul...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227689
更新日期:1997-05-01 00:00:00
abstract::Several reports have demonstrated an adverse effect of perioperative blood transfusions on the survival of patients with various solid tumors treated surgically. We retrospectively investigated the relationship between perioperative blood transfusions and the survival of 501 patients who underwent radical subtotal gas...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227452
更新日期:1995-03-01 00:00:00
abstract::One hundred and seventy-five patients selected at random were prospectively studied. All patients were assessed at least after the first cycle of treatment by a self-report questionnaire which covered the occurrence of nausea and vomiting 24 before chemotherapy, as well as information regarding 22 clinical parameters....
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226675
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:Our aim is to assess the clinicopathological significance of E-cadherin and beta-catenin expression, as well as their association with apoptosis in gallbladder cancers. METHODS:The expression of E-cadherin and beta-catenin proteins was examined in 4 biliary tract cancer cell lines and 49 gallbladder cancer s...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000100478
更新日期:2006-01-01 00:00:00
abstract:GOALS OF WORK:There is a need for an effective and nontoxic chemotherapy for palliative indication in non-Hodgkin's lymphoma (NHL) patients who relapse after conventional or high-dose chemotherapy. The aim of this study was to investigate the feasibility and efficacy of peroral chemotherapy in the palliative treatment ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227672
更新日期:1997-03-01 00:00:00
abstract:PURPOSE:Breast cancer (BC) is the most frequent female carcinoma and the major cause of death in women aged 35--50 years. The total number of patients surviving BC and especially the morbidity rate of patients below the age of 55 years has increased significantly in the last several years. As a consequence, the number ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000055319
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:Pegylated liposomal doxorubicin (PLD) and capecitabine (CAP) have separately shown significant antitumor activity in a wide range of solid tumors. A phase I study was conducted in order to determine the maximum tolerated dose (MTD) and dose-limiting toxicities (DLTs) of their combination in patients with refr...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000090494
更新日期:2005-01-01 00:00:00
abstract::Thirty-five patients with metastatic breast cancer who had received one or two prior chemotherapeutic regimens were treated with elliptinium acetate at a dose of 80 mg/m2 for 3 days every 3 weeks. Of the 33 patients evaluable for response, 1 patient achieved complete remission, 4 achieved partial responses (15% overal...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226797
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:A novel oral agent that consists of trifluridine and tipiracil hydrochloride (TFTD) has been established as salvage-line treatment for metastatic colorectal cancer (mCRC). Adherence to TFTD is crucial to maintaining appropriate curative effects. This study sought to clarify adherence to TFTD and identify can...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000448717
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy of percutaneous cementoplasty for painful bone metastasis from hepatocellular carcinoma (HCC). METHODS:Cementoplasty was performed for 22 metastatic bone tumors in 13 patients. All patients had intractable pain and were diagnosed as metastatic bone tumor from HCC. The ostyneedle was in...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000113040
更新日期:2007-01-01 00:00:00
abstract::Aberrant glycosylation of membrane components due to specific alterations of glycosyltransferase activity is a common feature of carcinoma cells and is usually associated with invasion and metastasis. In a prospective study, the enzyme activity of the sialyltransferases ST6GAL-I and ST3GAL-III was studied in gastric c...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000072339
更新日期:2003-01-01 00:00:00
abstract::The report describes the lethal exitus of a 44-year-old woman after repeated criminal poisoning with N-nitrosodimethylamine. She died 32 months following the initial symptoms and developed a liver cirrhosis with multiple bleeding, a hemolytic syndrome and diabetes mellitus. ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225451
更新日期:1980-01-01 00:00:00
abstract::Primary fetal rat fibroblasts (FRF cells) were transfected with DNA extracted from BKV-transformed hamster kidney cells at low passage after transformation (HKBKlp cells) and at high passage after transformation (HKBKhp cells). Two transformed rat cell lines were obtained, FRF-DNA-HKBKlp cells and FRF-DNA-HKBKhp cells...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226404
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:The role of Interleukin-2 (IL-2)-based biochemotherapy (BCT) for patients with metastatic melanoma remains controversial and few data of patients treated outside a specialized trial setting are available. METHODS:Sixty-six consecutive patients treated with BCT for stage IV melanoma were analyzed retrospecti...
journal_title:Oncology
pub_type: 杂志文章,多中心研究
doi:10.1159/000120029
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The RUNX proteins are a family of transcriptional factors that have essential functions during embryogenesis and development, whereas deregulation in expression of RUNXs is often linked to tumor formation. To date, there has been no study describing the precise expression, prognostic impact and methylation s...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000135350
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:We recently demonstrated that papillary microcarcinomas with preoperatively detectable node metastasis in the lateral compartment on ultrasonography (clinically apparent metastasis) show worse postoperative relapse-free survival than those with no metastasis or metastasis that could not be detected preoperat...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000085701
更新日期:2005-01-01 00:00:00
abstract::6 cases of endodermal sinus tumor of the ovary are presented. In 4 patients pure endodermal sinus tumor was found microscopically. 1 patient had endodermal sinus tumor in one ovary and gonadoblastoma in the contralateral one. In another case endodermal sinus tumor was accompanied by an embryonal teratoma. Histological...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225338
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVE:In order to improve the prognosis of pancreatic cancer patients, it is crucial to explore novel tools for its early diagnosis. Here, we attempted to screen serum biomarkers to distinguish pancreatic cancer from non-cancer individuals. METHODS:47 serum samples from pancreatic cancer patients, 39 of whom had s...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000084824
更新日期:2005-01-01 00:00:00
abstract::To evaluate the influence of delay between first symptom and first treatment upon survival the medical records of 596 patients with breast cancer were reviewed. The following intervals were considered: less than 3 months; 3-6 months and greater than 6 months. Patients in the less than 3 months delay group had a better...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226689
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:We retrospectively investigated the treatment outcomes of second-line treatment with pazopanib or gemcitabine/docetaxel in patients with advanced soft tissue sarcoma (STS). METHODS:Ninety-one patients who were treated with pazopanib or gemcitabine/docetaxel for advanced STS between 1995 and 2015 were analyz...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000492597
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:An increasing number of patients with advanced pancreatic or biliary tract cancer who progress after a gemcitabine-containing regimen are candidates for further chemotherapy. We therefore evaluated a fully oral regimen of capecitabine and celecoxib (CapCel) as second-line treatment in these patients. METHODS...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000205388
更新日期:2009-01-01 00:00:00