Abstract:
OBJECTIVES:Superficially spreading early gastric cancer is characterized by wide horizontal extension without deep vertical invasion. This study aimed to clarify the clinicopathological characteristics and prognosis of this rare disease. METHODS:We defined superficially spreading early gastric cancer as any tumor invading the submucosal layer that measured > or =60 mm in diameter. The clinicopathological characteristics and results of surgery were compared between 60 patients with superficially spreading tumors and 621 patients with the common type (<60 mm in diameter). RESULTS:For superficially spreading cancers,significantly higher numbers of female patients, undifferentiated and scirrhous types, infiltrating growth and lymph node metastases were seen. The number of metastatic lymph nodes was greater than in the common type. There was no significant difference in the distribution of metastatic lymph nodes between the two groups. For superficially spreading tumors, wide gastrectomy with extended lymph node dissection was frequently employed. Lymph node metastasis, but not tumor diameter, was a prognostic factor in uni- and multivariate analyses. CONCLUSIONS:Although superficially spreading early gastric cancer has histologically distinct properties, gastrectomy with lymph node dissection with sufficient surgical margin could be a suitable treatment.
journal_name
Oncologyjournal_title
Oncologyauthors
Kunisaki C,Akiyama H,Nomura M,Matsuda G,Otsuka Y,Ono H,Shimada Hdoi
10.1159/000084820subject
Has Abstractpub_date
2005-01-01 00:00:00pages
52-7issue
1eissn
0030-2414issn
1423-0232pii
84820journal_volume
68pub_type
杂志文章相关文献
ONCOLOGY文献大全abstract::Thrombopoietin (TPO) is a recently discovered hematopoietic growth factor which stimulates the production and maturation of megakaryocytes. In this study, we used a modified MTT assay to examine the in vitro growth-stimulatory effects of recombinant human (rh) TPO and recombinant human stem cell factor (rhSCF) on eigh...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227600
更新日期:1996-09-01 00:00:00
abstract::Recent studies have demonstrated that nitroso chemical carcinogens activate guanylate cyclase (EC 4.6.1.2) which catalyzes the production of guanosine 3',5'-monophosphate. This nucleotide is thought to be involved in normal and abnormal cell growth. We examined the effect of 3 major classes of anticancer chemotherapeu...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225362
更新日期:1979-01-01 00:00:00
abstract::Information technology (IT) can enhance or change many scenarios in cancer research for the better. In this paper, we introduce several examples, starting with clinical data reuse and collaboration including data sharing in research networks. Key challenges are semantic interoperability and data access (including data...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000493638
更新日期:2020-01-01 00:00:00
abstract::There are numerous data on the immunostimulative and antitumorous activity of various Viscum album tissue extracts. Isorel (Novipharm, Austria) is one of these compounds. We found that in mice an increased number of plaque-forming cells to sheep red blood cells (SRBC) followed the injection of Isorel together with SRB...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227217
更新日期:1993-11-01 00:00:00
abstract::The energy status of HeLa cells arrested in the G2 phase of the cell cycle by the antineoplastic agent cis-acid was compared with that of normal G2-phase-synchronized cells. The results showed that treatment with the drug has significantly decreased the adenylate pool, adenylate energy charge and phosphorylation poten...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226444
更新日期:1987-01-01 00:00:00
abstract::One hundred and seventy-five patients selected at random were prospectively studied. All patients were assessed at least after the first cycle of treatment by a self-report questionnaire which covered the occurrence of nausea and vomiting 24 before chemotherapy, as well as information regarding 22 clinical parameters....
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226675
更新日期:1989-01-01 00:00:00
abstract::The MXT mouse transplantable mammary cancer is characterized by significant amounts of steroid hormone receptors. Moreover this model, as other solid tumors, contains diverse subpopulations of neoplastic cells. In the present study we have examined this pattern as well as the influence of exogenous physiologic doses o...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226015
更新日期:1985-01-01 00:00:00
abstract::Systemic chemotherapy for advanced gastric cancer is frequently associated with significant treatment-related toxicity, which is particularly serve in patients presenting with a poor general condition. A search for effective and low-toxic regimens for this group of patients is mandatory. A weekly 24-hour infusion of h...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227702
更新日期:1997-07-01 00:00:00
abstract::We studied the chemo-radiotherapy of testicular tumors in clinical stage III. Our study involved 54 patients with lung metastases of seminoma and nonseminoma, treated with a combination of radiotherapy and chemotherapy. The results obtained have not satisfied our expectations. While in the 16 seminoma patients only 43...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225493
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVES:Systematic investigation of a novel series of intercalating agents, 9-aza-anthrapyrazoles, has led to the identification of a promising analogue, BBR 3438. This study describes the antitumour efficacy of the novel compound in human prostate carcinoma models and the molecular/cellular basis of its activity. ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000055380
更新日期:2001-01-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) has been shown to be highly responsive to chemotherapy. The major limiting toxicity was myelotoxicity. Recently, the role of granulocyte colony-stimulating factor (G-CSF) in reducing chemotherapy-induced neutropenic sepsis has been well established. In this study, we tested whether recom...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227658
更新日期:1997-01-01 00:00:00
abstract::In order to assess the feasibility of a sequential hormonal treatment after tamoxifen failure, 24 postmenopausal advanced breast cancer patients (median age 60 years; ECOG PS < or = 1) were treated with formestane (4-hydroxyandrostenedione) 250 mg i.m. fortnightly; 19 patients were estrogen receptor-positive. The site...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227510
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:Neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision surgery is a standard treatment for locally advanced rectal cancer (LARC). Tumor-infiltrating lymphocytes (TILs) have been reported to be associated with tumor response; however, this remains to be established. We previously reported ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000508922
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Standard therapy for postoperative pain after laparoscopic colorectal surgeries at the Tan Tock Seng Hospital consists of intravenous morphine via patient-controlled analgesia (PCA) for the first 24-48 h, followed by oral analgesics. We compared the efficacy and safety of oral controlled-release (CR) oxycodo...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000143221
更新日期:2008-01-01 00:00:00
abstract::The association of MMP-2 (matrix metalloproteinase 2, 72-kD collagenase IV) with invasive and metastatic capacity of tumor cells has implicated a potential role in the prognosis for cancer patients. However, no larger study has been done to prove this hypothesis. The present study was therefore designed to investigate...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011850
更新日期:1998-03-01 00:00:00
abstract::To establish appropriate indications for endoscopic treatment of submucosal invasive gastric carcinoma, we investigated clinicopathologic features and proliferating cell nuclear antigen (PCNA) expression at the deepest invasive portion of 192 differentiated submucosal invasive gastric carcinomas that had been surgical...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227486
更新日期:1995-07-01 00:00:00
abstract::Methyl-CCNU (NSC-95441) was administered to patients with malignant melanoma in a split dose schedule. Nausea and vomiting were eliminated as clinical problems during therapy. Response rate to the drug seemed somewhat lower than the average of three previously reported disease-oriented phase II trials, though the diff...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225178
更新日期:1977-01-01 00:00:00
abstract::The effects on gastric and duodenal mucosa induced by cisplatin plus etoposide (PE) chemotherapy were investigated in 32 patients with lung cancer. They were submitted to gastroduodenoscopy before receiving cisplatin 100 mg/m2 (day 1) plus etoposide at a mean dose of 107 mg/m2 (days 1, 3 and 5). Endoscopic examination...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226958
更新日期:1991-01-01 00:00:00
abstract::The chemosensitivities of 62 human colon cancer tissues, 67 rectal cancer tissues and 31 tumor-adjacent normal mucosal tissues were determined using the in vitro succinate dehydrogenase inhibition (SDI) test. These tissues obtained at the time of surgery were exposed to carboquone (CQ), adriamycin (ADM), mitomycin C (...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226917
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:Ovarian cancer is the most lethal gynecological malignancy, but information relevant to prognosis and outcomes remain unknown. Here, we used statistical methods to focus specifically on interactions between candidate prognostic variables. METHODS AND RESULTS:Univariate, multivariate, and elastic net modeling...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000442710
更新日期:2016-01-01 00:00:00
abstract::We have measures serial carcinoembryonic antigen (CEA) titers in 92 patients, randomly selected from the patient population of a Radiotherapeutic Clinic, to correlate with clinical and follow-up evaluation. 57 out of 92 patients had positive CEA levels (2.5 ng/ml) or 62 percent of proven cancer patients. In this serie...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000224965
更新日期:1974-01-01 00:00:00
abstract::Growth-regulated oncogene-1 (GRO-1) is an autocrine growth factor in melanoma and is a member of the CXC family of chemokines which promote chemotaxis of granulocytes and endothelia through binding to CXC receptor 2. A previous article noted that GRO-1 was upregulated in oral cancer using a genome-wide microarray appr...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000078333
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:To investigate the potential benefit of intermittent chemotherapy, and to identify the eligibility criteria offering intermittent chemotherapy to patients with advanced urothelial cancer. MATERIALS AND METHODS:Twenty patients who responded or had stable disease after receiving 3 cycles of induction chemother...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000338770
更新日期:2012-01-01 00:00:00
abstract::Developmental pathways (e.g., Notch, Hippo, Hedgehog, Wnt, and TGF-β/BMP/FGF) are networks of genes that act co-ordinately to establish the body plan, and disruptions of genes in one pathway can have effects in related pathways and may result in serious dysmorphogenesis or cancer. Interestingly, all developmental path...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000478703
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:This phase I study (EudraCT No. 2006-001177-25) investigated aflibercept, a vascular endothelial growth factor decoy receptor protein (VEGF Trap), in combination with docetaxel, cisplatin, and 5-fluorouracil in patients with advanced solid tumors. PATIENTS AND METHODS:Patients received 2, 4, or 6 mg/kg of intr...
journal_title:Oncology
pub_type: 杂志文章,多中心研究
doi:10.1159/000440958
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:This pharmacokinetic study of S-1 was conducted in patients in whom glomerular filtration rate (GFR) was directly measured to explore the possibility of adjusting the S-1 dose on the basis of GFR in patients with normal or nearly normal renal function. METHODS:S-1 was given to 12 patients twice daily for 28 ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000337232
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Clinical significance of immunohistochemically detectable level of p53 protein has been reported, but with some limitation as a prognosticator of bladder cancer patients. Whether or not simultaneous evaluation of mdm2 and p53 expression in bladder cancer exceed the prognostic significance of conventional his...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011971
更新日期:1999-04-01 00:00:00
abstract::Fourteen patients with disseminated breast cancer with primary or secondary resistance to tamoxifen were treated with LY156758. There were no complete or partial responses and 1 patient showed a minor response. These data illustrate that LY156758 did not have significant antitumor activity in patients previously treat...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226637
更新日期:1988-01-01 00:00:00
abstract::Previous studies have demonstrated a rise in serum alpha-1-antitrypsin at advanced stages of malignancy. These, together with results of animal experiments with another anti-proteinase, aprotinin, have prompted studies of the plasma alpha-1-antitrypsin in the early stages of malignancy, using cervical carcinoma as a m...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225093
更新日期:1976-01-01 00:00:00
abstract::The present communication reports the inhibitory action of aminoglutethimide on 9,10-dimethyl-1,2-benzanthracene (DMBA) induced mammary carcinogenesis in virgin female Holtzman rats. When 20 mg of DMBA is given to the rats and maintained on normal diet for 32 weeks, approximately 70% of the animals develop mammary tum...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226013
更新日期:1985-01-01 00:00:00