Abstract:
OBJECTIVE:This study aimed to investigate clinicopathological responses and oncological outcome in patients receiving short- or long-course chemoradiotherapy (CRT) and to assess the predictive factor for recurrence in each treatment. METHODS:A total of 118 rectal cancer patients receiving preoperative CRT were enrolled. Clinicopathological responses and oncological outcome in patients receiving short- or long-course CRT were investigated. RESULTS:Despite there being no significant differences in the prognosis of disease-free survival (DFS) based on TNM stage classification in patients receiving long-course CRT, patients with advanced stage demonstrated poor DFS after short-course CRT. The presence of lymph node metastasis was a predictor of poor DFS in short-course CRT, whereas poor pathological response was a predictor of recurrence in long-course CRT. CONCLUSIONS:Distinct predictors of recurrence depending on the CRT course might be needed to discriminate candidates from rectal cancer patients receiving preoperative CRT who might benefit from more intensive adjuvant therapy after surgery.
journal_name
Oncologyjournal_title
Oncologyauthors
Yamamoto A,Toiyama Y,Okugawa Y,Saigusa S,Ide S,Fujikawa H,Hiro J,Yasuda H,Yoshiyama S,Ohi M,Araki T,Kusunoki Mdoi
10.1159/000492617subject
Has Abstractpub_date
2019-01-01 00:00:00pages
70-78issue
2eissn
0030-2414issn
1423-0232pii
000492617journal_volume
96pub_type
杂志文章相关文献
ONCOLOGY文献大全abstract::The priming action of estradiol and the antiestrogen tamoxifen (TMX) on progesterone receptor (PgR) synthesis has been investigated in the 7,12-dimethylbenz(a)anthracene-induced rat mammary tumor model testing different priming times. Rats received either TMX or estradiol benzoate (E2B) for 3 or 7 days. Tumors were as...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226488
更新日期:1987-01-01 00:00:00
abstract:PURPOSE:This phase I study (EudraCT No. 2006-001177-25) investigated aflibercept, a vascular endothelial growth factor decoy receptor protein (VEGF Trap), in combination with docetaxel, cisplatin, and 5-fluorouracil in patients with advanced solid tumors. PATIENTS AND METHODS:Patients received 2, 4, or 6 mg/kg of intr...
journal_title:Oncology
pub_type: 杂志文章,多中心研究
doi:10.1159/000440958
更新日期:2016-01-01 00:00:00
abstract::The Abelson-virus-induced murine lymphosarcoma cell line RAW117-P and its in vivo selected highly malignant and metastatic variant RAW117-H10 have been studied for their growth in vivo, in vitro and in semi-solid agar. The highly malignant metastatic variant RAW117-H10 cells killed syngeneic Balb/c mice rapidly and fo...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226473
更新日期:1987-01-01 00:00:00
abstract::HER2 amplification/overexpression is a marker of poor prognosis in breast cancer. The prognostic impact of HER2 positivity is lower in node-negative compared with node-positive women. The only significant, independent prognostic factors in breast cancer are node status, HER2 status and menopausal status. HER2-positive...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000055404
更新日期:2001-01-01 00:00:00
abstract::Acute myeloid leukemia (AML) originates from self-renewing leukemic stem cells (LSCs), an ultimate therapeutic target in AML. Eradication of LSCs should be a critical and efficient therapeutic approach for the cure of AML. T-cell immunoglobulin mucin-3 (TIM-3) is expressed in most types of AML LSCs, but not in normal ...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000431062
更新日期:2015-01-01 00:00:00
abstract::5-Azacytidine (NSC-102 816) was prepared synthetically and independently isolated from the culture filtrate of Streptoverticillium ladakanus. It is an s-triazine analogue of cytidine possessing a broad spectrum of biological effects. In mammalian tissueit is phosphorylated to 5-azacytidine 5-phosphates and incorporate...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000224981
更新日期:1974-01-01 00:00:00
abstract::While central ports are located at the chest, peripheral ports (PP) are inserted at the patients' forearms. Two new PPs (Healthport miniMax((R)) and Bard Titan Low Profile Port) and two well-established types (Port-A-Cath((R)) P.A.S. Port and PeriPort(TM) peripheral access system) were tested. 125 patients were given ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000012059
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVE:Transarterial chemoembolization (TACE) is recommended as a first-line therapy for hepatocellular carcinoma (HCC) patients ineligible for curative therapy and without portal invasion. The Assessment for Retreatment with TACE (ART) scoring system was recently proposed for identifying patients who would not show...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000440625
更新日期:2015-01-01 00:00:00
abstract::Until a few decades ago neck dissection (ND) was the standard surgical approach for node-positive tumours. Nowadays patients with locally advanced head and neck cancer can be treated with definitive chemoradiation (CRT), which includes the treatment of the neck; however, results on residual viable tumour after conserv...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000346132
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Whether recurrence after surgery and primary metastatic pancreatic cancer should be included in the same category when conducting gemcitabine-based clinical trials remains controversial. OBJECTIVE:To clarify the outcomes of recurrent and metastatic pancreatic cancers. METHODS:326 patients who received gemc...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000236022
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision surgery is a standard treatment for locally advanced rectal cancer (LARC). Tumor-infiltrating lymphocytes (TILs) have been reported to be associated with tumor response; however, this remains to be established. We previously reported ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000508922
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND AND AIM:In vitro, methotrexate (MTX) is the best modulator for bolus 5-fluorouracil (5FU), whereas folinic acid (FA) is the best for continuous infusion. We evaluated the effect of 5FU modulated by both MTX (bolus administration) and FA (continuous infusion) as second-line treatment of patients with metastat...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000065468
更新日期:2002-01-01 00:00:00
abstract::Further biochemical characterization of the Albert hepatoma has been performed. The following results were obtained: In spite of often repeated transplantations and a medium growth rate, the Albert hepatoma does still contain organ-characteristic enzymes. We have found significant activities of glucokinase, glucose-6-...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225357
更新日期:1979-01-01 00:00:00
abstract::We conducted a prospective multicenter phase II trial of patients with borderline resectable pancreatic carcinoma to investigate the efficacy of neoadjuvant nab-paclitaxel plus gemcitabine therapy on overall survival (OS). The clinical trial primarily evaluated OS time from the first day of protocol therapy as a prima...
journal_title:Oncology
pub_type: 杂志文章,多中心研究
doi:10.1159/000478660
更新日期:2017-01-01 00:00:00
abstract::The paper presents the experience with watch-and-wait policy following radical surgery in 25 patients with primary gastric non-Hodgkin's (NH) lymphoma localized to the gastric wall. The median follow-up is at the moment 40 months (range 18-85). Only 3/25 patients have relapsed (during the first year of the follow-up) ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227347
更新日期:1994-05-01 00:00:00
abstract::67Ga-subtraction scan was found to be useful and a promising new method for the pre-treatment evaluation of the patient with Hodgkin's disease or non-Hodgkin's lymphoma. The scan appeared to be most accurate in the neck, chest, and axillary regions. It appears to offer a means of increasing the accuracy of evaluating ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225217
更新日期:1977-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the clinical and cost benefits of the administration of aprepitant for the prophylaxis of chemotherapy-induced nausea and vomiting (CINV) during high-dose chemotherapy (HDCT). METHODS:We retrospectively reviewed the charts of patients who received HDCT at our institution between January 2009 and ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000479032
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:There are a few long-term follow-up studies of patients with stage I ovarian carcinoma. The objective of this study was to evaluate prognostic factors for long-term survival. METHODS:Two hundred fourteen stage I ovarian carcinomas (registered by the Tokai Ovarian Tumor Study Group from 1988 to 1999) were ana...
journal_title:Oncology
pub_type: 杂志文章,多中心研究
doi:10.1159/000071202
更新日期:2003-01-01 00:00:00
abstract::Objective tumor responses and survival rates with standard chemotherapy options for small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC) have been disappointing. However, several promising new classes of agents have emerged in recent years, including the taxanes, mitotic spindle inhibitors, antimetabol...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000055387
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:To determine the relationship between treatment outcomes and hand-foot syndrome (HFS), and the relationship between survival rate and post-progression treatment after sorafenib therapy. METHODS:The study assessed 314 patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib at 5 general ho...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000481241
更新日期:2017-01-01 00:00:00
abstract::To establish appropriate indications for endoscopic treatment of submucosal invasive gastric carcinoma, we investigated clinicopathologic features and proliferating cell nuclear antigen (PCNA) expression at the deepest invasive portion of 192 differentiated submucosal invasive gastric carcinomas that had been surgical...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227486
更新日期:1995-07-01 00:00:00
abstract::Twenty-two evaluable patients with metastatic breast cancer were treated with a combination of 4-(acridinylamino)methanesulfon-m-anisidide (AMSA) and doxorubicin. All patients but one had received prior therapy with fluorouracil, cyclophosphamide, and methotrexate. Eight patients had partial responses (36%) with a med...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226365
更新日期:1986-01-01 00:00:00
abstract::Since aspirin was found to cause a persistent decrease in pyruvate kinase activity, which is a prominent characteristic of the hepatic promoters, the effect of aspirin on hepatic tumorigenesis in the rat has been studied. Male Wistar rats were initiated with a diet containing 0.06% 3'-methyl-4-dimethylamino-azobenzene...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227195
更新日期:1993-07-01 00:00:00
abstract::The antiemetic effect of graded, single high-dose intravenous dexamethasone was studied in 27 patients receiving combination chemotherapy with either doxorubicin (50 mg/m2) or cis-platinum (100 mg/m2). A total of 57 cycles were individually evaluated, utilizing a detailed rating system. Nausea and vomiting did not occ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000226099
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:N-Acetylglucosaminyltransferase V (GnT-V) is a key enzyme in the formation of branching asparagine-linked oligosaccharides and is linked to tumor invasion and metastasis in colon and breast cancers. In normal esophageal epithelium, beta1,6-branched asparagine-linked oligosaccharides synthesized by GnT-V are s...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000089680
更新日期:2005-01-01 00:00:00
abstract::58 consecutively referred, previously untreated patients with nodular lymphomas (stages III and IV) were treated with two different combination chemotherapy regimens-(cyclophosphamide, vincristine and prednisone (COP), and BCNU , cyclophosphamide, vincristine, melphalan and prednisone (M-2) - to compare remission indu...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225814
更新日期:1984-01-01 00:00:00
abstract::We have measures serial carcinoembryonic antigen (CEA) titers in 92 patients, randomly selected from the patient population of a Radiotherapeutic Clinic, to correlate with clinical and follow-up evaluation. 57 out of 92 patients had positive CEA levels (2.5 ng/ml) or 62 percent of proven cancer patients. In this serie...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000224965
更新日期:1974-01-01 00:00:00
abstract::The levels of bone-specific alkaline phosphatase (BALP) in plasma and tumour tissue samples of 20 Chinese patients with osteosarcoma in Hong Kong were measured by the wheat germ lectin precipitation technique. The plasma BALP levels in these patients were significantly higher than those of the normal subjects (p < 0.0...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227573
更新日期:1996-07-01 00:00:00
abstract::Thrombopoietin (TPO) is a recently discovered hematopoietic growth factor which stimulates the production and maturation of megakaryocytes. In this study, we used a modified MTT assay to examine the in vitro growth-stimulatory effects of recombinant human (rh) TPO and recombinant human stem cell factor (rhSCF) on eigh...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227600
更新日期:1996-09-01 00:00:00
abstract::Inhibitors of polyamine synthesis were tested for therapeutic effectiveness on transplantable prostate cancer. Inhibition of either ornithine decarboxylase or S-adenosyl-L-methionine decarboxylase (AMDC) by alpha-difluormethylornithine (DFMO) or methylglyoxal-bis[guanylhydrazone] (MGBG), respectively, was associated w...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225692
更新日期:1983-01-01 00:00:00