Mitomycin therapy in gastric cancer.

Abstract:

:Adenocarcinoma of the stomach remains a significant cause of mortality worldwide. The majority of patients present with stage III or IV disease, negating surgery as a curative option. Numerous drugs have been tested over the past 2 decades in single-agent and combination chemotherapy trials. Given by intravenous bolus, mitomycin has induced responses as high as 63% and as low as 24% in patients with various gastrointestinal malignancies. Mitomycin has also demonstrated efficacy when given in combination with doxorubicin and in the three-drug regimen FAM (5-fluorouracil/doxorubicin/mitomycin). FAM has been explored in multiple phase II and III trials and has become the standard with which many new combinations are compared. Compared with other doxorubicin-containing regimens, it has demonstrated the longest median survival (29.5 weeks) and the lowest incidence of severe toxicity. The addition of semustine or leucovorin to FAM has yielded responses comparable with those attained by FAM alone. In Japan, where treatment of gastric cancer has been more successful, possibly due to earlier diagnosis and more aggressive surgical approaches, mitomycin has been given intraperitoneally during surgery and postoperatively in combination with fluorinated pyrimidines or other agents. Mitomycin will undoubtedly play a role in the development of new approaches to the treatment of gastric cancer.

journal_name

Oncology

journal_title

Oncology

authors

Schnall S,Macdonald JS

doi

10.1159/000227249

subject

Has Abstract

pub_date

1993-04-01 00:00:00

pages

70-7

eissn

0030-2414

issn

1423-0232

journal_volume

50 Suppl 1

pub_type

临床试验,杂志文章,评审

相关文献

ONCOLOGY文献大全
  • Reduced expression of manganese superoxide dismutase mRNA may correlate with invasiveness in esophageal carcinoma.

    abstract::Little is known about the expression and antioxidant function of manganese superoxide dismutase (Mn-SOD) in esophageal squamous cell carcinoma. To determine the significance of Mn-SOD in esophageal squamous cell carcinomas, Mn-SOD mRNA expression was examined in 45 esophageal squamous cell carcinomas and the correspon...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000012165

    authors: Toh Y,Kuninaka S,Mori M,Oshiro T,Ikeda Y,Nakashima H,Baba H,Kohnoe S,Okamura T,Sugimachi K

    更新日期:2000-09-01 00:00:00

  • Therapeutic management of stage I-II high-grade primary gastric lymphomas.

    abstract::The best treatment for primary gastric lymphomas (PGL) has not yet been defined. Eighty-three patients with stage I/II PGL are documented, focusing on prognostic factors, treatment-related morbidity and mortality, and therapeutic outcome. Chemotherapy improved survival in comparison to local treatments, i.e. gastrecto...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000011978

    authors: Ferreri AJ,Cordio S,Paro S,Ponzoni M,Freschi M,Veglia F,Villa E

    更新日期:1999-01-01 00:00:00

  • Cardiac Troponin I Predicts Elevated B-type Natriuretic Peptide in Patients Treated with Anthracycline-Containing Chemotherapy.

    abstract:BACKGROUND:Anthracycline is used to treat various types of cancer; however, cardiotoxicity negatively affects patient prognosis. OBJECTIVES:The aim of the present study was to investigate serial changes in levels of cardiac troponin I (TnI) and B-type natriuretic peptide (BNP) in patients treated with anthracycline-co...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000507585

    authors: Oikawa M,Yoshihisa A,Yokokawa T,Misaka T,Yaegashi D,Miyata M,Nakazato K,Ishida T,Takeishi Y

    更新日期:2020-01-01 00:00:00

  • Clinical Impact of Aprepitant in Patients Receiving High-Dose Chemotherapy prior to Autologous Peripheral Blood Stem Cell Transplantation: A Cost-Effectiveness Analysis.

    abstract:OBJECTIVE:To evaluate the clinical and cost benefits of the administration of aprepitant for the prophylaxis of chemotherapy-induced nausea and vomiting (CINV) during high-dose chemotherapy (HDCT). METHODS:We retrospectively reviewed the charts of patients who received HDCT at our institution between January 2009 and ...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000479032

    authors: Nakamura A,Kojima Y,Miyazawa K,Matsumoto S,Iida H,Nagai H

    更新日期:2017-01-01 00:00:00

  • Immunohistological approach to tumor diagnosis.

    abstract::Immunoperoxidase methods permit the demonstration of a variety of antigens in routinely processed tissues. The morphological detail obtained by this procedure is comparable to orthodox haematoxylin and eosin stained sections, and so offers the diagnostic pathologist the opportunity of simultaneously identifying normal...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:

    authors: Taylor CR

    更新日期:1978-01-01 00:00:00

  • Bile acid load on the DNA distribution pattern of bile ductules and cholangiocarcinoma induced by diisopropanolnitrosamine in hamsters.

    abstract::This study evaluated the influence of bile acid load on the DNA distribution pattern of proliferated bile ductules and cholangiocarcinoma induced by diisopropanolnitrosamine. Ninety hamsters were separated into control, tauro- and deoxycholic acid (DCA) groups. The DNA distribution pattern of intrahepatic lesions at 1...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000011839

    authors: Kinami Y,Miyakoshi M,Fujikawa K

    更新日期:1998-01-01 00:00:00

  • Evaluation of chemotherapy in a murine model for bladder cancer.

    abstract::A transplantable transitional cell murine bladder tumor induced by N-[4-(5-nitro-2-furyl)-thiazolyl] formamide (FANFT) was characterized by tumor growth, survival time and response to chemotherapy drugs, cis-dichloro-trans-dihydroxy-bis-iso-propylamine platinum IV (CHIP), cis- diaminedichloro platinum II (DDP), cyclop...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000225822

    authors: Murphy GP,Pontes JE,Williams PD

    更新日期:1984-01-01 00:00:00

  • HER-targeted tyrosine-kinase inhibitors.

    abstract::Improved understanding of tumor biology has led to the identification of numerous growth factors that are involved in malignant transformation and tumor progression. Many of these factors induce cellular responses through receptors with intrinsic tyrosine kinase (TK) activity. Therefore, inhibiting receptor TK activit...

    journal_title:Oncology

    pub_type: 杂志文章,评审

    doi:10.1159/000066198

    authors: Baselga J,Hammond LA

    更新日期:2002-01-01 00:00:00

  • Body Mass Index as a Risk Factor for Toxicities in Patients with Advanced Soft-Tissue Sarcoma Treated with Trabectedin.

    abstract:OBJECTIVES:Low body mass index (BMI) and/or low lean body mass have been shown to be risk factors for chemotherapy-related toxicities in a number of different cancers. However, no data are available regarding the role of BMI as a risk factor for developing toxicities related to the novel anticancer agent, trabectedin, ...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000487266

    authors: Vincenzi B,Badalamenti G,Armento G,Silletta M,Spalato Ceruso M,Catania G,Napolitano A,Maltese G,Valeri S,Incorvaia L,Santini D,Tonini G

    更新日期:2018-01-01 00:00:00

  • Clinical Characteristics of Metastatic Prostate Cancer Patients Infected with COVID-19 in South Italy.

    abstract:BACKGROUND:To date, the clinical characteristics of coronavirus disease 19 (COVID-19)-infected urologic cancer patients are unknown. METHODS:We have analyzed all patients with prostate cancer undergoing hormonal or chemotherapy treatment and receiving telephone and in person pre-triage between March 1 and 27, 2020, at...

    journal_title:Oncology

    pub_type: 新闻

    doi:10.1159/000509434

    authors: Di Lorenzo G,Buonerba L,Ingenito C,Crocetto F,Buonerba C,Libroia A,Sciarra A,Ragone G,Sanseverino R,Iaccarino S,Napodano G,Imbimbo C,Leo E,Kozlakidis Z,De Placido S

    更新日期:2020-01-01 00:00:00

  • Functionally active duplications of the CYP2D6 gene are more prevalent among larynx and lung cancer patients.

    abstract::The cytochrome P450 CYP2D6 is a polymorphic drug-metabolizing enzyme that is involved in the metabolism of several drugs and xenobiotics. Several independent studies indicate that the CYP2D6 metabolic status is a secondary factor in the risk of developing lung cancer, with individuals with high activity being at incre...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000055354

    authors: Agúndez JA,Gallardo L,Ledesma MC,Lozano L,Rodriguez-Lescure A,Pontes JC,Iglesias-Moreno MC,Poch J,Ladero JM,Benítez J

    更新日期:2001-01-01 00:00:00

  • Comparative effects of piroxicam and esculetin on incidence, proliferation, and cell kinetics of mammary carcinomas induced by 7,12-dimethylbenz[a]anthracene in rats on high- and low-fat diets.

    abstract::We investigated the effects of piroxicam, a cyclooxygenase inhibitor, and esculetin, a lipoxygenase inhibitor, on 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female rats. Seven days after receiving a 5-mg dose of DMBA, rats were fed either a high-fat (20% soybean oil) or low-fat (0.5% soybe...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000227374

    authors: Kitagawa H,Noguchi M

    更新日期:1994-09-01 00:00:00

  • Clear cell renal cell carcinoma associated with bilateral atypical acute posterior multifocal placoid pigment epitheliopathy.

    abstract:BACKGROUND/OBJECTIVE:Clear cell renal cell carcinoma (CCRCC) is a malignant neoplasm frequently associated with an increase in circulating immune complexes (CIC). Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is a disease involving the chorioretinal structures of the eye, and it is commonly observe...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000079505

    authors: Parmeggiani F,Costagliola C,D'Angelo S,Incorvaia C,Perri P,Sebastiani A

    更新日期:2004-01-01 00:00:00

  • Integrative Assessment of Pretreatment Inflammation-, Nutrition-, and Muscle-Based Prognostic Markers in Patients with Muscle-Invasive Bladder Cancer Undergoing Radical Cystectomy.

    abstract:OBJECTIVE:The present study evaluated the clinical relevance of an integrative preoperative assessment of inflammation-, nutrition-, and muscle-based markers for patients with muscle-invasive bladder cancer (MIBC) undergoing curative radical cystectomy (RC). METHODS:The analysis enrolled 117 patients and the variables...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000477405

    authors: Miyake M,Morizawa Y,Hori S,Marugami N,Iida K,Ohnishi K,Gotoh D,Tatsumi Y,Nakai Y,Inoue T,Anai S,Torimoto K,Aoki K,Tanaka N,Shimada K,Konishi N,Fujimoto K

    更新日期:2017-01-01 00:00:00

  • The trophoblast theory of cancer (John Beard, 1857-1924) revisited.

    abstract::Beard's theory can be restated in a modified form in modern terms in the following way. Cancer represents primarily trophoblastic tissue derived either from an aberrant germ cell or from a somatic cell whose normally repressed 'asexual generation' genes are abnormally reactivated ('derepressed'). The variety of tumors...

    journal_title:Oncology

    pub_type: 传,历史文章,杂志文章

    doi:10.1159/000225037

    authors: Gurchot C

    更新日期:1975-01-01 00:00:00

  • Serum Exosomal Gamma-Glutamyltransferase Activity Increased in Patients with Renal Cell Carcinoma with Advanced Clinicopathological Features.

    abstract:BACKGROUND:There has been no clinically useful diagnostic or prognostic biomarker for renal cell carcinoma (RCC). Serum γ-glutamyltransferase (GGT) activity has been reported to be a prognostic marker for several types of cancer including RCC. Exosomes or small extracellular vesicles present in body fluids have potenti...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000508688

    authors: Horie K,Kawakami K,Fujita Y,Matsuda Y,Arai T,Suzui N,Miyazaki T,Koie T,Mizutani K,Ito M

    更新日期:2020-01-01 00:00:00

  • Bone-specific alkaline phosphatase in plasma as tumour marker for osteosarcoma.

    abstract::The levels of bone-specific alkaline phosphatase (BALP) in plasma and tumour tissue samples of 20 Chinese patients with osteosarcoma in Hong Kong were measured by the wheat germ lectin precipitation technique. The plasma BALP levels in these patients were significantly higher than those of the normal subjects (p < 0.0...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000227573

    authors: Liu PP,Leung KS,Kumta SM,Lee KM,Fung KP

    更新日期:1996-07-01 00:00:00

  • Yttrium-90-Ibritumomab Tiuxetan (Zevalin®) Radioimmunotherapy after Cytoreduction with ESHAP Chemotherapy in Patients with Relapsed Follicular Non-Hodgkin Lymphoma: Final Results of a Phase II Study.

    abstract:BACKGROUND:Radioimmunotherapy (RIT) is effective in treating relapsed/refractory follicular lymphoma (FL), with durable remissions in first-line consolidation. We hypothesized that RIT with ibritumomab tiuxetan (Zevalin®) would result in durable remissions by eliminating minimal residual disease after cytoreduction. M...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000486788

    authors: Puvvada SD,Guillén-Rodríguez JM,Yan J,Inclán L,Heard K,Rivera XI,Anwer F,Mahadevan D,Schatz JH,Persky DO

    更新日期:2018-01-01 00:00:00

  • Prognostic value of nm23 protein expression in renal cell carcinomas.

    abstract::In the present study, an analysis of whether expression of nm23-H1 and nm23-H2 proteins has prognostic significance was performed. A series of 95 renal cell carcinomas was analyzed for nuclear grade, tumor size (larger than 50 mm or not), staging in the Robson system and expression of nm23-H1 and nm23-H2, as well as p...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000011880

    authors: Nakagawa Y,Tsumatani K,Kurumatani N,Cho M,Kitahori Y,Konishi N,Ozono S,Okajima E,Hirao Y,Hiasa Y

    更新日期:1998-07-01 00:00:00

  • Patient-controlled analgesia versus oral controlled-release oxycodone - are they interchangeable for acute postoperative pain after laparoscopic colorectal surgeries?

    abstract:BACKGROUND:Standard therapy for postoperative pain after laparoscopic colorectal surgeries at the Tan Tock Seng Hospital consists of intravenous morphine via patient-controlled analgesia (PCA) for the first 24-48 h, followed by oral analgesics. We compared the efficacy and safety of oral controlled-release (CR) oxycodo...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000143221

    authors: Ho HS

    更新日期:2008-01-01 00:00:00

  • Single-agent gemcitabine for biliary tract cancers. Study outcomes and systematic review of the literature.

    abstract:OBJECTIVE:The aim of this study was to investigate the outcomes of gemcitabine-treated patients with inoperable biliary tract cancers. METHODS:We conducted a retrospective study of consecutively treated 22 inoperable biliary tract cancer patients with gemcitabine (500-1,000 mg/m(2) on days 1, 8, 15 every 4 weeks) as f...

    journal_title:Oncology

    pub_type: 杂志文章,评审

    doi:10.1159/000098109

    authors: Kiba T,Nishimura T,Matsumoto S,Hatano E,Mori A,Yasumi S,Doi R,Ikai I,Kitano T,Nishimura T,Yoshikawa K,Ishiguro H,Yanagihara K,Doi E,Teramukai S,Fukushima M

    更新日期:2006-01-01 00:00:00

  • Three primary cancers in different organs.

    abstract::In a registry of 24,105 cancers, 15 patients were found to have three primary cancers in different organs. Decreasing time intervals between sequential diagnoses and then death were noted. Occurrence and sequence of cancer sites appeared to be random. Stage of second and third cancers tended, on the average, to be mor...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000225051

    authors: Holmes FF,Cole PA Jr

    更新日期:1975-01-01 00:00:00

  • Efficacy of percutaneous cementoplasty for bone metastasis from hepatocellular carcinoma.

    abstract:OBJECTIVE:To assess the efficacy of percutaneous cementoplasty for painful bone metastasis from hepatocellular carcinoma (HCC). METHODS:Cementoplasty was performed for 22 metastatic bone tumors in 13 patients. All patients had intractable pain and were diagnosed as metastatic bone tumor from HCC. The ostyneedle was in...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000113040

    authors: Kodama H,Aikata H,Uka K,Takaki S,Mori N,Waki K,Jeong SC,Kawakami Y,Shirakawa H,Takahashi S,Toyota N,Ito K,Chayama K

    更新日期:2007-01-01 00:00:00

  • Male breast cancer: immunohistochemical subtypes and clinical outcome characterization.

    abstract:AIM:The aim of this study was to assess the molecular subtype profiles of male breast cancer (MBC) and subsequent clinical outcome using a validated 6-marker immunohistochemical panel. METHODS:A total of 43 cases of MBC were examined retrospectively using a semiquantitative immunohistochemical analysis of estrogen rec...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000341537

    authors: Sánchez-Muñoz A,Román-Jobacho A,Pérez-Villa L,Sánchez-Rovira P,Miramón J,Pérez D,Sáez MI,de Luque V,Medina L,Ramírez-Tortosa CL,Vicioso L,Medina JA,Ribelles N,Alba E

    更新日期:2012-01-01 00:00:00

  • Genetic damage caused by methylazoxymethanol acetate, the aglycone of cycasin. Analysis of sister-chromatid exchange frequency under in vivo conditions and in cell cultures.

    abstract::To extend the information on the mutagenic effect of methylazoxymethanol (MAM) acetate, which has been established as a potent carcinogen, the frequency of sister-chromatid exchange (SCE) was determined in bone marrow cells of Sprague Dawley rats and in cultured rat lymphocytes. To get differentially stained chromatid...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000225615

    authors: Gloser H

    更新日期:1982-01-01 00:00:00

  • Prognostic relevance of MMP-2 (72-kD collagenase IV) in gastric cancer.

    abstract::The association of MMP-2 (matrix metalloproteinase 2, 72-kD collagenase IV) with invasive and metastatic capacity of tumor cells has implicated a potential role in the prognosis for cancer patients. However, no larger study has been done to prove this hypothesis. The present study was therefore designed to investigate...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000011850

    authors: Allgayer H,Babic R,Beyer BC,Grützner KU,Tarabichi A,Schildberg FW,Heiss MM

    更新日期:1998-03-01 00:00:00

  • c-Rel Promotes Invasion of Choriocarcinoma Cells via PI3K/AKT Signaling.

    abstract:OBJECTIVE:Choriocarcinoma is the most common epithelial cancer among gestational trophoblastic diseases (GTDs); the mechanism of trophoblastic carcinogenesis is unknown. This study aimed to examine the expression of NF-κB family proteins in GTDs and placental tissues as well as the roles of c-Rel in choriocarcinoma. M...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000458529

    authors: Sekiya Y,Yamamoto E,Niimi K,Nishino K,Nakamura K,Kotani T,Kajiyama H,Shibata K,Kikkawa F

    更新日期:2017-01-01 00:00:00

  • Prognostic value of estrogen receptor and Ki-67 index after neoadjuvant chemotherapy in locally advanced breast cancer expressing high levels of proliferation at diagnosis.

    abstract:PURPOSE:Breast cancers expressing high levels of Ki-67, a nuclear marker of cell proliferation, are associated with worse outcome. Recent data from neoadjuvant studies indicate that a single measurement of the nuclear proliferation marker Ki-67 in breast carcinoma during neoadjuvant therapy is strongly predictive of lo...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000322189

    authors: Miglietta L,Vanella P,Canobbio L,Naso C,Cerisola N,Meszaros P,Parodi MA,Morabito F

    更新日期:2010-01-01 00:00:00

  • Serrated adenoma of the colorectum undergoes a proliferation versus differentiation process: new conceptual interpretation of morphogenesis.

    abstract:OBJECTIVE:Serrated adenoma (SA) consists of glands both with intraluminal projection of tall columnar cells, which resemble the terminally differentiated cells in the surface epithelium, and with concave short cells, which resemble progenitor crypt cells of the colon. The aim of this study was to clarify the relationsh...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000151359

    authors: Jiao YF,Nakamura S,Sugai T,Yamada N,Habano W

    更新日期:2008-01-01 00:00:00

  • Mitomycin C, vinorelbine, carboplatin plus granulocyte-macrophage colony-stimulating factor for treatment of advanced non-small cell lung carcinoma.

    abstract:BACKGROUND:The therapeutic potential of chemotherapy in the treatment of recurrent or metastatic non-small cell lung carcinoma (NSCLC) seems modest. Thus, the search for novel agents and combination regimens with a superior therapeutic index has a high priority. The present combination regimen consisting of mitomycin C...

    journal_title:Oncology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000011909

    authors: Hejna M,Kornek GV,Raderer M,Marosi L,Schneeweiss B,Greul R,Weinländer G,Valencak J,Huber H,Scheithauer W

    更新日期:1998-11-01 00:00:00