Abstract:
:Empiric clinical trials have revealed new mechanisms by which hormonal therapies may exert their antitumor effects. Initial studies using escalated doses of agents like toremifene and megestrol acetate have yielded interesting results, showing responses in hormone-receptor-negative patients and in patients progressing after standard doses, respectively. A trial by Cancer and Leukemia Group B randomizing patients with advanced breast cancer to standard-dose (160 mg) megestrol acetate or to 5 or 10 times the standard dose (800 and 1,600 mg) has completed accrual. It is hoped that these results will provide a definitive answer to the dose-response issue for breast cancer. However, regardless of this trial's ultimate outcome, higher doses of megestrol acetate have demonstrated important new effects on appetite stimulation and weight gain; ongoing laboratory research promises potential roles for megestrol acetate in the reversal of chemotherapeutic drug-induced tumor resistance.
journal_name
Oncologyjournal_title
Oncologyauthors
Abrams JS,Gutheil J,Aisner Jdoi
10.1159/000227121subject
Has Abstractpub_date
1992-01-01 00:00:00pages
12-7eissn
0030-2414issn
1423-0232journal_volume
49 Suppl 2pub_type
临床试验,杂志文章相关文献
ONCOLOGY文献大全abstract:BACKGROUND:The Oncotype DX Breast Cancer Assay is a 21-gene assay used to predict the likelihood of distant recurrence and the benefit of chemotherapy in patients with node-negative, tamoxifen-treated breast cancer. Prior studies demonstrated 7-19% discordance, or a difference between the recurrence score (RS) and tumo...
journal_title:Oncology
pub_type: 新闻
doi:10.1159/000504965
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:A germline BIM deletion polymorphism has been proposed to predict a poor treatment efficacy of certain kinase inhibitors. The current study aimed to explore whether the BIM deletion polymorphism predicts the treatment efficacy of sorafenib for advanced hepatocellular carcinoma (HCC). METHODS:All patients wh...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000356019
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate the longitudinal changes in quality of life (QoL) for patients with advanced stage (stage III or IV) head and neck squamous cell carcinoma (HNSCC) following primary radiotherapy (RT) or concomitant chemoradiotherapy. METHODS:From January 2001 to January 2003, 149 ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000086982
更新日期:2005-01-01 00:00:00
abstract::We evaluated changes in serum albumin concentrations in 15 patients with advanced malignancy who were also receiving cisplatin. All 15 patients had serial measurements of serum albumin. The decrease in serum albumin from the time of the first dose of cisplatin to death correlated with liver platinum levels at autopsy ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226100
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVES:Systematic investigation of a novel series of intercalating agents, 9-aza-anthrapyrazoles, has led to the identification of a promising analogue, BBR 3438. This study describes the antitumour efficacy of the novel compound in human prostate carcinoma models and the molecular/cellular basis of its activity. ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000055380
更新日期:2001-01-01 00:00:00
abstract::Vascular endothelial growth factor C (VEGF-C) is considered to be potentially lymphangiogenic and can selectively induce hyperplasia of the lymphatic vasculature. In this study, we clarified the clinicopathological features of early gastric carcinoma (EGC) that has metastasized to the lymph nodes, as well as the corre...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000055312
更新日期:2001-01-01 00:00:00
abstract::A unique case of multiple keratoacanthomas is described, with involvement of the face and lower extremities with persistent lesions clinically and histologically diagnostic of keratoacanthomas. The lower extremity lesions appear as giant keratoacanthomas, with evolution into a distinctive confluent plaque. This import...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225359
更新日期:1979-01-01 00:00:00
abstract::The prognosis of brain glioblastoma is still very poor and the median survival time is generally less than 6 months. At present, no chemotherapy has appeared to influence its prognosis. On the other hand, recent advances in brain tumor biology have suggested that brain tumor growth is at least in part under a neuroend...
journal_title:Oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000227533
更新日期:1996-01-01 00:00:00
abstract::Coagulation disorders are frequently detected in patients affected by different tumours even though clinical symptoms occur in a very small percentage of such subjects. Coagulation processes are probably involved in the mechanism of metastatic spread. We assayed the plasma levels of thrombin-antithrombin III (TAT) com...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227086
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Transcatheter arterial chemoembolization (TACE) is a standard therapy used in the treatment of intermediate hepatocellular carcinoma (HCC). Recently, balloon-occluded TACE (B-TACE) has been developed. PURPOSE:This study aimed to clarify the effects of B-TACE in patients with HCC, with a focus on which drug ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000492822
更新日期:2019-01-01 00:00:00
abstract::In order to determine the operative indications of three-field lymph node dissection of esophageal cancer, attempts were made to collect data concerning procedures performed between 1983 and 1989 in major institutions in Japan, and the results from institutions performing three-field or two-field lymph node dissection...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226971
更新日期:1991-01-01 00:00:00
abstract::Topotecan is indicated in the treatment of advanced-stage ovarian cancers refractory to prior platinum-based regimen. The aim of this study was to compare the standard therapeutic strategy with a novel strategy of weekly administration of topotecan. The primary endpoints were dose density and overall tolerance. This r...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000127384
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to examine the prognostic value of the preoperative serum alpha-L-fucosidase (AFU) activity in colorectal cancer and to assess whether it could add prognostic information that Dukes' stages do not give. METHODS:A postoperative follow-up of 137 colorectal cancer patients was perform...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000066521
更新日期:2003-01-01 00:00:00
abstract::Twenty-two patients with metastatic breast carcinoma were treated with a combination of cisplatin (100 mg/m2 i.v. day 1) and etoposide (100 mg/m2 i.v. days 1-3). Eligible patients had measurable disease with normal organ functions, performance status < 3, age < 70 years and no previous chemotherapy for metastatic dise...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227364
更新日期:1994-07-01 00:00:00
abstract::A number of therapeutic agents including L-asparaginase, Actinomycin-D, CCNU, Hydroxyurea, 5-FU, Cis-platinum, Cyclophosphamide, orchiectomy, Adriamycin and DES alone and in various combinations has been applied against the Dunning R-3327 rat prostatic adenocarcinoma subline G. We have found a parallel between the res...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225202
更新日期:1977-01-01 00:00:00
abstract::Studies were made of the therapeutic response of six human colorectal tumor lines serially transplanted in immunosuppressed mice. The tumors with adenomatous structure showed greater sensitivity against different cytotoxic agents than the gelatinous ones. Among the drugs, 5-FU, BCNU and MeCCNU proved to be the most ef...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225496
更新日期:1980-01-01 00:00:00
abstract::Three polycyclic hydrocarbons: benzo(a)pyrene; dibenz(a,h)-anthracene and dibenz(a,c)anthracene, differing in their carcinogenicity, were administered to female rats. The comparative intracellular localization of these compounds was studied by fluorescence microscopy. The two carcinogenic molecules were localized both...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225395
更新日期:1980-01-01 00:00:00
abstract::This randomised, single-blind, parallel-group study was carried out in 48 French pneumology centres to compare the anti-emetic efficacy of ondansetron and an alizapride plus methylprednisolone (ALI/MPS) combination in patients receiving high-dose cisplatin. A total of 220 patients were recruited of whom 209 were evalu...
journal_title:Oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000227061
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:We evaluated the efficacy and safety of bolus 5-fluorouracil (5-FU) and leucovorin combined with weekly paclitaxel (FLTAX) in advanced gastric cancer (GC) patients. METHODS:Patients with untreated stage IV GC received paclitaxel 80 mg/m(2) as a 1-hour infusion, followed by 5-FU 600 mg/m(2) as a bolus infusio...
journal_title:Oncology
pub_type: 杂志文章,多中心研究
doi:10.1159/000334462
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:Cancer-related fatigue is a common complaint during cancer treatment and is often associated with cognitive impairment. This study examined cognitive deficits that were associated with fatigue symptoms during external-beam radiation therapy (EBRT) in men with localized prostate cancer. METHODS:A total of 36 pa...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000487081
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Elevated histone deacetylase (HDAC) isoenzyme levels have been described in patients with carcinomas and leukemias. HDAC inhibitors (HDACi) have shown promise in the treatment of carcinomas and are currently under intense research. To make better use of HDACi in treating chronic lymphocytic leukemia (CLL), H...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000334577
更新日期:2011-01-01 00:00:00
abstract::Twenty-two evaluable patients with metastatic breast cancer were treated with a combination of 4-(acridinylamino)methanesulfon-m-anisidide (AMSA) and doxorubicin. All patients but one had received prior therapy with fluorouracil, cyclophosphamide, and methotrexate. Eight patients had partial responses (36%) with a med...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226365
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVES AND METHODS:The association oxaliplatin (OXA)-5-fluorouracil/folinic acid (FUFA) is currently a standard first-line treatment for advanced colorectal cancer. The main objective of this experimental study was to examine the cytotoxic effects resulting from the addition of ionizing radiation (Rgamma) to the co...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000069308
更新日期:2003-01-01 00:00:00
abstract::In patients affected with different tumours, disorders concerning clotting are frequently observed. The biological processes leading to coagulation are probably involved in the mechanisms of metastasis. We studied plasma levels of thrombin-antithrombin III complexes (TAT) in 90 patients affected with lung tumours subg...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227620
更新日期:1996-11-01 00:00:00
abstract::Etoposide is a highly schedule-dependent agent. We previously reported that a 21-day schedule of oral etoposide had good activity in small cell lung cancer (SCLC). The current phase II study was designed to test the combination of 21-day oral etoposide with cisplatin in hopes of capitalizing on etoposide's schedule de...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227108
更新日期:1992-01-01 00:00:00
abstract::This is a phase II study to evaluate the efficacy and toxicity of short-course carboplatin in advanced-stage nasopharyngeal carcinoma (NPC). Thirty-three previously untreated stage III-IV NPC patients were studied. Carboplatin was given as a rapid intravenous injection every 3 weeks. The dose of carboplatin was calcul...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227689
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:To investigate the potential benefit of intermittent chemotherapy, and to identify the eligibility criteria offering intermittent chemotherapy to patients with advanced urothelial cancer. MATERIALS AND METHODS:Twenty patients who responded or had stable disease after receiving 3 cycles of induction chemother...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000338770
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:BRAF D594G mutations in colorectal cancer patients are not clearly understood. We retrospectively investigated the clinicopathological features of colorectal cancers with BRAF D594G mutations. METHODS:We selected 908 colorectal cancer patients who underwent surgical resection from January 2008 to January 201...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000447402
更新日期:2016-01-01 00:00:00
abstract::Tumor cell apoptosis, proliferation and p27 expression using an in situ apoptosis detection kit, anti-Ki67 antibody and anti-p27 antibody were investigated in 171 colorectal adenocarcinoma specimens, together with the assessment of mutated p53 expression. No apparent association was observed among p27 expression, muta...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000012078
更新日期:2000-01-01 00:00:00
abstract::58 consecutively referred, previously untreated patients with nodular lymphomas (stages III and IV) were treated with two different combination chemotherapy regimens-(cyclophosphamide, vincristine and prednisone (COP), and BCNU , cyclophosphamide, vincristine, melphalan and prednisone (M-2) - to compare remission indu...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225814
更新日期:1984-01-01 00:00:00