Latent coagulation disorders evaluated by the assay of plasma thrombin-antithrombin III complexes in a large series of 'solid tumours'.

abstract：:Chromosomal analysis of three human non-Hodgkin's lymphoma (NHL) xenografts revealed common extra 14q+ segment and other individual clonal markers without involvement of immunoglobulin light-chain regions. Two NHL xenografts (HT 58 and HT 130) showed restricted lambda light chain expression and deleted kappa and rearr...

journal_title：Oncology

authors： Kopper L,Bánkfalvi A,Földi J,Mihalik R,Magyar M,Aczél A

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Bevacizumab (Avastin) significantly improves overall survival (OS) and progression-free survival (PFS) when combined with first-line irinotecan (IFL) plus bolus 5-fluorouracil (5-FU) and leucovorin (LV) in patients with metastatic colorectal cancer (CRC). This open-label, phase IV trial evaluated the efficac...

journal_title：Oncology

authors： Sobrero A,Ackland S,Clarke S,Perez-Carrión R,Chiara S,Gapski J,Mainwaring P,Langer B,Young S,AVIRI Trial investigators.

更新日期：2009-01-01 00:00:00

abstract：:Zinostatin stimalamer (SMANCS) is a lipophilic intra-arterial chemotherapeutic agent for hepatocellular carcinoma (HCC). In our previous study, transcatheter arterial infusion chemotherapy using SMANCS for HCC showed a response rate of 20%. In an effort to obtain a superior anti-tumor effect against HCC, we conducted ...

journal_title：Oncology

authors： Okusaka T,Okada S,Ueno H,Ikeda M,Iwata R,Furukawa H,Takayasu K,Moriyama N,Sato T,Sato K

更新日期：2002-01-01 00:00:00

abstract：:Our previous trial with a docetaxel, cisplatin, and 5-fluorouracil (DCF) regimen showed high response rates in metastatic squamous cell carcinoma of the esophagus (SCCE). The observed increased toxicity of the DCF regimen, however, was clinically harmful. S-1, an oral anticancer drug, has been approved as a combinatio...

journal_title：Oncology

authors： Ojima T,Nakamura M,Nakamori M,Katsuda M,Hayata K,Maruoka S,Shimokawa T,Yamaue H

更新日期：2018-01-01 00:00:00

abstract：:The diagnostic imaging of hepatocellular carcinoma (HCC) has recently undergone marked progress. The advent of the ultrasound (US) contrast agent Sonazoid, approved in January 2007, and magnetic resonance imaging (MRI) with the liver-specific MRI contrast agent gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic ac...

journal_title：Oncology

authors： Kudo M

更新日期：2011-01-01 00:00:00

abstract：:Stem cell mimicry of cancer cells has been known for a long time and is considered to be responsible for ectopic gene expressions. The stem cell characteristics of tumor cells are shown to be involved in epithelial-mesenchymal transition and in the phenomenon of vascular mimicry. Certain cancer types acquire a geno-ph...

journal_title：Oncology

authors： Tímár J,Tóvári J,Rásó E,Mészáros L,Bereczky B,Lapis K

更新日期：2005-01-01 00:00:00

abstract：:The antiemetic effect of graded, single high-dose intravenous dexamethasone was studied in 27 patients receiving combination chemotherapy with either doxorubicin (50 mg/m2) or cis-platinum (100 mg/m2). A total of 57 cycles were individually evaluated, utilizing a detailed rating system. Nausea and vomiting did not occ...

journal_title：Oncology

authors： Zaglama NE,Rosenblum SL,Sartiano GP,Brady M,Gonzalez MF,Valdivieso JG

更新日期：1986-01-01 00:00:00

abstract：:Flow cytometric (FCM) DNA studies were performed on cell suspensions obtained by endoscopic biopsy in 73 patients with gastric cancer and in 61 patients with gastric remnant. In cancer, DNA aneuploidies were detected in 49 tumors (67.1%), including 51.7% (15/29) of early gastric cancers and 77.3% (34/44) of advanced g...

journal_title：Oncology

authors： Kimura H,Kanno M,Takamura H,Arakawa H,Maeda K,Uogishi M,Sodani H,Kawashima T

更新日期：1994-11-01 00:00:00

abstract：:Various oncogenic agents were employed in tumor susceptibility studies of an inbred subline of BALB/cGn mice, BALB/cGnDu, which carries a mutant gene that results in spontaneous thymic involution in homozygous recessive individuals. Of 18 transplantable tumors, 3 in vitro transformed cell lines, 2 oncogenic papovaviru...

journal_title：Oncology

authors： Morrison DG,Moyer MP,Lynd FT,Rogers W,Moyer RC

更新日期：1982-01-01 00:00:00

abstract：:In squamous cell carcinoma of the head and neck (SCCHN), hypoxia is considered a crucial physiological modulator for malignant progression, wherebythe plasminogen activation system is involved in overlapping functions such as moulding of the extracellular matrix, cell proliferation and signal transduction. Little is k...

journal_title：Oncology

authors： Sprague LD,Mengele K,Schilling D,Geurts-Moespot A,Sweep FC,Stadler P,Schmitt M,Molls M

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Breast cancer is one of the leading causes of death worldwide and is the result of dysregulation of various signaling pathways in mammary epithelial cells. The mortality rate in patients suffering from breast cancer is high because the tumor cells have a prominent invasive capacity towards the surrounding ...

journal_title：Oncology

authors： González-González L,González-Ramírez R,Flores A,Avelino-Cruz JE,Felix R,Monjaraz E

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES AND METHODS:The association oxaliplatin (OXA)-5-fluorouracil/folinic acid (FUFA) is currently a standard first-line treatment for advanced colorectal cancer. The main objective of this experimental study was to examine the cytotoxic effects resulting from the addition of ionizing radiation (Rgamma) to the co...

journal_title：Oncology

authors： Magné N,Fischel JL,Formento P,Etienne MC,Dubreuil A,Marcié S,Lagrange JL,Milano G

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Identification of high-risk stage II colorectal cancer (CRC) patients, potential candidates for adjuvant chemotherapy, is challenging. Current clinical guidelines rely mainly on histopathological markers with relatively weak prognostic value. This motivates further search for prognostic markers. METHODS:Thi...

journal_title：Oncology

authors： Dimberg J,Andersson RE,Haglund S

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Bladder cancer is the fifth most common cancer among men and the seventh among women. At diagnosis, at least 25% of bladder cancer tumors are locally or systemically advanced. Systemic chemotherapy is the only current modality for advanced or metastatic transitional cell carcinoma of the bladder. Recently, a...

journal_title：Oncology

authors： Adamo V,Magno C,Spitaleri G,Garipoli C,Maisano C,Alafaci E,Adamo B,Rossello R,Scandurra G,Scimone A

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:To compare chemotherapy-related and total medical costs among patients with colorectal cancer (CRC) receiving capecitabine or 5-fluorouracil (5-FU) monotherapy after surgical resection. METHODS:This retrospective, claim-based study utilized the Thomson Reuters Market Scan(R) databases to identify 1,396 CRC p...

journal_title：Oncology

authors： Chu E,Shi N,Wei W,Bendell JC,Cartwright T

更新日期：2009-01-01 00:00:00

abstract：:Fourteen patients with disseminated breast cancer with primary or secondary resistance to tamoxifen were treated with LY156758. There were no complete or partial responses and 1 patient showed a minor response. These data illustrate that LY156758 did not have significant antitumor activity in patients previously treat...

journal_title：Oncology

authors： Buzdar AU,Marcus C,Holmes F,Hug V,Hortobagyi G

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Immuno-oncological (IO) therapies such as PD-1 and PD-L1 antibodies have been introduced in the treatment of advanced non-small cell lung cancer (NSCLC) since 2015 based on randomized trials showing unprecedented advantages in overall survival (OS) with hazard ratios (HRs) between 0.5 and 0.7. The impact of ...

journal_title：Oncology

authors： Faehling M,Kopp M,Schwenk B,Fallscheer S,Kramberg S,Eckert R

更新日期：2019-01-01 00:00:00

abstract：:Thirty-eight patients with metastatic renal-cell carcinoma (RCC) and 1 patient with a second primary RCC were treated with coumarin and cimetidine. Patients received 400 mg cimetidine p.o. daily and after 1 week 100 mg coumarin p.o. daily in addition until tumour progression. Two complete remission (30 and 50+ months)...

journal_title：Oncology

authors： Kokron O,Maca S,Gasser G,Schmidt PR

更新日期：1991-01-01 00:00:00

abstract：:The chemosensitivities of 62 human colon cancer tissues, 67 rectal cancer tissues and 31 tumor-adjacent normal mucosal tissues were determined using the in vitro succinate dehydrogenase inhibition (SDI) test. These tissues obtained at the time of surgery were exposed to carboquone (CQ), adriamycin (ADM), mitomycin C (...

journal_title：Oncology

authors： Ueo H,Maehara Y,Saito A,Sakaguchi Y,Kohnoe S,Sugimachi K

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVES:To assess the feasibility and efficacy of intensity-modulated radiation implemented with helical tomotherapy image-guided with daily megavoltage computed tomography for head and neck cancer. METHODS:Between May 2010 and May 2013, 72 patients were treated with curative intent. The median age was 64 years, wi...

journal_title：Oncology

authors： Santa Cruz O,Tsoutsou P,Castella C,Khanfir K,Anchisi S,Bouayed S,Matzinger O,Ozsahin M

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVES:A phase II study was performed to investigate the safety and efficacy of concurrent chemoradiotherapy (CCRT) combined with an orally active fluoropyrimidine, S-1, plus cisplatin for locally advanced esophageal cancer (LAEC). METHODS:CCRT comprised 2 courses, a 30-Gy radiotherapy over 3 weeks plus daily oral...

journal_title：Oncology

authors： Iwase H,Shimada M,Tsuzuki T,Hirashima N,Okeya M,Hibino Y,Ryuge N,Yokoi M,Kida Y,Kuno T,Tanaka Y,Kato B,Esaki M,Urata N,Kato E

更新日期：2013-01-01 00:00:00

abstract：:The relationship of vitamins to cancer is very complex. Three types of interactions are possible: the effect of vitamins on tumor growth, the effect of tumors on vitamin metabolism, and the effect of vitamins on chemical carcinogens and anti-tumor chemotherapeutic agents. The significance of vitamins with particular r...

journal_title：Oncology

authors： Basu TK

更新日期：1976-01-01 00:00:00

abstract：:Several reports have demonstrated an adverse effect of perioperative blood transfusions on the survival of patients with various solid tumors treated surgically. We retrospectively investigated the relationship between perioperative blood transfusions and the survival of 501 patients who underwent radical subtotal gas...

journal_title：Oncology

authors： Choi JH,Chung HC,Yoo NC,Lee HR,Lee KH,Kim JH,Roh JK,Min JS,Lee KS,Kim BS

更新日期：1995-03-01 00:00:00

abstract：OBJECTIVE:The objective of this phase III trial was to compare chemotherapy combined with bevacizumab versus chemotherapy alone in the treatment of patients with advanced colorectal cancer. METHODS:From September 2004 till September 2008, 222 treatment-naive patients were enrolled and divided into 2 arms: 114 arm A pa...

journal_title：Oncology

authors： Stathopoulos GP,Batziou C,Trafalis D,Koutantos J,Batzios S,Stathopoulos J,Legakis J,Armakolas A

更新日期：2010-01-01 00:00:00

abstract：:We have provided an in-depth, longitudinal, clinical/genetic/pathologic investigation of a family consonant with the sarcoma, breast cancer and brain tumors, lung and laryngeal cancer, leukemia, lymphoma, and adrenalcortical carcinoma syndrome. The pattern of cancer expression involves all three germinal layers with t...

journal_title：Oncology

authors： Lynch HT,Radford B,Lynch JF

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:The clinical features of hepatocellular carcinoma (HCC) differ in patients with and without cirrhosis. OBJECTIVE:We aimed to investigate the long-term outcomes of noncirrhotic HCC patients after curative resection. METHODS:We retrospectively examined 649 consecutive patients with HCC who underwent curative...

journal_title：Oncology

authors： Lee HW,Choi GH,Kim DY,Park YN,Kim KS,Choi JS,Ahn SH,Han KH

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The survival rate of patients with lung cancer has increased significantly over the years, but there has been no further progress in third- or fourth-line therapy. We investigated the efficacy and tolerability of monotherapy with weekly vinorelbine, a semi-synthetic vinca alkaloid, in advanced non-small-cell...

journal_title：Oncology

authors： Kang DH,Kim JO,Jung SS,Park HS,Chung C,Park D,Lee JE

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:Our aim was to assess FDG-PET/CT as a surrogate biomarker of the pathological complete response in locally advanced rectal cancer treated with neoadjuvant chemoradiation. METHODS:T3-4 and/or N+ rectal cancer patients were treated prospectively with capecitabine-based chemoradiation and total mesorectal exci...

journal_title：Oncology

authors： Bampo C,Alessi A,Fantini S,Bertarelli G,de Braud F,Bombardieri E,Valvo F,Crippa F,Di Bartolomeo M,Mariani L,Milione M,Biondani P,Avuzzi B,Chiruzzi C,Pietrantonio F

更新日期：2013-01-01 00:00:00

abstract：:Male and female mice of strains C3H/eB and C57BL/6 were injected subcutaneously with methylcholanthrene (MCA) dissolved in olive oil; mice injected with olive oil served as controls. After intervals of from 2 to 13 weeks, experimental and control mice were injected intraperitoneally with 51Cr-labeled rat red cells (RR...

journal_title：Oncology

authors： Schrieber R,Stern K

更新日期：1984-01-01 00:00:00

abstract：BACKGROUNDS AND AIMS:Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a phospholipid mediator and acts by binding to a specific G-protein-coupled receptor. Though various functions of PAF have been associated with tumor activities, the mechanism of PAF-PAF receptor signaling in the de...

journal_title：Oncology

authors： Kitagawa D,Taketomi A,Kayashima H,Kuroda Y,Itoh S,Yamashita Y,Maehara Y

更新日期：2007-01-01 00:00:00