Expression of platelet-activating factor receptor: a novel prognosticator in patients with hepatocellular carcinoma following hepatectomy.

Abstract:

BACKGROUNDS AND AIMS:Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a phospholipid mediator and acts by binding to a specific G-protein-coupled receptor. Though various functions of PAF have been associated with tumor activities, the mechanism of PAF-PAF receptor signaling in the development of hepatocellular carcinoma (HCC) remains to be elucidated. METHODS:In this study, PAF receptor (PAFR) expression was examined in hepatoma cell lines (Huh7, PLC/PRF/5 and HepG2) and clinical samples of HCC (n = 60) using immunohistochemical staining. The relationships between the expression of PAFR and clinicopathological parameters were also investigated. RESULTS:An immunohistochemical study showed that 24 HCC cases (40%) showed a lower PAFR expression than non-cancerous hepatocytes. The patients were divided into two groups according to the degree of PAFR expression: the high (n = 36) and low PAFR groups (n = 24). Lower expression of PAFR was correlated with poor differentiation, portal vein invasion, high levels of serum alpha-fetoprotein and poor prognosis after surgery. In the low PAFR group, multiple recurrences and distant metastases were more often observed than in the high PAFR group. Multivariate analysis revealed that lower PAFR expression in addition to portal vein invasion is significantly related to survival after hepatectomy. CONCLUSIONS:A lower expression of PAFR correlated with poor differentiation and a poor prognosis, and may therefore be used as a prognostic marker in HCC after hepatectomy.

journal_name

Oncology

journal_title

Oncology

authors

Kitagawa D,Taketomi A,Kayashima H,Kuroda Y,Itoh S,Yamashita Y,Maehara Y

doi

10.1159/000113149

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

381-7

issue

5-6

eissn

0030-2414

issn

1423-0232

pii

000113149

journal_volume

72

pub_type

杂志文章

相关文献

ONCOLOGY文献大全
  • Comparison of spontaneous and induced mutation rates in an immortalized human bronchial epithelial cell line and its tumorigenic derivative.

    abstract::To determine the relationship between neoplastic transformation and increased genetic instability, spontaneous and induced mutation rates were compared in a nontumorigenic, immortalized human bronchial epithelial cell line (NL20) and a tumorigenic cell line (NL20T) spontaneously derived from the NL20 line. Using the h...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000227713

    authors: Wittenkeller JL,Storer B,Bittner G,Schiller JH

    更新日期:1997-07-01 00:00:00

  • Implications of flow cytometry in preoperative detection of biologic variables of gastric cancer and malignant condition of gastric remnant cells obtained by endoscopic biopsy.

    abstract::Flow cytometric (FCM) DNA studies were performed on cell suspensions obtained by endoscopic biopsy in 73 patients with gastric cancer and in 61 patients with gastric remnant. In cancer, DNA aneuploidies were detected in 49 tumors (67.1%), including 51.7% (15/29) of early gastric cancers and 77.3% (34/44) of advanced g...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000227389

    authors: Kimura H,Kanno M,Takamura H,Arakawa H,Maeda K,Uogishi M,Sodani H,Kawashima T

    更新日期:1994-11-01 00:00:00

  • Anal carcinoma: a clinical approach to p53 and RB gene proteins.

    abstract::The role of p53, retinoblastoma (RB) and c-erbB-2 gene proteins in the pathogenesis of anal carcinomas has been examined. A total of 97 patients were included in the study. c-erbB-2, RB and p53 proteins were abnormal in 0, 5 and 34% of the cases, respectively. No correlation was observed between p53 and age, sex, tumo...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000227590

    authors: Tanum G,Holm R

    更新日期:1996-09-01 00:00:00

  • Multicenter phase I study of irinotecan plus raltitrexed in patients with 5-fluorouracil-refractory advanced colorectal cancer.

    abstract::Irinotecan and raltitrexed are active against advanced colorectal cancer, act through different mechanisms, and have non-overlapping toxicity profiles. In vitro studies have shown a schedule-dependent synergism between both drugs. The aim of this multicenter study was to determine the maximum tolerated dose (MTD) of t...

    journal_title:Oncology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1159/000065719

    authors: Aparicio J,de las Peñas R,Vicent JM,Garcerá S,Llorca C,Maestu I,Yuste AL,Farrés J

    更新日期:2002-01-01 00:00:00

  • Elevated serum iron levels following administration of cisplatinum.

    abstract::An increase in serum iron levels and a decrease in serum unsaturated iron binding capacity (uIBC) were noted following the administration of cisplatinum to 9 children with malignancies. The mean serum iron concentration increased from a pretreatment level of 75.7 +/- 30.5 micrograms/ml to a posttreatment level of 162....

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000226657

    authors: Kletter G,Parks BR Jr,Bhatnagar A,Iyer RV

    更新日期:1988-01-01 00:00:00

  • High-dose megestrol acetate as third-line endocrine therapy for metastatic breast cancer.

    abstract::High-dose megestrol acetate (800 mg/day) was administered to 34 patients as third-line endocrine therapy for metastatic breast cancer after progression on standard-dose megestrol acetate (160 mg/day). Among the 32 evaluable patients, no complete or partial response occurred. Ten patients remained stable and 22 progres...

    journal_title:Oncology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000227119

    authors: Cruz JM,Muss HB,Russell G

    更新日期:1992-01-01 00:00:00

  • Surgery for exocrine pancreatic cancer--who are the 5- and 10-year survivors?

    abstract::38 of 306 patients survived beyond 5 years after resection of an exocrine pancreatic carcinoma during a period from 1971 to 1993. Amongst the long-term survivors there were 12 patients with ductal, 22 with ampullary, 3 with distal bile duct and 1 with duodenal cancer. An active operative strategy was employed in order...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000227488

    authors: Klempnauer J,Ridder GJ,Bektas H,Pichlmayr R

    更新日期:1995-09-01 00:00:00

  • Phase II study of bolus 5-fluorouracil and leucovorin combined with weekly paclitaxel as first-line therapy for advanced gastric cancer.

    abstract:OBJECTIVE:We evaluated the efficacy and safety of bolus 5-fluorouracil (5-FU) and leucovorin combined with weekly paclitaxel (FLTAX) in advanced gastric cancer (GC) patients. METHODS:Patients with untreated stage IV GC received paclitaxel 80 mg/m(2) as a 1-hour infusion, followed by 5-FU 600 mg/m(2) as a bolus infusio...

    journal_title:Oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000334462

    authors: Matsubara J,Shimada Y,Kato K,Nagai Y,Iwasa S,Nakajima TE,Hamaguchi T,Yamada Y,Takagi S,Kobayashi K,Yoshioka A,Nakayama N,Tsuji A

    更新日期:2011-01-01 00:00:00

  • Polycythemia Vera Management and Challenges in the Community Health Setting.

    abstract::Patients with polycythemia vera (PV) experience shortened survival, increased risk of thromboembolic and hemorrhagic events, and burdensome symptoms. For all patients with PV, treatment with aspirin and hematocrit control with phlebotomy are recommended. In addition, patients with high-risk status or poor hematocrit c...

    journal_title:Oncology

    pub_type: 杂志文章,评审

    doi:10.1159/000454953

    authors: Gerds AT,Dao KH

    更新日期:2017-01-01 00:00:00

  • Targeting Developmental Pathways: The Achilles Heel of Cancer?

    abstract::Developmental pathways (e.g., Notch, Hippo, Hedgehog, Wnt, and TGF-β/BMP/FGF) are networks of genes that act co-ordinately to establish the body plan, and disruptions of genes in one pathway can have effects in related pathways and may result in serious dysmorphogenesis or cancer. Interestingly, all developmental path...

    journal_title:Oncology

    pub_type: 杂志文章,评审

    doi:10.1159/000478703

    authors: Dempke WCM,Fenchel K,Uciechowski P,Chevassut T

    更新日期:2017-01-01 00:00:00

  • Costs associated with capecitabine or 5-fluorouracil monotherapy after surgical resection in patients with colorectal cancer.

    abstract:OBJECTIVE:To compare chemotherapy-related and total medical costs among patients with colorectal cancer (CRC) receiving capecitabine or 5-fluorouracil (5-FU) monotherapy after surgical resection. METHODS:This retrospective, claim-based study utilized the Thomson Reuters Market Scan(R) databases to identify 1,396 CRC p...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000236048

    authors: Chu E,Shi N,Wei W,Bendell JC,Cartwright T

    更新日期:2009-01-01 00:00:00

  • TC21/R-Ras2 upregulation in esophageal tumorigenesis: potential diagnostic implications.

    abstract:OBJECTIVES:Early detection of esophageal cancer is hampered by paucity of molecular markers for diagnosis of this aggressive gastrointestinal malignancy in early stages. We recently identified TC21/R-Ras2, a small GTP-binding protein (SMG) in esophageal squamous cell carcinomas (ESCCs) by differential display. This stu...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000087283

    authors: Sharma R,Sud N,Chattopadhyay TK,Ralhan R

    更新日期:2005-01-01 00:00:00

  • Serum alphafetoprotein in bladder carcinoma.

    abstract::112 cases, of varying ages, which were diagnosed as having carcinoma of the bladder by cystoscopy and biopsy from the tumor, were investigated for the presence of alphafetoprotein (AFP) in the sera. 59 (52.6%) out of the total, showed positive results, and no false positive results occured. Radioimmunoassay was capabl...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000225188

    authors: Alsabti EA

    更新日期:1977-01-01 00:00:00

  • The role of neck dissection after radical chemoradiation for locally advanced head and neck cancer: should we move back?.

    abstract::Until a few decades ago neck dissection (ND) was the standard surgical approach for node-positive tumours. Nowadays patients with locally advanced head and neck cancer can be treated with definitive chemoradiation (CRT), which includes the treatment of the neck; however, results on residual viable tumour after conserv...

    journal_title:Oncology

    pub_type: 杂志文章,评审

    doi:10.1159/000346132

    authors: Denaro N,Russi EG,Numico G,Pazzaia T,Vitiello R,Merlano MC

    更新日期:2013-01-01 00:00:00

  • PET scans for decision-making in metastatic renal cell carcinoma: a single-institution evaluation.

    abstract:OBJECTIVE:Therapeutic decision-making in metastatic renal cell carcinoma (MRCC) is based on conventional radiological evaluation. Fluorodeoxyglucose positron emission tomography (FDG-PET) scans may modify this strategy. METHODS:Patients with MRCC for whom a therapeutic decision had been made underwent an FDG-PET scan ...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000097946

    authors: Dilhuydy MS,Durieux A,Pariente A,de Clermont H,Pasticier G,Monteil J,Ravaud A

    更新日期:2006-01-01 00:00:00

  • Effect of single carcinogenic dose of dimethylnitrosamine on antibody responses in the rat.

    abstract::The immunodepressive effect of a single, carcinogenic dose of dimethylnitrosamine was tested in a potent model of renal cancer induction using two antigens which differ in their cellular processing. Responsiveness to sheep red blood cells (SRBC), an antigen requiring the collaboration of both thymus-dependent (T) and ...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000225521

    authors: Hard GC

    更新日期:1981-01-01 00:00:00

  • Elevated levels of substances immunologically cross-reactive with insulin in blood of patients with malignant and nonmalignant pulmonary tissue proliferation.

    abstract::Results of a survey of concentrations of substances immunologically cross-reactive with insulin (SICRI), glucose and growth hormone in preprandially drawn blood of 84 patients suffering from bronchial epidermoid, microcellular and adenocarcinomas and 22 patients from sarcoidosis, tuberculosis and obstructive bronchiti...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000226026

    authors: Baltić V,Levanat S,Petek M,Bratić-Mikes V,Pavelić K,Vuk-Pavlović S

    更新日期:1985-01-01 00:00:00

  • Perioperative blood transfusions and prognosis in patients with curatively resected locally advanced gastric cancer.

    abstract::Several reports have demonstrated an adverse effect of perioperative blood transfusions on the survival of patients with various solid tumors treated surgically. We retrospectively investigated the relationship between perioperative blood transfusions and the survival of 501 patients who underwent radical subtotal gas...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000227452

    authors: Choi JH,Chung HC,Yoo NC,Lee HR,Lee KH,Kim JH,Roh JK,Min JS,Lee KS,Kim BS

    更新日期:1995-03-01 00:00:00

  • Increased survival time in brain glioblastomas by a radioneuroendocrine strategy with radiotherapy plus melatonin compared to radiotherapy alone.

    abstract::The prognosis of brain glioblastoma is still very poor and the median survival time is generally less than 6 months. At present, no chemotherapy has appeared to influence its prognosis. On the other hand, recent advances in brain tumor biology have suggested that brain tumor growth is at least in part under a neuroend...

    journal_title:Oncology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000227533

    authors: Lissoni P,Meregalli S,Nosetto L,Barni S,Tancini G,Fossati V,Maestroni G

    更新日期:1996-01-01 00:00:00

  • Reevaluation of C-reactive protein in cancer sera by radioimmunoassay and radial immunodiffusion. I. Diagnostic value and use in battery of conventional tumor markers.

    abstract::C-reactive protein (CRP) has been found to be ubiquitous in sera when determined by a highly sensitive methods such as radioimmunoassay. Patients with some tumors appear to have much higher serum levels of CRP than others; in these, CRP seems to reflect the tumor burden. There is a positive correlation with TNM stagin...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000225572

    authors: Drahovsky D,Dunzendorfer U,Ziegenhagen G,Drahovsky M,Kellen JA

    更新日期:1981-01-01 00:00:00

  • Immunohistological approach to tumor diagnosis.

    abstract::Immunoperoxidase methods permit the demonstration of a variety of antigens in routinely processed tissues. The morphological detail obtained by this procedure is comparable to orthodox haematoxylin and eosin stained sections, and so offers the diagnostic pathologist the opportunity of simultaneously identifying normal...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:

    authors: Taylor CR

    更新日期:1978-01-01 00:00:00

  • Phase-I clinical trial of sodium cyanate in patients with advanced colorectal carcinoma.

    abstract::Sodium cyanate, a drug that selectively suppresses amino acid incorporation for protein synthesis in tumor tissue, was given to patients with advanced colorectal carcinoma who had failed to conventional therapy, with the purpose of assessing a maximum tolerable oral dose. At 35 mg/kg p.o. daily, the drug had to be sto...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000226038

    authors: Herrera-Ornelas L,Petrelli NJ,Madajewicz S,Mittelman A,Allfrey VG

    更新日期:1985-01-01 00:00:00

  • Single-agent gemcitabine for biliary tract cancers. Study outcomes and systematic review of the literature.

    abstract:OBJECTIVE:The aim of this study was to investigate the outcomes of gemcitabine-treated patients with inoperable biliary tract cancers. METHODS:We conducted a retrospective study of consecutively treated 22 inoperable biliary tract cancer patients with gemcitabine (500-1,000 mg/m(2) on days 1, 8, 15 every 4 weeks) as f...

    journal_title:Oncology

    pub_type: 杂志文章,评审

    doi:10.1159/000098109

    authors: Kiba T,Nishimura T,Matsumoto S,Hatano E,Mori A,Yasumi S,Doi R,Ikai I,Kitano T,Nishimura T,Yoshikawa K,Ishiguro H,Yanagihara K,Doi E,Teramukai S,Fukushima M

    更新日期:2006-01-01 00:00:00

  • Pharmacokinetic study of S-1 in patients in whom inulin clearance was measured.

    abstract:OBJECTIVE:This pharmacokinetic study of S-1 was conducted in patients in whom glomerular filtration rate (GFR) was directly measured to explore the possibility of adjusting the S-1 dose on the basis of GFR in patients with normal or nearly normal renal function. METHODS:S-1 was given to 12 patients twice daily for 28 ...

    journal_title:Oncology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000337232

    authors: Ando Y,Kawada K,Inada M,Morita S,Mitsuma A,Yasuda Y,Hiramatsu M,Fujimoto Y,Fujita K

    更新日期:2012-01-01 00:00:00

  • Oxaliplatin-5-fluorouracil and ionizing radiation. Importance of the sequence and influence of p53 status.

    abstract:OBJECTIVES AND METHODS:The association oxaliplatin (OXA)-5-fluorouracil/folinic acid (FUFA) is currently a standard first-line treatment for advanced colorectal cancer. The main objective of this experimental study was to examine the cytotoxic effects resulting from the addition of ionizing radiation (Rgamma) to the co...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000069308

    authors: Magné N,Fischel JL,Formento P,Etienne MC,Dubreuil A,Marcié S,Lagrange JL,Milano G

    更新日期:2003-01-01 00:00:00

  • Larotaxel with Cisplatin in the first-line treatment of locally advanced/metastatic urothelial tract or bladder cancer: a randomized, active-controlled, phase III trial (CILAB).

    abstract:BACKGROUND:This open-label, randomized phase III trial evaluated larotaxel/cisplatin versus gemcitabine/cisplatin as first-line treatment for locally advanced (T4b) or metastatic urothelial tract or bladder cancer. METHODS:Patients were randomized to larotaxel 50 mg/m(2) with cisplatin 75 mg/m(2) every 3 weeks (larota...

    journal_title:Oncology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1159/000354085

    authors: Sternberg CN,Skoneczna IA,Castellano D,Theodore C,Blais N,Voog E,Bellmunt J,Peters F,Le-Guennec S,Cerbone L,Risse ML,Machiels JP

    更新日期:2013-01-01 00:00:00

  • Phase II study of combined administration of 5-fluorouracil, epirubicin and mitomycin-C by hepatic artery infusion in patients with liver metastases of gastric cancer.

    abstract::This multicenter phase II study evaluated the efficacy of the FEM regimen (5-fluorouracil 333 mg/m(2) each week, epirubicin 30 mg/m(2) once every 4 weeks and mitomycin-C 2.7 mg/m(2) once every 2 weeks) administered by hepatic artery infusion (HAI) for unresectable hepatic metastases of gastric cancer. The response rat...

    journal_title:Oncology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1159/000012034

    authors: Kumada T,Arai Y,Itoh K,Takayasu Y,Nakamura K,Ariyoshi Y,Tajima K

    更新日期:1999-10-01 00:00:00

  • Nicotinamide cooperates with retinoic acid and 1,25-dihydroxyvitamin D(3) to regulate cell differentiation and cell cycle arrest of human myeloblastic leukemia cells.

    abstract::Nicotinamide, the amide derivative of vitamin B(3), cooperates with retinoic acid (RA), a form of vitamin A, and 1,25-dihydroxyvitamin D(3) (D3), to regulate cell differentiation and proliferation of human myeloblastic leukemia cells. In human myeloblastic leukemia cells, RA or D3 are known to cause MAPK signaling lea...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000188664

    authors: Shen M,Yen A

    更新日期:2009-01-01 00:00:00

  • Papillary microcarcinomas of the thyroid with preoperatively detectable lymph node metastasis show significantly higher aggressive characteristics on immunohistochemical examination.

    abstract:OBJECTIVES:We recently demonstrated that papillary microcarcinomas with preoperatively detectable node metastasis in the lateral compartment on ultrasonography (clinically apparent metastasis) show worse postoperative relapse-free survival than those with no metastasis or metastasis that could not be detected preoperat...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000085701

    authors: Ito Y,Uruno T,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Kuma K,Miyauchi A

    更新日期:2005-01-01 00:00:00

  • Benzodiazepine use in breast cancer survivors: findings from a consecutive series of 1,000 patients.

    abstract:OBJECTIVE:This study reports the percentage of breast cancer survivors receiving ongoing benzodiazepines and the circumstances surrounding their usage. METHODS:The medical records of 1,000 consecutive breast cancer survivors who were no longer receiving adjuvant chemotherapy were reviewed. RESULTS:Among those patient...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000330814

    authors: Vaidya R,Sood R,Karlin N,Jatoi A

    更新日期:2011-01-01 00:00:00