Less Fibrotic Burden Differently Affects the Long-Term Outcomes of Hepatocellular Carcinoma after Curative Resection.

abstract：:This study evaluated the influence of bile acid load on the DNA distribution pattern of proliferated bile ductules and cholangiocarcinoma induced by diisopropanolnitrosamine. Ninety hamsters were separated into control, tauro- and deoxycholic acid (DCA) groups. The DNA distribution pattern of intrahepatic lesions at 1...

journal_title：Oncology

authors： Kinami Y,Miyakoshi M,Fujikawa K

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:Pediatric-type sarcomas such as Ewing's sarcoma (EWS)/primitive neuroectodermal tumor family and rhabdomyosarcoma are relatively uncommon in adult patients. Optimal treatment strategies for this population and prognosis in adult patients compared with pediatric patients remain controversial. METHODS:We retro...

journal_title：Oncology

authors： Ahn HK,Uhm JE,Lee J,Lim DH,Seo SW,Sung KS,Lee SJ,Lee DJ,Baek KK,Kim WS,Park JO

更新日期：2011-01-01 00:00:00

abstract：:Male and female mice of strains C3H/eB and C57BL/6 were injected subcutaneously with methylcholanthrene (MCA) dissolved in olive oil; mice injected with olive oil served as controls. After intervals of from 2 to 13 weeks, experimental and control mice were injected intraperitoneally with 51Cr-labeled rat red cells (RR...

journal_title：Oncology

authors： Schrieber R,Stern K

更新日期：1984-01-01 00:00:00

abstract：:Various oncogenic agents were employed in tumor susceptibility studies of an inbred subline of BALB/cGn mice, BALB/cGnDu, which carries a mutant gene that results in spontaneous thymic involution in homozygous recessive individuals. Of 18 transplantable tumors, 3 in vitro transformed cell lines, 2 oncogenic papovaviru...

journal_title：Oncology

authors： Morrison DG,Moyer MP,Lynd FT,Rogers W,Moyer RC

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:Choriocarcinoma is the most common epithelial cancer among gestational trophoblastic diseases (GTDs); the mechanism of trophoblastic carcinogenesis is unknown. This study aimed to examine the expression of NF-κB family proteins in GTDs and placental tissues as well as the roles of c-Rel in choriocarcinoma. M...

journal_title：Oncology

authors： Sekiya Y,Yamamoto E,Niimi K,Nishino K,Nakamura K,Kotani T,Kajiyama H,Shibata K,Kikkawa F

更新日期：2017-01-01 00:00:00

abstract：:While central ports are located at the chest, peripheral ports (PP) are inserted at the patients' forearms. Two new PPs (Healthport miniMax((R)) and Bard Titan Low Profile Port) and two well-established types (Port-A-Cath((R)) P.A.S. Port and PeriPort(TM) peripheral access system) were tested. 125 patients were given ...

journal_title：Oncology

authors： Lersch C,Eckel F,Sader R,Paschalidis M,Zeilhofer F,Schulte-Frohlinde E,Theiss W

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVES:Recently, it has been reported that expression of the HRK gene was significantly reduced by hypermethylation in astrocytic tumors. Our aim is to verify the alterations in the HRK gene in primary central nervous system lymphomas (PCNSLs). METHODS:We analyzed the hypermethylation status and expression of the ...

journal_title：Oncology

authors： Nakamura M,Ishida E,Shimada K,Nakase H,Sakaki T,Konishi N

更新日期：2006-01-01 00:00:00

abstract：:Immunochemical analysis of various tumors, representing 12 different tissue sites of origin, revealed a gamma-fetal antigen(gamma-FA)-like component in 17 of 23 malignant neoplasms of the mouse. This antigen was identified in extracts of spontaneous and carcinogen-induced murine tumors as well as in extracts of hepati...

journal_title：Oncology

authors： Higgins PJ,Tong C,Borenfreund E

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:In most guidelines, no other interventional therapy but liver transplantation is recommended for the treatment of hepatocellular carcinoma (HCC) with Child-Pugh C cirrhosis (CP-C). However, in Japan, patients were sometimes treated with expectation of benefit. SUMMARY:A workshop was conducted to explore the...

journal_title：Oncology

authors： Nouso K,Kokudo N,Tanaka M,Kuromatsu R,Nishikawa H,Toyoda H,Oishi N,Kuwaki K,Kusanaga M,Sakaguchi T,Morise Z,Kitai S,Kudo M

更新日期：2014-01-01 00:00:00

abstract：:72 patients with advanced malignant lymphoma resistant to standard chemotherapy were treated with 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea (CCNU) at 130 mg/m2 orally every six weeks. Objective responses were noted in 13 of 39 evaluable patients with Hodgkin's disease, three of 15 patients with lymphocytic lymphoma...

journal_title：Oncology

authors： Stolinsky DC,Solomon J,Weiner JM,Bateman JR

更新日期：1976-01-01 00:00:00

abstract：:Systemic chemotherapy for advanced gastric cancer is frequently associated with significant treatment-related toxicity, which is particularly serve in patients presenting with a poor general condition. A search for effective and low-toxic regimens for this group of patients is mandatory. A weekly 24-hour infusion of h...

journal_title：Oncology

authors： Hsu CH,Yeh KH,Chen LT,Liu JM,Jan CM,Lin JT,Chen YC,Cheng AL

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:It is unclear for whom new anti-human epidermal growth factor receptor 2 (anti-HER2) agents, such as pertuzumab and T-DM1, should be considered. We investigated prognostic factors before neoadjuvant chemotherapy (NAC) among HER2-positive invasive breast cancer patients and those after NAC among patients who ...

journal_title：Oncology

authors： Fujita N,Enomoto Y,Inakami K,Yanagisawa T,Iguchi C,Aono T,Nomura T,Yamamoto H,Kasugai T,Shiba E

更新日期：2020-01-01 00:00:00

abstract：:An in vitro system was used to study the uptake of 5-fluorouracil by LSA ascites tumor cells. Changes in drug uptake with cell age and following a 1,000-rad radiation perturbation of the cell population were studied. DNA synthesis and drug uptake were highest during early rapid tumor growth and decreased with tumor ag...

journal_title：Oncology

authors： Young JA,Maruyama Y

更新日期：1981-01-01 00:00:00

abstract：:A cultured cell line (SHIN-3) derived from a human ovarian serous cystadenocarcinoma which consistently produces two tumor markers, CA-125 and tissue polypeptide antigen (TPA) was established. After 1 week of culture of 1 x 10(5) cells, high levels of tumor marker were observed (the total CA-125 release was 1,500 U an...

journal_title：Oncology

authors： Imai S,Kiyozuka Y,Maeda H,Noda T,Hosick HL

更新日期：1990-01-01 00:00:00

abstract：:C-reactive protein (CRP) has been found to be ubiquitous in sera when determined by a highly sensitive methods such as radioimmunoassay. Patients with some tumors appear to have much higher serum levels of CRP than others; in these, CRP seems to reflect the tumor burden. There is a positive correlation with TNM stagin...

journal_title：Oncology

authors： Drahovsky D,Dunzendorfer U,Ziegenhagen G,Drahovsky M,Kellen JA

更新日期：1981-01-01 00:00:00

abstract：:The levels of 3',5'-cyclic adenosine monophosphate (cAMP) were measured in a high malignant and a low malignant clone of murine fibrosarcoma cells isolated from a common parent in a normal mouse fibroblasts at various stages of growth. There was an inverse correlation between the degree of malignant potential and the ...

journal_title：Oncology

authors： Elgebaly S,Kunkel S,Lovett EJ,Varani J

更新日期：1982-01-01 00:00:00

abstract：:The purpose of this study was to evaluate in a dog model whether intrapericardial instillation of tetracycline is superior to the effect of drainage alone in causing pericardial adhesions and cavity obliteration. Twelve mongrel dogs were randomly divided into two experimental groups. All dogs received a pericardial dr...

journal_title：Oncology

authors： Markiewicz W,Ben-Arieh Y,Best L,Mordochovich D,Rinkevitch D

更新日期：1993-11-01 00:00:00

abstract：:A patient seen at presentation for Hodgkin's disease (HD) at stage IV B was successfully treated with MOPP. In remission he developed coeliac disease, controlled by dietary measures, but 26 months after the end of chemotherapy a severe dyspeptic syndrome appeared; endoscopy and barium meal suggested the presence of a ...

journal_title：Oncology

authors： Eridani S,Singh AK

更新日期：1986-01-01 00:00:00

abstract：:The use of the blood-brain barrier and of tumor-specific antibodies to concentrate boron selectivity in gliomas for neutron capture therapy is considered experimentally and theoretically. The time-dependent concentration of two anionic boranes, B12 H11 SH2- and B12 H11 SOSB12 H114-, in the blood, brain, and tumor of ...

journal_title：Oncology

authors： Tolpin EI,Wellum GR,Dohan FC Jr,Kornblith PL,Zamenhof RG

更新日期：1975-01-01 00:00:00

abstract：OBJECTIVE:Anti-p53 levels detected by different methods were compared in a predefined group of patients with breast cancer and correlated with p53 antigen expression in the corresponding tumors. METHODS:P53 autoantibodies were investigated in 165 patients with primary breast cancer using ELISAs with recombinant or nat...

journal_title：Oncology

authors： Volkmann M,Sinn HP,Gaugel D,Frey M,Hajjar Y,Ludwig J,Hänsel S,Bastert G,Wallwiener D,Fiehn W,Zentgraf H,Huober J

更新日期：2002-01-01 00:00:00

abstract：:We studied the chemo-radiotherapy of testicular tumors in clinical stage III. Our study involved 54 patients with lung metastases of seminoma and nonseminoma, treated with a combination of radiotherapy and chemotherapy. The results obtained have not satisfied our expectations. While in the 16 seminoma patients only 43...

journal_title：Oncology

authors： Mechl Z,Malír A

更新日期：1980-01-01 00:00:00

abstract：:The diagnostic imaging of hepatocellular carcinoma (HCC) has recently undergone marked progress. The advent of the ultrasound (US) contrast agent Sonazoid, approved in January 2007, and magnetic resonance imaging (MRI) with the liver-specific MRI contrast agent gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic ac...

journal_title：Oncology

authors： Kudo M

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES AND METHODS:The association oxaliplatin (OXA)-5-fluorouracil/folinic acid (FUFA) is currently a standard first-line treatment for advanced colorectal cancer. The main objective of this experimental study was to examine the cytotoxic effects resulting from the addition of ionizing radiation (Rgamma) to the co...

journal_title：Oncology

authors： Magné N,Fischel JL,Formento P,Etienne MC,Dubreuil A,Marcié S,Lagrange JL,Milano G

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the feasibility of conducting a patient satisfaction survey in the oncology hospital setting, using a multidimensional patient satisfaction questionnaire to be completed at home. METHODS:Socio-demographic and clinical data were collected for 133 consecutive patients. Patients were asked to comple...

journal_title：Oncology

authors： Brédart A,Razavi D,Robertson C,Didier F,Scaffidi E,Fonzo D,Autier P,de Haes JC

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:This study was performed to investigate the activity and safety of high dose 5-fluorouracil (5-FU) given as a weekly 24-hour infusion in combination with folinic acid plus mitomycin C in patients with advanced gastric cancer. PATIENTS AND METHODS:Chemonaive patients with locally advanced inoperable, recurrent ...

journal_title：Oncology

authors： Kretzschmar A,Reichardt P,Thuss-Patience PC,Hohenberger P,Benter T,Dörken B,Köhne CH

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to evaluate the antitumor, survival, and adverse effects of hepatic arterial infusion chemotherapy using epirubicin in patients with advanced hepatocellular carcinoma and portal vein tumor thrombosis. METHODS:The study population comprised 45 consecutive patients with advanced...

journal_title：Oncology

authors： Ikeda M,Okusaka T,Ueno H,Morizane C,Iwasa S,Hagihara A,Kojima Y

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:To evaluate the efficacy and toxicity of irinotecan and oxaliplatin plus 5-fluorouracil (FU) and leucovorin (FOLFIRINOX) as second-line therapy in metastatic pancreatic adenocarcinoma (MPA). PATIENTS AND METHODS:We retrospectively analyzed the medical records of 27 patients with MPA treated with FOLFIRINOX ...

journal_title：Oncology

authors： Assaf E,Verlinde-Carvalho M,Delbaldo C,Grenier J,Sellam Z,Pouessel D,Bouaita L,Baumgaertner I,Sobhani I,Tayar C,Paul M,Culine S

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:Anaplastic oligodendrogliomas (AO) are uncommon primary brain tumors whose natural history, prognosis, and optimal management are not yet fully understood. However, they are associated with a better prognosis and response to multimodality therapy based on specific molecular changes. In this multicenter retro...

journal_title：Oncology

authors： Puduvalli VK,Hashmi M,McAllister LD,Levin VA,Hess KR,Prados M,Jaeckle KA,Yung WK,Buys SS,Bruner JM,Townsend JJ,Davis R,Sawaya R,Kyritsis AP

更新日期：2003-01-01 00:00:00

abstract：:Sodium cyanate, a drug that selectively suppresses amino acid incorporation for protein synthesis in tumor tissue, was given to patients with advanced colorectal carcinoma who had failed to conventional therapy, with the purpose of assessing a maximum tolerable oral dose. At 35 mg/kg p.o. daily, the drug had to be sto...

journal_title：Oncology

authors： Herrera-Ornelas L,Petrelli NJ,Madajewicz S,Mittelman A,Allfrey VG

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:Nucleoside and nucleobase derivatives are currently used in the treatment of a variety of solid tumors; however, the role of plasma membrane transporters as biomarkers of drug metabolism has not been fully addressed. Thus, the purpose of this study was to determine whether the concentrative nucleoside transport...

journal_title：Oncology

authors： Gloeckner-Hofmann K,Guillén-Gómez E,Schmidtgen C,Porstmann R,Ziegler R,Stoss O,Casado FJ,Rüschoff J,Pastor-Anglada M

更新日期：2006-01-01 00:00:00