Unexpectedly low incorporation of isotopic acetate into lipids of Ehrlich ascites tumor cells cultured in lipid-poor medium.

abstract：PURPOSE:We investigated whether a 5-fluorouracil (5-FU)-resistant tumor could regain chemosensitivity after the administration of 5-aza-2'-deoxycytidine (DAC) as a demethylating agent. METHODS:Human colorectal cancer cells (SW48) are characterized by the hypermethylation of proapoptotic genes. They were transplanted i...

journal_title：Oncology

authors： Morita S,Iida S,Kato K,Takagi Y,Uetake H,Sugihara K

更新日期：2006-01-01 00:00:00

abstract：:Patients with polycythemia vera (PV) experience shortened survival, increased risk of thromboembolic and hemorrhagic events, and burdensome symptoms. For all patients with PV, treatment with aspirin and hematocrit control with phlebotomy are recommended. In addition, patients with high-risk status or poor hematocrit c...

journal_title：Oncology

authors： Gerds AT,Dao KH

更新日期：2017-01-01 00:00:00

abstract：:In the present study, an analysis of whether expression of nm23-H1 and nm23-H2 proteins has prognostic significance was performed. A series of 95 renal cell carcinomas was analyzed for nuclear grade, tumor size (larger than 50 mm or not), staging in the Robson system and expression of nm23-H1 and nm23-H2, as well as p...

journal_title：Oncology

authors： Nakagawa Y,Tsumatani K,Kurumatani N,Cho M,Kitahori Y,Konishi N,Ozono S,Okajima E,Hirao Y,Hiasa Y

更新日期：1998-07-01 00:00:00

abstract：:The registry of digestive cancer set up for the French department of Côte d'Or (455, 727) enables a morbidity study about esophageal cancer to be made among residents. The crude animal incidence rate was 16.7/100,000 for males and 1.2/100,000 for females. Corresponding age-standardized rates were 13.2 and 0.5. The sex...

journal_title：Oncology

authors： Faivre J,Milan C,Martin F,Michiels R,Cabanne F,Klepping C

更新日期：1981-01-01 00:00:00

abstract：:In 86 children with acute lymphocytic leukemia (ALL) and in 6 children with medulloblastoma 253 24-hour methotrexate (MTX) infusions with 150, 500, and 700 mg/m2 were performed. MTX concentrations in plasma and cerebrospinal fluid (CSF) were measured with a specific radioimmunoassay. In 131 infusions with 500 mg/m2 gi...

journal_title：Oncology

authors： Janka GE,Mack R,Helmig M,Haas RJ,Bidlingmaier F

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVES:A germline BIM deletion polymorphism has been proposed to predict a poor treatment efficacy of certain kinase inhibitors. The current study aimed to explore whether the BIM deletion polymorphism predicts the treatment efficacy of sorafenib for advanced hepatocellular carcinoma (HCC). METHODS:All patients wh...

journal_title：Oncology

authors： Shao YY,Chang YL,Huang CY,Hsu CH,Cheng AL

更新日期：2013-01-01 00:00:00

abstract：:Primary fetal rat fibroblasts (FRF cells) were transfected with DNA extracted from BKV-transformed hamster kidney cells at low passage after transformation (HKBKlp cells) and at high passage after transformation (HKBKhp cells). Two transformed rat cell lines were obtained, FRF-DNA-HKBKlp cells and FRF-DNA-HKBKhp cells...

journal_title：Oncology

authors： Possati L,Collesi A,Rosciani C,Rubini C

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:To assess the feasibility and efficacy of intensity-modulated radiation implemented with helical tomotherapy image-guided with daily megavoltage computed tomography for head and neck cancer. METHODS:Between May 2010 and May 2013, 72 patients were treated with curative intent. The median age was 64 years, wi...

journal_title：Oncology

authors： Santa Cruz O,Tsoutsou P,Castella C,Khanfir K,Anchisi S,Bouayed S,Matzinger O,Ozsahin M

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:Cancer-related fatigue is a common complaint during cancer treatment and is often associated with cognitive impairment. This study examined cognitive deficits that were associated with fatigue symptoms during external-beam radiation therapy (EBRT) in men with localized prostate cancer. METHODS:A total of 36 pa...

journal_title：Oncology

authors： Feng LR,Espina A,Saligan LN

更新日期：2018-01-01 00:00:00

abstract：:Beard's theory can be restated in a modified form in modern terms in the following way. Cancer represents primarily trophoblastic tissue derived either from an aberrant germ cell or from a somatic cell whose normally repressed 'asexual generation' genes are abnormally reactivated ('derepressed'). The variety of tumors...

journal_title：Oncology

authors： Gurchot C

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:Previous data showed that distant metastatic breast cancer (MBC) might be curable in up to 3% of the cases in selected patients, mostly young, with good performance status and with low-volume metastatic disease, mainly by an aggressive multidisciplinary approach including aggressive combination chemotherapy ...

journal_title：Oncology

authors： Güth U,Elfgen C,Montagna G,Schmid SM

更新日期：2019-01-01 00:00:00

abstract：:One hundred and seventy-five patients selected at random were prospectively studied. All patients were assessed at least after the first cycle of treatment by a self-report questionnaire which covered the occurrence of nausea and vomiting 24 before chemotherapy, as well as information regarding 22 clinical parameters....

journal_title：Oncology

authors： Alba E,Bastus R,de Andres L,Sola C,Paredes A,Lopez Lopez JJ

更新日期：1989-01-01 00:00:00

abstract：:The disease provoked by injections of water and other harmless liquids or wounds without tissue loss, is characterized by the regression of certain organs, opening in the epidermis, pigmentary anomalies and malignant tumors. The very few worms which recover spontaneously, regenerate the eliminated parts or develop sup...

journal_title：Oncology

authors： Chandebois R

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:Postoperative management of patients with pancreatic adenocarcinoma (PA) is controversial. METHODS:The aim of this pilot study was to assess the feasibility of postoperative combination chemotherapy followed by radiotherapy in patients aged 18-70 years with a histological diagnosis of PA, and Karnofsky perf...

journal_title：Oncology

authors： Reni M,Passoni P,Bonetto E,Balzano G,Panucci MG,Zerbi A,Ronzoni M,Staudacher C,Villa E,Di Carlo V

更新日期：2005-01-01 00:00:00

abstract：:Mice of four different inbred strains (CBA, Balb/c, C57Bl/6 and DBA/2), bearing different transplanted tumours (methylcholanthrene-induced sarcomas, B16 melanoma and P-815 mastocytoma), were tested for cellular immune reactivity to the synthetic encephalitogenic peptide of human myelin basic protein by the leucocyte a...

journal_title：Oncology

authors： Yong WK,Halliday WJ

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:Nucleoside and nucleobase derivatives are currently used in the treatment of a variety of solid tumors; however, the role of plasma membrane transporters as biomarkers of drug metabolism has not been fully addressed. Thus, the purpose of this study was to determine whether the concentrative nucleoside transport...

journal_title：Oncology

authors： Gloeckner-Hofmann K,Guillén-Gómez E,Schmidtgen C,Porstmann R,Ziegler R,Stoss O,Casado FJ,Rüschoff J,Pastor-Anglada M

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:There is no standard second-line therapy for patients with oesophagogastric cancer who progress following first-line chemotherapy for advanced disease or relapse following radical multi-modality therapy. The aim of this retrospective study was to evaluate survival following rechallenge with platinum plus fluoro...

journal_title：Oncology

authors： Okines AF,Asghar U,Cunningham D,Ashley S,Ashton J,Jackson K,Hawkes E,Chau I

更新日期：2010-01-01 00:00:00

abstract：:Twenty-seven patients with advanced measurable colorectal carcinoma were treated with a combination protocol consisting of folinic acid (FA) 200 mg/m2 i.v. bolus followed by 5-fluorouracil (5-FU) 550 mg/m2, and cisplatin (CIS) 20 mg/m2 each administered as a 2-hour i.v. infusion. Treatment was given on 4 consecutive d...

journal_title：Oncology

authors： Scheithauer W,Depisch D,Schiessel R,Ludwig H

更新日期：1989-01-01 00:00:00

abstract：:Surgical resection, transarterial chemoembolization, percutaneous ethanol injection therapy, radiofrequency ablation, and orthotopic liver transplantation are generally accepted treatment modalities in hepatocellular carcinoma, but there has been no standard therapy for patients at the advanced stage. Several combinat...

journal_title：Oncology

authors： Lee HC

更新日期：2008-01-01 00:00:00

abstract：:Improved understanding of tumor biology has led to the identification of numerous growth factors that are involved in malignant transformation and tumor progression. Many of these factors induce cellular responses through receptors with intrinsic tyrosine kinase (TK) activity. Therefore, inhibiting receptor TK activit...

journal_title：Oncology

authors： Baselga J,Hammond LA

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:Patient nonadherence to oral antineoplastic therapy is a well-recognized barrier to effective treatment. In order to identify patients who may need additional support to become adherent, it is important to have a useful tool that takes into account all the parameters of adherence to prescription. The aim of thi...

journal_title：Oncology

authors： Thivat E,Van Praagh I,Belliere A,Mouret-Reynier MA,Kwiatkowski F,Durando X,Mahammedi H,Dillies AF,Chollet P,Chevrier R

更新日期：2013-01-01 00:00:00

abstract：:After nearly four decades of clinical experience with the fluoropyrimidines, 5-fluorouracil (5-FU) remains an integral part of chemotherapy for colorectal cancer. A range of 5-FU treatment regimens with or without biochemical modulation are currently used and toxicity appears to be schedule dependent. The use of oral ...

journal_title：Oncology

authors： Brito RA,Medgyesy D,Zukowski TH,Royce ME,Ravandi-Kashani F,Hoff PM,Pazdur R

更新日期：1999-07-01 00:00:00

abstract：:Between 1986 and 1991, 35 patients with esophageal cancer (TNM stages II-IV) underwent transthoracic esophagectomy with lymph adenectomy and were subsequently treated with 5,000 cGy of radiation (days 1-40) and concurrently with two courses of chemotherapy (cisplatin, vindesine and pepleomycin, days 21-26 and 49-54). ...

journal_title：Oncology

authors： Saito T,Shigemitsu Y,Kinoshita T,Shimoda K,Abe T,Nakamura A,Chikuba K,Kobayashi M

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to examine the prognostic value of the preoperative serum alpha-L-fucosidase (AFU) activity in colorectal cancer and to assess whether it could add prognostic information that Dukes' stages do not give. METHODS:A postoperative follow-up of 137 colorectal cancer patients was perform...

journal_title：Oncology

authors： Ayude D,Páez De La Cadena M,Martínez-Zorzano VS,Fernández-Briera A,Rodríguez-Berrocal FJ

更新日期：2003-01-01 00:00:00

abstract：:An in vitro system was used to study the uptake of 5-fluorouracil by LSA ascites tumor cells. Changes in drug uptake with cell age and following a 1,000-rad radiation perturbation of the cell population were studied. DNA synthesis and drug uptake were highest during early rapid tumor growth and decreased with tumor ag...

journal_title：Oncology

authors： Young JA,Maruyama Y

更新日期：1981-01-01 00:00:00

abstract：:The effects of theophylline treatment on mouse B-16 melanoma cell growth, metabolism, and membrane antigen expression in vitro were studied. Theophylline treatment inhibited DNA synthesis and the cell growth rate, and caused an elevation of intracellular cAMP levels. Cells treated with theophylline became elongated an...

journal_title：Oncology

authors： Kolb CA,Mansfield JM

更新日期：1980-01-01 00:00:00

abstract：:The purpose of the present study was to determine with two-dimensional electrophoresis whether two sublines (high and low metastatic potential to lymph nodes) of rat fibrosarcoma induced by methylcholanthrene have differences in cellular proteins. The high metastatic potential subline had a specific protein in the pro...

journal_title：Oncology

authors： Minato K,Manabe T,Okuyama N,Sasaki Y,Nakagawa K,Saijo N

更新日期：1992-01-01 00:00:00

abstract：:Nontumor-bearing C3H/He mice were splenectomized and intravenously inoculated 7 days later with Streptococcus pneumoniae, Pseudomonas aeruginosa, or Escherichia coli. The survival rate was reduced by splenectomy in the animals inoculated with S. pneumoniae, but did not change in those inoculated with P. aeruginosa or ...

journal_title：Oncology

authors： Ando T,Motokawa I,Sakurai K,Ohmura Y,Matsunaga K,Fujii T,Yoshikumi C,Taguchi T

更新日期：1988-01-01 00:00:00

abstract：:Three polycyclic hydrocarbons: benzo(a)pyrene; dibenz(a,h)-anthracene and dibenz(a,c)anthracene, differing in their carcinogenicity, were administered to female rats. The comparative intracellular localization of these compounds was studied by fluorescence microscopy. The two carcinogenic molecules were localized both...

journal_title：Oncology

authors： Stora C

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:The tumor suppressor gene p53 is a nuclear protein which plays a key role in tumor progression by regulating DNA repair, cell division and apoptosis. One major function of wild-type p53 is to control the onset of DNA replication at the G1-S boundary by inducing p21 protein, which promotes cell cycle arrest b...

journal_title：Oncology

authors： Okuyama T,Maehara Y,Kabashima A,Takahashi I,Kakeji Y,Sugimachi K

更新日期：2002-01-01 00:00:00