Abstract:
:To extend the information on the mutagenic effect of methylazoxymethanol (MAM) acetate, which has been established as a potent carcinogen, the frequency of sister-chromatid exchange (SCE) was determined in bone marrow cells of Sprague Dawley rats and in cultured rat lymphocytes. To get differentially stained chromatids under in vivo conditions, the rats received 5-bromodeoxyuridine adsorbed on activated charcoal intraperitoneally. Chromosomes were stained with fluorescence plus Giemsa. In this study a significant increase of SCE frequency after the application of various concentrations of MAM acetate could be observed both in vivo and in vivo.
journal_name
Oncologyjournal_title
Oncologyauthors
Gloser Hdoi
10.1159/000225615subject
Has Abstractpub_date
1982-01-01 00:00:00pages
101-3issue
2eissn
0030-2414issn
1423-0232journal_volume
39pub_type
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