Abstract:
:After exposure to the mutagen, ethylmethanesulfonate (EMS), or the carcinogen, urethane (UR), anchorage independence was observed in cultures derived from normal skin biopsies from patients with the heritable cancer syndrome, adenomatosis of the colon and rectum (ACR). Such colonies from methylcellulose suspension cultures did not produce tumors in athymic mice. Dissociation of growth in suspension from tumorigenicity was considered to be consistent with the hypothesis that a series of somatic mutation-like events occur in carcinogenesis. Such ACR cells should prove to be useful in studies on the genetic predisposition to cancer.
journal_name
Oncologyjournal_title
Oncologyauthors
Danes BSdoi
10.1159/000225478subject
Has Abstractpub_date
1980-01-01 00:00:00pages
386-9issue
6eissn
0030-2414issn
1423-0232journal_volume
37pub_type
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