Abstract:
:203 tumor specimens from 175 patients were studied. Amplification of ERBB-2 was detected in 14 out of 63 (22%) cases of breast carcinoma, in 1 out of 23 patients with ovarian cancers, in 1 out of 19 cases of colon carcinoma and in 1 out of 27 patients with thyroid cancer. We failed to find more than one copy of ERBB-2 in 34 patients with lung cancers, 6 with sarcomas and 3 with melanomas. There was tendency toward correlation between ERBB-2 amplification and lymph node involvement in patients with breast carcinoma. Thus, the oncogene ERBB-2 is often amplified in human tumors, but breast cancer is characterized by an especially high frequency of ERBB-2 amplification.
journal_name
Oncologyjournal_title
Oncologyauthors
Knyazev PG,Imyanitov EN,Chernitca OI,Nikiforova IF,Hanson KPdoi
10.1159/000227032subject
Has Abstractpub_date
1992-01-01 00:00:00pages
162-5issue
2eissn
0030-2414issn
1423-0232journal_volume
49pub_type
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