Abstract:
:An experimental model is introduced for the study of liver metastases using intrasplenically injected EL-4 and Lewis lung tumor cells. Fluorinated pyrimidine derivatives, 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil, showed inhibitory effects on the frequencies of liver metastases. Immunosuppressive effects of these drugs were compared at the doses capable of showing 50% inhibition of the development of metastatic nodules. These derivatives strongly suppressed the phagocytic activity and the number of Kupffer cells of the liver and then the humoral response against sheep red blood cells, the delayed hypersensitivity against picryl chloride. On the contrary, combined administration of protein-bound polysaccharide (PSK) and 1-(2-tetrahydrofuryl)-5-fluorouracil showed no inhibitory effect on these activities.
journal_name
Oncologyjournal_title
Oncologyauthors
Tsuru S,Shinomiya N,Katsura Y,Gotoh M,Noritake M,Nomoto Kdoi
10.1159/000226989subject
Has Abstractpub_date
1991-01-01 00:00:00pages
498-504issue
6eissn
0030-2414issn
1423-0232journal_volume
48pub_type
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