Trial of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU; NSC-79037) in advanced bronchogenic carcinoma 1,2,3.

abstract：:We report four cases of Hodgkin's disease (HD) relapsing after complete remission for over a 10-year period after the initial therapy. Three of the patients had mixed-cellularity subtypes as a primary histological diagnosis, and the rebiopsies demonstrated mixed cellularity in all very late relapse cases. Two patients...

journal_title：Oncology

authors： Illés A,Bányai A,Vadász G,Szegedi G

更新日期：1995-07-01 00:00:00

abstract：:Lymphomas, which are frequently subdivided into Hodgkin's disease and non-Hodgkin's lymphoma, represent one of the more curable cancers that present as a solid tumor. Unfortunately, most patients cannot be cured with conventional chemotherapy, therefore new techniques have been developed including high-dose chemothera...

journal_title：Oncology

authors： Armitage JO

更新日期：2000-04-01 00:00:00

abstract：:C-reactive protein (CRP) has been found to be ubiquitous in sera when determined by a highly sensitive methods such as radioimmunoassay. Patients with some tumors appear to have much higher serum levels of CRP than others; in these, CRP seems to reflect the tumor burden. There is a positive correlation with TNM stagin...

journal_title：Oncology

authors： Drahovsky D,Dunzendorfer U,Ziegenhagen G,Drahovsky M,Kellen JA

更新日期：1981-01-01 00:00:00

abstract：:6 cases of endodermal sinus tumor of the ovary are presented. In 4 patients pure endodermal sinus tumor was found microscopically. 1 patient had endodermal sinus tumor in one ovary and gonadoblastoma in the contralateral one. In another case endodermal sinus tumor was accompanied by an embryonal teratoma. Histological...

journal_title：Oncology

authors： Sikorowa L,Morawski A,Piatkowski Z

更新日期：1979-01-01 00:00:00

abstract：:To determine the relationship between neoplastic transformation and increased genetic instability, spontaneous and induced mutation rates were compared in a nontumorigenic, immortalized human bronchial epithelial cell line (NL20) and a tumorigenic cell line (NL20T) spontaneously derived from the NL20 line. Using the h...

journal_title：Oncology

authors： Wittenkeller JL,Storer B,Bittner G,Schiller JH

更新日期：1997-07-01 00:00:00

abstract：:Mice of four different inbred strains (CBA, Balb/c, C57Bl/6 and DBA/2), bearing different transplanted tumours (methylcholanthrene-induced sarcomas, B16 melanoma and P-815 mastocytoma), were tested for cellular immune reactivity to the synthetic encephalitogenic peptide of human myelin basic protein by the leucocyte a...

journal_title：Oncology

authors： Yong WK,Halliday WJ

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Bladder cancer is the fifth most common cancer among men and the seventh among women. At diagnosis, at least 25% of bladder cancer tumors are locally or systemically advanced. Systemic chemotherapy is the only current modality for advanced or metastatic transitional cell carcinoma of the bladder. Recently, a...

journal_title：Oncology

authors： Adamo V,Magno C,Spitaleri G,Garipoli C,Maisano C,Alafaci E,Adamo B,Rossello R,Scandurra G,Scimone A

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:ETS-1 has been identified as a proto-oncogene and a transcription factor for tumor angiogenesis, which is essential for the growth, invasion and metastasis of solid tumors. The aim is to investigate the clinical implications of ETS-1 expression in peritoneal metastatic lesions of ovarian cancers. METHODS:In ...

journal_title：Oncology

authors： Fujimoto J,Aoki I,Toyoki H,Khatun S,Sato E,Sakaguchi H,Tamaya T

更新日期：2004-01-01 00:00:00

abstract：:A demonstration multiphasic cancer screening program was conducted in a rural village in Thailand under the coordination of Bangkok's National Cancer Institute. The village's physician, mayor, and other members of the community assumed a variety of volunteer roles in order to provide logistical support. In short, this...

journal_title：Oncology

authors： Lynch HT,Pitakspraiwan P,Sombooncharoen S,Phanthumchinda P,Vechmon U,Srivanwat G,Schutz RJ,Lynch JF

更新日期：1985-01-01 00:00:00

abstract：:Gastrointestinal stem cells have the capacity for long-term self-replication and the ability to give rise to all other epithelial cell lineages. These properties make them essential since they maintain tissue homeostasis by regulating cell turnover depending on the current demand. However, they are also important play...

journal_title：Oncology

authors： Schier S,Wright NA

更新日期：2005-01-01 00:00:00

abstract：:Nucleophosmin/B23 is a nucleolar phosphoprotein which redistributes from nucleoli to nucleoplasm (B23-translocation) when cells are exposed to certain anticancer drugs, particularly intercalators. The B23-translocation assay has been demonstrated in cell culture to correlate with drug effects and to detect drug-resist...

journal_title：Oncology

authors： Finch RA,Chan PK

更新日期：1992-01-01 00:00:00

abstract：:Sixteen patients with histologically confirmed inoperable hepatocellular carcinoma were treated with vindesine 3 mg/m2 i.v. weekly. Anemia, leukopenia and neuritis were documented but no severe or life-threatening toxicity was seen. There were no objective responses among the 14 evaluable patients. Eight had a no chan...

journal_title：Oncology

authors： Falkson G,Burger W

更新日期：1995-01-01 00:00:00

abstract：:Oxaliplatin-based chemotherapy is an effective first-line treatment option for patients with metastatic colorectal cancer (mCRC), which, in combination with targeted therapies and a sequential treatment approach using all active agents, has extended median overall survival to 2 years and beyond. Prolonged survival bri...

journal_title：Oncology

authors： Grothey A

更新日期：2010-01-01 00:00:00

abstract：:To clarify the inhibitory effect of telomere-mimic oligonucleotides on human cancer cell lines, we synthesized 18-mers (18T; n = 3), 24-mers (24T; n = 4) and 30-mers (30T; n = 5) of telomere-mimic phosphorothioate oligodeoxy nucleotides [5'-d(TTA GGG)n-3'] and examined their effects on the proliferation of human tumor...

journal_title：Oncology

authors： Saeki T,Takashima S,Tachibana M,Koga M,Hiyama E,Salomon DS,Holland JF,Ohnuma T

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Brain metastases develop frequently in patients with non-small cell lung cancer (NSCLC), and the prognosis for these patients is very poor. We evaluated the role of chemotherapy for patients with brain metastases from NSCLC. METHODS:We analyzed 30 patients who were discovered to have brain metastases during...

journal_title：Oncology

authors： Fujita A,Fukuoka S,Takabatake H,Tagaki S,Sekine K

更新日期：2000-11-01 00:00:00

abstract：:While central ports are located at the chest, peripheral ports (PP) are inserted at the patients' forearms. Two new PPs (Healthport miniMax((R)) and Bard Titan Low Profile Port) and two well-established types (Port-A-Cath((R)) P.A.S. Port and PeriPort(TM) peripheral access system) were tested. 125 patients were given ...

journal_title：Oncology

authors： Lersch C,Eckel F,Sader R,Paschalidis M,Zeilhofer F,Schulte-Frohlinde E,Theiss W

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the outcomes of gemcitabine-treated patients with inoperable biliary tract cancers. METHODS:We conducted a retrospective study of consecutively treated 22 inoperable biliary tract cancer patients with gemcitabine (500-1,000 mg/m(2) on days 1, 8, 15 every 4 weeks) as f...

journal_title：Oncology

authors： Kiba T,Nishimura T,Matsumoto S,Hatano E,Mori A,Yasumi S,Doi R,Ikai I,Kitano T,Nishimura T,Yoshikawa K,Ishiguro H,Yanagihara K,Doi E,Teramukai S,Fukushima M

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Hormone receptor-positive breast cancer accounts for nearly two-thirds of breast cancer cases; it ultimately acquires resistance during endocrine treatment and becomes more aggressive. This study evaluated the role of developmental endothelial locus (Del)-1 in tamoxifen-resistant (TAM-R) breast cancer. METH...

journal_title：Oncology

authors： Lee J,Jeong JH,Jung JH,Kim WW,Lee SJ,Park JY,Park JY,Kang SH,Kim EA,Park JH,Chae YS,Park HY

更新日期：2019-01-01 00:00:00

abstract：:One hundred and seventy-five patients selected at random were prospectively studied. All patients were assessed at least after the first cycle of treatment by a self-report questionnaire which covered the occurrence of nausea and vomiting 24 before chemotherapy, as well as information regarding 22 clinical parameters....

journal_title：Oncology

authors： Alba E,Bastus R,de Andres L,Sola C,Paredes A,Lopez Lopez JJ

更新日期：1989-01-01 00:00:00

abstract：:Previous studies have demonstrated a rise in serum alpha-1-antitrypsin at advanced stages of malignancy. These, together with results of animal experiments with another anti-proteinase, aprotinin, have prompted studies of the plasma alpha-1-antitrypsin in the early stages of malignancy, using cervical carcinoma as a m...

journal_title：Oncology

authors： Latner AL,Turner GA,Lamin MM

更新日期：1976-01-01 00:00:00

abstract：:Results of a survey of concentrations of substances immunologically cross-reactive with insulin (SICRI), glucose and growth hormone in preprandially drawn blood of 84 patients suffering from bronchial epidermoid, microcellular and adenocarcinomas and 22 patients from sarcoidosis, tuberculosis and obstructive bronchiti...

journal_title：Oncology

authors： Baltić V,Levanat S,Petek M,Bratić-Mikes V,Pavelić K,Vuk-Pavlović S

更新日期：1985-01-01 00:00:00

abstract：:Between 1986 and 1991, 35 patients with esophageal cancer (TNM stages II-IV) underwent transthoracic esophagectomy with lymph adenectomy and were subsequently treated with 5,000 cGy of radiation (days 1-40) and concurrently with two courses of chemotherapy (cisplatin, vindesine and pepleomycin, days 21-26 and 49-54). ...

journal_title：Oncology

authors： Saito T,Shigemitsu Y,Kinoshita T,Shimoda K,Abe T,Nakamura A,Chikuba K,Kobayashi M

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVES:It was the aim of this study to investigate the clinical differences between the tyrosine kinase inhibitors (TKIs) sorafenib and sunitinib as second-line treatment for cytokine-refractory kidney cancer patients. METHODS:Twenty consecutive patients received continuous treatment of oral sorafenib at a dose of...

journal_title：Oncology

authors： Herrmann E,Bierer S,Gerss J,Köpke T,Hertle L,Wülfing C

更新日期：2008-01-01 00:00:00

abstract：:In the present study, an analysis of whether expression of nm23-H1 and nm23-H2 proteins has prognostic significance was performed. A series of 95 renal cell carcinomas was analyzed for nuclear grade, tumor size (larger than 50 mm or not), staging in the Robson system and expression of nm23-H1 and nm23-H2, as well as p...

journal_title：Oncology

authors： Nakagawa Y,Tsumatani K,Kurumatani N,Cho M,Kitahori Y,Konishi N,Ozono S,Okajima E,Hirao Y,Hiasa Y

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Circulating tumor cells (CTCs) have been identified and shown to have prognostic and predictive roles in several types of carcinoma. More recently, aneuploid CTCs have become subject of a growing interest, as aneuploidy is considered a hallmark of cancer often associated with poor prognosis. Here, we aimed t...

journal_title：Oncology

authors： Napolitano A,Minelli A,Santini D,Tonini G,Vincenzi B

更新日期：2020-01-01 00:00:00

abstract：:Primary pancreatic lymphoma (PL) is an extremely rare disease, and large-scale studies are rarely performed even in Western countries, in which all cases of PL reported to date were of the B-cell type. Little information regarding PL is available in Japan. Nineteen cases of PL were collected through a nationwide study...

journal_title：Oncology

authors： Nishimura R,Takakuwa T,Hoshida Y,Tsujimoto M,Aozasa K

更新日期：2001-01-01 00:00:00

abstract：:Surgical resection, transarterial chemoembolization, percutaneous ethanol injection therapy, radiofrequency ablation, and orthotopic liver transplantation are generally accepted treatment modalities in hepatocellular carcinoma, but there has been no standard therapy for patients at the advanced stage. Several combinat...

journal_title：Oncology

authors： Lee HC

更新日期：2008-01-01 00:00:00

abstract：:Various oncogenic agents were employed in tumor susceptibility studies of an inbred subline of BALB/cGn mice, BALB/cGnDu, which carries a mutant gene that results in spontaneous thymic involution in homozygous recessive individuals. Of 18 transplantable tumors, 3 in vitro transformed cell lines, 2 oncogenic papovaviru...

journal_title：Oncology

authors： Morrison DG,Moyer MP,Lynd FT,Rogers W,Moyer RC

更新日期：1982-01-01 00:00:00

abstract：:The purpose of the present study was to determine with two-dimensional electrophoresis whether two sublines (high and low metastatic potential to lymph nodes) of rat fibrosarcoma induced by methylcholanthrene have differences in cellular proteins. The high metastatic potential subline had a specific protein in the pro...

journal_title：Oncology

authors： Minato K,Manabe T,Okuyama N,Sasaki Y,Nakagawa K,Saijo N

更新日期：1992-01-01 00:00:00

abstract：:The effect of the differentiation-inducing agent dimethylsulfoxide (DMSO) on the protein composition of hepatic tumor cells was evaluated using the BW77-1 line of murine hepatoma cells previously determined to be DMSO-inducible for enhanced liver function. DMSO-mediated suppression of BW77-1 proliferation was accompan...

journal_title：Oncology

authors： Higgins PJ

更新日期：1984-01-01 00:00:00