Abstract:
:The effect of the differentiation-inducing agent dimethylsulfoxide (DMSO) on the protein composition of hepatic tumor cells was evaluated using the BW77-1 line of murine hepatoma cells previously determined to be DMSO-inducible for enhanced liver function. DMSO-mediated suppression of BW77-1 proliferation was accompanied by a stimulated uptake of [35S]-methionine and incorporation of the isotope into acid-insoluble product. DMSO produced a quantitative increase in the major cellular and secreted protein species per 10(6) cells although qualitatively the pattern of major peptides among control and DMSO-treated populations was basically similar; increases in two minor peptides of 90,000 and 110,000 daltons was noted, however, in the secreted protein fraction of DMSO-treated cells relative to controls. The data collectively suggest that the enhanced levels of differentiated liver cell gene products previously observed as a consequence of DMSO exposure reflects a stimulation in the synthesis, accumulation and secretion of at least all of the major proteins normally produced by BW77-1 hepatoma cells.
journal_name
Oncologyjournal_title
Oncologyauthors
Higgins PJdoi
10.1159/000225850subject
Has Abstractpub_date
1984-01-01 00:00:00pages
338-42issue
5eissn
0030-2414issn
1423-0232journal_volume
41pub_type
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