Abstract:
:Retinoids are differentiating agents that have been used successfully for the treatment of acute promyelocytic leukemia. When combined with interferons, they are active in preventing second malignancies in patients with head and neck cancer. Our previous studies have demonstrated cytostatic effects of alltrans-retinoic acid (tRA) on SC-M1 gastric cancer cells in vitro. The activity of tRA and 13-cis-retinoic acid (cRA) on SC-M1 cells was compared both in vitro and in vivo in this study. Measurement of total cellular DNA was used to determine cell growth in vitro. The effect of retinoic acid on tumor growth was evaluated by implanting sustained release tRA or cRA pellets into athymic nude mice. The results showed that tRA was more potent than cRA in suppressing the growth of SC-M1 gastric cancer cells in vitro. Both tRA and cRA were effective in suppressing the growth of SC-M1 tumors in athymic nude mice. No change in the differentiation status and cell cycle phase distribution in excised tumors was observed. Side effects such as bone fractures and weight loss were observed in mice of both treatment groups. The results suggest that retinoic acid may provide therapeutic advantages for the treatment of gastric cancer.
journal_name
Oncologyjournal_title
Oncologyauthors
Jiang SY,Shyu RY,Chen HY,Lee MM,Wu KL,Yeh MYdoi
10.1159/000227583subject
Has Abstractpub_date
1996-07-01 00:00:00pages
334-40issue
4eissn
0030-2414issn
1423-0232journal_volume
53pub_type
杂志文章相关文献
ONCOLOGY文献大全abstract::Lonidamine alone or in combination with hyperthermic perfusion, with or without melphalan, was investigated in 12 patients with stage II, III, and IV malignant melanoma. The authors evaluated the most effective methods and sequence of Lonidamine administration. Preliminary results suggest that the highest effectivenes...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225899
更新日期:1984-01-01 00:00:00
abstract::A number of therapeutic agents including L-asparaginase, Actinomycin-D, CCNU, Hydroxyurea, 5-FU, Cis-platinum, Cyclophosphamide, orchiectomy, Adriamycin and DES alone and in various combinations has been applied against the Dunning R-3327 rat prostatic adenocarcinoma subline G. We have found a parallel between the res...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225202
更新日期:1977-01-01 00:00:00
abstract::Intraperitoneal injection of trace amounts of corn oil prior to and following the injection of 40-50 mg of tissue from hepatoma 7777 or 7800 into the thigh of adult male Buffalo rats resulted in a marked decrease in the growth rate of both tumors. Exhaustive extraction of the corn oil with water indicated that the act...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225184
更新日期:1977-01-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy of percutaneous cementoplasty for painful bone metastasis from hepatocellular carcinoma (HCC). METHODS:Cementoplasty was performed for 22 metastatic bone tumors in 13 patients. All patients had intractable pain and were diagnosed as metastatic bone tumor from HCC. The ostyneedle was in...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000113040
更新日期:2007-01-01 00:00:00
abstract::The levels of 3',5'-cyclic adenosine monophosphate (cAMP) were measured in a high malignant and a low malignant clone of murine fibrosarcoma cells isolated from a common parent in a normal mouse fibroblasts at various stages of growth. There was an inverse correlation between the degree of malignant potential and the ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225629
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:The role of Interleukin-2 (IL-2)-based biochemotherapy (BCT) for patients with metastatic melanoma remains controversial and few data of patients treated outside a specialized trial setting are available. METHODS:Sixty-six consecutive patients treated with BCT for stage IV melanoma were analyzed retrospecti...
journal_title:Oncology
pub_type: 杂志文章,多中心研究
doi:10.1159/000120029
更新日期:2007-01-01 00:00:00
abstract::Antineoplastic properties of different Schiff bases obtained by the interaction of 5-nitrofuran with substituted pyrimidines have been examined both in vitro and in vivo. In vitro studies on L 5178Y/asparaginase sensitive, HL 60 and P 388 cell lines and in vivo studies on the P 388 cell line indicate that all the comp...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226864
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Standard therapy for postoperative pain after laparoscopic colorectal surgeries at the Tan Tock Seng Hospital consists of intravenous morphine via patient-controlled analgesia (PCA) for the first 24-48 h, followed by oral analgesics. We compared the efficacy and safety of oral controlled-release (CR) oxycodo...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000143221
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:We investigated stanniocalcin 1 (STC 1) expression to assess its clinical utility as a blood marker in patients with gastric cancer and evaluated its biological impact in terms of tumor aggressiveness. METHODS:Blood specimens from 93 patients with gastric cancer and 21 normal healthy volunteers were assessed...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000341390
更新日期:2012-01-01 00:00:00
abstract::The paper presents the experience with watch-and-wait policy following radical surgery in 25 patients with primary gastric non-Hodgkin's (NH) lymphoma localized to the gastric wall. The median follow-up is at the moment 40 months (range 18-85). Only 3/25 patients have relapsed (during the first year of the follow-up) ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227347
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND AND AIM:In vitro, methotrexate (MTX) is the best modulator for bolus 5-fluorouracil (5FU), whereas folinic acid (FA) is the best for continuous infusion. We evaluated the effect of 5FU modulated by both MTX (bolus administration) and FA (continuous infusion) as second-line treatment of patients with metastat...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000065468
更新日期:2002-01-01 00:00:00
abstract::Improved understanding of tumor biology has led to the identification of numerous growth factors that are involved in malignant transformation and tumor progression. Many of these factors induce cellular responses through receptors with intrinsic tyrosine kinase (TK) activity. Therefore, inhibiting receptor TK activit...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000066198
更新日期:2002-01-01 00:00:00
abstract::Inhibitors of polyamine synthesis were tested for therapeutic effectiveness on transplantable prostate cancer. Inhibition of either ornithine decarboxylase or S-adenosyl-L-methionine decarboxylase (AMDC) by alpha-difluormethylornithine (DFMO) or methylglyoxal-bis[guanylhydrazone] (MGBG), respectively, was associated w...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225692
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVES:To assess the feasibility and efficacy of intensity-modulated radiation implemented with helical tomotherapy image-guided with daily megavoltage computed tomography for head and neck cancer. METHODS:Between May 2010 and May 2013, 72 patients were treated with curative intent. The median age was 64 years, wi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000489217
更新日期:2018-01-01 00:00:00
abstract::A poorly differentiated adenocarcinoma of the human oviduct was studied by light and transmission electron microscopy. Cells contained abundant mitochondria, bound and free ribosomes, prominent Golgi's bodies and aggregates of membrane-bound dense bodies. The small glandular lumina with numerous microvilli were genera...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225135
更新日期:1976-01-01 00:00:00
abstract::Nucleophosmin/B23 is a nucleolar phosphoprotein which redistributes from nucleoli to nucleoplasm (B23-translocation) when cells are exposed to certain anticancer drugs, particularly intercalators. The B23-translocation assay has been demonstrated in cell culture to correlate with drug effects and to detect drug-resist...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227043
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:To investigate the potential benefit of intermittent chemotherapy, and to identify the eligibility criteria offering intermittent chemotherapy to patients with advanced urothelial cancer. MATERIALS AND METHODS:Twenty patients who responded or had stable disease after receiving 3 cycles of induction chemother...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000338770
更新日期:2012-01-01 00:00:00
abstract::Zinostatin stimalamer (SMANCS) is a lipophilic intra-arterial chemotherapeutic agent for hepatocellular carcinoma (HCC). In our previous study, transcatheter arterial infusion chemotherapy using SMANCS for HCC showed a response rate of 20%. In an effort to obtain a superior anti-tumor effect against HCC, we conducted ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000059570
更新日期:2002-01-01 00:00:00
abstract::Calcitriol (1,25-dihydroxycholecalciferol) has antiproliferative and/or proapoptotic effects on many cell types and the glucocorticoid dexamethasone enhances these effects. We have shown that calcitriol modulates several key signaling proteins involved in differentiation, proliferation and apoptosis in tumor-derived m...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000098872
更新日期:2006-01-01 00:00:00
abstract::Tumor cell apoptosis, proliferation and p27 expression using an in situ apoptosis detection kit, anti-Ki67 antibody and anti-p27 antibody were investigated in 171 colorectal adenocarcinoma specimens, together with the assessment of mutated p53 expression. No apparent association was observed among p27 expression, muta...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000012078
更新日期:2000-01-01 00:00:00
abstract::Lewis lung carcinoma (3LL), which has been most frequently used for various investigations of cancer, was converted to an ascitic form designated 3LL-SA. Ascites tumor cells showed a mixed population of single cells and about 10% islands which were made up of 2 to about 50 cells. Transplantability was 100%. The biolog...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226712
更新日期:1989-01-01 00:00:00
abstract::An immunohistochemical stain to the c-ErbB-2 protein was performed in 225 paraffin-embedded tissue blocks from patients with locally advanced gastric cancer who underwent curative resection. The overexpression of the c-ErbB-2 protein was observed in 27.4% of the patients. The c-ErbB-2 positivity showed a statistically...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227559
更新日期:1996-05-01 00:00:00
abstract::67Ga-subtraction scan was found to be useful and a promising new method for the pre-treatment evaluation of the patient with Hodgkin's disease or non-Hodgkin's lymphoma. The scan appeared to be most accurate in the neck, chest, and axillary regions. It appears to offer a means of increasing the accuracy of evaluating ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225217
更新日期:1977-01-01 00:00:00
abstract::The Abelson-virus-induced murine lymphosarcoma cell line RAW117-P and its in vivo selected highly malignant and metastatic variant RAW117-H10 have been studied for their growth in vivo, in vitro and in semi-solid agar. The highly malignant metastatic variant RAW117-H10 cells killed syngeneic Balb/c mice rapidly and fo...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226473
更新日期:1987-01-01 00:00:00
abstract::The serum detection of S100B, a new melanoma marker, has shown clinical significance in early studies. The aim of our study of 1, 339 serum samples from 412 different melanoma patients and 107 control patients was to prove the prognostic value of serum S100B levels in melanoma patients at different stages of disease a...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011989
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:It was the aim of our study to evaluate the efficacy and safety of weekly topotecan in patients with advanced or recurrent cervical disease. METHODS:Topotecan was administered intravenously as a weekly infusion at a dose of 3.5 mg/m(2) on days 1, 8 and 15 of a 28-day cycle. After the second cycle, the dose w...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000330537
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:We evaluated the efficacy and safety of bolus 5-fluorouracil (5-FU) and leucovorin combined with weekly paclitaxel (FLTAX) in advanced gastric cancer (GC) patients. METHODS:Patients with untreated stage IV GC received paclitaxel 80 mg/m(2) as a 1-hour infusion, followed by 5-FU 600 mg/m(2) as a bolus infusio...
journal_title:Oncology
pub_type: 杂志文章,多中心研究
doi:10.1159/000334462
更新日期:2011-01-01 00:00:00
abstract::Human papillomaviruses (HPVs) have been linked to a variety of human diseases, most notably cancer of the cervix. In the majority of cases, HPV proteins E6 and E7 are continuously expressed and bind a variety of cellular proteins. The precise mechanism of HPV-induced carcinogenesis has not been fully elucidated; there...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000322188
更新日期:2010-01-01 00:00:00
abstract::We investigated facilitation of invasion by growth factors and chemotactic factors in tumor cell lines, particularly hepatocellular carcinoma. Hepatoma cells (PLC/PRF/5 and Hep G2) showed strong chemotaxis toward their respective conditioned media while metastatic pancreatic cancer cells (SU.86.86) and colon cancer ce...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000012110
更新日期:2000-04-01 00:00:00
abstract::Our previous trial with a docetaxel, cisplatin, and 5-fluorouracil (DCF) regimen showed high response rates in metastatic squamous cell carcinoma of the esophagus (SCCE). The observed increased toxicity of the DCF regimen, however, was clinically harmful. S-1, an oral anticancer drug, has been approved as a combinatio...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000488861
更新日期:2018-01-01 00:00:00