Role of mammography, ultrasound and large core biopsy in the diagnostic evaluation of papillary breast lesions.

abstract：BACKGROUND:This open-label, randomized phase III trial evaluated larotaxel/cisplatin versus gemcitabine/cisplatin as first-line treatment for locally advanced (T4b) or metastatic urothelial tract or bladder cancer. METHODS:Patients were randomized to larotaxel 50 mg/m(2) with cisplatin 75 mg/m(2) every 3 weeks (larota...

journal_title：Oncology

authors： Sternberg CN,Skoneczna IA,Castellano D,Theodore C,Blais N,Voog E,Bellmunt J,Peters F,Le-Guennec S,Cerbone L,Risse ML,Machiels JP

更新日期：2013-01-01 00:00:00

abstract：:Improved understanding of tumor biology has led to the identification of numerous growth factors that are involved in malignant transformation and tumor progression. Many of these factors induce cellular responses through receptors with intrinsic tyrosine kinase (TK) activity. Therefore, inhibiting receptor TK activit...

journal_title：Oncology

authors： Baselga J,Hammond LA

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVES:Surgery has traditionally been the treatment of choice for patients with potentially resectable esophageal carcinoma. Recently, however, definitive chemoradiotherapy (CRT) has been suggested as a preferred treatment modality. In this study, CRT results with or without surgery are compared. METHODS:A total o...

journal_title：Oncology

authors： Salek R,Tabrizi FV,Bezenjani SE,Saedi HS,Ashkiki MH,Hosainzadeh SM,Mohtashami S

更新日期：2011-01-01 00:00:00

abstract：:Information technology (IT) can enhance or change many scenarios in cancer research for the better. In this paper, we introduce several examples, starting with clinical data reuse and collaboration including data sharing in research networks. Key challenges are semantic interoperability and data access (including data...

journal_title：Oncology

authors： Ahlbrandt J,Lablans M,Glocker K,Stahl-Toyota S,Maier-Hein K,Maier-Hein L,Ückert F

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Anti-p53 levels detected by different methods were compared in a predefined group of patients with breast cancer and correlated with p53 antigen expression in the corresponding tumors. METHODS:P53 autoantibodies were investigated in 165 patients with primary breast cancer using ELISAs with recombinant or nat...

journal_title：Oncology

authors： Volkmann M,Sinn HP,Gaugel D,Frey M,Hajjar Y,Ludwig J,Hänsel S,Bastert G,Wallwiener D,Fiehn W,Zentgraf H,Huober J

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:To investigate the potential benefit of intermittent chemotherapy, and to identify the eligibility criteria offering intermittent chemotherapy to patients with advanced urothelial cancer. MATERIALS AND METHODS:Twenty patients who responded or had stable disease after receiving 3 cycles of induction chemother...

journal_title：Oncology

authors： Onishi T,Sasaki T,Hoshina A

更新日期：2012-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a homodimeric glycoprotein with a molecular weight of approximately 45 kDa. It is the key mediator of angiogenesis (the formation of new blood vessels), and binds two VEGF receptors (VEGF receptor-1 and VEGF receptor-2), which are expressed on vascular endothelial cells. In...

journal_title：Oncology

authors： Carmeliet P

更新日期：2005-01-01 00:00:00

abstract：:Twenty-five patients with cutaneous melanoma were imaged with F(ab')2 fragments of antimelanoma monoclonal antibody (MoAb) 225.28S labeled with 99mTc and 131I or 111In. Out of 16 patients without evidence of metastatic lesions, 6 false-positive cases were observed. Only 4 out of 9 patients with known lesions showed po...

journal_title：Oncology

authors： Repetto L,Scopinaro G,Michelotti A,Claudiani F,Fusco V,Grimaldi A,Sertoli MR,Rosso R

更新日期：1988-01-01 00:00:00

abstract：:The expression of cyclin-dependent kinase 1 (cdc2), cyclin A and cyclin B1 was immunohistochemically studied in 101 hepatocellular carcinomas (HCC). cdc2 overexpression was directly related to advanced stage, portal invasion, intrahepatic metastasis, poor differentiation, high alpha-fetoprotein level, large size, high...

journal_title：Oncology

authors： Ito Y,Takeda T,Sakon M,Monden M,Tsujimoto M,Matsuura N

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Gemcitabine monotherapy is the cornerstone of the treatment of patients suffering from advanced pancreatic cancer (PC). For a few years, new chemotherapeutic agents and combinations have been under validation. The use of such treatment makes it necessary to determine factors that could predict survival time....

journal_title：Oncology

authors： Maréchal R,Demols A,Gay F,De Maertelaere V,Arvanitaki M,Hendlisz A,Van Laethem JL

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:Breast cancers expressing high levels of Ki-67, a nuclear marker of cell proliferation, are associated with worse outcome. Recent data from neoadjuvant studies indicate that a single measurement of the nuclear proliferation marker Ki-67 in breast carcinoma during neoadjuvant therapy is strongly predictive of lo...

journal_title：Oncology

authors： Miglietta L,Vanella P,Canobbio L,Naso C,Cerisola N,Meszaros P,Parodi MA,Morabito F

更新日期：2010-01-01 00:00:00

abstract：:14 patients developed acute nonlymphocytic leukemia and 1 patient developed Burkitt's leukemia following longterm chemotherapy and/or radiotherapy for other disorders. The main primary disorders included multiple myeloma, Hodgkin's disease, non-Hodgkin's lymphoma and breast carcinoma. Acute leukemia developed earlier ...

journal_title：Oncology

authors： Brenner B,Carter A,Sharon R,Tatarsky I

更新日期：1984-01-01 00:00:00

abstract：:Acute myeloid leukemia (AML) originates from self-renewing leukemic stem cells (LSCs), an ultimate therapeutic target in AML. Eradication of LSCs should be a critical and efficient therapeutic approach for the cure of AML. T-cell immunoglobulin mucin-3 (TIM-3) is expressed in most types of AML LSCs, but not in normal ...

journal_title：Oncology

authors： Kikushige Y,Miyamoto T

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Elevated histone deacetylase (HDAC) isoenzyme levels have been described in patients with carcinomas and leukemias. HDAC inhibitors (HDACi) have shown promise in the treatment of carcinomas and are currently under intense research. To make better use of HDACi in treating chronic lymphocytic leukemia (CLL), H...

journal_title：Oncology

authors： Wang JC,Kafeel MI,Avezbakiyev B,Chen C,Sun Y,Rathnasabapathy C,Kalavar M,He Z,Burton J,Lichter S

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:This study aimed to evaluate any correlations between baseline creatinine clearance and the development of grade 3/4 toxicities during treatment within oncology phase I trials of molecularly targeted agents where entry criteria mandate a serum creatinine of ≤ 1.5 × the upper limit of normal. METHODS:Documen...

journal_title：Oncology

authors： Basu B,Vitfell-Pedersen J,Moreno Garcia V,Puglisi M,Tjokrowidjaja A,Shah K,Malvankar S,Anghan B,de Bono JS,Kaye SB,Molife LR,Banerji U

更新日期：2012-01-01 00:00:00

abstract：:To improve our understanding of the basic biological mechanisms of Hürthle cell tumours (HCT), proliferative activity in 20 HCT was determined by Ag-NOR (nucleolar organiser regions) counting and by immunohistochemical markers proliferating cell nuclear antigen (PCNA) and MIB-1. Ten surgically removed Hürthle cell ade...

journal_title：Oncology

authors： Cör A

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:There are a few long-term follow-up studies of patients with stage I ovarian carcinoma. The objective of this study was to evaluate prognostic factors for long-term survival. METHODS:Two hundred fourteen stage I ovarian carcinomas (registered by the Tokai Ovarian Tumor Study Group from 1988 to 1999) were ana...

journal_title：Oncology

authors： Mizuno M,Kikkawa F,Shibata K,Kajiyama H,Suzuki T,Ino K,Kawai M,Mizutani S

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:This study aimed to investigate clinicopathological responses and oncological outcome in patients receiving short- or long-course chemoradiotherapy (CRT) and to assess the predictive factor for recurrence in each treatment. METHODS:A total of 118 rectal cancer patients receiving preoperative CRT were enrolle...

journal_title：Oncology

authors： Yamamoto A,Toiyama Y,Okugawa Y,Saigusa S,Ide S,Fujikawa H,Hiro J,Yasuda H,Yoshiyama S,Ohi M,Araki T,Kusunoki M

更新日期：2019-01-01 00:00:00

abstract：:Malignant gastrointestinal neuroectodermal tumor (GNET) is an aggressive rare tumor, primarily occurring in young adults with frequent local-regional metastases and recurrence after local control. The tumor is characterized by the presence of EWSR1-ATF1 or EWSR1-CREB1 and immunohistochemical positivity for S-100 prote...

journal_title：Oncology

authors： Subbiah V,Holmes O,Gowen K,Spritz D,Amini B,Wang WL,Schrock AB,Meric-Bernstam F,Zinner R,Piha-Paul S,Zarzour M,Elvin JA,Erlich RL,Stockman DL,Vergilio JA,Suh JH,Stephens PJ,Miller V,Ross JS,Ali SM

更新日期：2016-01-01 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), the most abundant food-derived mutagenic/carcinogenic heterocyclic amine (HCA), has attracted particular attention as a probable human colon carcinogen. Some studies have shown that PhIP administered in the post-initiation phase is able to enhance rat colon carci...

journal_title：Oncology

authors： Doi K,Hagihara A,Wei M,Yunoki T,Fukushima S,Wanibuchi H

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The clinical features of hepatocellular carcinoma (HCC) differ in patients with and without cirrhosis. OBJECTIVE:We aimed to investigate the long-term outcomes of noncirrhotic HCC patients after curative resection. METHODS:We retrospectively examined 649 consecutive patients with HCC who underwent curative...

journal_title：Oncology

authors： Lee HW,Choi GH,Kim DY,Park YN,Kim KS,Choi JS,Ahn SH,Han KH

更新日期：2017-01-01 00:00:00

abstract：:The treatment of metastatic renal cell carcinoma (MRCC) has evolved from being predominantly cytokine-based to being grounded in the use of drugs targeting vascular endothelial growth factor, platelet-derived growth factor and mammalian target of rapamycin (mTOR) pathways. New agents including the small-molecule targe...

journal_title：Oncology

authors： Di Lorenzo G,Scagliarini S,Di Napoli M,Scognamiglio F,Rizzo M,Carteni' G

更新日期：2009-01-01 00:00:00

abstract：UNLABELLED:The outlook for patients with testicular germ cell cancer was dramatically improved by the introduction of cisplatin. Well-known side effects of cisplatin (nausea, vomiting, nephrotoxicity, myelosuppression) can be managed with preventive methods. The long life expectancy after this therapy draws attention t...

journal_title：Oncology

authors： Biró K,Baki M,Büki B,Noszek L,Jókúti L

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the clinical and cost benefits of the administration of aprepitant for the prophylaxis of chemotherapy-induced nausea and vomiting (CINV) during high-dose chemotherapy (HDCT). METHODS:We retrospectively reviewed the charts of patients who received HDCT at our institution between January 2009 and ...

journal_title：Oncology

authors： Nakamura A,Kojima Y,Miyazawa K,Matsumoto S,Iida H,Nagai H

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Ethnic disparities in cancers are associated with variability in clinical outcomes. We present a Surveillance Epidemiology and End RESULTS (SEER)-based outcome analysis of multiethnic Waldenström's macroglobulinemia (WM) patients. METHODS:Adult WM patients diagnosed in 1992 or later (n = 3,175) were analyze...

journal_title：Oncology

authors： Ailawadhi S,Kardosh A,Yang D,Cozen W,Patel G,Alamgir MA,Chanan-Khan AA

更新日期：2014-01-01 00:00:00

abstract：:23 patients received cis-platinum, doxorubicin and cyclophosphamide for gynecologic malignancy between December 1, 1980 and December 1, 1982. Each patient was randomized with each course of chemotherapy to receive intravenous droperidol or the combination of promethazine and chlorpromazine rectal suppositories as an a...

journal_title：Oncology

authors： Roberts WS,Wisniewski BJ,Cavanagh D,Marsden DE

更新日期：1985-01-01 00:00:00

abstract：:We evaluated changes in serum albumin concentrations in 15 patients with advanced malignancy who were also receiving cisplatin. All 15 patients had serial measurements of serum albumin. The decrease in serum albumin from the time of the first dose of cisplatin to death correlated with liver platinum levels at autopsy ...

journal_title：Oncology

authors： Nanji AA,Mikhael NZ,Stewart DJ

更新日期：1986-01-01 00:00:00

abstract：:The Abelson-virus-induced murine lymphosarcoma cell line RAW117-P and its in vivo selected highly malignant and metastatic variant RAW117-H10 have been studied for their growth in vivo, in vitro and in semi-solid agar. The highly malignant metastatic variant RAW117-H10 cells killed syngeneic Balb/c mice rapidly and fo...

journal_title：Oncology

authors： Joshi SS,Sharp JG,Brunson KW

更新日期：1987-01-01 00:00:00

abstract：:Two randomized controlled trials identified that transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) shows a significant survival benefit compared with controls, after a long-term controversy. Thus, TACE is the current standard of care for patients presenting with multinodular HCC. Monit...

journal_title：Oncology

authors： Minami Y,Kudo M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Both irinotecan (CPT) and paclitaxel (Pac) are effective against non-small cell lung cancer (NSCLC), and besides, preclinical studies have demonstrated an additive or synergistic interaction between camptothecin and taxane. METHODS:We conducted a phase I/II study of combination chemotherapy consisting of Pa...

journal_title：Oncology

authors： Yamada K,Ikehara M,Tanaka G,Nomura I,Oshita F,Noda K

更新日期：2004-01-01 00:00:00