Abstract:
:This paper reviews the effectiveness of local interleukin-2 (IL-2) therapy and its effector induction mechanisms in vivo. Local therapy with IL-2 and/or lymphokine-activated killer (LAK) cells is associated with far fewer side effects than systemic treatment. Local infusions of IL-2 into malignant pleural effusions and the peritoneal cavity induce LAK cells and secondary production of other cytokines responsible for up- or down-regulation of LAK activity. An understanding of the regulatory mechanism of local LAK induction in vivo may provide the rationale for a more effective therapeutic modality for cancer in humans.
journal_name
Oncologyjournal_title
Oncologyauthors
Sone S,Ogura Tdoi
10.1159/000227331subject
Has Abstractpub_date
1994-03-01 00:00:00pages
170-6issue
2eissn
0030-2414issn
1423-0232journal_volume
51pub_type
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