Differential synthesis and replication of DNA in the Neurospora crassa slime mutant versus normal cells: role of carcinogens.

abstract：:Three lung tumor-associated markers (LTAM), previously identified as a Cohn Fraction IV alpha-globulin (LTAM-1), ferritin (LTAM-2) and lactoferrin (LTAM-3) were separated by a combination of ion exchange, dye-affinity and molecular sieve chromatography. They were further purified by polyacrylamide gel electrophoresis ...

journal_title：Oncology

authors： Maxim PE,Veltri RW,Sprinkle PM

更新日期：1981-01-01 00:00:00

abstract：OBJECTIVE:To evaluate two docetaxel-based regimens as first-line treatment in advanced breast cancer patients. METHODS:Patients were randomly assigned to docetaxel/gemcitabine (arm A: docetaxel 75 mg/m(2) on day 1, gemcitabine 1,000 mg/m(2) on days 1 and 8) or docetaxel/capecitabine (arm B: docetaxel 75 mg/m(2) on day...

journal_title：Oncology

authors： Vici P,Giotta F,Di Lauro L,Sergi D,Vizza E,Mariani L,Latorre A,Pizzuti L,D'Amico C,Giannarelli D,Colucci G

更新日期：2011-01-01 00:00:00

abstract：:Novel human estrogen receptor (ER)-beta was identified in cDNA libraries from human testis. ER-beta specifically expresses in testis, ovary, thymus, spleen, osteoblasts and fetus. ER-beta might not conserve the same physiological functions as does ER-alpha. Therefore, the clinical significance of the expression of ER-...

journal_title：Oncology

authors： Fujimoto J,Hirose R,Sakaguchi H,Tamaya T

更新日期：2000-05-01 00:00:00

abstract：:Developmental pathways (e.g., Notch, Hippo, Hedgehog, Wnt, and TGF-β/BMP/FGF) are networks of genes that act co-ordinately to establish the body plan, and disruptions of genes in one pathway can have effects in related pathways and may result in serious dysmorphogenesis or cancer. Interestingly, all developmental path...

journal_title：Oncology

authors： Dempke WCM,Fenchel K,Uciechowski P,Chevassut T

更新日期：2017-01-01 00:00:00

abstract：:Many patients on cytotoxic chemotherapy show reduced frequency of menstrual bleeding due to a reduction in ovarian follicular activity. The endocrine perturbations related to these changed menstrual patterns were studied in detail. Nineteen regularly menstruating patients with primary breast cancer were given either c...

journal_title：Oncology

authors： Dowsett M,Richner J

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:In order to determine whether infection with Helicobacter pylori might be associated with pancreatic adenocarcinoma, we performed a study to compare the H. pylori seroprevalence rate between patients with pancreatic carcinoma and matched control subjects. PATIENTS AND METHODS:Blood samples from 92 patients wit...

journal_title：Oncology

authors： Raderer M,Wrba F,Kornek G,Maca T,Koller DY,Weinlaender G,Hejna M,Scheithauer W

更新日期：1998-01-01 00:00:00

abstract：UNLABELLED:The outlook for patients with testicular germ cell cancer was dramatically improved by the introduction of cisplatin. Well-known side effects of cisplatin (nausea, vomiting, nephrotoxicity, myelosuppression) can be managed with preventive methods. The long life expectancy after this therapy draws attention t...

journal_title：Oncology

authors： Biró K,Baki M,Büki B,Noszek L,Jókúti L

更新日期：1997-09-01 00:00:00

abstract：:To assess the prognostic value of pretreatment serum neuron-specific enolase (NSE) in nonsmall cell lung cancer (NSCLC), levels were measured in 84 NSCLC patients, 40 healthy controls, and 20 patients with benign pulmonary diseases. NSE concentration was higher in NSCLC (11.7 +/- 10.8 ng/ml) (mean +/- SD; median = 9.7...

journal_title：Oncology

authors： Diez M,Torres A,Ortega L,Maestro M,Hernando F,Gomez A,Picardo A,Granell J,Balibrea JL

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVE:This phase II study examined the efficacy and safety of alternating regimens of mFOLFOX6 and FOLFIRI as a first-line treatment for unresectable or metastatic colorectal cancer. PATIENTS AND METHODS:Forty-eight patients were enrolled in this study. Patients received an alternating regimen of 4 cycles of mFOLF...

journal_title：Oncology

authors： Oki E,Emi Y,Akagi Y,Tokunaga S,Sadanaga N,Tanaka T,Ogata Y,Saeki H,Kakeji Y,Baba H,Nishimaki T,Natsugoe S,Shirouzu K,Maehara Y,Kyushu Study Group of Clinical Cancer.

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Osteosarcoma is a rare malignancy, and patients with this disease benefit from adjuvant chemotherapy. While cisplatin, anthracyclines and ifosfamide are the most commonly used agents in the treatment of osteosarcoma, a search for the best combination with higher efficacy and minimal toxicity continues. We pl...

journal_title：Oncology

authors： Basaran M,Bavbek ES,Saglam S,Eralp L,Sakar B,Atalar AC,Bilgic B,Ozger H,Onat H

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:The objective of this phase III trial was to compare chemotherapy combined with bevacizumab versus chemotherapy alone in the treatment of patients with advanced colorectal cancer. METHODS:From September 2004 till September 2008, 222 treatment-naive patients were enrolled and divided into 2 arms: 114 arm A pa...

journal_title：Oncology

authors： Stathopoulos GP,Batziou C,Trafalis D,Koutantos J,Batzios S,Stathopoulos J,Legakis J,Armakolas A

更新日期：2010-01-01 00:00:00

abstract：:To improve our understanding of the basic biological mechanisms of Hürthle cell tumours (HCT), proliferative activity in 20 HCT was determined by Ag-NOR (nucleolar organiser regions) counting and by immunohistochemical markers proliferating cell nuclear antigen (PCNA) and MIB-1. Ten surgically removed Hürthle cell ade...

journal_title：Oncology

authors： Cör A

更新日期：1999-07-01 00:00:00

abstract：:The survival, and the patterns and mechanisms of failure of 41 patients with pure testicular seminoma treated at the Northern Israel Oncology Center from 1968 to 1983 were analyzed. The actuarial 5-year survival of all patients was 85.4% and of stage I patients, 92.2%. Treatment failures were analyzed. The following c...

journal_title：Oncology

authors： Stein M,Steiner M,Koten A,Cohen Y,Robinson E

更新日期：1986-01-01 00:00:00

abstract：:Immunoperoxidase methods permit the demonstration of a variety of antigens in routinely processed tissues. The morphological detail obtained by this procedure is comparable to orthodox haematoxylin and eosin stained sections, and so offers the diagnostic pathologist the opportunity of simultaneously identifying normal...

journal_title：Oncology

authors： Taylor CR

更新日期：1978-01-01 00:00:00

abstract：:Recombinant human granulocyte colony-stimulating factor (G-CSF) has been used worldwide in cancer patients for over 1 year, and (only 5 years from the first publication on the clinical use of this growth factor) experience is rapidly accumulating in many oncological situations. Several randomized studies have confirme...

journal_title：Oncology

authors： Bronchud MH

更新日期：1994-03-01 00:00:00

abstract：:We examined the effects of cycloheximide on the amount of chromatin-bound and -unbound PCNA subpopulations in HeLa cells. The chromatin-bound PCNA content decreased rapidly in the presence of cycloheximide, whereas the reduction of the total amount of PCNA was minimal even 24 h after the treatment with cycloheximide. ...

journal_title：Oncology

authors： Sasaki K,Kurose A,Uesugi N,Kato A

更新日期：1995-09-01 00:00:00

abstract：:Lonidamine was studied in advanced cancer patients. The drug was given orally by single or repeated administrations. Single doses ranged from 150 to 450 mg. Repeated administrations were performed with progressively increasing doses: 450-900 mg daily. Lonidamine lacked severe toxic effects after both single and prolon...

journal_title：Oncology

authors： Barduagni A,Barduagni M,Di Lauro L,Nardi M,Gallo Curcio C,Tonachella R,Ciottoli GB,Delle Chiaie S

更新日期：1984-01-01 00:00:00

abstract：:Malignant fibrous histiocytoma (MFH), the most common soft-tissue sarcoma, consists mainly of two different cell populations: histiocytelike and fibroblastlike cells. It has been suggested to contain a large amount of reactive histiocytes and fibroblasts hard to distinguish from the tumor cells. In this study, the clo...

journal_title：Oncology

authors： Fujita MQ,Hashida N,Shin M,Nakanishi H,Yoshihara W,Aozasa K

更新日期：1998-11-01 00:00:00

abstract：PURPOSE:Breast cancers expressing high levels of Ki-67, a nuclear marker of cell proliferation, are associated with worse outcome. Recent data from neoadjuvant studies indicate that a single measurement of the nuclear proliferation marker Ki-67 in breast carcinoma during neoadjuvant therapy is strongly predictive of lo...

journal_title：Oncology

authors： Miglietta L,Vanella P,Canobbio L,Naso C,Cerisola N,Meszaros P,Parodi MA,Morabito F

更新日期：2010-01-01 00:00:00

abstract：:The levels of bone-specific alkaline phosphatase (BALP) in plasma and tumour tissue samples of 20 Chinese patients with osteosarcoma in Hong Kong were measured by the wheat germ lectin precipitation technique. The plasma BALP levels in these patients were significantly higher than those of the normal subjects (p < 0.0...

journal_title：Oncology

authors： Liu PP,Leung KS,Kumta SM,Lee KM,Fung KP

更新日期：1996-07-01 00:00:00

abstract：INTRODUCTION:Carcinoma of the biliary system is a rare tumor entity, and patients with advanced disease face a dismal prognosis. Because of the absence of standard chemotherapy for advanced biliary carcinoma, we have performed two consecutive studies to evaluate the clinical potential of 5-fluorouracil, leucovorin and ...

journal_title：Oncology

authors： Raderer M,Hejna MH,Valencak JB,Kornek GV,Weinländer GS,Bareck E,Lenauer J,Brodowicz T,Lang F,Scheithauer W

更新日期：1999-04-01 00:00:00

abstract：:14 patients developed acute nonlymphocytic leukemia and 1 patient developed Burkitt's leukemia following longterm chemotherapy and/or radiotherapy for other disorders. The main primary disorders included multiple myeloma, Hodgkin's disease, non-Hodgkin's lymphoma and breast carcinoma. Acute leukemia developed earlier ...

journal_title：Oncology

authors： Brenner B,Carter A,Sharon R,Tatarsky I

更新日期：1984-01-01 00:00:00

abstract：:The purpose of the present study was to determine with two-dimensional electrophoresis whether two sublines (high and low metastatic potential to lymph nodes) of rat fibrosarcoma induced by methylcholanthrene have differences in cellular proteins. The high metastatic potential subline had a specific protein in the pro...

journal_title：Oncology

authors： Minato K,Manabe T,Okuyama N,Sasaki Y,Nakagawa K,Saijo N

更新日期：1992-01-01 00:00:00

abstract：:The present communication reports data on the lipid biosynthesis of Ehrlich ascites tumor cells grown in culture media supplemented with modified sera. Whereas the metabolisms of [14C]pyruvate and [14C]mevalonate are identical in all media tested, the incorporation of [14C] acetate is higher in medium with dialyzed se...

journal_title：Oncology

authors： Löffler M,Schneider F

更新日期：1979-01-01 00:00:00

abstract：PURPOSE:To determine the dose-limiting toxicities (DLTs) and the maximum-tolerated doses of the paclitaxel, oxaliplatin (LOHP) and capecitabine combination in patients with advanced solid tumors. PATIENTS AND METHODS:Patients received escalating doses of paclitaxel (starting dose 100 mg/m2) and LOHP (starting dose 40 ...

journal_title：Oncology

authors： Saridaki Z,Bozionelou V,Kentepozidis N,Kotsakis A,Vardakis N,Kalykaki A,Gioulbasanis I,Karampeazis A,Vamvakas L,Georgoulias V,Mavroudis D

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Both irinotecan (CPT) and paclitaxel (Pac) are effective against non-small cell lung cancer (NSCLC), and besides, preclinical studies have demonstrated an additive or synergistic interaction between camptothecin and taxane. METHODS:We conducted a phase I/II study of combination chemotherapy consisting of Pa...

journal_title：Oncology

authors： Yamada K,Ikehara M,Tanaka G,Nomura I,Oshita F,Noda K

更新日期：2004-01-01 00:00:00

abstract：:Effects of the SH inhibitor sodium iodoacetate, alone and with adjuncts menadiol diphosphate, sodium malonate, sodium fluoride and heparin, on incorporation of tryptophane-3 H into nonhistone chromosomal proteins of HeLa cells were examined. The drugs block incorporation of tryptophane-3 H into nonhistone chromosomal ...

journal_title：Oncology

authors： Knock FE,Stein GS,Davis J,Galt RM,Oester YT,Sylvester R

更新日期：1975-01-01 00:00:00

abstract：:Topotecan is indicated in the treatment of advanced-stage ovarian cancers refractory to prior platinum-based regimen. The aim of this study was to compare the standard therapeutic strategy with a novel strategy of weekly administration of topotecan. The primary endpoints were dose density and overall tolerance. This r...

journal_title：Oncology

authors： Largillier R,Valenza B,Ferrero JM,Novo C,Creisson A,Lesbats G,Mari V,Hebert C,Chamorey E

更新日期：2007-01-01 00:00:00

abstract：:We conducted a prospective multicenter phase II trial of patients with borderline resectable pancreatic carcinoma to investigate the efficacy of neoadjuvant nab-paclitaxel plus gemcitabine therapy on overall survival (OS). The clinical trial primarily evaluated OS time from the first day of protocol therapy as a prima...

journal_title：Oncology

authors： Okada KI,Shimokawa T,Hirono S,Kawai M,Sho M,Satoi S,Matsumoto I,Eguchi H,Murakami Y,Yamada S,Doi M,Yamaue H,NAC-GA investigators.

更新日期：2017-01-01 00:00:00

abstract：:Lymph node and distant metastasis were comparatively studied in 225 oral carcinomas, and factors predisposing toward metastasis were investigated using clinical and immunohistopathological approaches. Neither the sites of tumors nor T-stage was correlated with either type of metastasis. Tumor cell differentiation was ...

journal_title：Oncology

authors： Osaki T,Kimura T,Tatemoto Y,Yamamoto T,Yoneda K

更新日期：2000-02-01 00:00:00