Comparative effects of piroxicam and esculetin on incidence, proliferation, and cell kinetics of mammary carcinomas induced by 7,12-dimethylbenz[a]anthracene in rats on high- and low-fat diets.

Abstract:

:We investigated the effects of piroxicam, a cyclooxygenase inhibitor, and esculetin, a lipoxygenase inhibitor, on 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female rats. Seven days after receiving a 5-mg dose of DMBA, rats were fed either a high-fat (20% soybean oil) or low-fat (0.5% soybean oil) diet. One third of the rats received diets containing 0.01% piroxicam and one third received diets containing 0.03% esculetin. Esculetin significantly inhibited mammary tumorigenesis and tumor proliferation in the rats fed the high-fat and the low-fat diets. Piroxicam had no inhibitory effect. Our findings indicate that DMBA-induced mammary tumorigenesis is affected by lipoxygenase products rather than by cyclooxygenase products.

journal_name

Oncology

journal_title

Oncology

authors

Kitagawa H,Noguchi M

doi

10.1159/000227374

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

401-10

issue

5

eissn

0030-2414

issn

1423-0232

journal_volume

51

pub_type

杂志文章

相关文献

ONCOLOGY文献大全
  • A multicenter phase II randomized trial of docetaxel/gemcitabine versus docetaxel/capecitabine as first-line treatment for advanced breast cancer: a Gruppo Oncologico Italia Meridionale study.

    abstract:OBJECTIVE:To evaluate two docetaxel-based regimens as first-line treatment in advanced breast cancer patients. METHODS:Patients were randomly assigned to docetaxel/gemcitabine (arm A: docetaxel 75 mg/m(2) on day 1, gemcitabine 1,000 mg/m(2) on days 1 and 8) or docetaxel/capecitabine (arm B: docetaxel 75 mg/m(2) on day...

    journal_title:Oncology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1159/000334432

    authors: Vici P,Giotta F,Di Lauro L,Sergi D,Vizza E,Mariani L,Latorre A,Pizzuti L,D'Amico C,Giannarelli D,Colucci G

    更新日期:2011-01-01 00:00:00

  • Transforming activity of DNA extracted from BKV-transformed hamster cells after passages in culture.

    abstract::Primary fetal rat fibroblasts (FRF cells) were transfected with DNA extracted from BKV-transformed hamster kidney cells at low passage after transformation (HKBKlp cells) and at high passage after transformation (HKBKhp cells). Two transformed rat cell lines were obtained, FRF-DNA-HKBKlp cells and FRF-DNA-HKBKhp cells...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000226404

    authors: Possati L,Collesi A,Rosciani C,Rubini C

    更新日期:1986-01-01 00:00:00

  • Expression of the high-affinity fluoropyrimidine-preferring nucleoside transporter hCNT1 correlates with decreased disease-free survival in breast cancer.

    abstract:PURPOSE:Nucleoside and nucleobase derivatives are currently used in the treatment of a variety of solid tumors; however, the role of plasma membrane transporters as biomarkers of drug metabolism has not been fully addressed. Thus, the purpose of this study was to determine whether the concentrative nucleoside transport...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000094541

    authors: Gloeckner-Hofmann K,Guillén-Gómez E,Schmidtgen C,Porstmann R,Ziegler R,Stoss O,Casado FJ,Rüschoff J,Pastor-Anglada M

    更新日期:2006-01-01 00:00:00

  • 5-fluorouracil uptake by irradiation perturbed tumor.

    abstract::An in vitro system was used to study the uptake of 5-fluorouracil by LSA ascites tumor cells. Changes in drug uptake with cell age and following a 1,000-rad radiation perturbation of the cell population were studied. DNA synthesis and drug uptake were highest during early rapid tumor growth and decreased with tumor ag...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000225540

    authors: Young JA,Maruyama Y

    更新日期:1981-01-01 00:00:00

  • Energy status in HeLa cells after treatment with an arresting anticancer drug.

    abstract::The energy status of HeLa cells arrested in the G2 phase of the cell cycle by the antineoplastic agent cis-acid was compared with that of normal G2-phase-synchronized cells. The results showed that treatment with the drug has significantly decreased the adenylate pool, adenylate energy charge and phosphorylation poten...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000226444

    authors: Al-Awadi FM,Al-Bader AA

    更新日期:1987-01-01 00:00:00

  • miRNA-503 Promotes Tumor Progression and Is Associated with Early Recurrence and Poor Prognosis in Human Colorectal Cancer.

    abstract:OBJECTIVES:MicroRNA (miR)-503 is downregulated in several cancers and plays a tumor-suppressive role in carcinogenesis. However, the miR-503 expression pattern, its clinical significance and its molecular mechanism in colorectal cancer (CRC) have not been investigated. METHODS:We analyzed miR-503 expression in normal ...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000444493

    authors: Noguchi T,Toiyama Y,Kitajima T,Imaoka H,Hiro J,Saigusa S,Tanaka K,Inoue Y,Mohri Y,Toden S,Kusunoki M

    更新日期:2016-01-01 00:00:00

  • Carcinoma of the pancreas in Iraq.

    abstract::This paper presents clinical observations on 130 patients with carcinoma of the pancreas, including 19 with periampullary cancer, the first large study of this disease in Iraq. All of the patients were admitted to the First (one of three) Surgical Unit of the University of Baghdad Teaching Hospital (the Medical City) ...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000225670

    authors: Al-Bahrani ZR,Al-Mondhiry HA,Al-Saleem T

    更新日期:1982-01-01 00:00:00

  • Treatment of myelodysplastic syndromes with orally administered 1-beta-D-arabinofuranosylcytosine-5'-stearylphosphate.

    abstract::1-beta-D-Arabinofuranosylcytosine-5'-stearylphosphate (fosteabine) was administered orally to patients with myelodysplastic syndromes (MDS); refractory anemia with excess of blasts (RAEB), RAEB in transformation, acute leukemia derived from RAEB and chronic myelomonocytic leukemia, in an early phase II study in a mult...

    journal_title:Oncology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1159/000226979

    authors: Ohno R,Tatsumi N,Hirano M,Imai K,Mizoguchi H,Nakamura T,Kosaka M,Takatsuki K,Yamaya T,Toyama K

    更新日期:1991-01-01 00:00:00

  • Prognostic factors in patients with advanced hepatocellular carcinoma treated with sorafenib: a retrospective comparison with previously known prognostic models.

    abstract:BACKGROUND:Sorafenib, a multitargeted tyrosine kinase inhibitor, is now the treatment of choice for systemic therapy of patients with advanced hepatocellular carcinoma (HCC). Herein, we present the clinical characteristics and outcomes of patients with advanced HCC who were treated with sorafenib. METHODS:Data of 201 ...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000327591

    authors: Baek KK,Kim JH,Uhm JE,Park SH,Lee J,Park JO,Park YS,Kang WK,Lim HY

    更新日期:2011-01-01 00:00:00

  • Clinicopathological features and prognostic significance of HER2 expression in gastric cancer.

    abstract:BACKGROUND:HER2 positivity is reported to be <20% in gastric cancer. Clinicopathological characteristics will be helpful to understand the biological features of HER2-positive gastric cancer. METHODS:A total of 813 gastric cancer patients who underwent HER2 testing between January 2005 and December 2010 were included ...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000368555

    authors: Park JS,Rha SY,Chung HC,Jung M,Kim KH,Jun HJ,Kim H,An JY,Kim HI,Cheong JH,Hyung WJ,Noh SH,Kim HS

    更新日期:2015-01-01 00:00:00

  • Phase II study of weekly paclitaxel in patients with non-small cell lung cancer who have failed previous treatments.

    abstract:OBJECTIVE:New effective therapy is desirable for patients with non-small cell lung cancer (NSCLC) who have failed previous treatments. Fractionated administration of paclitaxel may be less toxic and more active against NSCLC. The aim of this study was to evaluate the activity and toxicity of weekly paclitaxel therapy f...

    journal_title:Oncology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000079481

    authors: Yasuda K,Igishi T,Kawasaki Y,Kato K,Matsumoto S,Katayama S,Sako T,Shigeoka Y,Suyama H,Sugitani A,Yamamoto M,Hitsuda Y,Shimizu E

    更新日期:2004-01-01 00:00:00

  • Lack of c-mpl proto-oncogene transcripts and growth-stimulatory effects of thrombopoietin on human small cell lung cancer cell lines.

    abstract::Thrombopoietin (TPO) is a recently discovered hematopoietic growth factor which stimulates the production and maturation of megakaryocytes. In this study, we used a modified MTT assay to examine the in vitro growth-stimulatory effects of recombinant human (rh) TPO and recombinant human stem cell factor (rhSCF) on eigh...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000227600

    authors: Shinohara A,Shimizu E,Takada M,Sone S

    更新日期:1996-09-01 00:00:00

  • Soluble tumor-associated markers in lung cancer extracts.

    abstract::Three lung tumor-associated markers (LTAM), previously identified as a Cohn Fraction IV alpha-globulin (LTAM-1), ferritin (LTAM-2) and lactoferrin (LTAM-3) were separated by a combination of ion exchange, dye-affinity and molecular sieve chromatography. They were further purified by polyacrylamide gel electrophoresis ...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000225542

    authors: Maxim PE,Veltri RW,Sprinkle PM

    更新日期:1981-01-01 00:00:00

  • Tumor-associated antigen of spontaneous mammary tumor in rats.

    abstract::The present study was undertaken to detect the spontaneous mammary tumor-associated antigen ( MTAA ), and to find the cross-reacting antigen in chemically-induced mammary tumor. The antisera against spontaneous mammary tumor were raised in the WAF1 rats of the same strain and tested for the detection of tumor-associat...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000225824

    authors: Imamura N,Yanagihara K,Kusunoki Y

    更新日期:1984-01-01 00:00:00

  • Droperidol as an antiemetic in cis-platinum-induced nausea and vomiting.

    abstract::23 patients received cis-platinum, doxorubicin and cyclophosphamide for gynecologic malignancy between December 1, 1980 and December 1, 1982. Each patient was randomized with each course of chemotherapy to receive intravenous droperidol or the combination of promethazine and chlorpromazine rectal suppositories as an a...

    journal_title:Oncology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000225997

    authors: Roberts WS,Wisniewski BJ,Cavanagh D,Marsden DE

    更新日期:1985-01-01 00:00:00

  • Serum Exosomal Gamma-Glutamyltransferase Activity Increased in Patients with Renal Cell Carcinoma with Advanced Clinicopathological Features.

    abstract:BACKGROUND:There has been no clinically useful diagnostic or prognostic biomarker for renal cell carcinoma (RCC). Serum γ-glutamyltransferase (GGT) activity has been reported to be a prognostic marker for several types of cancer including RCC. Exosomes or small extracellular vesicles present in body fluids have potenti...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000508688

    authors: Horie K,Kawakami K,Fujita Y,Matsuda Y,Arai T,Suzui N,Miyazaki T,Koie T,Mizutani K,Ito M

    更新日期:2020-01-01 00:00:00

  • Second-line chemotherapy in recurrent clear cell ovarian cancer: results from the multicenter italian trials in ovarian cancer (MITO-9).

    abstract:BACKGROUND AND AIMS:Ovarian clear cell carcinoma (CCC) has a poorer prognosis than other subtypes of ovarian cancer. In this study, we evaluated the responsiveness to second-line chemotherapy in recurrent ovarian CCC. METHODS:The MITO-9 project investigated a cohort of patients observed between 1991 and 2007 in 20 cen...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000358730

    authors: Esposito F,Cecere SC,Magazzino F,Katsaros D,Ottaiano A,Gadducci A,Pisano C,Scalone S,Rabaiotti E,Salutari V,Cormio G,Canuto EM,Greggi S,Savarese A,Marinaccio M,Scollo P,Santeufemia DA,Sacco C,Facchini G,Pignata S

    更新日期:2014-01-01 00:00:00

  • Synchronous Hodgkin's disease and gastric adenocarcinoma.

    abstract:BACKGROUND:Adenocarcinoma is the most frequent pathological type of stomach cancer. Hodgkin's lymphoma is a lymphoproliferative disease arising from lymphoid tissue which is characterized by Reed-Sternberg cells. Synchronous occurrence of these two malignancies has not been reported in the English literature so far. C...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000136799

    authors: Comez G,Pehlivan Y,Kalender ME,Sevinc A,Sari I,Camci C

    更新日期:2007-01-01 00:00:00

  • Clinical characteristics and outcomes of lung cancer with pulmonary embolism.

    abstract:BACKGROUND:Cancer patients have a higher risk for thrombosis that is usually related to advanced stage and poor prognosis. This study aimed to identify the clinical picture and outcome of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) patients with pulmonary embolism (PE). PATIENTS AND METHODS:Fr...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000229503

    authors: Chuang YM,Yu CJ

    更新日期:2009-01-01 00:00:00

  • Pretreatment Neutrophil-to-Lymphocyte Ratio Was a Predictor of Lymph Node Metastasis in Endometrial Cancer Patients.

    abstract:OBJECTIVE:The pretreatment neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) have been reported to be useful as markers for prognostic factors and metastasis in several cancers. The aim of this study was to identify the predictor of lymph node (LN) metastasis by pretreatment NLR and PLR in...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000497184

    authors: Aoyama T,Takano M,Miyamoto M,Yoshikawa T,Kato K,Sakamoto T,Takasaki K,Matsuura H,Soyama H,Hirata J,Suzuki A,Sasa H,Tsuda H,Furuya K

    更新日期:2019-01-01 00:00:00

  • Inhibition of growth of Morris hepatomas 7777 and 7800 by corn oil.

    abstract::Intraperitoneal injection of trace amounts of corn oil prior to and following the injection of 40-50 mg of tissue from hepatoma 7777 or 7800 into the thigh of adult male Buffalo rats resulted in a marked decrease in the growth rate of both tumors. Exhaustive extraction of the corn oil with water indicated that the act...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000225184

    authors: Gilbertson JR,Gelman RA,Ove P,Coetzee ML

    更新日期:1977-01-01 00:00:00

  • Detection of early ototoxic effect in testicular-cancer patients treated with cisplatin by transiently evoked otoacoustic emission: a pilot study.

    abstract:UNLABELLED:The outlook for patients with testicular germ cell cancer was dramatically improved by the introduction of cisplatin. Well-known side effects of cisplatin (nausea, vomiting, nephrotoxicity, myelosuppression) can be managed with preventive methods. The long life expectancy after this therapy draws attention t...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000227724

    authors: Biró K,Baki M,Büki B,Noszek L,Jókúti L

    更新日期:1997-09-01 00:00:00

  • Immunological properties of lymphoblasts and lymphocytes in children with acute lymphatic or undifferentiated leukemia.

    abstract::In 35 children with acute lymphatic or undifferentiated leukemia, immunological properties of normal lymphocytes and lymphoblasts were investigated. In most cases the number of circulating normal lymphocytes with surface or B markers and delayed type hypersensitivity was depressed. On the other hand, the response to m...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000225300

    authors: Winterleitner H,Rella W,Eibl M,Krepler P

    更新日期:1978-01-01 00:00:00

  • A novel 9-aza-anthrapyrazole effective against human prostatic carcinoma xenografts.

    abstract:OBJECTIVES:Systematic investigation of a novel series of intercalating agents, 9-aza-anthrapyrazoles, has led to the identification of a promising analogue, BBR 3438. This study describes the antitumour efficacy of the novel compound in human prostate carcinoma models and the molecular/cellular basis of its activity. ...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000055380

    authors: Supino R,Polizzi D,Pavesi R,Pratesi G,Guano F,Capranico G,Palumbo M,Sissi C,Richter S,Beggiolin G,Menta E,Pezzoni G,Spinelli S,Torriani D,Carenini N,Dal Bo L,Facchinetti F,Tortoreto M,Zunino F

    更新日期:2001-01-01 00:00:00

  • Rechallenge with platinum plus fluoropyrimidine +/- epirubicin in patients with oesophagogastric cancer.

    abstract:PURPOSE:There is no standard second-line therapy for patients with oesophagogastric cancer who progress following first-line chemotherapy for advanced disease or relapse following radical multi-modality therapy. The aim of this retrospective study was to evaluate survival following rechallenge with platinum plus fluoro...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000322114

    authors: Okines AF,Asghar U,Cunningham D,Ashley S,Ashton J,Jackson K,Hawkes E,Chau I

    更新日期:2010-01-01 00:00:00

  • Lethal exitus of a patient with N-nitrosodimethylamine poisoning, 2.5 years following the first ingestion and signs of intoxication.

    abstract::The report describes the lethal exitus of a 44-year-old woman after repeated criminal poisoning with N-nitrosodimethylamine. She died 32 months following the initial symptoms and developed a liver cirrhosis with multiple bleeding, a hemolytic syndrome and diabetes mellitus. ...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000225451

    authors: Fussgaenger RD,Ditschuneit H

    更新日期:1980-01-01 00:00:00

  • Phase II trial of alternating mFOLFOX6 and FOLFIRI regimens in the first-line treatment for unresectable or metastatic colorectal cancer (KSCC0701).

    abstract:OBJECTIVE:This phase II study examined the efficacy and safety of alternating regimens of mFOLFOX6 and FOLFIRI as a first-line treatment for unresectable or metastatic colorectal cancer. PATIENTS AND METHODS:Forty-eight patients were enrolled in this study. Patients received an alternating regimen of 4 cycles of mFOLF...

    journal_title:Oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000346690

    authors: Oki E,Emi Y,Akagi Y,Tokunaga S,Sadanaga N,Tanaka T,Ogata Y,Saeki H,Kakeji Y,Baba H,Nishimaki T,Natsugoe S,Shirouzu K,Maehara Y,Kyushu Study Group of Clinical Cancer.

    更新日期:2013-01-01 00:00:00

  • Locoregional Control and Toxicity in Head and Neck Carcinoma Patients following Helical Tomotherapy-Delivered Intensity-Modulated Radiation Therapy Compared with 3D-CRT Data.

    abstract:OBJECTIVES:To assess the feasibility and efficacy of intensity-modulated radiation implemented with helical tomotherapy image-guided with daily megavoltage computed tomography for head and neck cancer. METHODS:Between May 2010 and May 2013, 72 patients were treated with curative intent. The median age was 64 years, wi...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000489217

    authors: Santa Cruz O,Tsoutsou P,Castella C,Khanfir K,Anchisi S,Bouayed S,Matzinger O,Ozsahin M

    更新日期:2018-01-01 00:00:00

  • Serological detection of common human melanoma membrane antigens by microcomplement fixation and immunofluorescence.

    abstract::An antiserum to human melanoma antigens was obtained from a melanoma patient after immunization with autologous irradiated cultured melanoma cells and bacillus Calmette-Guerin. Using the microcomplement fixation assay, the antiserum, at a titer of 1/1,800, was noted to bind strongly with 7 of 10 allogeneic cultured hu...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000225702

    authors: Leong SP,Cooperband SR,Deckers PJ,Sutherland CM,Fried RM,Krementz ET

    更新日期:1983-01-01 00:00:00

  • Mitomycin C, vinorelbine, carboplatin plus granulocyte-macrophage colony-stimulating factor for treatment of advanced non-small cell lung carcinoma.

    abstract:BACKGROUND:The therapeutic potential of chemotherapy in the treatment of recurrent or metastatic non-small cell lung carcinoma (NSCLC) seems modest. Thus, the search for novel agents and combination regimens with a superior therapeutic index has a high priority. The present combination regimen consisting of mitomycin C...

    journal_title:Oncology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000011909

    authors: Hejna M,Kornek GV,Raderer M,Marosi L,Schneeweiss B,Greul R,Weinländer G,Valencak J,Huber H,Scheithauer W

    更新日期:1998-11-01 00:00:00