Abstract:
:In 35 children with acute lymphatic or undifferentiated leukemia, immunological properties of normal lymphocytes and lymphoblasts were investigated. In most cases the number of circulating normal lymphocytes with surface or B markers and delayed type hypersensitivity was depressed. On the other hand, the response to mitogenic stimulation with PHA as well as the antibody and immunoglobulin serum concentrations were found to be normal. Lymphoblasts did not exhibit surface receptors in any but four patients, who showed 10--18% of leukemic blasts being positive for E-rosette formation at 0 degree but not at 37 degrees.
journal_name
Oncologyjournal_title
Oncologyauthors
Winterleitner H,Rella W,Eibl M,Krepler Pdoi
10.1159/000225300subject
Has Abstractpub_date
1978-01-01 00:00:00pages
258-62issue
6eissn
0030-2414issn
1423-0232journal_volume
35pub_type
杂志文章相关文献
ONCOLOGY文献大全abstract:BACKGROUND:We retrospectively investigated the treatment outcomes of second-line treatment with pazopanib or gemcitabine/docetaxel in patients with advanced soft tissue sarcoma (STS). METHODS:Ninety-one patients who were treated with pazopanib or gemcitabine/docetaxel for advanced STS between 1995 and 2015 were analyz...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000492597
更新日期:2019-01-01 00:00:00
abstract::We analyzed the differential gene expression in the pancreatic cancer cell line NP-18 upon induction of apoptosis caused by cyclin-dependent kinase inhibition triggered by either overexpression of the tumor suppressor gene p16(INK4A)using an adenoviral construction or incubation with the chemical inhibitors, roscoviti...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000081329
更新日期:2004-01-01 00:00:00
abstract::Aberrant glycosylation of membrane components due to specific alterations of glycosyltransferase activity is a common feature of carcinoma cells and is usually associated with invasion and metastasis. In a prospective study, the enzyme activity of the sialyltransferases ST6GAL-I and ST3GAL-III was studied in gastric c...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000072339
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVES:It was the aim of this study to investigate the clinical differences between the tyrosine kinase inhibitors (TKIs) sorafenib and sunitinib as second-line treatment for cytokine-refractory kidney cancer patients. METHODS:Twenty consecutive patients received continuous treatment of oral sorafenib at a dose of...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000151369
更新日期:2008-01-01 00:00:00
abstract::To improve our understanding of the basic biological mechanisms of Hürthle cell tumours (HCT), proliferative activity in 20 HCT was determined by Ag-NOR (nucleolar organiser regions) counting and by immunohistochemical markers proliferating cell nuclear antigen (PCNA) and MIB-1. Ten surgically removed Hürthle cell ade...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011995
更新日期:1999-07-01 00:00:00
abstract::To assess the prognostic value of pretreatment serum neuron-specific enolase (NSE) in nonsmall cell lung cancer (NSCLC), levels were measured in 84 NSCLC patients, 40 healthy controls, and 20 patients with benign pulmonary diseases. NSE concentration was higher in NSCLC (11.7 +/- 10.8 ng/ml) (mean +/- SD; median = 9.7...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227163
更新日期:1993-03-01 00:00:00
abstract::The role of estrogen and estrogen-related growth factors in the mechanism of hormone dependency of endometrial adenocarcinoma cells was investigated. The proliferation of hormone-responsive human endometrial adenocarcinoma cells (Ishikawa cells), which possess both estrogen and progesterone receptors, was optimally st...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000055257
更新日期:1998-12-01 00:00:00
abstract::Improved understanding of tumor biology has led to the identification of numerous growth factors that are involved in malignant transformation and tumor progression. Many of these factors induce cellular responses through receptors with intrinsic tyrosine kinase (TK) activity. Therefore, inhibiting receptor TK activit...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000066198
更新日期:2002-01-01 00:00:00
abstract::Recombinant human granulocyte colony-stimulating factor (G-CSF) has been used worldwide in cancer patients for over 1 year, and (only 5 years from the first publication on the clinical use of this growth factor) experience is rapidly accumulating in many oncological situations. Several randomized studies have confirme...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000227333
更新日期:1994-03-01 00:00:00
abstract::38 of 306 patients survived beyond 5 years after resection of an exocrine pancreatic carcinoma during a period from 1971 to 1993. Amongst the long-term survivors there were 12 patients with ductal, 22 with ampullary, 3 with distal bile duct and 1 with duodenal cancer. An active operative strategy was employed in order...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227488
更新日期:1995-09-01 00:00:00
abstract::Peripheral blood T-cell subsets of 70 patients with untreated gastric cancer and 55 age- and sex-matched normal controls were studied by using monoclonal antibodies and flow cytometry. The number of T cells (Leu 4+ cells) was significantly decreased in stage IV patients. Statistically significant decreases in the numb...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226007
更新日期:1985-01-01 00:00:00
abstract::Autoantibodies (AAb) directed against the nuclear phosphoprotein p53 can be detected in patients with various forms of cancer. The objective was to determine the prevalence of p53 AAb at the time of diagnosis in ovarian cancer patients and to correlate the presence of p53 AAb with clinicopathological parameters. Sera ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000012069
更新日期:1999-11-01 00:00:00
abstract::Hemostatic abnormalities are rather frequent in cancer patients either in hematological or in solid tumors. Acute disseminated intravascular coagulation (DIC) is a rare coagulopathy in cancer patients, but when it develops it becomes rapidly fatal. Between June 1988 and December 1992 we observed 8 cases of acute DIC o...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227520
更新日期:1995-11-01 00:00:00
abstract:OBJECTIVES:Early detection of esophageal cancer is hampered by paucity of molecular markers for diagnosis of this aggressive gastrointestinal malignancy in early stages. We recently identified TC21/R-Ras2, a small GTP-binding protein (SMG) in esophageal squamous cell carcinomas (ESCCs) by differential display. This stu...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000087283
更新日期:2005-01-01 00:00:00
abstract::A number of therapeutic agents including L-asparaginase, Actinomycin-D, CCNU, Hydroxyurea, 5-FU, Cis-platinum, Cyclophosphamide, orchiectomy, Adriamycin and DES alone and in various combinations has been applied against the Dunning R-3327 rat prostatic adenocarcinoma subline G. We have found a parallel between the res...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225202
更新日期:1977-01-01 00:00:00
abstract::We conducted a prospective multicenter phase II trial of patients with borderline resectable pancreatic carcinoma to investigate the efficacy of neoadjuvant nab-paclitaxel plus gemcitabine therapy on overall survival (OS). The clinical trial primarily evaluated OS time from the first day of protocol therapy as a prima...
journal_title:Oncology
pub_type: 杂志文章,多中心研究
doi:10.1159/000478660
更新日期:2017-01-01 00:00:00
abstract::This is a phase II study to evaluate the efficacy and toxicity of short-course carboplatin in advanced-stage nasopharyngeal carcinoma (NPC). Thirty-three previously untreated stage III-IV NPC patients were studied. Carboplatin was given as a rapid intravenous injection every 3 weeks. The dose of carboplatin was calcul...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227689
更新日期:1997-05-01 00:00:00
abstract:PURPOSE:There is no standard second-line therapy for patients with oesophagogastric cancer who progress following first-line chemotherapy for advanced disease or relapse following radical multi-modality therapy. The aim of this retrospective study was to evaluate survival following rechallenge with platinum plus fluoro...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000322114
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:The present study sought to evaluate an inflammation-based prognostic score (Glasgow prognostic score, GPS) and the neutrophil to lymphocyte ratio (NLR) as prognostic factors in patients receiving chemotherapy for advanced gastric cancer. METHODS:The study enrolled 224 patients who received chemotherapy for...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000446373
更新日期:2016-01-01 00:00:00
abstract::Chromosomal analysis of three human non-Hodgkin's lymphoma (NHL) xenografts revealed common extra 14q+ segment and other individual clonal markers without involvement of immunoglobulin light-chain regions. Two NHL xenografts (HT 58 and HT 130) showed restricted lambda light chain expression and deleted kappa and rearr...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226855
更新日期:1990-01-01 00:00:00
abstract::The efficacy of recombinant interferon-alpha 2 in the treatment of advanced hairy cell leukaemia is investigated in 31 patients. Preliminary results show a complete and partial response rate of 69%. An optimal dose study utilizing maximal stimulation of an interferon-dependent pathway was carried out in 5 patients. Th...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226076
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the clinical and cost benefits of the administration of aprepitant for the prophylaxis of chemotherapy-induced nausea and vomiting (CINV) during high-dose chemotherapy (HDCT). METHODS:We retrospectively reviewed the charts of patients who received HDCT at our institution between January 2009 and ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000479032
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:Systematic investigation of a novel series of intercalating agents, 9-aza-anthrapyrazoles, has led to the identification of a promising analogue, BBR 3438. This study describes the antitumour efficacy of the novel compound in human prostate carcinoma models and the molecular/cellular basis of its activity. ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000055380
更新日期:2001-01-01 00:00:00
abstract::Cyclin D3 promotes cell cycle progression but its expression and prognostic significance in human colorectal cancer is unknown. This study assayed cyclin D3 expression against cell cycle phase fraction and Duke's stage in 35 fresh human primary colorectal cancers. DNA content, cell cycle phase fraction and cyclin D3 e...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011932
更新日期:1999-01-01 00:00:00
abstract::Until a few decades ago neck dissection (ND) was the standard surgical approach for node-positive tumours. Nowadays patients with locally advanced head and neck cancer can be treated with definitive chemoradiation (CRT), which includes the treatment of the neck; however, results on residual viable tumour after conserv...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000346132
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate the longitudinal changes in quality of life (QoL) for patients with advanced stage (stage III or IV) head and neck squamous cell carcinoma (HNSCC) following primary radiotherapy (RT) or concomitant chemoradiotherapy. METHODS:From January 2001 to January 2003, 149 ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000086982
更新日期:2005-01-01 00:00:00
abstract::We have measures serial carcinoembryonic antigen (CEA) titers in 92 patients, randomly selected from the patient population of a Radiotherapeutic Clinic, to correlate with clinical and follow-up evaluation. 57 out of 92 patients had positive CEA levels (2.5 ng/ml) or 62 percent of proven cancer patients. In this serie...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000224965
更新日期:1974-01-01 00:00:00
abstract::The effects of mesna (sodium 2-mercaptoethane-sulfonate) on the frequency of sister chromatid exchange (SCE) and chromosomal aberrations were studied in PHA-stimulated lymphocytes in vitro. Our data give no evidence for either an increase of SCE or chromosomal aberrations and, thus, do not suggest a mutagenic or cance...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225745
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVES:Low body mass index (BMI) and/or low lean body mass have been shown to be risk factors for chemotherapy-related toxicities in a number of different cancers. However, no data are available regarding the role of BMI as a risk factor for developing toxicities related to the novel anticancer agent, trabectedin, ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000487266
更新日期:2018-01-01 00:00:00
abstract::Thrombopoietin (TPO) is a recently discovered hematopoietic growth factor which stimulates the production and maturation of megakaryocytes. In this study, we used a modified MTT assay to examine the in vitro growth-stimulatory effects of recombinant human (rh) TPO and recombinant human stem cell factor (rhSCF) on eigh...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227600
更新日期:1996-09-01 00:00:00