Polycythemia Vera Management and Challenges in the Community Health Setting.


:Patients with polycythemia vera (PV) experience shortened survival, increased risk of thromboembolic and hemorrhagic events, and burdensome symptoms. For all patients with PV, treatment with aspirin and hematocrit control with phlebotomy are recommended. In addition, patients with high-risk status or poor hematocrit control benefit from cytoreductive therapy with hydroxyurea, although approximately 1 in 4 patients develops resistance or intolerance. For patients who are resistant to or intolerant of hydroxyurea, studies have shown that ruxolitinib, a Janus kinase 1/2 inhibitor, provides hematocrit control, reduces spleen size, normalizes blood counts, and improves PV-related symptoms. For many patients, PV is managed in a community health setting, and it is important that community hematologists, oncologists, and internists are familiar with the contemporary management of PV to improve patient outcomes, including management for patients who present with unique health-care needs. This review provides an overview of current treatment options for patients with PV and discusses challenging circumstances encountered by community providers in the management of PV, including symptom assessment, identification of hydroxyurea resistance/intolerance, pregnancy, elective surgeries, concomitant immunosuppressants, and managing patients in areas with limited access to specialized hematologic care.






Gerds AT,Dao KH




Has Abstract


2017-01-01 00:00:00
















  • Role of anastrozole across the breast cancer continuum: from advanced to early disease and prevention.

    abstract::Breast tumorigenesis is a continuum from preinvasive lesions to early breast cancer and advanced disease. In this article the data supporting the use of the aromatase inhibitor anastrozole in postmenopausal women across this continuum are reviewed. In advanced disease, anastrozole has a significant survival benefit an...


    pub_type: 杂志文章,评审


    authors: Nabholtz JM

    更新日期:2006-01-01 00:00:00

  • Unexpectedly low incorporation of isotopic acetate into lipids of Ehrlich ascites tumor cells cultured in lipid-poor medium.

    abstract::The present communication reports data on the lipid biosynthesis of Ehrlich ascites tumor cells grown in culture media supplemented with modified sera. Whereas the metabolisms of [14C]pyruvate and [14C]mevalonate are identical in all media tested, the incorporation of [14C] acetate is higher in medium with dialyzed se...


    pub_type: 杂志文章


    authors: Löffler M,Schneider F

    更新日期:1979-01-01 00:00:00

  • Impact of Socioeconomic Status and Ethnicity on Melanoma Presentation and Recurrence in Caucasian Patients.

    abstract:OBJECTIVES:The impact of ethnicity and the socioeconomic status (SES) among Caucasians is not well studied. Here, we examine the impact of income on melanoma presentation and prognosis within a Caucasian cohort, accounting for ethnicity, as some reports suggest increased melanoma incidence in Ashkenazi Jewish (AJ) BRCA...


    pub_type: 杂志文章


    authors: Salvaggio C,Han SW,Martires K,Robinson E,Madankumar R,Gumaste P,Polsky D,Stein J,Berman R,Shapiro R,Zhong J,Osman I

    更新日期:2016-01-01 00:00:00

  • Capecitabine and celecoxib as second-line treatment of advanced pancreatic and biliary tract cancers.

    abstract:OBJECTIVE:An increasing number of patients with advanced pancreatic or biliary tract cancer who progress after a gemcitabine-containing regimen are candidates for further chemotherapy. We therefore evaluated a fully oral regimen of capecitabine and celecoxib (CapCel) as second-line treatment in these patients. METHODS...


    pub_type: 杂志文章


    authors: Pino MS,Milella M,Gelibter A,Sperduti I,De Marco S,Nuzzo C,Bria E,Carpanese L,Ruggeri EM,Carlini P,Cognetti F

    更新日期:2009-01-01 00:00:00

  • Papillary microcarcinomas of the thyroid with preoperatively detectable lymph node metastasis show significantly higher aggressive characteristics on immunohistochemical examination.

    abstract:OBJECTIVES:We recently demonstrated that papillary microcarcinomas with preoperatively detectable node metastasis in the lateral compartment on ultrasonography (clinically apparent metastasis) show worse postoperative relapse-free survival than those with no metastasis or metastasis that could not be detected preoperat...


    pub_type: 杂志文章


    authors: Ito Y,Uruno T,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Kuma K,Miyauchi A

    更新日期:2005-01-01 00:00:00

  • Prognostic value of syndecan-1 expression in breast cancer.

    abstract:OBJECTIVE:Syndecan-1 is a cell surface heparan sulphate proteoglycan which participates in cell proliferation, cell migration and cell-matrix interactions. Epithelial syndecan-1 expression is reduced in several malignant tumours, but in breast and pancreatic cancer, increased expression has also been described. Loss of...


    pub_type: 杂志文章


    authors: Leivonen M,Lundin J,Nordling S,von Boguslawski K,Haglund C

    更新日期:2004-01-01 00:00:00

  • Irinotecan and Gemcitabine as Second-Line Treatment in Patients with Malignant Pleural Mesothelioma following Platinum plus Pemetrexed Chemotherapy: A Retrospective Study.

    abstract:BACKGROUND:Cisplatin-pemetrexed combination chemotherapy is the current standard primary treatment for malignant pleural mesothelioma (MPM). It was first approved for untreated and unresectable MPM in the 2003 National Comprehensive Cancer Network (NCCN) guidelines. However, to date, standard treatments for patients wi...


    pub_type: 杂志文章


    authors: Koda Y,Kuribayashi K,Doi H,Kitajima K,Nakajima Y,Ishigaki H,Nakamura A,Minami T,Takahashi R,Yokoi T,Kijima T

    更新日期:2020-10-14 00:00:00

  • BK virus-induced tumors in hamsters: a morphological, histochemical and ultrastructural study.

    abstract::Macroscopic morphology, histology and ultrastructure of BK virus (BKV)-induced hamster and mouse tumors were investigated. Groups of animals were immunosuppressed to study the relationship between immune system and BKV oncogenesis. Ependymomas had the highest incidence, followed by tumors of pancreatic islets, osteosa...


    pub_type: 杂志文章


    authors: Altavilla G,Carrà L,Alberti S,Corallini A,Cavazzini L,Fabris G,Aleotti A,Barbanti-Brodano G

    更新日期:1983-01-01 00:00:00

  • Studies on the standardization of mistletoe preparations.

    abstract::The newly isolated phenylpropanoids syringin, syringenin-apiosylglucoside, eleutheroside E and the high molecular lectins and viscotoxins were selected for a standardization of mistletoe extracts and drug preparation. The phenylpropanoids found in all alcoholic and aqueous extracts were suitable for an HPLC fingerprin...


    pub_type: 杂志文章


    authors: Wagner H,Jordan E,Feil B

    更新日期:1986-01-01 00:00:00

  • Differential expression of RUNX genes in human esophageal squamous cell carcinoma: downregulation of RUNX3 worsens patient prognosis.

    abstract:BACKGROUND:The RUNX proteins are a family of transcriptional factors that have essential functions during embryogenesis and development, whereas deregulation in expression of RUNXs is often linked to tumor formation. To date, there has been no study describing the precise expression, prognostic impact and methylation s...


    pub_type: 杂志文章


    authors: Tonomoto Y,Tachibana M,Dhar DK,Onoda T,Hata K,Ohnuma H,Tanaka T,Nagasue N

    更新日期:2007-01-01 00:00:00

  • Activity of formestane in de novo tamoxifen-resistant patients with metastatic breast cancer.

    abstract::In order to assess the feasibility of a sequential hormonal treatment after tamoxifen failure, 24 postmenopausal advanced breast cancer patients (median age 60 years; ECOG PS < or = 1) were treated with formestane (4-hydroxyandrostenedione) 250 mg i.m. fortnightly; 19 patients were estrogen receptor-positive. The site...


    pub_type: 临床试验,杂志文章


    authors: Noberasco C,Bajetta E,Zilembo N,Di Leo A,Cappuzzo F,Bartoli C,Bono A,Bichisao E

    更新日期:1995-11-01 00:00:00

  • Prognostic relevance of circulating tumor cells in metastatic uveal melanoma.

    abstract:OBJECTIVE:Uveal melanoma primarily metastasizes hematogenously with metastases often confined to the liver. The aim of this study was to investigate the presence of circulating tumor cells (CTC) in patients with metastatic disease as a marker for systemic disease and to determine their prognostic relevance. METHODS:Bl...


    pub_type: 杂志文章


    authors: Schuster R,Bechrakis NE,Stroux A,Busse A,Schmittel A,Thiel E,Foerster MH,Keilholz U

    更新日期:2011-01-01 00:00:00

  • A phase II study of carboplatin in nasopharyngeal carcinoma.

    abstract::This is a phase II study to evaluate the efficacy and toxicity of short-course carboplatin in advanced-stage nasopharyngeal carcinoma (NPC). Thirty-three previously untreated stage III-IV NPC patients were studied. Carboplatin was given as a rapid intravenous injection every 3 weeks. The dose of carboplatin was calcul...


    pub_type: 临床试验,杂志文章


    authors: Chi KH,Chang YC,Chan WK,Liu JM,Law CK,Lo SS,Shu CH,Yen SH,Whang-Peng J,Chen KY

    更新日期:1997-05-01 00:00:00

  • Changing quality of life in patients with advanced head and neck cancer after primary radiotherapy or chemoradiation.

    abstract:OBJECTIVE:The purpose of this study was to investigate the longitudinal changes in quality of life (QoL) for patients with advanced stage (stage III or IV) head and neck squamous cell carcinoma (HNSCC) following primary radiotherapy (RT) or concomitant chemoradiotherapy. METHODS:From January 2001 to January 2003, 149 ...


    pub_type: 杂志文章


    authors: Fang FM,Tsai WL,Chien CY,Chiu HC,Wang CJ,Chen HC,Hsiung CY

    更新日期:2005-01-01 00:00:00

  • Characterization of vincristine-resistant HOB1 lymphoma cell line showing the classical MDR phenotype and altered expression of membrane glycoproteins.

    abstract::A multidrug-resistant (MDR) cell line isolated from HOB1 lymphoma cells was characterized. The MDR phenotype in this cell line was typified by resistance to vincristine with varying degrees of cross-resistance to Adriamycin, colcemid and actinomycin D. Decreased intracellular [3H]vincristine with concurrent increase i...


    pub_type: 杂志文章


    authors: Lee WP,Lee CL

    更新日期:1994-01-01 00:00:00

  • Mathematical aspects of dose-response studies in carcinogenesis--the concept of thresholds.

    abstract::Many of the previously proposed theories of carcinogenesis which relate the exposure level of a carcinogen to expected tumor response, are summarized and it is pointed out that these theories assume the existence of no threshold level. A modification of the one-hit carcinogenic model which would incorporate a threshol...


    pub_type: 杂志文章


    authors: Brown CC

    更新日期:1976-01-01 00:00:00

  • Phase II study of gemcitabine and cisplatin in patients with advanced or metastatic bladder cancer: long-term follow-up of a 3-week regimen.

    abstract:BACKGROUND:Bladder cancer is the fifth most common cancer among men and the seventh among women. At diagnosis, at least 25% of bladder cancer tumors are locally or systemically advanced. Systemic chemotherapy is the only current modality for advanced or metastatic transitional cell carcinoma of the bladder. Recently, a...


    pub_type: 杂志文章


    authors: Adamo V,Magno C,Spitaleri G,Garipoli C,Maisano C,Alafaci E,Adamo B,Rossello R,Scandurra G,Scimone A

    更新日期:2005-01-01 00:00:00

  • Carcinoembryonic antigen (CEA) monitoring in the management of radiotherapeutic patients.

    abstract::We have measures serial carcinoembryonic antigen (CEA) titers in 92 patients, randomly selected from the patient population of a Radiotherapeutic Clinic, to correlate with clinical and follow-up evaluation. 57 out of 92 patients had positive CEA levels (2.5 ng/ml) or 62 percent of proven cancer patients. In this serie...


    pub_type: 杂志文章


    authors: Vider M,Kashmiri R,Hunter L,Moses B,Meeker WR,Utley JF,Maruyama Y

    更新日期:1974-01-01 00:00:00

  • Do recurrent and metastatic pancreatic cancer patients have the same outcomes with gemcitabine treatment?

    abstract:BACKGROUND:Whether recurrence after surgery and primary metastatic pancreatic cancer should be included in the same category when conducting gemcitabine-based clinical trials remains controversial. OBJECTIVE:To clarify the outcomes of recurrent and metastatic pancreatic cancers. METHODS:326 patients who received gemc...


    pub_type: 杂志文章


    authors: Hashimoto K,Ueno H,Ikeda M,Kojima Y,Hagihara A,Kondo S,Morizane C,Okusaka T

    更新日期:2009-01-01 00:00:00

  • Long-term prognosis of stage I ovarian carcinoma. Prognostic importance of intraoperative rupture.

    abstract:OBJECTIVE:There are a few long-term follow-up studies of patients with stage I ovarian carcinoma. The objective of this study was to evaluate prognostic factors for long-term survival. METHODS:Two hundred fourteen stage I ovarian carcinomas (registered by the Tokai Ovarian Tumor Study Group from 1988 to 1999) were ana...


    pub_type: 杂志文章,多中心研究


    authors: Mizuno M,Kikkawa F,Shibata K,Kajiyama H,Suzuki T,Ino K,Kawai M,Mizutani S

    更新日期:2003-01-01 00:00:00

  • Effect of canthaxanthin on chemically induced mammary carcinogenesis.

    abstract::Canthaxanthin, a carotenoid with no vitamin A activity, was evaluated for its efficacy in the prevention of chemically induced mammary cancers. Canthaxanthin was administered in the diet at two dose levels (3,390 or 1,130 mg/kg diet). In the dimethylbenzanthracene-induced mammary cancer model, diet supplementation wit...


    pub_type: 杂志文章


    authors: Grubbs CJ,Eto I,Juliana MM,Whitaker LM

    更新日期:1991-01-01 00:00:00

  • HER2 as a prognostic factor in breast cancer.

    abstract::HER2 amplification/overexpression is a marker of poor prognosis in breast cancer. The prognostic impact of HER2 positivity is lower in node-negative compared with node-positive women. The only significant, independent prognostic factors in breast cancer are node status, HER2 status and menopausal status. HER2-positive...


    pub_type: 杂志文章,评审


    authors: Ménard S,Fortis S,Castiglioni F,Agresti R,Balsari A

    更新日期:2001-01-01 00:00:00

  • Long-Term Survival and Cure in Distant Metastatic Breast Cancer.

    abstract:BACKGROUND:Previous data showed that distant metastatic breast cancer (MBC) might be curable in up to 3% of the cases in selected patients, mostly young, with good performance status and with low-volume metastatic disease, mainly by an aggressive multidisciplinary approach including aggressive combination chemotherapy ...


    pub_type: 杂志文章


    authors: Güth U,Elfgen C,Montagna G,Schmid SM

    更新日期:2019-01-01 00:00:00

  • Models, mechanisms and management of anticipatory nausea and emesis.

    abstract::Anticipatory nausea and vomiting (ANV) are learned responses to chemotherapy that develop in up to 25% of patients by the fourth treatment cycle. Post-treatment nausea and emesis must occur before development of ANV can take place. Certain patient characteristics and other responses to chemotherapy can also be used to...


    pub_type: 杂志文章,评审


    authors: Morrow GR,Rosenthal SN

    更新日期:1996-06-01 00:00:00

  • PET scans for decision-making in metastatic renal cell carcinoma: a single-institution evaluation.

    abstract:OBJECTIVE:Therapeutic decision-making in metastatic renal cell carcinoma (MRCC) is based on conventional radiological evaluation. Fluorodeoxyglucose positron emission tomography (FDG-PET) scans may modify this strategy. METHODS:Patients with MRCC for whom a therapeutic decision had been made underwent an FDG-PET scan ...


    pub_type: 杂志文章


    authors: Dilhuydy MS,Durieux A,Pariente A,de Clermont H,Pasticier G,Monteil J,Ravaud A

    更新日期:2006-01-01 00:00:00

  • Testing prospective anticancer drugs against human tumors using simple in vivo models.

    abstract::The activities of established and experimental antitumor drugs were tested against the BRO and MeWo human melanomas transplanted in the subrenal capsule of phenotypically immunocompetent (CBA x C57BL/6)F1 mice. Immunosuppression was achieved with preliminary whole-body radiation, and cytological examination showed tha...


    pub_type: 杂志文章


    authors: Ryabkova VI,Lockshin A,Strukov IG,Sokolova VK

    更新日期:1994-11-01 00:00:00

  • Studies on the antineoplasticity of Schiff bases containing 5-nitrofuran and pyrimidine.

    abstract::Antineoplastic properties of different Schiff bases obtained by the interaction of 5-nitrofuran with substituted pyrimidines have been examined both in vitro and in vivo. In vitro studies on L 5178Y/asparaginase sensitive, HL 60 and P 388 cell lines and in vivo studies on the P 388 cell line indicate that all the comp...


    pub_type: 杂志文章


    authors: Sur B,Chatterjee SP,Sur P,Maity T,Roychoudhury S

    更新日期:1990-01-01 00:00:00

  • Concurrent chemoradiotherapy with a novel fluoropyrimidine, S-1, and cisplatin for locally advanced esophageal cancer: long-term results of a phase II trial.

    abstract:OBJECTIVES:A phase II study was performed to investigate the safety and efficacy of concurrent chemoradiotherapy (CCRT) combined with an orally active fluoropyrimidine, S-1, plus cisplatin for locally advanced esophageal cancer (LAEC). METHODS:CCRT comprised 2 courses, a 30-Gy radiotherapy over 3 weeks plus daily oral...


    pub_type: 杂志文章


    authors: Iwase H,Shimada M,Tsuzuki T,Hirashima N,Okeya M,Hibino Y,Ryuge N,Yokoi M,Kida Y,Kuno T,Tanaka Y,Kato B,Esaki M,Urata N,Kato E

    更新日期:2013-01-01 00:00:00

  • Comparative effects of piroxicam and esculetin on incidence, proliferation, and cell kinetics of mammary carcinomas induced by 7,12-dimethylbenz[a]anthracene in rats on high- and low-fat diets.

    abstract::We investigated the effects of piroxicam, a cyclooxygenase inhibitor, and esculetin, a lipoxygenase inhibitor, on 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female rats. Seven days after receiving a 5-mg dose of DMBA, rats were fed either a high-fat (20% soybean oil) or low-fat (0.5% soybe...


    pub_type: 杂志文章


    authors: Kitagawa H,Noguchi M

    更新日期:1994-09-01 00:00:00

  • Inhibition of growth of Morris hepatomas 7777 and 7800 by corn oil.

    abstract::Intraperitoneal injection of trace amounts of corn oil prior to and following the injection of 40-50 mg of tissue from hepatoma 7777 or 7800 into the thigh of adult male Buffalo rats resulted in a marked decrease in the growth rate of both tumors. Exhaustive extraction of the corn oil with water indicated that the act...


    pub_type: 杂志文章


    authors: Gilbertson JR,Gelman RA,Ove P,Coetzee ML

    更新日期:1977-01-01 00:00:00