Higher farnesyl diphosphate synthase activity in human colorectal cancer inhibition of cellular apoptosis.

abstract：OBJECTIVE:To compare chemotherapy-related and total medical costs among patients with colorectal cancer (CRC) receiving capecitabine or 5-fluorouracil (5-FU) monotherapy after surgical resection. METHODS:This retrospective, claim-based study utilized the Thomson Reuters Market Scan(R) databases to identify 1,396 CRC p...

journal_title：Oncology

authors： Chu E,Shi N,Wei W,Bendell JC,Cartwright T

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:This study reports the percentage of breast cancer survivors receiving ongoing benzodiazepines and the circumstances surrounding their usage. METHODS:The medical records of 1,000 consecutive breast cancer survivors who were no longer receiving adjuvant chemotherapy were reviewed. RESULTS:Among those patient...

journal_title：Oncology

authors： Vaidya R,Sood R,Karlin N,Jatoi A

更新日期：2011-01-01 00:00:00

abstract：:The aim of this study is to compare the levels of carcinoembryonic antigen (CEA) in the gastric juice, stomach mucosa and plasma of gastrectomy patients at risk of developing cancer with those in normal controls and gastric cancer subjects. Blood samples, gastric juices and biopsy material were taken from 52 patients ...

journal_title：Oncology

authors： Castelli M,Guadagni S,Bagnato A,Pistoia MA,Carboni M,Sega E

更新日期：1986-01-01 00:00:00

abstract：:Anticipatory nausea and vomiting (ANV) are learned responses to chemotherapy that develop in up to 25% of patients by the fourth treatment cycle. Post-treatment nausea and emesis must occur before development of ANV can take place. Certain patient characteristics and other responses to chemotherapy can also be used to...

journal_title：Oncology

authors： Morrow GR,Rosenthal SN

更新日期：1996-06-01 00:00:00

abstract：:Studies were made of the therapeutic response of six human colorectal tumor lines serially transplanted in immunosuppressed mice. The tumors with adenomatous structure showed greater sensitivity against different cytotoxic agents than the gelatinous ones. Among the drugs, 5-FU, BCNU and MeCCNU proved to be the most ef...

journal_title：Oncology

authors： Kopper L,Lapis K,Hegedüs C

更新日期：1980-01-01 00:00:00

abstract：:Empiric clinical trials have revealed new mechanisms by which hormonal therapies may exert their antitumor effects. Initial studies using escalated doses of agents like toremifene and megestrol acetate have yielded interesting results, showing responses in hormone-receptor-negative patients and in patients progressing...

journal_title：Oncology

authors： Abrams JS,Gutheil J,Aisner J

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy and safety of neoadjuvant treatment comprising weekly high-dose 5-fluorouracil (5-FU) as a 24-hour infusion, folinic acid (FA) and biweekly oxaliplatin (L-OHP), followed by metastatic resection in patients with primarily resectable liver metastases of colorectal cancer (CRC). PATIENTS ...

journal_title：Oncology

authors： Wein A,Riedel C,Brückl W,Merkel S,Ott R,Hanke B,Baum U,Fuchs F,Günther K,Reck T,Papadopoulos T,Hahn EG,Hohenberger W

更新日期：2003-01-01 00:00:00

abstract：:In patients affected with different tumours, disorders concerning clotting are frequently observed. The biological processes leading to coagulation are probably involved in the mechanisms of metastasis. We studied plasma levels of thrombin-antithrombin III complexes (TAT) in 90 patients affected with lung tumours subg...

journal_title：Oncology

authors： Tricerri A,Vangeli M,Errani AR,Guidi L,Canetta M,Vaccarino M,De Santis C,Ipsevich F,Salvati F,Bartoloni C

更新日期：1996-11-01 00:00:00

abstract：:The present study was undertaken to detect the spontaneous mammary tumor-associated antigen ( MTAA ), and to find the cross-reacting antigen in chemically-induced mammary tumor. The antisera against spontaneous mammary tumor were raised in the WAF1 rats of the same strain and tested for the detection of tumor-associat...

journal_title：Oncology

authors： Imamura N,Yanagihara K,Kusunoki Y

更新日期：1984-01-01 00:00:00

abstract：:The activities of established and experimental antitumor drugs were tested against the BRO and MeWo human melanomas transplanted in the subrenal capsule of phenotypically immunocompetent (CBA x C57BL/6)F1 mice. Immunosuppression was achieved with preliminary whole-body radiation, and cytological examination showed tha...

journal_title：Oncology

authors： Ryabkova VI,Lockshin A,Strukov IG,Sokolova VK

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Immuno-oncological (IO) therapies such as PD-1 and PD-L1 antibodies have been introduced in the treatment of advanced non-small cell lung cancer (NSCLC) since 2015 based on randomized trials showing unprecedented advantages in overall survival (OS) with hazard ratios (HRs) between 0.5 and 0.7. The impact of ...

journal_title：Oncology

authors： Faehling M,Kopp M,Schwenk B,Fallscheer S,Kramberg S,Eckert R

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:Carcinoma of the biliary system is a rare tumor entity, and patients with advanced disease face a dismal prognosis. Because of the absence of standard chemotherapy for advanced biliary carcinoma, we have performed two consecutive studies to evaluate the clinical potential of 5-fluorouracil, leucovorin and ...

journal_title：Oncology

authors： Raderer M,Hejna MH,Valencak JB,Kornek GV,Weinländer GS,Bareck E,Lenauer J,Brodowicz T,Lang F,Scheithauer W

更新日期：1999-04-01 00:00:00

abstract：:Breast conservation treatment followed, if useful, by adjuvant therapy is the treatment of choice in early breast cancer. Late cosmetic outcome and toxicity are important in comparing conservative treatment to mastectomy. We reviewed the records of 225 patients treated from 1981 to 1988 with a median follow-up of 74 m...

journal_title：Oncology

authors： Amichetti M,Busana L,Caffo O

更新日期：1995-05-01 00:00:00

abstract：:Stem cell mimicry of cancer cells has been known for a long time and is considered to be responsible for ectopic gene expressions. The stem cell characteristics of tumor cells are shown to be involved in epithelial-mesenchymal transition and in the phenomenon of vascular mimicry. Certain cancer types acquire a geno-ph...

journal_title：Oncology

authors： Tímár J,Tóvári J,Rásó E,Mészáros L,Bereczky B,Lapis K

更新日期：2005-01-01 00:00:00

abstract：:We studied the chemo-radiotherapy of testicular tumors in clinical stage III. Our study involved 54 patients with lung metastases of seminoma and nonseminoma, treated with a combination of radiotherapy and chemotherapy. The results obtained have not satisfied our expectations. While in the 16 seminoma patients only 43...

journal_title：Oncology

authors： Mechl Z,Malír A

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVES:Angiogenesis plays an important role in ovarian cancer. The interaction of platelet-derived growth factor receptor-beta (PDGFR-β) with vascular endothelial growth factor (VEGF) in the process of angiogenesis may represent an essential feature in the progression of the disease. METHODS:Patients with epitheli...

journal_title：Oncology

authors： Mathey S,Graeser MK,Zu Eulenburg C,Woelber L,Trillsch F,Jaenicke F,Müller V,Milde-Langosch K,Mahner S

更新日期：2013-01-01 00:00:00

abstract：:Vascular endothelial growth factor C (VEGF-C) is considered to be potentially lymphangiogenic and can selectively induce hyperplasia of the lymphatic vasculature. In this study, we clarified the clinicopathological features of early gastric carcinoma (EGC) that has metastasized to the lymph nodes, as well as the corre...

journal_title：Oncology

authors： Kabashima A,Maehara Y,Kakeji Y,Sugimachi K

更新日期：2001-01-01 00:00:00

abstract：:Aberrant glycosylation of membrane components due to specific alterations of glycosyltransferase activity is a common feature of carcinoma cells and is usually associated with invasion and metastasis. In a prospective study, the enzyme activity of the sialyltransferases ST6GAL-I and ST3GAL-III was studied in gastric c...

journal_title：Oncology

authors： Gretschel S,Haensch W,Schlag PM,Kemmner W

更新日期：2003-01-01 00:00:00

abstract：:Using a Gompertzian pharmacodynamic model, we have studied the changes induced by graded doses of adriamycin (AM) on the growth of intramuscular Lewis lung carcinoma (3LL) and its lung metastases in C57Bl/6 mice. An interpretation of the drug's effects on free growth of the tumor cells is given in the Appendix. Unlike...

journal_title：Oncology

authors： Madonna M,Colombo T,Donelli MG,Dagnino G

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:The herpes simplex virus thymidine kinase (HSVtk)/ganciclovir suicide gene therapy system has been considered as one of the most promising therapeutic strategies for malignant gliomas. We have been using HSVtk gene-transduced neural stem cells (NSCtk) that possess an ability to migrate toward a tumor mass for...

journal_title：Oncology

authors： Li S,Tokuyama T,Yamamoto J,Koide M,Yokota N,Namba H

更新日期：2005-01-01 00:00:00

abstract：:We report four cases of Hodgkin's disease (HD) relapsing after complete remission for over a 10-year period after the initial therapy. Three of the patients had mixed-cellularity subtypes as a primary histological diagnosis, and the rebiopsies demonstrated mixed cellularity in all very late relapse cases. Two patients...

journal_title：Oncology

authors： Illés A,Bányai A,Vadász G,Szegedi G

更新日期：1995-07-01 00:00:00

abstract：:The activity of deoxycytidylate aminohydrolase, a pivotal enzyme for pyrimidine biosynthesis in mammalian tissue, is 100x greater in the Novikoff hepatoma harvested from the intraperitoneal cavity than in the same tumor excised from either subcutaneous or intramuscular sites. The increased enzyme activity in the intra...

journal_title：Oncology

authors： Sheid B

更新日期：1990-01-01 00:00:00

abstract：:A demonstration multiphasic cancer screening program was conducted in a rural village in Thailand under the coordination of Bangkok's National Cancer Institute. The village's physician, mayor, and other members of the community assumed a variety of volunteer roles in order to provide logistical support. In short, this...

journal_title：Oncology

authors： Lynch HT,Pitakspraiwan P,Sombooncharoen S,Phanthumchinda P,Vechmon U,Srivanwat G,Schutz RJ,Lynch JF

更新日期：1985-01-01 00:00:00

abstract：:Thirteen samples of gastric tumors that had developed in the remnant stomach (remnant gastric cancer) were compared with 63 samples of primary gastric tumors located in the upper third of the stomach (primary gastric cancer) by both clinicopathologic and flow cytometric analysis. The depths of invasion of all these tu...

journal_title：Oncology

authors： Ikeguchi M,Kondou A,Oka A,Tsujitani S,Maeta M,Kaibara N

更新日期：1995-03-01 00:00:00

abstract：:The relative risk of breast cancer incidence and tumor promotion associated with psychotropic drug consumption was evaluated in 151 patients with newly diagnosed neoplasms and 151 hospital controls. No significantly altered risk of breast cancer was found in association with the use of diazepam, chlordiazepoxide, anti...

journal_title：Oncology

authors： Wallace RB,Sherman BM,Bean JA

更新日期：1982-01-01 00:00:00

abstract：:Eleven postmenopausal patients with advanced breast cancer were assessed for their response and endocrine changes to low-dose aminoglutethimide (250 mg twice a day) therapy without steroid administration. In 7 cases an objective response was registered; 1 patient had a stabilization of the disease lasting for 9 months...

journal_title：Oncology

authors： Kahán Z,Tóth I,Vecsernyés M

更新日期：1992-01-01 00:00:00

abstract：:Beard's theory can be restated in a modified form in modern terms in the following way. Cancer represents primarily trophoblastic tissue derived either from an aberrant germ cell or from a somatic cell whose normally repressed 'asexual generation' genes are abnormally reactivated ('derepressed'). The variety of tumors...

journal_title：Oncology

authors： Gurchot C

更新日期：1975-01-01 00:00:00

abstract：:Since aspirin was found to cause a persistent decrease in pyruvate kinase activity, which is a prominent characteristic of the hepatic promoters, the effect of aspirin on hepatic tumorigenesis in the rat has been studied. Male Wistar rats were initiated with a diet containing 0.06% 3'-methyl-4-dimethylamino-azobenzene...

journal_title：Oncology

authors： Yanagi S,Yamashita M,Hiasa Y

更新日期：1993-07-01 00:00:00

abstract：:After exposure to the mutagen, ethylmethanesulfonate (EMS), or the carcinogen, urethane (UR), anchorage independence was observed in cultures derived from normal skin biopsies from patients with the heritable cancer syndrome, adenomatosis of the colon and rectum (ACR). Such colonies from methylcellulose suspension cul...

journal_title：Oncology

authors： Danes BS

更新日期：1980-01-01 00:00:00

abstract：:Malignant fibrous histiocytoma (MFH), the most common soft-tissue sarcoma, consists mainly of two different cell populations: histiocytelike and fibroblastlike cells. It has been suggested to contain a large amount of reactive histiocytes and fibroblasts hard to distinguish from the tumor cells. In this study, the clo...

journal_title：Oncology

authors： Fujita MQ,Hashida N,Shin M,Nakanishi H,Yoshihara W,Aozasa K

更新日期：1998-11-01 00:00:00