Abstract:
:The activity of deoxycytidylate aminohydrolase, a pivotal enzyme for pyrimidine biosynthesis in mammalian tissue, is 100x greater in the Novikoff hepatoma harvested from the intraperitoneal cavity than in the same tumor excised from either subcutaneous or intramuscular sites. The increased enzyme activity in the intraperitoneal tumor is not due to an increase in protein synthesis, since there are no significant differences in enzyme activity between normal liver, and either the subcutaneous or intramuscular hepatomas. Evidence is presented which indicates that deoxycytidylate aminohydrolase activity, and the expression of alternate pathways of pyrimidine biosynthesis in the Novikoff hepatoma, is dependent on the localization of the tumor within the host.
journal_name
Oncologyjournal_title
Oncologyauthors
Sheid Bdoi
10.1159/000226832subject
Has Abstractpub_date
1990-01-01 00:00:00pages
278-81issue
3eissn
0030-2414issn
1423-0232journal_volume
47pub_type
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