Fetal antigens in the precursor stages of gastric cancer.

abstract：:Sodium cyanate, a drug that selectively suppresses amino acid incorporation for protein synthesis in tumor tissue, was given to patients with advanced colorectal carcinoma who had failed to conventional therapy, with the purpose of assessing a maximum tolerable oral dose. At 35 mg/kg p.o. daily, the drug had to be sto...

journal_title：Oncology

authors： Herrera-Ornelas L,Petrelli NJ,Madajewicz S,Mittelman A,Allfrey VG

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:The De Gramont regimen (or high-dose LV5FU2, HD-LV5FU2) is considered a standard treatment for metastatic colorectal cancer. The aim of the study was to evaluate the efficacy and the costs of three regimens as compared to HD-LV5FU2: raltitrexed (R), LV5FU2 with a lower dose of folinic acid (LD-LV5FU2), and w...

journal_title：Oncology

authors： Borget I,Aupérin A,Pignon JP,Abbas M,Bouché O,Mousseau M,Raoul JL,Bedenne L,Cassan P,Clavero-Fabri MC,Stremsdoerfer N,Nasca S,Queuniet AM,Ducreux M,Fédération Francophone de Cancérologie Digestive.

更新日期：2006-01-01 00:00:00

abstract：:As the antitumor activity of radiation is mediated via its interaction with oxygen to form labile free radicals, the intratumoral oxygen level has an important influence on the ability of radiation therapy to kill malignant cells. By decreasing the oxygen-carrying capacity of the blood, anemia may result in tumor hypo...

journal_title：Oncology

authors： Harrison LB,Shasha D,Homel P

更新日期：2002-01-01 00:00:00

abstract：:Cancer pain management had received relatively little attention until the late 1990s, when approximately 100,000 new cancer cases and 60,000 cancer deaths occurred each year in Korea. In 2001, a Cancer Pain Management Guideline was prepared for the first time by the Korean Society of Hospice and Palliative Care. This ...

journal_title：Oncology

authors： Lee JY,Ahn JS

更新日期：2008-01-01 00:00:00

abstract：:Fifteen patients, median age 64 years, presenting with advanced gastrointestinal adenocarcinomas, were included in this study. The treatment combination consisted of folinic acid (200 mg/m2, IV bolus injection) followed by 5-fluorouracil (5-FU; 400 mg/m2, 30-min infusion) for 5 consecutive days and mitomycin C (10 mg/...

journal_title：Oncology

authors： Becouarn Y,Brunet R,Bussières E,Marée D

更新日期：1988-01-01 00:00:00

abstract：INTRODUCTION:Because the frequency of bile duct invasion in hepatocellular carcinoma (HCC) patients is very rare, there is limited clinical evidence to demonstrate the outcomes of systemic therapy in HCC with bile duct invasion. OBJECTIVE:Our aim was to clarify the efficacy and safety of sorafenib treatment in patient...

journal_title：Oncology

authors： Tanaka T,Kuzuya T,Ishigami M,Ito T,Ishizu Y,Honda T,Ishikawa T,Fujishiro M

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Irinotecan has, in general, been administered as a 90-min infusion. However, several studies have demonstrated that continuous infusion seems to be a promising method of delivering irinotecan. This phase I/II trial was performed to evaluate the efficacy and safety of continuous infusion of irinotecan combined...

journal_title：Oncology

authors： Sadahiro S,Suzuki T,Maeda Y,Tanaka A,Ishikawa K,Makuuchi H,Murayama C

更新日期：2009-01-01 00:00:00

abstract：:Cisplatin is among the most active agents available for the therapy of non-small cell lung cancer (NSCLC). Its congener, carboplatin, has been the focus of intense clinical trials over the last several years because of its improved therapeutic index. Results from randomized trials have shown that carboplatin is active...

journal_title：Oncology

authors： Comis RL

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVE:Syndecan-1 is a cell surface heparan sulphate proteoglycan which participates in cell proliferation, cell migration and cell-matrix interactions. Epithelial syndecan-1 expression is reduced in several malignant tumours, but in breast and pancreatic cancer, increased expression has also been described. Loss of...

journal_title：Oncology

authors： Leivonen M,Lundin J,Nordling S,von Boguslawski K,Haglund C

更新日期：2004-01-01 00:00:00

abstract：:Culture-induced cytotoxic (CIC) activity developed in 7-day culture in the presence of fetal calf serum of pleural effusion lymphocytes from patients with lung cancer which initially showed markedly low or no natural killing (NK) activity against K562 cells. The development of CIC activity was proliferation-dependent....

journal_title：Oncology

authors： Uchida A,Micksche M

更新日期：1982-01-01 00:00:00

abstract：:The toxicity of 1-[2-(diethylamino)ethyl]reserpine (DL-152) has been measured for 4 transplantable mouse tumors. DL-152 was found to be toxic to cells of all the tumor models tested (KHT fibrosarcoma, RIF-1 fibrosarcoma, EMT-6 adenocarcinoma and Lewis lung carcinoma) when the drug was given by intraperitoneal injectio...

journal_title：Oncology

authors： Lehnert S

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Postoperative management of patients with pancreatic adenocarcinoma (PA) is controversial. METHODS:The aim of this pilot study was to assess the feasibility of postoperative combination chemotherapy followed by radiotherapy in patients aged 18-70 years with a histological diagnosis of PA, and Karnofsky perf...

journal_title：Oncology

authors： Reni M,Passoni P,Bonetto E,Balzano G,Panucci MG,Zerbi A,Ronzoni M,Staudacher C,Villa E,Di Carlo V

更新日期：2005-01-01 00:00:00

abstract：:One hundred and seventy-five patients selected at random were prospectively studied. All patients were assessed at least after the first cycle of treatment by a self-report questionnaire which covered the occurrence of nausea and vomiting 24 before chemotherapy, as well as information regarding 22 clinical parameters....

journal_title：Oncology

authors： Alba E,Bastus R,de Andres L,Sola C,Paredes A,Lopez Lopez JJ

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:It was the aim of this study to investigate the clinical differences between the tyrosine kinase inhibitors (TKIs) sorafenib and sunitinib as second-line treatment for cytokine-refractory kidney cancer patients. METHODS:Twenty consecutive patients received continuous treatment of oral sorafenib at a dose of...

journal_title：Oncology

authors： Herrmann E,Bierer S,Gerss J,Köpke T,Hertle L,Wülfing C

更新日期：2008-01-01 00:00:00

abstract：:Tumor cell apoptosis, proliferation and p27 expression using an in situ apoptosis detection kit, anti-Ki67 antibody and anti-p27 antibody were investigated in 171 colorectal adenocarcinoma specimens, together with the assessment of mutated p53 expression. No apparent association was observed among p27 expression, muta...

journal_title：Oncology

authors： Tenjo T,Toyoda M,Okuda J,Watanabe I,Yamamoto T,Tanaka K,Ohtani M,Nohara T,Kawasaki H,Tanigawa N

更新日期：2000-01-01 00:00:00

abstract：:Malignant gastrointestinal neuroectodermal tumor (GNET) is an aggressive rare tumor, primarily occurring in young adults with frequent local-regional metastases and recurrence after local control. The tumor is characterized by the presence of EWSR1-ATF1 or EWSR1-CREB1 and immunohistochemical positivity for S-100 prote...

journal_title：Oncology

authors： Subbiah V,Holmes O,Gowen K,Spritz D,Amini B,Wang WL,Schrock AB,Meric-Bernstam F,Zinner R,Piha-Paul S,Zarzour M,Elvin JA,Erlich RL,Stockman DL,Vergilio JA,Suh JH,Stephens PJ,Miller V,Ross JS,Ali SM

更新日期：2016-01-01 00:00:00

abstract：:Breast cancer is the most common cancer in women. Although survival rates have improved with the use of new therapeutic agents, many issues remain unresolved and new predictive and prognostic factors are needed in clinical practice. Several studies have suggested a prognostic and predictive role for circulating and di...

journal_title：Oncology

authors： Amadori A,Rossi E,Zamarchi R,Carli P,Pastorelli D,Jirillo A

更新日期：2009-01-01 00:00:00

abstract：:The relationship of vitamins to cancer is very complex. Three types of interactions are possible: the effect of vitamins on tumor growth, the effect of tumors on vitamin metabolism, and the effect of vitamins on chemical carcinogens and anti-tumor chemotherapeutic agents. The significance of vitamins with particular r...

journal_title：Oncology

authors： Basu TK

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:This open-label, randomized phase III trial evaluated larotaxel/cisplatin versus gemcitabine/cisplatin as first-line treatment for locally advanced (T4b) or metastatic urothelial tract or bladder cancer. METHODS:Patients were randomized to larotaxel 50 mg/m(2) with cisplatin 75 mg/m(2) every 3 weeks (larota...

journal_title：Oncology

authors： Sternberg CN,Skoneczna IA,Castellano D,Theodore C,Blais N,Voog E,Bellmunt J,Peters F,Le-Guennec S,Cerbone L,Risse ML,Machiels JP

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:Uveal melanoma primarily metastasizes hematogenously with metastases often confined to the liver. The aim of this study was to investigate the presence of circulating tumor cells (CTC) in patients with metastatic disease as a marker for systemic disease and to determine their prognostic relevance. METHODS:Bl...

journal_title：Oncology

authors： Schuster R,Bechrakis NE,Stroux A,Busse A,Schmittel A,Thiel E,Foerster MH,Keilholz U

更新日期：2011-01-01 00:00:00

abstract：:Liver is involved in about 5-8% of newly diagnosed Hodgkin's disease (HD) cases. The incidence reaches up to 50-60% in postmortem studies. In the literature only a few cases of idiopathic cholestatic jaundice have been described without an apparent cause and a paraneoplastic etiology has been suggested. We report 2 ca...

journal_title：Oncology

authors： Yalçin S,Kars A,Sökmensüer C,Atahan L

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:To date, the clinical characteristics of coronavirus disease 19 (COVID-19)-infected urologic cancer patients are unknown. METHODS:We have analyzed all patients with prostate cancer undergoing hormonal or chemotherapy treatment and receiving telephone and in person pre-triage between March 1 and 27, 2020, at...

journal_title：Oncology

authors： Di Lorenzo G,Buonerba L,Ingenito C,Crocetto F,Buonerba C,Libroia A,Sciarra A,Ragone G,Sanseverino R,Iaccarino S,Napodano G,Imbimbo C,Leo E,Kozlakidis Z,De Placido S

更新日期：2020-01-01 00:00:00

abstract：:Many of the previously proposed theories of carcinogenesis which relate the exposure level of a carcinogen to expected tumor response, are summarized and it is pointed out that these theories assume the existence of no threshold level. A modification of the one-hit carcinogenic model which would incorporate a threshol...

journal_title：Oncology

authors： Brown CC

更新日期：1976-01-01 00:00:00

abstract：:Lewis lung carcinoma (3LL), which has been most frequently used for various investigations of cancer, was converted to an ascitic form designated 3LL-SA. Ascites tumor cells showed a mixed population of single cells and about 10% islands which were made up of 2 to about 50 cells. Transplantability was 100%. The biolog...

journal_title：Oncology

authors： Sato T,Takusagawa K,Asoo N,Kumano N,Hasuike M,Konno K

更新日期：1989-01-01 00:00:00

abstract：:The methodology of future antiemetic studies will reflect the need to address the problems identified in current studies. New preclinical information on the mechanisms of emesis and antiemetic action will allow more rational clinical study design. Prior to large randomized studies, phase I and II trials should define ...

journal_title：Oncology

authors： Olver IN

更新日期：1996-06-01 00:00:00

abstract：:This study evaluated the influence of bile acid load on the DNA distribution pattern of proliferated bile ductules and cholangiocarcinoma induced by diisopropanolnitrosamine. Ninety hamsters were separated into control, tauro- and deoxycholic acid (DCA) groups. The DNA distribution pattern of intrahepatic lesions at 1...

journal_title：Oncology

authors： Kinami Y,Miyakoshi M,Fujikawa K

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:The phosphatidylinositol 3-kinase (PI3K) pathway plays a critical role in ovarian cancer cell survival and proliferation. The aim of this study was to determine whether the suppression of the PI3K catalytic subunit p110alphainhibits the growth of ovarian cancer cells in vitro and in vivo. METHODS:The short h...

journal_title：Oncology

authors： Zhang X,Deng HX,Zhao X,Su D,Chen XC,Chen LJ,Wei YQ,Zhong Q,Li ZY,He X,Yi T

更新日期：2009-01-01 00:00:00

abstract：:The present communication reports the inhibitory action of aminoglutethimide on 9,10-dimethyl-1,2-benzanthracene (DMBA) induced mammary carcinogenesis in virgin female Holtzman rats. When 20 mg of DMBA is given to the rats and maintained on normal diet for 32 weeks, approximately 70% of the animals develop mammary tum...

journal_title：Oncology

authors： Rao AR,Das MG,Das P

更新日期：1985-01-01 00:00:00

abstract：:Canthaxanthin, a carotenoid with no vitamin A activity, was evaluated for its efficacy in the prevention of chemically induced mammary cancers. Canthaxanthin was administered in the diet at two dose levels (3,390 or 1,130 mg/kg diet). In the dimethylbenzanthracene-induced mammary cancer model, diet supplementation wit...

journal_title：Oncology

authors： Grubbs CJ,Eto I,Juliana MM,Whitaker LM

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVES:The neutrophil-to-lymphocyte ratio (NLR) has been proposed as an indicator of cancer-related inflammation. The aim of our study was to examine the prognostic value of the NLR for patients with advanced gastric cancer receiving second-line chemotherapy. METHODS:The association of overall survival (OS) in sec...

journal_title：Oncology

authors： Inoue D,Sekiguchi S,Yamagata W,Maeda G,Yamada D,Fujiwara S,Itou S,Kurihara M,Hijioka Y,Shimoji K,Fujiki J,Nakazono A,Horike H,Yoshioka A,Ogura Y,Hatao F,Imamura K,Namiki S

更新日期：2019-01-01 00:00:00