Abstract:
:Fourteen patients with advanced ovarian carcinoma (FIGO stages III-IV) resistant to cisplatin were submitted to an alternating regimen with doxorubicin (A), cyclophosphamide (C), bleomycin (B) and mitomycin C (M). All patients had measurable disease on entry into the study. No responses were observed while 3 patients, previously showing no change in cisplatin, had disease stabilization lasting 3, 4 and 6 months, respectively. All but 1 patient died with a median survival from the start of ACBM therapy of 7 months (range 6-11). ACBM-induced toxicity was remarkable with 50% grade II-III myelotoxicity which required a dose reduction in 43%, treatment delays in 64% and treatment discontinuation in 14%. All patients suffered from mild to moderate nausea and vomiting while reversible alopecia was seen in 42.8%. The lack of response and the substantial toxicity observed suggest that the ACBM regimen in the doses and schedule employed is not beneficial in ovarian carcinoma resistant to cisplatin.
journal_name
Oncologyjournal_title
Oncologyauthors
Benedetti Panici P,Scambia G,Greggi S,Salerno G,Cento R,Mancuso Sdoi
10.1159/000226836subject
Has Abstractpub_date
1990-01-01 00:00:00pages
296-8issue
4eissn
0030-2414issn
1423-0232journal_volume
47pub_type
杂志文章相关文献
ONCOLOGY文献大全abstract::Beard's theory can be restated in a modified form in modern terms in the following way. Cancer represents primarily trophoblastic tissue derived either from an aberrant germ cell or from a somatic cell whose normally repressed 'asexual generation' genes are abnormally reactivated ('derepressed'). The variety of tumors...
journal_title:Oncology
pub_type: 传,历史文章,杂志文章
doi:10.1159/000225037
更新日期:1975-01-01 00:00:00
abstract:OBJECTIVE:Esophagogastric cancer occurs more frequently in older patients, but these are underrepresented in clinical studies establishing the current treatment standards for perioperative chemotherapy in locally advanced disease. This leads to uncertainty regarding the treatment of older patients with potentially toxi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000458531
更新日期:2017-01-01 00:00:00
abstract::There are numerous data on the immunostimulative and antitumorous activity of various Viscum album tissue extracts. Isorel (Novipharm, Austria) is one of these compounds. We found that in mice an increased number of plaque-forming cells to sheep red blood cells (SRBC) followed the injection of Isorel together with SRB...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227217
更新日期:1993-11-01 00:00:00
abstract::The activity of deoxycytidylate aminohydrolase, a pivotal enzyme for pyrimidine biosynthesis in mammalian tissue, is 100x greater in the Novikoff hepatoma harvested from the intraperitoneal cavity than in the same tumor excised from either subcutaneous or intramuscular sites. The increased enzyme activity in the intra...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226832
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Variations in the incidence of cancer can be influenced by diet and specific lifestyles. In the last years, diet has been evaluated as an important factor in the development of ovarian cancer, even though the results have not been consistent. Dietary factors related to the risk of ovarian cancer in Mexican w...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000063814
更新日期:2002-01-01 00:00:00
abstract::Persistent infection with hepatitis C virus (HCV) is a major risk for the development of hepatocellular carcinoma (HCC). One of the characteristics of HCV infection is the unusual augmentation of oxidative stress, which is exacerbated by iron accumulation in the liver, as observed frequently in hepatitis C patients. U...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000333253
更新日期:2011-01-01 00:00:00
abstract::Thirteen samples of gastric tumors that had developed in the remnant stomach (remnant gastric cancer) were compared with 63 samples of primary gastric tumors located in the upper third of the stomach (primary gastric cancer) by both clinicopathologic and flow cytometric analysis. The depths of invasion of all these tu...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227441
更新日期:1995-03-01 00:00:00
abstract::Fifteen patients, median age 64 years, presenting with advanced gastrointestinal adenocarcinomas, were included in this study. The treatment combination consisted of folinic acid (200 mg/m2, IV bolus injection) followed by 5-fluorouracil (5-FU; 400 mg/m2, 30-min infusion) for 5 consecutive days and mitomycin C (10 mg/...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226620
更新日期:1988-01-01 00:00:00
abstract::6 cases of endodermal sinus tumor of the ovary are presented. In 4 patients pure endodermal sinus tumor was found microscopically. 1 patient had endodermal sinus tumor in one ovary and gonadoblastoma in the contralateral one. In another case endodermal sinus tumor was accompanied by an embryonal teratoma. Histological...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225338
更新日期:1979-01-01 00:00:00
abstract::While central ports are located at the chest, peripheral ports (PP) are inserted at the patients' forearms. Two new PPs (Healthport miniMax((R)) and Bard Titan Low Profile Port) and two well-established types (Port-A-Cath((R)) P.A.S. Port and PeriPort(TM) peripheral access system) were tested. 125 patients were given ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000012059
更新日期:1999-11-01 00:00:00
abstract:PURPOSE:In order to broaden the possibility for anti-MAGE-3 immune targeting, it is important to identify HLA-A24-restricted epitopes derived from MAGE-3, since HLA-A24 is one of the most common alleles in Japanese and Asian people. In the present study, we defined a new MAGE-3 derived, HLA-A24-binding peptide presente...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000091185
更新日期:2006-01-01 00:00:00
abstract::In 86 children with acute lymphocytic leukemia (ALL) and in 6 children with medulloblastoma 253 24-hour methotrexate (MTX) infusions with 150, 500, and 700 mg/m2 were performed. MTX concentrations in plasma and cerebrospinal fluid (CSF) were measured with a specific radioimmunoassay. In 131 infusions with 500 mg/m2 gi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225828
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVE:BRAF D594G mutations in colorectal cancer patients are not clearly understood. We retrospectively investigated the clinicopathological features of colorectal cancers with BRAF D594G mutations. METHODS:We selected 908 colorectal cancer patients who underwent surgical resection from January 2008 to January 201...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000447402
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Tyrosine kinase B (TrkB) is associated with aggressive behavior and poor prognosis in various cancers. Here we examined the association between TrkB expression and distant metastases/prognosis in gastric carcinoma (GC). PATIENTS AND METHODS:We analyzed TrkB expression in 161 GC patients by immunohistochemist...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000151615
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To determine the relationship between treatment outcomes and hand-foot syndrome (HFS), and the relationship between survival rate and post-progression treatment after sorafenib therapy. METHODS:The study assessed 314 patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib at 5 general ho...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000481241
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to evaluate the antitumor activity and safety of an epirubicin, cisplatin, and capecitabine (ECX) combination in patients with metastatic or advanced gastric cancer. PATIENTS AND METHODS:Patients with metastatic or advanced measurable gastric adenocarcinoma received ECX combina...
journal_title:Oncology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1159/000086972
更新日期:2005-01-01 00:00:00
abstract::The cytochrome P450 CYP2D6 is a polymorphic drug-metabolizing enzyme that is involved in the metabolism of several drugs and xenobiotics. Several independent studies indicate that the CYP2D6 metabolic status is a secondary factor in the risk of developing lung cancer, with individuals with high activity being at incre...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000055354
更新日期:2001-01-01 00:00:00
abstract::Gastrointestinal stem cells have the capacity for long-term self-replication and the ability to give rise to all other epithelial cell lineages. These properties make them essential since they maintain tissue homeostasis by regulating cell turnover depending on the current demand. However, they are also important play...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000086625
更新日期:2005-01-01 00:00:00
abstract::The association of MMP-2 (matrix metalloproteinase 2, 72-kD collagenase IV) with invasive and metastatic capacity of tumor cells has implicated a potential role in the prognosis for cancer patients. However, no larger study has been done to prove this hypothesis. The present study was therefore designed to investigate...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011850
更新日期:1998-03-01 00:00:00
abstract::Male and female mice of strains C3H/eB and C57BL/6 were injected subcutaneously with methylcholanthrene (MCA) dissolved in olive oil; mice injected with olive oil served as controls. After intervals of from 2 to 13 weeks, experimental and control mice were injected intraperitoneally with 51Cr-labeled rat red cells (RR...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225871
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Patients with localized esophageal and esophagogastric junction cancer (EAC) receive chemoradiation and then surgery (trimodality, TMT) or definitive chemoradiation (bimodality, BMT). Distant metastases (DMs) are common but the details of their distribution and timing in a large cohort have not been describe...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000360703
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Identification of high-risk stage II colorectal cancer (CRC) patients, potential candidates for adjuvant chemotherapy, is challenging. Current clinical guidelines rely mainly on histopathological markers with relatively weak prognostic value. This motivates further search for prognostic markers. METHODS:Thi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000507118
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy and safety of neoadjuvant treatment comprising weekly high-dose 5-fluorouracil (5-FU) as a 24-hour infusion, folinic acid (FA) and biweekly oxaliplatin (L-OHP), followed by metastatic resection in patients with primarily resectable liver metastases of colorectal cancer (CRC). PATIENTS ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000067772
更新日期:2003-01-01 00:00:00
abstract::Little is known about the expression and antioxidant function of manganese superoxide dismutase (Mn-SOD) in esophageal squamous cell carcinoma. To determine the significance of Mn-SOD in esophageal squamous cell carcinomas, Mn-SOD mRNA expression was examined in 45 esophageal squamous cell carcinomas and the correspon...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000012165
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:This pharmacokinetic study of S-1 was conducted in patients in whom glomerular filtration rate (GFR) was directly measured to explore the possibility of adjusting the S-1 dose on the basis of GFR in patients with normal or nearly normal renal function. METHODS:S-1 was given to 12 patients twice daily for 28 ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000337232
更新日期:2012-01-01 00:00:00
abstract::We examined the effects of cycloheximide on the amount of chromatin-bound and -unbound PCNA subpopulations in HeLa cells. The chromatin-bound PCNA content decreased rapidly in the presence of cycloheximide, whereas the reduction of the total amount of PCNA was minimal even 24 h after the treatment with cycloheximide. ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227500
更新日期:1995-09-01 00:00:00
abstract::The survival, and the patterns and mechanisms of failure of 41 patients with pure testicular seminoma treated at the Northern Israel Oncology Center from 1968 to 1983 were analyzed. The actuarial 5-year survival of all patients was 85.4% and of stage I patients, 92.2%. Treatment failures were analyzed. The following c...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226341
更新日期:1986-01-01 00:00:00
abstract::A loss of heterozygosity (LOH) at the DCC gene locus was detected in colorectal tumors, and this LOH might be related to metastasis. The aim of this study was to determine DCC protein expression in colorectal cancer and to evaluate its prognostic value. Allelic loss of the DCC locus was observed in 16 of the 23 patien...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011954
更新日期:1999-01-01 00:00:00
abstract::The present communication reports data on the lipid biosynthesis of Ehrlich ascites tumor cells grown in culture media supplemented with modified sera. Whereas the metabolisms of [14C]pyruvate and [14C]mevalonate are identical in all media tested, the incorporation of [14C] acetate is higher in medium with dialyzed se...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225321
更新日期:1979-01-01 00:00:00
abstract::5-Azacytidine (NSC-102 816) was prepared synthetically and independently isolated from the culture filtrate of Streptoverticillium ladakanus. It is an s-triazine analogue of cytidine possessing a broad spectrum of biological effects. In mammalian tissueit is phosphorylated to 5-azacytidine 5-phosphates and incorporate...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000224981
更新日期:1974-01-01 00:00:00