Abstract:
:With the human Plasma Proteome Project (PPP) pilot phase completed, the largest and most ambitious proteomics experiment to date has reached its first milestone. The correspondingly impressive amount of data that came from this pilot project emphasized the need for a centralized dissemination mechanism and led to the development of a detailed, PPP specific data gathering infrastructure at the University of Michigan, Ann Arbor as well as the protein identifications database project at the European Bioinformatics Institute as a general proteomics data repository. One issue that crept up while discussing which data to store for the PPP concerns whether the raw, binary data coming from the mass spectrometers should be stored, or rather the more compact and already significantly processed peak lists. As this debate is not restricted to the PPP but relates to the proteomics community in general, we will attempt to detail the relative merits and caveats associated with centralized storage and dissemination of raw data and/or peak lists, building on the extensive experience gained during the PPP pilot phase. Finally, some suggestions are made for both immediate and future storage of MS data in public repositories.
journal_name
Proteomicsjournal_title
Proteomicsauthors
Martens L,Nesvizhskii AI,Hermjakob H,Adamski M,Omenn GS,Vandekerckhove J,Gevaert Kdoi
10.1002/pmic.200401302subject
Has Abstractpub_date
2005-08-01 00:00:00pages
3501-5issue
13eissn
1615-9853issn
1615-9861journal_volume
5pub_type
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