Abstract:
:Head and neck cancers, including oral squamous cell carcinoma (OSCC), are the sixth most common malignancy in the world and are characterized by poor prognosis and a low survival rate. Saliva is oral fluid with intimate contact with OSCC. Besides non-invasive, simple, and rapid to collect, saliva is a potential source of biomarkers. In this study, we build an SRM assay that targets fourteen OSCC candidate biomarker proteins, which were evaluated in a set of clinically-derived saliva samples. Using Skyline software package, we demonstrated a statistically significant higher abundance of the C1R, LCN2, SLPI, FAM49B, TAGLN2, CFB, C3, C4B, LRG1, SERPINA1 candidate biomarkers in the saliva of OSCC patients. Furthermore, our study also demonstrated that CFB, C3, C4B, SERPINA1 and LRG1 are associated with the risk of developing OSCC. Overall, this study successfully used targeted proteomics to measure in saliva a panel of biomarker candidates for OSCC.
journal_name
Proteomicsjournal_title
Proteomicsauthors
Kawahara R,Bollinger JG,Rivera C,Ribeiro AC,Brandão TB,Paes Leme AF,MacCoss MJdoi
10.1002/pmic.201500224subject
Has Abstractpub_date
2016-01-01 00:00:00pages
159-73issue
1eissn
1615-9853issn
1615-9861journal_volume
16pub_type
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