Abstract:
:Here, we describe the Interactorium, a tool in which a Virtual Cell is used as the context for the seamless visualisation of the yeast protein interaction network, protein complexes and protein 3-D structures. The tool has been designed to display very complex networks of up to 40 000 proteins or 6000 multiprotein complexes and has a series of toolboxes and menus to allow real-time data manipulation and control the manner in which data are displayed. It incorporates new algorithms that reduce the complexity of the visualisation by the generation of putative new complexes from existing data and by the reduction of edges through the use of protein "twins" when they occur in multiple locations. Since the Interactorium permits multi-level viewing of the molecular biology of the cell, it is a considerable advance over existing approaches. We illustrate its use for Saccharomyces cerevisiae but note that it will also be useful for the analysis of data from simpler prokaryotes and higher eukaryotes, including humans. The Interactorium is available for download at http://www.interactorium.net.
journal_name
Proteomicsjournal_title
Proteomicsauthors
Widjaja YY,Pang CN,Li SS,Wilkins MR,Lambert TDdoi
10.1002/pmic.200900260subject
Has Abstractpub_date
2009-12-01 00:00:00pages
5309-15issue
23eissn
1615-9853issn
1615-9861journal_volume
9pub_type
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