Abstract:
:With recent progress in the analysis of the salivary proteome, the number of salivary proteins identified has increased dramatically. However, the physiological functions of many of the newly discovered proteins remain unclear. Closely related to the study of a protein's function is the identification of its interaction partners. We investigated interactions among and functions of histatin 1 and the other proteins that are present in saliva by using high-throughput mass spectrometric techniques. This led to the identification of 43 proteins able to interact with histatin 1. In addition, we found that these protein-protein interactions protect complex partners from proteolysis and modulate their antifungal activity. Our data contribute significantly to characterization of the salivary interactome and to understanding the biology of salivary protein complexes.
journal_name
Proteomicsjournal_title
Proteomicsauthors
Siqueira WL,Lee YH,Xiao Y,Held K,Wong Wdoi
10.1002/pmic.201100665subject
Has Abstractpub_date
2012-11-01 00:00:00pages
3426-35issue
22eissn
1615-9853issn
1615-9861journal_volume
12pub_type
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