Abstract:
OBJECTIVES:Reactive oxygen species (ROS) are implicated in the destruction of the periodontium during inflammatory periodontal diseases. The imbalance in oxidant/antioxidant activity may be a key factor in the damaging effects of ROS. This study aimed to determine the lipid peroxidation levels in gingival crevicular fluid and saliva, and glutathione (GSH) and glutathione peroxidase (GPx) in saliva in patients with chronic periodontitis. METHODS:Gingival crevicular fluid and saliva were collected from 13 patients and 9 healthy control subjects during the preliminary study, and from 21 patients during the subsequent study. Lipid peroxidation level, GSH level and GPx activity were determined by spectrophotometric assay. RESULTS:The preliminary study found that when comparing patients to healthy controls, the gingival crevicular fluid samples produced the following results, respectively: higher lipid peroxidation concentration (microm) (by sites: 167.55 vs. 53.71, p < 0.0001; by subjects: 151.99 vs. 50.66, p < 0.005) and total amount (pmol) (by sites: 93.02 vs. 8.47, p < 0.0001, by subjects: 80.44 vs. 7.84, p < 0.0005). In saliva samples, lower GSH concentration (microm) (373.04 vs. 606.67, p < 0.05), higher lipid peroxidation concentration (microm) (0.66 vs. 0.13, p < 0.0005), and no difference in GPx activity were found in patients than in those of healthy controls. The subsequent study showed statistically significant (p < 0.05) improvement of clinical periodontal parameters (plaque index, gingival index, probing attachment level, probing pocket depth and gingival crevicular fluid volume), decreases in gingival crevicular fluid lipid peroxidation levels (concentration and total amount) at the sites after the completion of phase 1 periodontal treatment. Similarly, the periodontal treatment resulted in a significant decrease of lipid peroxidation concentrations (p < 0.05), increase in GSH concentration (p < 0.001), and no change in GPx activity in saliva samples. CONCLUSION:The increased levels of lipid peroxidation may play a role in the inflammation and destruction of the periodontium in periodontitis.
journal_name
J Periodontal Resjournal_title
Journal of periodontal researchauthors
Tsai CC,Chen HS,Chen SL,Ho YP,Ho KY,Wu YM,Hung CCdoi
10.1111/j.1600-0765.2005.00818.xsubject
Has Abstractpub_date
2005-10-01 00:00:00pages
378-84issue
5eissn
0022-3484issn
1600-0765pii
JRE818journal_volume
40pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVES:The aim of this study was to evaluate the effect of radiotherapy on the osseointegration of dental implants in the tibia and the action of platelet-rich plasma (PRP) as an adjuvant therapy. MATERIAL AND METHODS:A total of 18 rabbits received two implants in each tibial epiphysis, totalizing 7...
journal_title:Journal of periodontal research
pub_type: 杂志文章
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更新日期:2017-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Periodontitis is an increasingly prevalent complication of diabetes mellitus (known as diabetes mellitus-associated periodontitis), and 25-hydroxyvitamin D3 (25VD3 ) was recently found to be a critical regulator of innate immunity in this disease, but the underlying mechanisms remain poorly und...
journal_title:Journal of periodontal research
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doi:10.1111/jre.12535
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Tobacco use is associated with increased periodontal destruction in both cigarette smokers and smokeless tobacco users. Gingival keratinocytes are the first cells in contact with microbial and tobacco components and play a key role in the innate immune response to these agents. The objective of...
journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/j.1600-0765.2009.01262.x
更新日期:2010-08-01 00:00:00
abstract::This study uses cytokeratins (CK) as markers to investigate the phenotype of the junctional epithelium (JE) in partially erupted human teeth. The gingival samples, which were clinically healthy, were carefully dissected from the teeth. Cryostat sections were cut for histological staining, immunofluorescence microscopy...
journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/j.1600-0765.1994.tb01212.x
更新日期:1994-05-01 00:00:00
abstract::Clinical trials designed to estimate the sensitivity and specificity of periodontal diagnostic tests often use multiple sites per patient as experimental units of analyses. Since site-specific test results within a patient are dependent observations, a correlated binomial model should be employed to estimate the sensi...
journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/j.1600-0765.1990.tb00903.x
更新日期:1990-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The transplantation of cell sheets of mesenchymal stem cells (MSCs) is expected to be the next generation of periodontal regenerative therapy. An adequate method of multilayering MSCs has yet to be established. When cell sheets proliferate, they usually contract and detach from culture dishes a...
journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/jre.12114
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Porphyromonas gingivalis lipopolysaccharide (LPS) is a ligand for cell surface toll-like receptors (TLR), TLR2 and TLR4 while stimulation of either leads to cardioprotection. We hypothesized that: (1) pretreatment with P. gingivalis LPS at appropriate concentrations would induce cardioprotectio...
journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/j.1600-0765.2009.01206.x
更新日期:2010-02-01 00:00:00
abstract::Using the high iron diamine thiocarbohydrazide silver proteinate (HID-TCH-SP) staining technique, we investigated ultrastructural localization of sulfated glycosaminoglycans (GAGs) in the rat gingiva shortly after eruption, especially those associated with internal and external basal laminae. In the apical portion of ...
journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/j.1600-0765.1989.tb02006.x
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Endotoxin tolerance is characterized by a state of hyporesponsiveness after confrontation with endotoxins such as lipopolysaccharides (LPS) at low concentrations. The aim of this study was to investigate, whether pretreatment with Porphyromonas gingivalis leads to endotoxin tolerance induction and...
journal_title:Journal of periodontal research
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更新日期:2018-08-01 00:00:00
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journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/j.1600-0765.2004.00764.x
更新日期:2004-12-01 00:00:00
abstract::This study was designed to study wound strength at the dentine/connective tissue interface and at the bone/connective tissue interface following full thickness flap surgery. Flaps of uniform dimension were outlined in four young adult beagle dogs using a standardised double bladed knife and vertical incisions 10 mm ap...
journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1034/j.1600-0765.2002.01375.x
更新日期:2002-10-01 00:00:00
abstract::In the present study, the effect of bacterial protease on the periodontal tissues in rats was investigated histologically and histometrically. In the control group, 0.03 ml distilled water was applied to the lingual marginal gingiva of the mandibular incisor while, in the experimental group, 0.03 ml bacterial protease...
journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/j.1600-0765.1989.tb02009.x
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Osteogenic proteins of the transforming growth factor-beta superfamily induce periodontal tissue regeneration in animal models, including primates. To our knowledge, no studies have been performed in periodontal regeneration using the transforming growth factor-beta 3 isoform. In the present st...
journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/j.1600-0765.2007.00987.x
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The combination of EMD with root-coverage procedures has been shown to promote periodontal regeneration on the exposed root surface. The aim of this randomized clinical study was to compare the efficacy of EMD with connective tissue graft (CTG) for the treatment of Miller Class I and Class II s...
journal_title:Journal of periodontal research
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0765.2011.01381.x
更新日期:2011-12-01 00:00:00
abstract::Thirteen periodontally healthy subjects were monitored clinically for 6-12 months. Clinical measurements at 6-weekly intervals included duplicate PD measurements, presence of plaque, redness, and bleeding on probing. Baseline measurements consisted of 2 visits 1 wk apart. Microbial samples were taken from 11 of the su...
journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/j.1600-0765.1996.tb00484.x
更新日期:1996-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Vitamin D-1,25(OH)2 D3 or 1,25D3-maintains healthy osseous tissue, stimulates the production of the antimicrobial peptide cathelicidin and has anti-inflammatory effects, but it can cause hypercalcemia. Evidence links diminished serum levels of 1,25D3 with increased gingival inflammation. Period...
journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/jre.12452
更新日期:2017-10-01 00:00:00
abstract::The onset and progression of periodontal disease is associated with significant changes in the epithelial component of the attachment complex. From the early to the advanced stages of periodontal disease increased epithelial cell proliferation, migration and invasion into the surrounding connective tissue takes place....
journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:
更新日期:2002-02-01 00:00:00
abstract::The immunoglobulin class distribution of antibody to human collagen type I has been examined in sera and gingival extracts from patients with adult chronic periodontitis. Tissue extracts were made either by simple washing or ultrasonication. With either method, IgG and IgA antibodies to collagen were present in higher...
journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/j.1600-0765.1992.tb02086.x
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:This study aimed to assess the effectiveness of the treatment with alpha-terpineol (αTPN) complexed with beta-cyclodextrin (βCD) on oral, blood, and hepatic parameters in ligature-induced periodontitis. MATERIAL AND METHODS:Forty female rats were distributed among the following groups: control...
journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/jre.12780
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Activated potassium channels were found to be strongly correlated with gingival overgrowth (GO) phenotype as we reviewed syndromic hereditary gingival fibromatosis (HGF). Nevertheless, the functional roles of potassium channels in gingival fibrosis or gingival overgrowth remained uncovered. The...
journal_title:Journal of periodontal research
pub_type: 杂志文章
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更新日期:2020-12-31 00:00:00
abstract::In general, randomized clinical trials (RCT) in dentistry involve longitudinal observations. In such studies, the total cost is a function of the number of study subjects and visits, the study duration, and the type and number of examinations at each visit. In this paper, we derived the minimum cost design for longitu...
journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/j.1600-0765.1999.tb02233.x
更新日期:1999-04-01 00:00:00
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journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/jre.12272
更新日期:2015-12-01 00:00:00
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journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/jre.12006
更新日期:2013-06-01 00:00:00
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journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1034/j.1600-0765.2003.00654.x
更新日期:2003-06-01 00:00:00
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journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/j.1600-0765.2005.00811.x
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate whether a peptide-based coating can prevent the adhesion of Porphyromonas gingivalis, a key human pathogen associated with periodontitis and peri-implantitis. BACKGROUND:Nonsurgical and surgical interventions have been used for the treatment of peri-implantitis; howe...
journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/jre.12737
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:During periodontitis or orthodontic tooth movement, the periodontal vasculature is severely impaired by chronic inflammation or excessive mechanical force. This leads to a hypoxic microenvironment of the periodontal cells and enhances the expression of various cytokines and growth factors that ...
journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/j.1600-0765.2012.01503.x
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:To ascertain whether interdental cleaning behaviours of Australian adults were associated with lower levels of plaque, gingivitis and periodontal disease. MATERIAL AND METHODS:Data were obtained from the National Survey of Adult Oral Health 2004-06. Outcome variables were three indicators of o...
journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/j.1600-0765.2011.01420.x
更新日期:2012-04-01 00:00:00
abstract::Recently, a relationship was demonstrated between the thickness of the cementum layer in rat molars and the activity of alkaline phosphatase (ALP) in the adjoining periodontal ligament (PDL). It was the aim of the present study to investigate whether such a relationship also exists in the periodontium of man. Healthy ...
journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/j.1600-0765.1999.tb02215.x
更新日期:1999-01-01 00:00:00
abstract::The influence of occlusal loading on periodontal fibroblasts was investigated in hypoloaded (shortened out of occlusion), functionally loaded and hyperloaded (constant linguointrusive mechanical loads of 9.4 +/- 0.06 g) lower left rat incisors. One hour following injection of 3H-thymidine, half of the animals in each ...
journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/j.1600-0765.1994.tb01087.x
更新日期:1994-01-01 00:00:00