Autoimmunity to collagen in adult periodontal disease: immunoglobulin classes in sera and tissue.

abstract：BACKGROUND AND OBJECTIVE:Occlusal trauma is an important factor that influences the progression of periodontitis, but it is unclear whether occlusal trauma influences periodontal destruction at the onset of periodontitis. We established an experimental periodontitis model with both site-specific loss of attachment and ...

journal_title：Journal of periodontal research

authors： Nakatsu S,Yoshinaga Y,Kuramoto A,Nagano F,Ichimura I,Oshino K,Yoshimura A,Yano Y,Hara Y

更新日期：2014-06-01 00:00:00

abstract：:Interleukin-8 (IL-8) is believed to play an important role in the pathogenesis of various forms of periodontitis. In addition, the anti-IL-8 autoantibody has been recently recognized as a potent modulator of IL-8 function. In the current study, the concentrations of IL-8 and its autoantibody in gingival crevicular flu...

journal_title：Journal of periodontal research

authors： Kurdowska AK,Noble JM,Adcock JE

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:It remains controversial whether or not the junctional epithelium cells that are directly attached to teeth migrate on the enamel surface, as those cells are able to adhere firmly to the enamel. The aim of this study was to investigate the expression patterns of laminin gamma(2), integrin beta(...

journal_title：Journal of periodontal research

authors： Sugisawa M,Masaoka T,Enokiya Y,Muramatsu T,Hashimoto S,Yamada S,Shimono M

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Inducible nitric oxide synthase (iNOS) activity is known to regulate the immune response. The present study was carried out to determine the effect of L-N6-(1-iminoethyl)-lysine (L-NIL), an iNOS inhibitor, on the induction of immune response to Actinobacillus actinomycetemcomitans lipopolysacc...

journal_title：Journal of periodontal research

authors： Sosroseno W,Musa M,Ravichandran M,Fikri Ibrahim M,Bird PS,Seymour GJ

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Long-term tooth retention is the ultimate goal of periodontal therapy. Aim of this study was to evaluate tooth loss (TL) during 10 years of supportive periodontal therapy (SPT) in periodontal compromised patients and to identify factors influencing TL on patient level. MATERIAL AND METHODS:Pat...

journal_title：Journal of periodontal research

authors： Petsos H,Schacher B,Ramich T,Nickles K,Dannewitz B,Arendt S,Seidel K,Eickholz P

更新日期：2020-12-01 00:00:00

abstract：:The 3 human salivary cystatins S, SA and SN are multifunctional proteins that possess a cysteine protease inhibitory property, but their ability to act as such is very different (SN > SA > S). One form, S, also appears to possess antibacterial properties towards the bacterium Porphyromonas gingivalis, often associated...

journal_title：Journal of periodontal research

authors： Baron AC,Gansky SA,Ryder MI,Featherstone JD

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The potential of salivary microorganisms to diagnose periodontal disease and to guide periodontal treatment is a research topic of current interest. This study aimed to determine whether the salivary counts of periodontopathic microbes correlated with the periodontal pocket counts of the same ...

journal_title：Journal of periodontal research

authors： Saygun I,Nizam N,Keskiner I,Bal V,Kubar A,Açıkel C,Serdar M,Slots J

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Cigarette smoking is a major risk factor for periodontitis, and smoking perturbs neutrophil reactive oxygen species production. This study tested the hypothesis that cigarette smoke extract (CSE) and its components/metabolites nicotine, cotinine and thiocyanate (SCN-), may influence neutrophil ...

journal_title：Journal of periodontal research

authors： White PC,Hirschfeld J,Milward MR,Cooper PR,Wright HJ,Matthews JB,Chapple ILC

更新日期：2018-08-01 00:00:00

abstract：:Colonization or emergence of microbial pathogens may result in tissue destruction by activation of one or more of five distinct host degradative pathways (matrix metalloproteinase pathway, plasminogen-dependent pathway, phagocytic pathway, PMN-serine proteinase pathway and osteoclastic bone resorption) or by direct cl...

journal_title：Journal of periodontal research

authors： Birkedal-Hansen H

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The use of cyclosporine A induces fibrous enlargement of the gingival connective tissue. Existing treatment modalities, although effective, do not necessarily prevent the recurrence of the lesion. Emerging evidence indicates that tanshinone IIA (Tan IIA) could effectively attenuate a variety of...

journal_title：Journal of periodontal research

authors： Ma S,Liu W,Liu P,Liu J,Chen L,Qin C

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate whether a peptide-based coating can prevent the adhesion of Porphyromonas gingivalis, a key human pathogen associated with periodontitis and peri-implantitis. BACKGROUND:Nonsurgical and surgical interventions have been used for the treatment of peri-implantitis; howe...

journal_title：Journal of periodontal research

authors： Fang D,Yuran S,Reches M,Catunda R,Levin L,Febbraio M

更新日期：2020-08-01 00:00:00

abstract：:This study uses cytokeratins (CK) as markers to investigate the phenotype of the junctional epithelium (JE) in partially erupted human teeth. The gingival samples, which were clinically healthy, were carefully dissected from the teeth. Cryostat sections were cut for histological staining, immunofluorescence microscopy...

journal_title：Journal of periodontal research

authors： Feghali-Assaly M,Sawaf MH,Serres G,Forest N,Ouhayoun JP

更新日期：1994-05-01 00:00:00

abstract：:This study investigated the cell surface expression of CD11b (Mo 1, Mac-1, CR 3) by neutrophils (PMNs) from human crevicular fluid (CF-PMNs). CD11b expression on CF-PMNs was compared, using flow cytometry, to that on peripheral blood PMNs (PB-PMNs) isolated simultaneously from the same subjects. CD11b expression by CF...

journal_title：Journal of periodontal research

authors： Watanabe K,Hagen KL,Andersen BR

更新日期：1991-03-01 00:00:00

abstract：OBJECTIVE AND BACKGROUND:To evaluate the association between periodontal disease, tooth loss and coronary heart disease (CHD). There is still controversy about the relationship between periodontal disease and tooth loss with vessel obstruction assessed using coronary angiography. MATERIAL AND METHODS:This cross-sectio...

journal_title：Journal of periodontal research

authors： Zanella SM,Pereira SS,Barbisan JN,Vieira L,Saba-Chujfi E,Haas AN,Rösing CK

更新日期：2016-04-01 00:00:00

abstract：:Recently, nitric oxide (NO) has been shown to be vital in inflammatory processes. Nitric oxide synthase (NOS) exists in three different isoforms, two constitutively produced with physiological roles, and an inducible form, iNOS, which is involved in inflammation. This study examined the localisation of iNOS in biopsie...

journal_title：Journal of periodontal research

authors： Lappin DF,Kjeldsen M,Sander L,Kinane DF

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:Proinflammatory cytokines such as interleukin-1beta are known to be synthesized in oral gingivitis and periodontitis and lead to the activation of the transcription factor nuclear factor-kappaB (NF-kappaB). Although numerous effects of interleukin-1beta on mesenchymal cells are known, e.g. up-regu...

journal_title：Journal of periodontal research

authors： Steinberg T,Dannewitz B,Tomakidi P,Hoheisel JD,Müssig E,Kohl A,Nees M

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In periodontitis, matrix metalloproteinases (MMPs) are upregulated in response to locally released inflammatory cytokines, resulting in pathologic processes. Roxithromycin is a 14-membered ring macrolide antibiotic with broad-spectrum antibacterial effects against oral pathogens and immunomodul...

journal_title：Journal of periodontal research

authors： Oyama T,Matsushita K,Sakuta T,Tokuda M,Tatsuyama S,Nagaoka S,Torii M

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Ciclosporin A (CsA)-induced gingival overgrowth is attributed to an exaggerated accumulation of extracellular matrix, which is mainly due to an increased expression of transforming growth factor-β1 (TGF-β1). Herein, the in vitro investigation of effects of overexpression of Smad7, a TGF-β1 sign...

journal_title：Journal of periodontal research

authors： Sobral LM,Aseredo F,Agostini M,Bufalino A,Pereira MC,Graner E,Coletta RD

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Alveolar bone resorption is a characteristic feature of periodontal diseases and involves removal of both the mineral and the organic constituents of the bone matrix, a process mainly carried out by multinucleated osteoclast cells. (-)-Epigallocatechin gallate, the main constituent of green tea...

journal_title：Journal of periodontal research

authors： Yun JH,Kim CS,Cho KS,Chai JK,Kim CK,Choi SH

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Chronic infections have been reported to be risk factors for coronary heart disease and ischemic stroke. However, the association of coronary heart disease and ischemic stroke with periodontal disease, which is also a chronic inflammatory disease, needs to be evaluated. The present case-control...

journal_title：Journal of periodontal research

authors： Pradeep AR,Hadge P,Arjun Raju P,Shetty SR,Shareef K,Guruprasad CN

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVES:Chronic periodontitis is a bone destructive inflammatory disease with an adverse impact on general health and suggested underlying factors in common with osteoporosis. A few studies have examined the possible relationship between chronic periodontitis and osteoporosis; however, the results remain inconclusiv...

journal_title：Journal of periodontal research

authors： Mau LP,Kuan YC,Tsai YC,Lin JJ,Huynh-Ba G,Weng PW,Shieh YS,Cheng WC,Huang RY

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Periodontitis may alter the systemic condition in patients with diabetes and hence interfere with glycemic control. The objective of this study was to determine the quantifiable changes in glycated hemoglobin (HbA1C) after periodontal non-surgical therapy plus azithromycin in a mixed population...

journal_title：Journal of periodontal research

authors： Botero JE,Yepes FL,Ochoa SP,Hincapie JP,Roldan N,Ospina CA,Castrillon CA,Becerra MA

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Polycan is a promising candidate for the treatment of periodontal disease. This study was undertaken to examine whether Polycan, a type of β-glucan, has a protective effect on ligature-induced experimental periodontitis and related alveolar bone loss in Sprague-Dawley rats. MATERIAL AND METHOD...

journal_title：Journal of periodontal research

authors： Kim YS,Kang SJ,Kim JW,Cho HR,Moon SB,Kim KY,Lee HS,Han CH,Ku SK,Lee YJ

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Periodontal ligament stem cells (PDLSCs) have potential for osteogenic differentiation and show a great foreground in treating bone diseases. Histone three lysine 27 (H3K27) demethylase lysine demethylase 6A (KDM6A) is a critical epigenetic modifier and plays an important role in regulating ost...

journal_title：Journal of periodontal research

authors： Jiang H,Jia P

更新日期：2020-12-24 00:00:00

abstract：BACKGROUND AND OBJECTIVE:CYP1A1 rs1048943 polymorphism was reported to be correlated with periodontitis; however, its association with aggressive periodontitis (AgP) has not yet been investigated. The aim of the study was to investigate the association between the CYP1A1 gene rs1048943 variant with generalized aggressi...

journal_title：Journal of periodontal research

authors： Wang X,Li W,Song W,Xu L,Zhang L,Feng X,Lu R,Meng H

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Fibronectin (FN) is an important cell adhesion molecule that is used widely to characterize cell behavior. Preparations of FN purified from human plasma by gelatin-Sepharose affinity chromatography typically also contain gelatin-binding gelatinases that may cleave FN, reduce its stability and a...

journal_title：Journal of periodontal research

authors： Pal S,Chen Z,Xu X,Mikhailova M,Steffensen B

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Interleukin (IL)-32, which has been recently reported to be associated with periodontitis, has been suggested to have pleiotropic effect due to its 9 different isoforms. The aim of this study was to investigate the levels of IL-32α, IL-32β, IL-32γ, IL-32δ isoforms in gingival crevicular fluid (...

journal_title：Journal of periodontal research

authors： Öngöz Dede F,Gökmenoğlu C,Deveci ET,Çelen S,Avci B,Kara C,Çanakçi V

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Dental rubber dams (RDs) were used as barrier membranes in guided tissue regeneration for the treatment of periodontal intraosseous defects with acceptable clinical results. The aim of the present study was to investigate the effects of autoclave sterilization on properties of RD as related to ...

journal_title：Journal of periodontal research

authors： Apinhasmit W,Limsombutanon S,Swasdison S,Suppipat N

更新日期：2003-10-01 00:00:00

abstract：:Previous observations suggest that interleukin-1 (IL-1) may play an important role in the progression of periodontitis. In the present study, we investigated whether a cell-associated IL-1 alpha (CAIL-1 alpha) produced in human gingival fibroblasts (HGF) induces biological activities related to the progression of peri...

journal_title：Journal of periodontal research

authors： Okamatsu Y,Kobayashi M,Nishihara T,Hasegawa K

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Neutrophil extracellular traps (NETs) are a recently discovered antimicrobial mechanism used by neutrophils that have been proposed as an intervention in the pathogenesis of periodontitis. The objective of our study was to characterize the expression of NETs in gingival tissues with periodontit...

journal_title：Journal of periodontal research

authors： Magán-Fernández A,O'Valle F,Abadía-Molina F,Muñoz R,Puga-Guil P,Mesa F

更新日期：2019-06-01 00:00:00