Abstract:
:Previous observations suggest that interleukin-1 (IL-1) may play an important role in the progression of periodontitis. In the present study, we investigated whether a cell-associated IL-1 alpha (CAIL-1 alpha) produced in human gingival fibroblasts (HGF) induces biological activities related to the progression of periodontitis. HGF were treated with recombinant human IL-1 beta (rhIL-1 beta) for 12 h. After that, the cell layers of HGF were washed 3 times with fresh medium and were then fixed with 1% paraformaldehyde. The fixed cell layers of HGF were used for assays for bone resorbing activity, prostaglandin E2 (PGE2) production and collagenase activity. Fixed cell layers of HGF treated with rhIL-1 beta enhanced not only calcium release from BALB/c mouse calvaria but also PGE2 production and collagenase activity in HGF and human periodontal ligament fibroblasts (HPLF) cultured on the fixed cell layers. These activities were neutralized by treatment with monoclonal mouse anti-human IL-1 alpha antibody, but monoclonal mouse anti-human IL-1 beta antibody showed no effects on these activities. The induction of these activities by fixed cell layers of HGF required direct contact between the fixed cell layers and the calvaria, HGF, or HPLF. These results suggest that CAIL-1 alpha produced in HGF treated with rhIL-1 beta induces bone resorbing activity, PGE2 production and collagenase activity in the target cells by direct contact; CAIL-1 alpha may play an important role in the progression of periodontitis.
journal_name
J Periodontal Resjournal_title
Journal of periodontal researchauthors
Okamatsu Y,Kobayashi M,Nishihara T,Hasegawa Kdoi
10.1111/j.1600-0765.1996.tb00503.xsubject
Has Abstractpub_date
1996-07-01 00:00:00pages
355-64issue
5eissn
0022-3484issn
1600-0765journal_volume
31pub_type
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journal_title:Journal of periodontal research
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journal_title:Journal of periodontal research
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journal_title:Journal of periodontal research
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pub_type: 杂志文章,随机对照试验
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journal_title:Journal of periodontal research
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doi:10.1111/j.1600-0765.2007.01010.x
更新日期:2008-04-01 00:00:00
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journal_title:Journal of periodontal research
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doi:10.1111/j.1600-0765.2004.00772.x
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journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/j.1600-0765.1992.tb02085.x
更新日期:1992-01-01 00:00:00
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journal_title:Journal of periodontal research
pub_type: 杂志文章
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更新日期:1975-05-01 00:00:00
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journal_title:Journal of periodontal research
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journal_title:Journal of periodontal research
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pub_type: 杂志文章,随机对照试验
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journal_title:Journal of periodontal research
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abstract::Glycosaminoglycans in normal and cyclosporin-induced gingival overgrowth were extracted by papain digestion and purified by Mono Q-FPLC chromatography. The purified glycosaminoglycans were analyzed by agarose gel electrophoresis and by the pattern of degradation products formed by chondroitin lyases on HPLC chromatogr...
journal_title:Journal of periodontal research
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doi:10.1034/j.1600-0765.2000.035003158.x
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