Abstract:
:Fish and other seafood may contain organic mercury but also beneficial nutrients such as n-3 polyunsaturated fatty acids. We endeavored to study whether maternal fish consumption during pregnancy harms or benefits fetal brain development. We examined associations of maternal fish intake during pregnancy and maternal hair mercury at delivery with infant cognition among 135 mother-infant pairs in Project Viva, a prospective U.S. pregnancy and child cohort study. We assessed infant cognition by the percent novelty preference on visual recognition memory (VRM) testing at 6 months of age. Mothers consumed an average of 1.2 fish servings per week during the second trimester. Mean maternal hair mercury was 0.55 ppm, with 10% of samples > 1.2 ppm. Mean VRM score was 59.8 (range, 10.9-92.5). After adjusting for participant characteristics using linear regression, higher fish intake was associated with higher infant cognition. This association strengthened after adjustment for hair mercury level: For each additional weekly fish serving, offspring VRM score was 4.0 points higher [95% confidence interval (CI), 1.3 to 6.7]. However, an increase of 1 ppm in mercury was associated with a decrement in VRM score of 7.5 (95% CI, -13.7 to -1.2) points. VRM scores were highest among infants of women who consumed > 2 weekly fish servings but had mercury levels = 1.2 ppm. Higher fish consumption in pregnancy was associated with better infant cognition, but higher mercury levels were associated with lower cognition. Women should continue to eat fish during pregnancy but choose varieties with lower mercury contamination.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Oken E,Wright RO,Kleinman KP,Bellinger D,Amarasiriwardena CJ,Hu H,Rich-Edwards JW,Gillman MWdoi
10.1289/ehp.8041subject
Has Abstractpub_date
2005-10-01 00:00:00pages
1376-80issue
10eissn
0091-6765issn
1552-9924journal_volume
113pub_type
杂志文章abstract::Rats were instilled intrabronchially with 1 mg UICC amosite suspended in 0.2 mL of filtered saline; control animals received the saline instillation only. Five animals from each group were killed on various days after instillation, up to day 128/129. Total retrieved cell counts and differential cell analysis were perf...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.835141
更新日期:1983-09-01 00:00:00
abstract::The association of blood lead (B-Pb) concentration to blood pressure was investigated in men aged 55 to 75 years living in the Rome area, who had no history of exposure to lead in the workplace and who participated between 1989 and 1990 in an epidemiologic survey for coronary heart disease (New Risk Factor Project). O...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s9107
更新日期:1994-11-01 00:00:00
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journal_title:Environmental health perspectives
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doi:10.1289/ehp.1308016
更新日期:2015-01-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.97105850
更新日期:1997-08-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Because of complex interactions of climate variables at the levels of the pathogen, vector, and host, the potential influence of climate change on vector-borne and zoonotic diseases (VBZDs) is poorly understood and difficult to predict. Climate effects on the nonvector-borne zoonotic diseases are especially ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.0901389
更新日期:2010-11-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.761377
更新日期:1976-02-01 00:00:00
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journal_title:Environmental health perspectives
pub_type:
doi:10.1289/ehp.98106441
更新日期:1998-04-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.02110791
更新日期:2002-08-01 00:00:00
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journal_title:Environmental health perspectives
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doi:10.1289/ehp.00108487
更新日期:2000-06-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.5709
更新日期:2003-04-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.1306639
更新日期:2014-02-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.11590
更新日期:2009-03-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.001081113
更新日期:2000-12-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7039
更新日期:2004-11-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9399129
更新日期:1993-03-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.5847
更新日期:2003-04-01 00:00:00
abstract::Several organophosphate and organochlorine compounds, including pesticides commonly found in the Great Lakes basin, have the potential to induce immunotoxicity. Because of biomagnification and accumulation in the food chain, Great Lakes residents may inadvertently be exposed to these compounds and thus face increased ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.95103s955
更新日期:1995-12-01 00:00:00
abstract::In recent years, exposure of man to increasing amounts of metals has occurred rather generally from industrial contamination and variably from intake of dietary mineral supplements. Adverse effects of individual metals can be markedly altered by dietary levels of other essential and nonessential inorganic elements, es...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7825137
更新日期:1978-08-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s6109
更新日期:1994-10-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:2000-12-01 00:00:00
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journal_title:Environmental health perspectives
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doi:10.1289/EHP1994
更新日期:2018-03-16 00:00:00
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journal_title:Environmental health perspectives
pub_type: 共识发展会议,杂志文章,评审
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更新日期:1994-12-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106s41041
更新日期:1998-08-01 00:00:00
abstract::Many thousand organic compounds are in common use and new ones introduced daily. With many of these materials, little is known about their toxic hazard. For years scientists have been investigating the relation of structure and properties to biological activity. Among the factors relating to toxicity are bioaccumulati...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.793075
更新日期:1979-06-01 00:00:00
abstract::New technologies and methods for assessing human exposure to chemicals, dietary and lifestyle factors, infectious agents, and other stressors provide an opportunity to extend the range of human health investigations and advance our understanding of the relationship between environmental exposure and disease. An ad hoc...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.7651
更新日期:2005-07-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106s51213
更新日期:1998-10-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.11927
更新日期:2009-01-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.9084155
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND:Experimental tools for studying the complex steroidogenic interactions that occur between placenta and fetus during human pregnancy are extremely limited. OBJECTIVES:We aimed to develop a co-culture model to study steroidogenesis by the human fetoplacental unit and its disruption by exposure to environmenta...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307518
更新日期:2014-04-01 00:00:00