Abstract:
:Noise exposure causes changes at different levels in human organs, particularly the cardiovascular system, where it is responsible for increasing heart rate, peripheral vascular resistance, and blood pressure. In this study, we evaluated the effect of noise exposure on DNA integrity and ultrastructure of rat cardiomyocytes. The exposure to loud noise (100 dBA) for 12 hr caused a significant increase of DNA damage, accompanied by swelling of mitochondrial membranes, dilution of the matrix, and cristolysis. These alterations were concomitant with increased in situ noradrenaline levels and utilization. Genetic and ultrastructural alterations did not decrease 24 hr after the cessation of the stimulus. An elevated oxyradical generation, possibly related to altered sympathetic innervation, is hypothesized as responsible for the induction and persistence of noise-induced cellular damage.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Lenzi P,Frenzilli G,Gesi M,Ferrucci M,Lazzeri G,Fornai F,Nigro Mdoi
10.1289/ehp.5847subject
Has Abstractpub_date
2003-04-01 00:00:00pages
467-71issue
4eissn
0091-6765issn
1552-9924journal_volume
111pub_type
杂志文章abstract:BACKGROUND:The metabolome is a collection of exogenous chemicals and metabolites from cellular processes that may reflect the body's response to environmental exposures. Studies of air pollution and metabolomics are limited. OBJECTIVES:To explore changes in the human metabolome before, during, and after the 2008 Beiji...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP3705
更新日期:2019-05-01 00:00:00
abstract::The role of lime in the formation of reactive oxygen species (ROS), i.e., O2-., H2O2, and OH., from betel-quid components (extracts of areca nut and catechu) was investigated in vitro using a chemiluminescence technique and an assay for oxidative DNA damage involving analysis of 8-hydroxy-2'-deoxyguanosine. Of the var...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9298203
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:Ocean pollution affects marine organisms and ecosystems as well as humans. The International Oceanographic Commission recommends ocean health monitoring programs to investigate the presence of marine contaminants and the health of threatened species and the use of multiple and early-warning biomarker approac...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0901809
更新日期:2011-03-01 00:00:00
abstract::A physiologically based pharmacokinetic model for trichloroethylene (TCE) in rodents and humans was calibrated with published toxicokinetic data sets. A Bayesian statistical framework was used to combine previous information about the model parameters with the data likelihood, to yield posterior parameter distribution...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.00108s2307
更新日期:2000-05-01 00:00:00
abstract::A review of the experimental studies relating boron to biological effects on appendicular and axial bones in animal models suggests that numerous influences, known and unknown, affect the responsiveness of bone to dietary boron. Degrees of skeletal response to boron are modified by other nutritional variables that inc...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.94102s749
更新日期:1994-11-01 00:00:00
abstract::The activities of plants and plant/microbial associations may offer a viable means of accomplishing the in situ remediation of contaminated soils. Two uses of plants for phytoremediation are reported here. In one set of studies, the ability of plants to foster degradative microorganisms was investigated. Results indic...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.95103s413
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:Benzene is a common industrial chemical known to induce leukemia and other blood disorders, as well as aneuploidy, in both human blood cells and sperm at exposures > 10 ppm. Recent reports have identified health effects at exposure levels < 1 ppm, the permissible exposure limit (PEL; 8 hr) set by the U.S. Oc...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0901531
更新日期:2010-06-01 00:00:00
abstract::The populations of the developed nations of the world exhibit an increase in blood pressure with age, while in primitive societies blood pressure remains relatively constant throughout adult life. Hypertension may be a complex of diseases all having the same clinical manifestations but not being caused necessarily by ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.792935
更新日期:1979-04-01 00:00:00
abstract::The possible risk for human health arising from consumption of lead-polluted shellfish was suggested by experiments on the bioavailability for mice of a "biologically detoxified" form of the metal. In this work, young mice were fed with a mixed diet including mussels collected in a Pb-polluted area. Metal concentratio...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s3335
更新日期:1994-09-01 00:00:00
abstract::Many naturally occurring and man-made chemicals present in the environment possess estrogenic activity. Examples include plant and fungal products, pesticides, plasticizers, and other agricultural and industrial chemicals. These environmental estrogens as well as endogenous ovarian estrogens are thought to initiate th...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.95103s729
更新日期:1995-10-01 00:00:00
abstract::Articles in the literature on alpha-1 antitrypsin (AAT) deficiency have been interpreted as indicating that AAT deficiency is a rare disease that affects mainly Caucasians (whites) from northern Europe. In a recent publication on the worldwide racial and ethnic distribution of AAT deficiency, new data were presented d...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.6511
更新日期:2003-12-01 00:00:00
abstract::Until recently, mutagenicity testing was done on preselected compounds in a manner in which the testing laboratories knew the identity of the substances under test and the "expected" results, i.e., positive for compounds selected because of their carcinogenicity and negative for food additives. There is no completed s...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7720253
更新日期:1977-10-01 00:00:00
abstract:BACKGROUND:Exposures to high-dose ionizing radiation and high-dose rate ionizing radiation are established risk factors for childhood acute leukemia (AL). The risk of AL following exposure to lower doses due to natural background radiation (NBR) has yet to be conclusively determined. METHODS:AL cases diagnosed over 19...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP296
更新日期:2017-04-01 00:00:00
abstract::Occupational and environmental asbestos exposure continues to represent a public health problem, despite increasingly restrictive laws adopted by most industrialized countries. Peritoneal mesothelioma is a rare and aggressive asbestos-related malignancy. We present the case of a 65-year-old man who developed recurrent...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6542
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:Exposure of the U.S. population to polybrominated diphenyl ethers (PBDEs) is thought to be via exposure to dust and diet. However, little work has been done to empirically link body burdens of these compounds to either route of exposure. OBJECTIVES:The primary goal of this research was to evaluate the dieta...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0900817
更新日期:2009-10-01 00:00:00
abstract::The cytotoxic action of a series of mineral dusts has been studied using Chinese hamster V79-4 cells obtained from three separate laboratories in the UK. The dusts which have been studied include samples of asbestos from the Union Internationale Contre le Cancer reference series and an internationally available sample...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8351189
更新日期:1983-09-01 00:00:00
abstract::The phenomenon of fiber-induced cytotoxicity to P388D1 macrophagelike cells has been demonstrated to parallel (thus far without exception) the probability that the fiber will induce a pleural sarcoma (mesothelioma) in rats. This startling parallel in both cases seems to be essentially independent of the chemical natur...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.803491
更新日期:1980-02-01 00:00:00
abstract::Human milk is a repository for certain classes of long-lived, fat-soluble environmental contaminant chemicals. Some members of this class, such as the chlorinated pesticides and the chlorinated biphenyls, can be expected to be present at chemical waste disposal sites. Analysis of samples of breast milk obtained from w...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.834887
更新日期:1983-02-01 00:00:00
abstract:BACKGROUND:A critical question regarding the association between short-term exposure to ozone and mortality is the extent to which this relationship is confounded by ambient exposure to particles. OBJECTIVES:We investigated whether particulate matter < 10 and < 2.5 microm in aerodynamic diameter (PM(10) and PM(2.5)) i...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10108
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor targeting estrogen receptors (ERs), has been implicated in the promotion of breast cancer. Perinatal exposure of BPA could induce longitudinal alteration of DNA hydroxymethylation in imprinted loci of mouse blood cells. To date, no data has be...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP5862
更新日期:2020-02-01 00:00:00
abstract::The U.S. Environmental Protection Agency is under a congressional mandate to revise its current standard for arsenic in drinking water. We present a risk assessment for cancers of the bladder, liver, and lung from exposure to arsenic in water, based on data from 42 villages in an arseniasis-endemic region of Taiwan. W...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.00108655
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Polychlorinated biphenyls (PCBs) may accelerate the cognitive and motor dysfunction found in normal aging, but few studies have examined these outcomes and PCB exposure among older adults. OBJECTIVE:We evaluated neuropsychological status and low-level PCB exposure among older adults living along contaminate...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10432
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:Ambient levels of pesticides ("pesticide drift") are detectable at residences near agricultural field sites. OBJECTIVE:Our goal was to evaluate the hypothesis that maternal residence near agricultural pesticide applications during key periods of gestation could be associated with the development of autism s...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10168
更新日期:2007-10-01 00:00:00
abstract::Metabolic enzymes involved in benzene activation or detoxification, including NAD(P)H, quinone oxidoreductase 1 (NQO1), cytochrome P450 2E1 (CYP2E1), myeloperoxidase (MPO), glutathione-S-transferase mu-1 (GSTM1), and glutathione-S-transferase theta-1 (GSTT1), were studied for their roles in human susceptibility to ben...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.021101213
更新日期:2002-12-01 00:00:00
abstract::Exposure to indoor air pollutants such as tobacco smoke and dust mites may exacerbate childhood asthma. Environmental interventions to reduce exposures to these pollutants can help prevent exacerbations of the disease. Among the most important interventions is the elimination of environmental tobacco smoke from the en...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.95103s655
更新日期:1995-09-01 00:00:00
abstract::Epidemiologic studies have shown that airborne particulate matter (PM) with a mass median aerodynamic diameter < 10 microm (PM10) is associated with an increase in respiratory-related disease. However, there is a growing consensus that particles < 2.5 microm (PM2.5), including many in the ultrafine (< 0.1 microm) size...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.5964
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVE:Nearly all China's rural residents and a shrinking fraction of urban residents use solid fuels (biomass and coal) for household cooking and/or heating. Consequently, global meta-analyses of epidemiologic studies indicate that indoor air pollution from solid fuel use in China is responsible for approximately 4...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.9479
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:Exposure to metals has been implicated in the pathogenesis of Parkinson disease (PD). OBJECTIVES:We sought to examine in a large prospective study of female nurses whether exposure to airborne metals was associated with risk of PD. METHODS:We linked the U.S. Environmental Protection Agency (EPA)'s Air Toxi...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307218
更新日期:2014-09-01 00:00:00
abstract::Following our first report on elevated polybrominated diphenyl ether (PBDE) concentrations in California women, we expanded our investigation to include diverse groups of local women. We analyzed additional adipose and serum samples collected in the late 1990s from San Francisco Bay Area women participating in a breas...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6220
更新日期:2003-07-01 00:00:00
abstract::Uranium accumulates in bone, affects bone metabolism in laboratory animals, and when ingested in drinking water increases urinary excretion of calcium and phosphate, important components in the bone structure. However, little is known about bone effects of ingested natural uranium in humans. We studied 146 men and 142...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7475
更新日期:2005-01-01 00:00:00