Abstract：
:The populations of the developed nations of the world exhibit an increase in blood pressure with age, while in primitive societies blood pressure remains relatively constant throughout adult life. Hypertension may be a complex of diseases all having the same clinical manifestations but not being caused necessarily by the same factors. A possible common denominator in the development of any chronic elevation of blood pressure is the need for the kidney to increase urine volume to promote sodium excretion and, thereby, prevent a chronically expanded extracellular fluid (ECF). Hypertension may be viewed as a maladaptation of the body in its attempt to maintain homeostasis of the ECF. Man evolved under conditions of relative scarcity of salt and even now can maintain normal body function with an intake of less than 2 g/day. The high risk person appears to have a hereditary predisposition to a rise in blood pressure in the presence of a high sodium (NaCl) intake. Actually, the degree of rise in blood pressure may be an interaction between the amount of genetic predisposition and the level of sodium and its relation to potassium intake. Recent work in two Massachusetts communities supports this interpretation and suggests that differences in blood pressure distribution may increase with age between a higher and lower sodium community.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Tuthill RW,Calabrese EJdoi
10.1289/ehp.792935subject
Has Abstractpub_date
1979-04-01 00:00:00pages
35-43eissn
0091-6765issn
1552-9924journal_volume
29pub_type
杂志文章abstract：:To study the effect of processing on polybrominated biphenyl (PBB) levels, milk from four dairy herds containing less than 0.3 ppm (fat basis) of physiologically incorporated PBBs was presented individually into cream, skim milk, butter, and stirred curd cheese. Pasteurized and freeze-dried whole milk, skim milk, and ...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.782337
更新日期：1978-04-01 00:00:00
abstract：:In most neurotoxicological studies morphological assessment focuses on pathological effects, like degenerative changes in neuronal perikarya, axonopathy, demyelination, and glial and endothelial cell reactions. Similarly, the assessment of physiological and behavioral effects center on evident neurological symptoms, l...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.8774153
更新日期：1987-10-01 00:00:00
abstract：:Of 240 pesticides screened for carcinogenicity by the U.S. Environmental Protection Agency Office of Pesticide Programs, at least 24 (10%) produce thyroid follicular cell tumors in rodents. Thirteen of the thyroid carcinogens also induce liver tumors, mainly in mice, and 9 chemicals produce tumors at other sites. Some...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.98106437
更新日期：1998-08-01 00:00:00
abstract：BACKGROUND:Cockroaches and mice, which are common in urban homes, are sources of allergens capable of triggering asthma symptoms. Traditional pest control involves the use of scheduled applications of pesticides by professionals as well as pesticide use by residents. In contrast, integrated pest management (IPM) involv...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.0800149
更新日期：2009-08-01 00:00:00
abstract：:Comments on "Determination of bisphenol A and related aromatic compounds released from Bis-GMA-based composites and sealants by high performance liquid chromatography." by ulgar R, Olea-Serrano MF, Novillo-Fertrell A, Rivas A, Pazos P, Pedraza V, Navajas J-M, Olea N. Environ Health Perspect 108:21-27 (2000). ...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.108-a546a
更新日期：2000-12-01 00:00:00
abstract：:The development of inhalation toxicology as a distinct discipline can be traced back well over one hundred years. The technology has advanced in terms of materials and designs used to construct inhalation chambers and the equipment used to generate controlled test atmospheres of a wide variety of gases, vapors, dusts,...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.85-1568347
更新日期：1990-04-01 00:00:00
abstract：:Occupational exposures to mineral particles cause pneumoconiosis and other diseases, including cancer. Recent studies have suggested that reactive oxygen species (ROS) may play a key role in the mechanisms of disease initiation and progression following exposure to these particles. ROS-induced primary stimuli result i...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.98106s51151
更新日期：1998-10-01 00:00:00
abstract：BACKGROUND:National disparities in asbestos use will likely lead to an unequal burden of asbestos diseases. OBJECTIVES:As economic status may be linked to asbestos use, we assessed, globally, the relationship between indicators of national economic development and asbestos use. METHODS:For the 135 countries that have...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.0901196
更新日期：2010-01-01 00:00:00
abstract：:A population of approximately 650 beluga (Delphinapterus leucas) inhabits a short segment of the St. Lawrence estuary (SLE). Over 17 years (1983-1999), we have examined 129 (or 49%) of 263 SLE beluga carcasses reported stranded. The major primary causes of death were respiratory and gastrointestinal infections with me...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.02110285
更新日期：2002-03-01 00:00:00
abstract：:We assessed exposure to dioxin-like compounds using chemical and bioassay analysis in different matrices in a female population. A total of 106 serum and 9 follicular fluid samples were collected from infertile women attending Centers for Reproductive Medicine in Belgium from 1996 to 1998. Major polychlorinated biphen...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.00108553
更新日期：2000-06-01 00:00:00
abstract：BACKGROUND:The Consortium Linking Academic and Regulatory Insights on Bisphenol-A (CLARITY-BPA) is a rare collaboration of guideline-compliant (core) studies and academic hypothesis-based studies to assess the effects of bisphenol A (BPA). OBJECTIVES:We aimed to a) determine whether BPA showed effects on the developin...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/EHP6301
更新日期：2020-05-01 00:00:00
abstract：:In numerous in vivo systems it has been shown that diets high in menhaden oil (a fish oil high in omega-3 fatty acids) can inhibit the carcinogenic process. In the present study, we have assessed the effects of a diet containing menhaden oil on 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-DNA adduct formation in targe...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.94102s657
更新日期：1994-10-01 00:00:00
abstract：:New technologies are providing innovative ways to reduce sound levels in many areas. Aircraft engineers are finding ways to reduce the noise produced by jet engines, while road builders are using rubber-enhanced pavement to quiet highway noise. Indoor acoustics are benefiting from materials that transform sound waves ...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.113-a46
更新日期：2005-01-01 00:00:00
abstract：:Under a mandate from the U.S. Congress, the National Toxicology Program (NTP) of the U.S. Department of Health and Human Services conducts animal bioassays for carcinogenicity of potentially toxic chemicals to which the U.S. population might be exposed. Methyleugenol, a natural as well as synthesized substance, was no...
journal_title：Environmental health perspectives
pub_type： 临床试验,杂志文章
doi：10.1289/ehp.6766
更新日期：2004-05-01 00:00:00
abstract：BACKGROUND:Incorporating the influence of genetic variation in the risk assessment process is often considered, but no generalized approach exists. Many common human diseases such as asthma, cancer, and cardiovascular disease are complex in nature, as they are influenced variably by environmental, physiologic, and gene...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.8870
更新日期：2007-02-01 00:00:00
abstract：:The 26th annual conference of the International Society for Environmental Epidemiology was held 24-28 August 2014 in Seattle, Washington. The conference theme was "From Local to Global: Advancing Science for Policy in Environmental Health." Sessions highlighted results assessing the burden of diseases from environment...
journal_title：Environmental health perspectives
pub_type：
doi：10.1289/ehp.isee2014
更新日期：2014-10-30 00:00:00
abstract：:Epidemiological studies examining the association between exposure to tap water contaminants (such as chlorination by-products) and disease outcomes (such as cancer and adverse reproductive outcomes) have been limited by inaccurate exposure assessment. Failure to take into account the variation in beverage and tap wat...
journal_title：Environmental health perspectives
pub_type： 临床试验,杂志文章
doi：10.1289/ehp.9810655
更新日期：1998-02-01 00:00:00
abstract：:Chemoprotective phytochemicals exhibit multiple activities and interact with several cellular receptors, including the aryl hydrocarbon (Ah) receptor (AhR). In this study we investigated the AhR agonist/antagonist activities of the following flavonoids: chrysin, phloretin, kaempferol, galangin, naringenin, genistein, ...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.6322
更新日期：2003-12-01 00:00:00
abstract：:Chronic exposure to inorganic arsenic (iAs) has been associated with increased risk of various forms of cancer and of noncancerous diseases. Metabolic conversions of iAs that yield highly toxic and genotoxic methylarsonite (MAsIII) and dimethylarsinite (DMAsIII) may play a significant role in determining the extent an...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.7519
更新日期：2005-03-01 00:00:00
abstract：:Lead encephalopathy was induced in developing Long-Evans rats by adding lead carbonate (4% w/w) to the diet of nursing mother immediately after delivery. The morphological and biochemical features of cerebral ontogenesis were studied in 30-day-old rats. By the 30th postnatal day, the overall effect of lead intoxicatio...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.747187
更新日期：1974-05-01 00:00:00
abstract：:Most air pollution in West Germany is caused by combustion products. Particulate organic matter released by incomplete combustion is suspected to contribute to the "urban factor" of lung cancer frequency in urban-industrial centers. The carcinogenic potential of single components, groups of compounds and total source ...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.8347293
更新日期：1983-01-01 00:00:00
abstract：:A review of the experimental studies relating boron to biological effects on appendicular and axial bones in animal models suggests that numerous influences, known and unknown, affect the responsiveness of bone to dietary boron. Degrees of skeletal response to boron are modified by other nutritional variables that inc...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.94102s749
更新日期：1994-11-01 00:00:00
abstract：:Humans are exposed to a large number of environmental genotoxic agents. These can increase the probability that somatic mutation will occur. The use of genotoxicity testing is essential for assessment of potential human toxicity so that hazards can be prevented. Cytogenetic monitoring of human populations exposed to c...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.94102s4131
更新日期：1994-10-01 00:00:00
abstract：:The occurrence of high cadmium levels in the digestive gland (hepatopancreas) of the crab Cancer pagurus is reviewed and its possible significance to human health is discussed. Previous attempts to isolate this cadmium in its native form are briefly reviewed and the present method used in this laboratory to isolate cr...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.8665101
更新日期：1986-03-01 00:00:00
abstract：:Chlordane is a polychlorinated hydrocarbon that causes liver enlargement and induces mixed-function oxidases similar to those induced by phenobarbitone in the mouse. We have assessed the hepatocarcinogenicity (after 2 years) and the time course (over 6 months) of liver and thyroid cell proliferation in C57Bl/10J mice ...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.93101s5219
更新日期：1993-12-01 00:00:00
abstract：:Systemic lupus erythematosus and systemic scleroderma are autoimmune diseases thought to have an exogenous trigger. This review summarizes relevant case-control and cohort studies that investigated exogenous sex hormones, silica, silicone, solvents, pesticides, mercuric chloride, and hair dyes as putative risk factors...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.99107s5743
更新日期：1999-10-01 00:00:00
abstract：:There is an increasing interest in the development and validation of biomarkers for use in biochemical/molecular epidemiological studies. Though the area of neurotoxicology has received much attention in the past several years, it still lags behind with regard to the development of biomarkers, particularly those of he...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.96104s155
更新日期：1996-03-01 00:00:00
abstract：BACKGROUND:Pterygium is a fibrovascular growth of the bulbar conjunctiva and underlying subconjunctival tissue that may cause blindness. The mechanism of pterygium formation is not yet fully understood, but pterygium has some tumorlike features. OBJECTIVES:The objective of this study was to evaluate the association be...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.11111
更新日期：2008-07-01 00:00:00
abstract：:Considerable attention has been given to the relationship between levels of fine particulate matter (particulate matter < or = 2.5 microm in aerodynamic diameter; PM(2.5) in the atmosphere and health effects in human populations. Since the U.S. Environmental Protection Agency began widespread monitoring of PM(2.5) lev...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.6980
更新日期：2004-09-01 00:00:00
abstract：:The central feature of hemopoiesis is life-long, stable cell renewal. This process is supported by hemopoietic stem cells which, in the steady state, appear to be dormant in cell cycling. The entry into cell cycle of the dormant stem cells may be promoted by such factors as interleukin-1, interleukin-6 (IL-6), and gra...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.8980199
更新日期：1989-03-01 00:00:00
