Abstract:
:Metabolic enzymes involved in benzene activation or detoxification, including NAD(P)H, quinone oxidoreductase 1 (NQO1), cytochrome P450 2E1 (CYP2E1), myeloperoxidase (MPO), glutathione-S-transferase mu-1 (GSTM1), and glutathione-S-transferase theta-1 (GSTT1), were studied for their roles in human susceptibility to benzene poisoning. The potential interactions of these metabolic enzymes with lifestyle factors such as cigarette smoking and alcohol consumption were also explored. We studied 156 benzene-poisoning patients and 152 workers occupationally exposed to benzene in South China. Sequencing, denaturing HPLC, restriction fragment-length polymorphism, and polymerase chain reaction were used to detect polymorphisms on the promoters and complete coding regions of NQO1, CYP2E1, MPO, and the null genotypes of GSTM1 and GSTT1. Seventeen single nucleotide polymorphisms (SNPs) were identified in NQO1, CYP2E1, and MPO genes, including 6 novel SNPs in CYP2E1 and MPO. Of the subjects who smoked and drank alcohol, an 8.15-fold [95% confidence interval (CI), 1.43-46.50] and a 21.50-fold (95% CI, 2.79-165.79) increased risk of benzene poisoning, respectively, were observed among the subjects with two copies of NQO1 with a C-to-T substitution in cDNA at nucleotide 609 (c.609 C>T variation; i.e., NQO1 c.609 T/T) compared to those with the heterozygous or wild (NQO1 c.609 C/T and c.609 C/C) genotypes. Our data also indicated that individuals with CYP2E1 c.-1293 C/C and c.-1293 G/C, and NQO1 c.609 T/T, and GSTT1 null genotypes tended to be more susceptible to benzene toxicity. Our results suggest that the combined effect of polymorphisms in NQO1, CYP2E1, and GSTT1 genes and lifestyle factors might contribute to benzene poisoning.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Wan J,Shi J,Hui L,Wu D,Jin X,Zhao N,Huang W,Xia Z,Hu Gdoi
10.1289/ehp.021101213subject
Has Abstractpub_date
2002-12-01 00:00:00pages
1213-8issue
12eissn
0091-6765issn
1552-9924pii
sc271_5_1835journal_volume
110pub_type
杂志文章abstract::The populations of the developed nations of the world exhibit an increase in blood pressure with age, while in primitive societies blood pressure remains relatively constant throughout adult life. Hypertension may be a complex of diseases all having the same clinical manifestations but not being caused necessarily by ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.792935
更新日期:1979-04-01 00:00:00
abstract::A comparative analysis was performed of the phenotype and function of peripheral blood leukocytes of two age-matched cohorts of industrial workers in chemical plants, one of which was exposed occupationally to high concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Median actual TCDD burdens were 116 ng/kg ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106701
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:Mortality displacement (or "harvesting") has been identified as a key issue in the assessment of the temperature-mortality relationship. However, only a few studies have addressed the "harvesting" issue and findings have not been consistent. OBJECTIVES:We examined the potential impact of both short- and lon...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307606
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Use of pyrethroid insecticides has increased dramatically over the past decade; however, data on their potential health effects, particularly on children, are limited. OBJECTIVE:We examined the cross-sectional association between postnatal pyrethroid exposure and parental report of learning disability (LD) ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1308031
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Bisphenol A (BPA) is widely used in the manufacture of polycarbonate plastic bottles, food and beverage can linings, thermal receipts, and dental sealants. Animal and human studies suggest that BPA may disrupt thyroid function. Although thyroid hormones play a determinant role in human growth and brain devel...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1205092
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Cadmium (Cd) is a human toxicant and carcinogen. Genetic variation might affect long-term accumulation. Cd is absorbed via iron transporters. OBJECTIVES:We evaluated the impact of iron homeostasis genes [divalent metal transporter 1 (SLC11A2), transferrin (TF), transferrin receptors (TFR2 and TFRC), and fer...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1205672
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Functional limitations are a major cause for needing care and institutionalization among older adults. Exposure to air pollution has been suggested to be associated with increased functional limitations in older people. OBJECTIVE:Our objective was to assess the association between air pollution and physical...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP2239
更新日期:2018-01-19 00:00:00
abstract::In this article we summarize the results of a series of studies that measured the relative bioavailability (RBA) of lead in a variety of soil and soil-like test materials. Reference material (Pb acetate) or Pb-contaminated soils were administered orally to juvenile swine twice a day for 15 days. Blood samples were col...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8852
更新日期:2006-08-01 00:00:00
abstract::The role of the knowledge of high risk groups in the standard-setting process is examined. The overall conclusion is that many potential high risk segments of the population have not been studied adequately and that this deficiency in our knowledge markedly reduces the ability of decision makers to derive appropriate ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8352257
更新日期:1983-10-01 00:00:00
abstract:OBJECTIVES:The National Environmental Policy Act and related state laws require many public agencies to analyze and disclose potentially significant environmental effects of agency actions, including effects on human health. In this paper we review the purpose and procedures of environmental impact assessment (EIA), ex...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.11132
更新日期:2008-08-01 00:00:00
abstract::Short articles on the following topics: *NIEHS Strategic Plan: New Frontiers in Environmental Sciences and Human Health; Beyond the Bench: Environmental Health Nursing: Putting Knowledge into Practice; Headliners: Inhibition of RLIP76 Causes Complete Regression of Melanoma in Mice. ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:
更新日期:2006-05-01 00:00:00
abstract::In August 1997 we performed a follow-up survey of 146 lead-poisoned children from a community near a previously active auto battery recycling smelter in Haina near Santo Domingo, Dominican Republic. Our follow-up survey confirmed a severe incidence of elevated blood lead (BPb) and erythrocyte protoporphyrin/zinc proto...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.99107917
更新日期:1999-11-01 00:00:00
abstract::In this study we investigated the risk of hearing loss among workers exposed to both toluene and noise. We recruited 58 workers at an adhesive materials manufacturing plant who were exposured to both toluene and noise [78.6-87.1 A-weighted decibels; dB(A)], 58 workers exposed to noise only [83.5-90.1 dB(A)], and 58 ad...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8959
更新日期:2006-08-01 00:00:00
abstract::In most neurotoxicological studies morphological assessment focuses on pathological effects, like degenerative changes in neuronal perikarya, axonopathy, demyelination, and glial and endothelial cell reactions. Similarly, the assessment of physiological and behavioral effects center on evident neurological symptoms, l...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8774153
更新日期:1987-10-01 00:00:00
abstract::Noise exposure causes changes at different levels in human organs, particularly the cardiovascular system, where it is responsible for increasing heart rate, peripheral vascular resistance, and blood pressure. In this study, we evaluated the effect of noise exposure on DNA integrity and ultrastructure of rat cardiomyo...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.5847
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:Particulate matter (PM) in outdoor air pollution was recently designated a Group I carcinogen by the International Agency for Research on Cancer (IARC). This determination was based on the evidence regarding the relationship of PM2.5 and PM10 to lung cancer risk; however, the IARC evaluation did not include ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,meta分析,评审
doi:10.1289/ehp/1408092
更新日期:2014-09-01 00:00:00
abstract::The identification of certain organic compounds in drinking water has led water treatment specialists to be increasingly concerned about the eventual risks of such pollutants to the health of consumers. Our experiments focused on the role of ozone and granular activated carbon in removing mutagenic compounds and precu...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8669159
更新日期:1986-11-01 00:00:00
abstract:BACKGROUND:When conducting research with American Indian tribes, informed consent beyond conventional institutional review board (IRB) review is needed because of the potential for adverse consequences at a community or governmental level that are unrecognized by academic researchers. OBJECTIVES:In this article, we re...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1103904
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Although numerous epidemiologic studies now use models of intraurban exposure, there has been little systematic evaluation of the performance of different models. OBJECTIVES:In this present article we proposed a modeling framework for assessing exposure model performance and the role of spatial autocorrelat...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9849
更新日期:2007-08-01 00:00:00
abstract::We present a pilot study of individuals (liquidators) who were engaged in clean-up operations after the disaster at the nuclear power plant at Chernobyl in Ukraine. In the 10 years since the disaster, adverse health effects among exposed individuals have not been clearly defined. There is widespread fear of damage to ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.97105s61445
更新日期:1997-12-01 00:00:00
abstract::The lung epithelium resorbs alveolar fluid through combined action of sodium channels and the sodium pump, Na,K-ATPase. The lung often is exposed to hyperoxia in disease states and hyperoxia generates a mixture of reactive oxygen species. In vivo and in vitro exposure of rat lung and alveolar type II cells, respective...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106s51213
更新日期:1998-10-01 00:00:00
abstract::Environmental health is a subject that has only relatively recently become prominent in the social consciousness. Even as its significance becomes known, finding ways to integrate the subject into education for primary and secondary students is difficult because of federal testing requirements under the No Child Left ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.112-a814
更新日期:2004-10-01 00:00:00
abstract::Organochlorines are persistent lipophilic compounds that accumulate in Inuit people living in circumpolar countries. Organochlorines accumulate as a result of the Inuits' large consumption of sea mammal fat; however, available data are limited to blood lipids, milk fat, and adipose tissue. We report results of organoc...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.99107823
更新日期:1999-10-01 00:00:00
abstract::Male reproduction has been given little attention in science and in medical practice. However, a recent metaanalysis on semen quality, which clearly pointed to a decrease over the past 50 years, has been repeatedly quoted. Three recent reports have found that semen quality has declined among candidate semen donors dur...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.95103s7137
更新日期:1995-10-01 00:00:00
abstract::The effects of chrysotile on DNA synthesis in the gastrointestinal tract of the rat were studied by measuring the uptake of tritium-labeled thymidine; whole stomach, small intestine, colon liver were removed, cleaned, and homogenized and the DNA was isolated and assayed for tritium label.A dose-response study indicate...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.749319
更新日期:1974-12-01 00:00:00
abstract::Because of its unique geology, Minnesota can be divided into four agricultural regions: south-central region one (corn, soybeans); west-central region two (wheat, corn, soybeans); northwest region three (wheat, sugar beets, potatoes); and northeast region four (forested and urban in character). Cancer mortality (1980-...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.99107205
更新日期:1999-03-01 00:00:00
abstract::The steroids trenbolone acetate (TbA) and melengestrol acetate (MGA) are licensed as growth promoters for farm animals in several meat-exporting countries. Although many studies have explored their safety for both animals and consumers, little is known about their fate after excretion by the animal. Our study aimed to...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.011091145
更新日期:2001-11-01 00:00:00
abstract::The articles in this monograph focus on the mechanisms whereby ambient particulate matter (PM) and co-pollutants deposited in the respiratory tract cause cardiovascular and systemic effects, especially in persons with preexisting conditions such as allergic hyperresponsiveness and pulmonary, cardiac, and vascular dise...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.01109s4479
更新日期:2001-08-01 00:00:00
abstract::Many populations of amphibians are declining on all six continents on which they occur. Some causes of amphibian declines, such as habitat destruction, direct application of xenobiotics, and introduction of predators or competitors, are clearly attributable to human activities. Infectious disease appears to be the dir...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.00108s1143
更新日期:2000-03-01 00:00:00
abstract::N-Substituted aromatic compounds can be metabolized in most species to N-acetylated derivatives that are themselves subject to further enzymatic transformations, including hydrolysis and N,O-acyltransfer. These proceses can either potentiate or ameliorate the biological responses to these N-substituted derivatives. De...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.834943
更新日期:1983-03-01 00:00:00