Airborne particles of the california central valley alter the lungs of healthy adult rats.

abstract：:Differences in genetic susceptibility to hazardous chemicals affect individuals of both human and nonhuman populations. In both cases, differences in response to chemicals or general ill health result as a function of these differences in genetic susceptibility. However, ecological systems are a compilation of hundred...

journal_title：Environmental health perspectives

authors： Burger J

更新日期：1997-06-01 00:00:00

abstract：:The consideration of ethical issues relating to pediatric environmental health is a recent phenomenon. Discussions of biomedical ethics, research on children, and environmental health research have a longer history. In the late 1990s, researchers at the Kennedy Krieger Institute in Baltimore, Maryland, undertook a stu...

journal_title：Environmental health perspectives

authors： Paulson JA

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Cadmium (Cd) is a ubiquitous environmental toxicant that can accumulate in the placenta during pregnancy, where it may impair placental function and affect fetal development. OBJECTIVES:We aimed to investigate Cd-associated variations in placental DNA methylation (DNAM) and associations with gene expression...

journal_title：Environmental health perspectives

authors： Everson TM,Punshon T,Jackson BP,Hao K,Lambertini L,Chen J,Karagas MR,Marsit CJ

更新日期：2018-01-22 00:00:00

abstract：:Rates of developmental and respiratory diseases are disproportionately high in underserved, minority populations such as those in New York City's Washington Heights, Harlem, and the South Bronx. Blacks and Latinos in these neighborhoods represent high risk groups for asthma, adverse birth outcomes, impaired developmen...

journal_title：Environmental health perspectives

authors： Perera FP,Illman SM,Kinney PL,Whyatt RM,Kelvin EA,Shepard P,Evans D,Fullilove M,Ford J,Miller RL,Meyer IH,Rauh VA

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Microcystin-LR, a cyclic heptapeptide, possesses the ability to inhibit the serine/threonine protein phosphatases PP1 and PP2A and, consequently, exhibits acute hepatocytotoxicity. Moreover, microcystin-LR induces cellular proliferation, resulting in tumor-promoting activity in hepatocytes. However, mechanis...

journal_title：Environmental health perspectives

authors： Takumi S,Komatsu M,Furukawa T,Ikeda R,Sumizawa T,Akenaga H,Maeda Y,Aoyama K,Arizono K,Ando S,Takeuchi T

更新日期：2010-09-01 00:00:00

abstract：:Children and their parents in residences are often protected by insecticides from nuisance and disease-bearing mosquitoes. The annual worldwide consumption of the four major types of residential insecticide products--aerosols, mosquito coils, liquid vaporizers, and vaporizing mats--is in the billions of units. Mosquit...

journal_title：Environmental health perspectives

authors： Krieger RI,Dinoff TM,Zhang X

更新日期：2003-09-01 00:00:00

abstract：:Once a sign of modernization and growth, dams are often seen today as symbols of environmental and social devastation. Over 800,000 dams have been built worldwide to provide drinking water, flood control, hydropower, irrigation, navigation, and water storage. Dams do indeed provide these things,but at the cost of seve...

journal_title：Environmental health perspectives

authors： Joyce S

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:Mercury is a pervasive environmental pollutant whose toxic effects have not been studied in sea turtles in spite of their threatened status and evidence of immunosuppression in diseased populations. OBJECTIVES:In the present study we investigate mercury toxicity in loggerhead sea turtles (Caretta caretta) b...

journal_title：Environmental health perspectives

authors： Day RD,Segars AL,Arendt MD,Lee AM,Peden-Adams MM

更新日期：2007-10-01 00:00:00

abstract：:comments on S. Patandin et al. : Dietary exposure to polychlorinated biphenyls and dioxins from infancy until adulthood: a comparison between breast-feeding, toddler, and long-term exposure. Environ Health Perspect 107:45-51 (1999). ...

journal_title：Environmental health perspectives

authors： LaKind JS,Filser JG

更新日期：1999-10-01 00:00:00

abstract：:A population of approximately 650 beluga (Delphinapterus leucas) inhabits a short segment of the St. Lawrence estuary (SLE). Over 17 years (1983-1999), we have examined 129 (or 49%) of 263 SLE beluga carcasses reported stranded. The major primary causes of death were respiratory and gastrointestinal infections with me...

journal_title：Environmental health perspectives

authors： Martineau D,Lemberger K,Dallaire A,Labelle P,Lipscomb TP,Michel P,Mikaelian I

更新日期：2002-03-01 00:00:00

abstract：:The immune system comprises a highly integrated network of multiple tissues and cell types with complicated interactions and effects. It is modulated by the endocrine and nervous systems and there is growing realization of its multifunctionality. The session focusing on immunologic effects of dioxin and related compou...

journal_title：Environmental health perspectives

authors： Birnbaum LS

更新日期：1995-03-01 00:00:00

abstract：:It has been estimated that 4 of 1,000 live births and 35% of spontaneous abortions are aneuploid and that an important proportion of embryo and newborn aneuploidy is of paternal origin. Exposure to organophosphorous pesticides (OP) has been associated with sperm hyperploidy/polyploidy. Therefore, we aimed to assess th...

journal_title：Environmental health perspectives

authors： Recio R,Robbins WA,Borja-Aburto V,Morán-Martínez J,Froines JR,Hernández RM,Cebrián ME

更新日期：2001-12-01 00:00:00

abstract：:Population monitoring using methods of molecular epidemiology combined with reliable data on exposure is an extremely powerful approach to determine the effect of mutagens on human populations. Although human blood and urine have traditionally been used for biomonitoring, an increase in the use of placental and buccal...

journal_title：Environmental health perspectives

authors： Srám RJ

更新日期：1996-05-01 00:00:00

abstract：:Occupational cancer research methods was identified in 1996 as 1 of 21 priority research areas in the National Occupational Research Agenda (NORA). To implement NORA, teams of experts from various sectors were formed and given the charge to further define research needs and develop strategies to enhance or augment res...

journal_title：Environmental health perspectives

authors： Ward EM,Schulte PA,Bayard S,Blair A,Brandt-Rauf P,Butler MA,Dankovic D,Hubbs AF,Jones C,Karstadt M,Kedderis GL,Melnick R,Redlich CA,Rothman N,Savage RE,Sprinker M,Toraason M,Weston A,Olshan AF,Stewart P,Zahm SH,

更新日期：2003-01-01 00:00:00

abstract：:Tobacco smoke contains a number of genotoxic compounds that are metabolized to their biologically active forms that subsequently react with cellular DNA to form covalently bound carcinogen-DNA adducts. Several analytical procedures have been developed to detect these adducts in human tissues. Using the nuclease P1-enh...

journal_title：Environmental health perspectives

authors： Hansen C,Asmussen I,Autrup H

更新日期：1993-03-01 00:00:00

abstract：:The timing of some key embryological events is given for man, rat, chick, and certain other animals. Such times, however, are approximations, and variations occur among members of the same strain and even among members of the same litter. Some differences in developmental patterns are indicated. ...

journal_title：Environmental health perspectives

authors： Monie IW

更新日期：1976-12-01 00:00:00

abstract：:Metallothionein (MT) promoter was methylated in rat hepatoma and in mouse lymphosarcoma cells by methylation of cytosine within the CpG dinucleotide region. After demethylation of MT-I promoter in mouse lymphosarcoma cells or in the transplanted rat hepatoma with 5-azacytidine, a potent inhibitor of DNA methyltransfer...

journal_title：Environmental health perspectives

authors： Jacob ST,Majumder S,Ghoshal K

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Human controlled-exposure studies have assessed the impact of ambient fine particulate matter on cardiac autonomic function measured by heart rate variability (HRV), but whether these effects are modified by concomitant ozone exposure remains unknown. OBJECTIVE:In this study we assessed the impact of O(3) a...

journal_title：Environmental health perspectives

authors： Fakhri AA,Ilic LM,Wellenius GA,Urch B,Silverman F,Gold DR,Mittleman MA

更新日期：2009-08-01 00:00:00

abstract：:This paper examines behavioral changes in natural populations of wildlife associated with pollution. Although some changes such as lack of nest attentiveness and decreased nest defense have been noted, the results have not been consistent and have been difficult to relate to specific pollutants. Experimental studies i...

journal_title：Environmental health perspectives

authors： Peakall DB

更新日期：1996-04-01 00:00:00

abstract：:Metals have been mined and used since ancient times. The industrial era has seen a sharp increase in both the amounts and variety of metals that find applications in industry. The inadvertent release of metals, such as from fossil fuel consumption, also adds to the global burden. A number of catastrophic outbreaks hav...

journal_title：Environmental health perspectives

authors： Clarkson T

更新日期：1995-02-01 00:00:00

abstract：:Although acute adverse effects on asthma have been frequently found for the U.S. Environmental Protection Agency's principal criteria air pollutants, there is little epidemiologic information on specific hydrocarbons from toxic emission sources. We conducted a panel study of 22 Hispanic children with asthma who were 1...

journal_title：Environmental health perspectives

authors： Delfino RJ,Gong H Jr,Linn WS,Pellizzari ED,Hu Y

更新日期：2003-04-01 00:00:00

abstract：:Unlike laboratory animals, people are rarely exposed to a single hazardous chemical. However, most of the information documenting adverse human health effects from environmental and occupational contaminants has come from studies focused on exposure to single chemicals, and there is little information available on how...

journal_title：Environmental health perspectives

authors： Carpenter DO,Arcaro KF,Bush B,Niemi WD,Pang S,Vakharia DD

更新日期：1998-12-01 00:00:00

abstract：:Worldwide climate change and loss of biodiversity are issues of global scope and importance that have recently become subjects of considerable public concern. Unlike classical public health issues and many environmental issues, their perceived threat lies in their potential to disrupt ecological functioning and stabil...

journal_title：Environmental health perspectives

authors： Jutro PR

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:Polybrominated diphenyl ethers (PBDEs) are persistent, bioaccumulative, and endocrine-disrupting chemicals. OBJECTIVES:We used handwipes to estimate exposure to PBDEs in house dust among toddlers and examined sex, age, breast-feeding, race, and parents' education as predictors of serum PBDEs. METHODS:Eight...

journal_title：Environmental health perspectives

authors： Stapleton HM,Eagle S,Sjödin A,Webster TF

更新日期：2012-07-01 00:00:00

abstract：:Atlantic coast estuaries recently have experienced fish kills and fish with lesions attributed to Pfiesteria piscicida and related dinoflagellates. Human health effects have been reported from laboratory exposure and from a 1997 Maryland fish kill. North Carolina has recorded Pfiesteria-related fish kill events over t...

journal_title：Environmental health perspectives

authors： Swinker M,Koltai D,Wilkins J,Hudnell K,Hall C,Darcey D,Robertson K,Schmechel D,Stopford W,Music S

更新日期：2001-01-01 00:00:00

abstract：:Nitrate contamination of drinking water implies a genotoxic risk to man due to the endogenous formation of carcinogenic N-nitroso compounds from nitrate-derived nitrite. Thus far, epidemiological studies have presented conflicting results on the relation of drinking water nitrate levels with gastric cancer incidence. ...

journal_title：Environmental health perspectives

authors： Kleinjans JC,Albering HJ,Marx A,van Maanen JM,van Agen B,ten Hoor F,Swaen GM,Mertens PL

更新日期：1991-08-01 00:00:00

abstract：:Spatial epidemiology is the description and analysis of geographic variations in disease with respect to demographic, environmental, behavioral, socioeconomic, genetic, and infectious risk factors. We focus on small-area analyses, encompassing disease mapping, geographic correlation studies, disease clusters, and clus...

journal_title：Environmental health perspectives

authors： Elliott P,Wartenberg D

更新日期：2004-06-01 00:00:00

abstract：:Reproduction is essential for the continuation of the species and for life itself. In biological terms, living and reproducing are essentially one and the same. There is, therefore, no sharp division between identifying factors harmful to reproduction and identifying factors harmful to life or vice versa. Detection of...

journal_title：Environmental health perspectives

authors： Palmer AK

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Traffic-related air pollution is emerging as a risk factor for Alzheimer's disease (AD) and impaired brain development. Individual differences in vulnerability to air pollution may involve the ε4 allele of Apolipoprotein E (APOE) gene, the primary genetic risk factor for AD. OBJECTIVE:We analyzed whether th...

journal_title：Environmental health perspectives

authors： Alemany S,Vilor-Tejedor N,García-Esteban R,Bustamante M,Dadvand P,Esnaola M,Mortamais M,Forns J,van Drooge BL,Álvarez-Pedrerol M,Grimalt JO,Rivas I,Querol X,Pujol J,Sunyer J

更新日期：2018-08-02 00:00:00

abstract：BACKGROUND:Modern toxicology is shifting from an observational to a mechanistic science. As part of this shift, high-throughput toxicity assays are being developed using alternative, nonmammalian species to prioritize chemicals and develop prediction models of human toxicity. METHODS:The nematode Caenorhabditis elegan...

journal_title：Environmental health perspectives

authors： Boyd WA,Smith MV,Co CA,Pirone JR,Rice JR,Shockley KR,Freedman JH

更新日期：2016-05-01 00:00:00