Abstract:
:Uranium accumulates in bone, affects bone metabolism in laboratory animals, and when ingested in drinking water increases urinary excretion of calcium and phosphate, important components in the bone structure. However, little is known about bone effects of ingested natural uranium in humans. We studied 146 men and 142 women 26-83 years of age who for an average of 13 years had used drinking water originating from wells drilled in bedrock, in areas with naturally high uranium content. Biochemical indicators of bone formation were serum osteocalcin and amino-terminal propeptide of type I procollagen, and a marker for bone resorption was serum type I collagen carboxy-terminal telopeptide (CTx). The primary measure of uranium exposure was uranium concentration in drinking water, with additional information on uranium intake and uranium concentration in urine. The data were analyzed separately for men and women with robust regression (which suppresses contributions of potential influential observations) models with adjustment for age, smoking, and estrogen use. The median uranium concentration in drinking water was 27 microg/L (interquartile range, 6-116 microg/L). The median of daily uranium intake was 36 microg (7-207 microg) and of cumulative intake 0.12 g (0.02-0.66 g). There was some suggestion that elevation of CTx (p = 0.05) as well as osteocalcin (p = 0.19) could be associated with increased uranium exposure (uranium in water and intakes) in men, but no similar relationship was found in women. Accordingly, bone may be a target of chemical toxicity of uranium in humans, and more detailed evaluation of bone effects of natural uranium is warranted.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Kurttio P,Komulainen H,Leino A,Salonen L,Auvinen A,Saha Hdoi
10.1289/ehp.7475subject
Has Abstractpub_date
2005-01-01 00:00:00pages
68-72issue
1eissn
0091-6765issn
1552-9924journal_volume
113pub_type
杂志文章abstract:BACKGROUND:Drinking water in multiple water districts in the Mid-Ohio Valley has been contaminated with perfluorooctanoic acid (PFOA), which was released by a nearby DuPont chemical plant. Two highly contaminated water districts began granular activated carbon filtration in 2007. OBJECTIVES:To determine the rate of de...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0901252
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Pesticides have been associated with Parkinson's disease (PD), but there are few data on important exposure characteristics such as dose-effect relations. It is unknown whether associations depend on clinical PD subtypes. OBJECTIVES:We examined quantitative aspects of occupational pesticide exposure associa...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307970
更新日期:2015-11-01 00:00:00
abstract::The association of blood lead (B-Pb) concentration to blood pressure was investigated in men aged 55 to 75 years living in the Rome area, who had no history of exposure to lead in the workplace and who participated between 1989 and 1990 in an epidemiologic survey for coronary heart disease (New Risk Factor Project). O...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s9107
更新日期:1994-11-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1308038
更新日期:2014-12-01 00:00:00
abstract::Erythropoietic cells in bone marrow are vulnerable to cytotoxic substances. There are three types of erythroid precursors: cells that can take up Fe but do not proliferate (reticulocytes), those that can take up Fe and proliferate (normoblasts and pronormoblasts), and those cells that do not take up Fe but can prolife...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.813929
更新日期:1981-06-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.95103s8287
更新日期:1995-11-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106155
更新日期:1998-03-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9337
更新日期:2006-10-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.02110591
更新日期:2002-06-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.897943
更新日期:1989-02-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94-1567968
更新日期:1991-08-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.814183
更新日期:1981-10-01 00:00:00
abstract::It has been hypothesized that environmental exposure to synthetic estrogenic chemicals and related endocrine-active compounds may be responsible for a global decrease in sperm counts, decreased male reproductive capacity, and breast cancer in women. Results of recent studies show that there are large demographic varia...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.00108487
更新日期:2000-06-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.749229
更新日期:1974-12-01 00:00:00
abstract::The development of inhalation toxicology as a distinct discipline can be traced back well over one hundred years. The technology has advanced in terms of materials and designs used to construct inhalation chambers and the equipment used to generate controlled test atmospheres of a wide variety of gases, vapors, dusts,...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.85-1568347
更新日期:1990-04-01 00:00:00
abstract::We assessed the reproducibility of X-ray fluorescence-based lead measurements from multiple measurements made on a low-concentration plaster of paris phantom and in five subjects measured five times on two occasions. Over a 6-month period, 220 measurements of the same phantom were obtained and showed a standard deviat...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102690
更新日期:1994-08-01 00:00:00
abstract::Lipocortins are structurally related, glucocorticoid-inducible proteins that inhibit phospholipase A2 (PLA2), thereby reducing the liberation of arachidonic acid from phospholipids and so limiting the synthesis of eicosanoid inflammatory mediators. This study is the first demonstration of one lipocortin, lipocortin 1 ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.85-1568329
更新日期:1990-04-01 00:00:00
abstract::Polycyclic aromatic hydrocarbons (PAHs) are toxic pollutants released by the World Trade Center (WTC) fires and various urban combustion sources. Benzo[a]pyrene (BaP) is a representative member of the class of PAHs. PAH-DNA adducts, or BaP-DNA adducts as their proxy, provide a measure of chemical-specific genetic dama...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7908
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND:Per- and polyfluoroalkyl substances (PFAS) are widespread persistent organic pollutants and endocrine disruptors. High doses of perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) exposure can cause pregnancy loss and infant deaths in animals, but the associations between PFAS exposures and...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP6202
更新日期:2020-04-01 00:00:00
abstract::To evaluate the effectiveness of mass screening for uterine cancer in Japan, we compared the changes in the age-adjusted rates of potential years of life lost (PYLL) due to uterine cancer between 1969 and 1972 to 1973 through 1977 between the high coverage-rate (intensively screened) areas and the comparable control a...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.908751
更新日期:1990-07-01 00:00:00
abstract::Laboratory and room-scale experiments were conducted with natural and synthetic polymers: cotton, paper, wood, wool, acetate, acrylic, nylon, and urethane. Smoke and off-gases from single materials were generated in a dual-compartment 110-liter exposure chamber. Multicomponent, composite fuel loads were burned within ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.761775
更新日期:1976-10-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1104594
更新日期:2012-04-01 00:00:00
abstract::The relationship between blood lead concentration and blood pressure is examined in a survey of 7371 men aged 40 to 59 from 24 British towns. After allowance for relevant confounding variables, including town of residence and alcohol consumption, there exists a very weak but statistically significant positive associat...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.887823
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND:Evidence on the association between colorectal cancer and exposure to disinfection by-products in drinking water is inconsistent. OBJECTIVES:We assessed long-term exposure to trihalomethanes (THMs), the most prevalent group of chlorination by-products, to evaluate the association with colorectal cancer. ME...
journal_title:Environmental health perspectives
pub_type: 杂志文章,多中心研究
doi:10.1289/EHP155
更新日期:2017-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1289/EHP2580.]. ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,已发布勘误
doi:10.1289/EHP4002
更新日期:2018-07-05 00:00:00
abstract:BACKGROUND:The Love Canal is a rectangular 16-acre, 10-ft deep chemical waste landfill situated in a residential neighborhood in Niagara Falls, New York. This seriously contaminated site first came to public attention in 1978. No studies have examined mortality in the former residents of the Love Canal neighborhood (LC...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.11350
更新日期:2009-02-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0800428
更新日期:2009-07-01 00:00:00
abstract::The current Good Manufacturing Practice (cGMP) and effluent emission (use and disposal) regulations of the U.S. Food and Drug Administration (FDA) and manufacturing effluent discharge and emission regulations of the U.S. Environmental Protection Agency (U.S. EPA) require contained manufacture, use, and disposal of pha...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.02110213
更新日期:2002-03-01 00:00:00
abstract::Research conducted in recent years has increased public health concern about the toxicity of lead at low dose and has supported a reappraisal of the levels of lead exposure that may be safely tolerated in the workplace. In this article, which appears as part of a mini-monograph on adult lead exposure, we summarize a b...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.9784
更新日期:2007-03-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.90-1519491
更新日期:1991-01-01 00:00:00