Role of lime in the generation of reactive oxygen species from betel-quid ingredients.

abstract：:The available data on the influence of selenium on the toxicity of methylmercury and of methylmercury on selenium as a nutrient and toxic agent are reviewed. Selenium as selenite has a relative protective effect on acute and subacute toxicity of methylmercury in the rat and the quail. The protective mechanism is far f...

journal_title：Environmental health perspectives

authors： Skerfving S

更新日期：1978-08-01 00:00:00

abstract：BACKGROUND:Perfluoroalkyl substances (PFASs) are synthetic compounds that are widely used in industry and are often detectable in humans. In pregnant rats and their pups, PFASs can interfere with thyroid hormone homeostasis. In humans, maternal thyroid hormones supply the fetus throughout pregnancy, and thyroid hormone...

journal_title：Environmental health perspectives

authors： Wang Y,Rogan WJ,Chen PC,Lien GW,Chen HY,Tseng YC,Longnecker MP,Wang SL

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Phthalates are metabolized and eliminated in urine within hours after exposure. Several reports suggest that concentrations of phthalate metabolites in a spot urine sample can provide a reliable estimation of exposure to phthalates for up to several months. OBJECTIVES:We examined inter- and intraperson and ...

journal_title：Environmental health perspectives

authors： Preau JL Jr,Wong LY,Silva MJ,Needham LL,Calafat AM

更新日期：2010-12-01 00:00:00

abstract：:Virginia Bioinformatics Institute, in conjunction with National Institutes of Environmental Health Sciences, hosted a conference, "Toxicogenomics through the Eyes of Informatics," in Bethesda, Maryland, USA, on 12-13 May 2003. Researchers around the world met to discuss how the application of bioinformatics tools, met...

journal_title：Environmental health perspectives

authors： Olden K,Call N,Sobral B,Oakes R

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Climate influences dengue ecology by affecting vector dynamics, agent development, and mosquito/human interactions. Although these relationships are known, the impact climate change will have on transmission is unclear. Climate-driven statistical and process-based models are being used to refine our knowledg...

journal_title：Environmental health perspectives

authors： Morin CW,Comrie AC,Ernst K

更新日期：2013-11-01 00:00:00

abstract：:Principles and practices of pediatric neurotoxicology are reviewed here with the purpose of guiding the design and execution of the planned National Children's Study. The developing human central nervous system is the target organ most vulnerable to environmental chemicals. An investigation of the effects of environme...

journal_title：Environmental health perspectives

authors： Dietrich KN,Eskenazi B,Schantz S,Yolton K,Rauh VA,Johnson CB,Alkon A,Canfield RL,Pessah IN,Berman RF

更新日期：2005-10-01 00:00:00

abstract：:Noise exposure causes changes at different levels in human organs, particularly the cardiovascular system, where it is responsible for increasing heart rate, peripheral vascular resistance, and blood pressure. In this study, we evaluated the effect of noise exposure on DNA integrity and ultrastructure of rat cardiomyo...

journal_title：Environmental health perspectives

authors： Lenzi P,Frenzilli G,Gesi M,Ferrucci M,Lazzeri G,Fornai F,Nigro M

更新日期：2003-04-01 00:00:00

abstract：:Asbestos and other mineral fibers are carcinogenic to humans and animals but differ from many carcinogens in that they do not induce gene mutations. An understanding of these interesting human carcinogens, therefore, is an important problem in cancer research. Asbestos and other fibers induce predominantly two types o...

journal_title：Environmental health perspectives

authors： Barrett JC,Lamb PW,Wiseman RW

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:"Airwave" is the new communication system currently being rolled out across the United Kingdom for the police and emergency services, based on the Terrestrial Trunked Radio Telecommunications System (TETRA). Some police officers have complained about skin rashes, nausea, headaches, and depression as a conseq...

journal_title：Environmental health perspectives

authors： Wallace D,Eltiti S,Ridgewell A,Garner K,Russo R,Sepulveda F,Walker S,Quinlan T,Dudley S,Maung S,Deeble R,Fox E

更新日期：2010-06-01 00:00:00

abstract：:Metals have been mined and used since ancient times. The industrial era has seen a sharp increase in both the amounts and variety of metals that find applications in industry. The inadvertent release of metals, such as from fossil fuel consumption, also adds to the global burden. A number of catastrophic outbreaks hav...

journal_title：Environmental health perspectives

authors： Clarkson T

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:A critical question regarding the association between short-term exposure to ozone and mortality is the extent to which this relationship is confounded by ambient exposure to particles. OBJECTIVES:We investigated whether particulate matter < 10 and < 2.5 microm in aerodynamic diameter (PM(10) and PM(2.5)) i...

journal_title：Environmental health perspectives

authors： Bell ML,Kim JY,Dominici F

更新日期：2007-11-01 00:00:00

abstract：:The formation of reactive oxygen species resulting from the interaction of silica dust particles with red blood cell membranes was investigated; particularly, the effect of surface hydroxyl (silanol) group concentration on the rate of formation of such reactive oxygen species was investigated. The rate of formation wa...

journal_title：Environmental health perspectives

authors： Razzaboni BL,Bolsaitis P

更新日期：1990-07-01 00:00:00

abstract：:Interleukin-3 (IL-3) and granulocyte/macrophage-colony-stimulating factor (GM-CSF) are responsible for maintaining survival and stimulating growth of early dormant hematopoietic progenitor cells (HPC). These cytokines exhibit extensive overlap, with GM-CSF supporting growth and differentiation of myeloid HPC. A charac...

journal_title：Environmental health perspectives

authors： Irons RD,Stillman WS

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:Warm sea surface temperatures (SSTs) are positively related to incidence of ciguatera fish poisoning (CFP). Increased severe storm frequency may create more habitat for ciguatoxic organisms. Although climate change could expand the endemic range of CFP, the relationship between CFP incidence and specific env...

journal_title：Environmental health perspectives

authors： Gingold DB,Strickland MJ,Hess JJ

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Hydraulically fractured wells produce 2-14 million liters of wastewater, which may contain toxic and radioactive compounds. The wastewater is predominantly disposed of using Class II injection wells. OBJECTIVE:Our objective was to evaluate the relationship between sociodemographic characteristics and inject...

journal_title：Environmental health perspectives

authors： Silva GS,Warren JL,Deziel NC

更新日期：2018-06-27 00:00:00

abstract：:Human fibroblasts (HFW) were 10-fold more susceptible than Chinese hamster ovary (CHO-K1) cells to sodium arsenite. Comparison of cellular antioxidant enzyme activities showed that CHO-K1 cells contained 3- and 8-fold more glutathione-peroxidase and catalase activities, respectively, than HFW cells. Since vitamin E, m...

journal_title：Environmental health perspectives

authors： Lee TC,Ho IC

更新日期：1994-09-01 00:00:00

abstract：:We used an improved method for trapping carbon-centered radicals (.R) from the gas-phase to compare radical suites trapped from various tobacco smoke and model smoke systems. Using a nitroxide trap, 3-amino-2,2,5,5-tetramethyl-1-pyrrolidinyloxy (3AP), on solid support, we trapped radicals directly from the gas phase, ...

journal_title：Environmental health perspectives

authors： Flicker TM,Green SA

更新日期：2001-08-01 00:00:00

abstract：:A co-culture clonal survival assay was developed to measure the cytotoxicity of test chemical treatments to BALB/c-3T3 cells because the standard clonal survival assay using 200 wild type (WT) cells frequently overestimates chemical cytotoxicity when compared with identical treatment doses in high-density cultures. Th...

journal_title：Environmental health perspectives

authors： Matthews EJ

更新日期：1993-07-01 00:00:00

abstract：:Differential CYP1A1 inducibility, reflecting variations in aromatic hydrocarbon receptor (AHR) affinity among inbred mouse strains, is an important determinant of environmental toxicity. We took advantage of the Ahr polymorphism in C57BL/6 and DBA/2 mice to develop an oligonucleotide-hybridization screening approach f...

journal_title：Environmental health perspectives

authors： Maier A,Micka J,Miller K,Denko T,Chang CY,Nebert DW,Alvaro Puga

更新日期：1998-07-01 00:00:00

abstract：:A biodosimetric approach to determine alpha-particle dose to the respiratory tract epithelium from known exposures to radon has been developed in the rat. Cytotoxicity assays have been used to obtain dose-conversion factors for cumulative exposures typical of those encountered by underground uranium miners. However, t...

journal_title：Environmental health perspectives

authors： Johnson NF,Carpenter TR,Jaramillo RJ,Liberati TA

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:Harmful algal blooms (HABs) produce potent neurotoxins that threaten human health, but current regulations may not be protective of sensitive populations. Early life exposure to low levels of the HAB toxin domoic acid (DomA) produces long-lasting behavioral deficits in rodent and primate models; however, the...

journal_title：Environmental health perspectives

authors： Panlilio JM,Aluru N,Hahn ME

更新日期：2020-11-01 00:00:00

abstract：:The combined effects of carbon monoxide and low temperature on daily variation in hospital admissions for congestive heart failure (CHF) were examined for a 4-year period in Chicago, Illinois. Medicare hospital admissions for CHF were analyzed as a function of the maximum hourly temperature, maximum hourly levels of c...

journal_title：Environmental health perspectives

authors： Morris RD,Naumova EN

更新日期：1998-10-01 00:00:00

abstract：:A set of 53 individuals from a population highly exposed to airborne hexachlorobenzene (HCB) were selected to study the elimination kinetics of this chemical in humans. The volunteers provided blood, 24-hr urine, and feces samples for analysis of HCB and metabolites. The serum HCB concentrations ranged from 2.4 to 1,4...

journal_title：Environmental health perspectives

authors： To-Figueras J,Barrot C,Sala M,Otero R,Silva M,Ozalla MD,Herrero C,Corbella J,Grimalt J,Sunyer J

更新日期：2000-07-01 00:00:00

abstract：:A system suitable for the detection of meiotic aneuploidy is described in which various different origins of the aneuploidy can be distinguished. Aneuploid meiotic products are detected as black disomic spores held in asci containing all the products of a single meiosis. Aneuploidy may result from nondisjunction or fr...

journal_title：Environmental health perspectives

authors： Bond DJ,McMillan L

更新日期：1979-08-01 00:00:00

abstract：:Determination of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in fly ash and cinders collected from nine municipal incinerators in Japan was made. The concentrations of PCDDs and PCDFs in this study were generally in the same range as those in Europe and North America. However, t...

journal_title：Environmental health perspectives

authors： Wakimoto T,Tatsukawa R

更新日期：1985-02-01 00:00:00

abstract：:Flavone and isoflavone phytoestrogens are plant chemicals and are known to be competitive inhibitors of cytochrome P450 aromatase with respect to the androgen substrate. Aromatase is the enzyme that converts androgen to estrogen; therefore, these plant chemicals are thought to be capable of modifying the estrogen leve...

journal_title：Environmental health perspectives

authors： Kao YC,Zhou C,Sherman M,Laughton CA,Chen S

更新日期：1998-02-01 00:00:00

abstract：:Prostaglandin-H synthase is unique among enzymes of the plant and animal kingdom in its ability to biosynthesize and metabolize hydroperoxides. Its cyclooxygenase activity oxygenates polyunsaturated fatty acids to hydroperoxy endoperoxides, and its peroxidase activity reduces the hydroperoxy group to hydroxy groups. H...

journal_title：Environmental health perspectives

authors： Marnett LJ

更新日期：1990-08-01 00:00:00

abstract：BACKGROUND:Cirrhosis of the liver is thought to be a major cause of morbidity and mortality in sub-Saharan Africa, but few controlled studies on the etiology of cirrhosis have been conducted in this region. OBJECTIVES:We aimed to elucidate the association between environmental and infectious exposures and cirrhosis in...

journal_title：Environmental health perspectives

authors： Kuniholm MH,Lesi OA,Mendy M,Akano AO,Sam O,Hall AJ,Whittle H,Bah E,Goedert JJ,Hainaut P,Kirk GD

更新日期：2008-11-01 00:00:00

abstract：:In recent years, it has become apparent that minerals can trigger alterations in gene expression by initiating signaling events upstream of gene transactivation. These cascades may be initiated at the cell surface after interaction of minerals with the plasma membrane either through receptorlike mechanisms or integrin...

journal_title：Environmental health perspectives

authors： Mossman BT,Faux S,Janssen Y,Jimenez LA,Timblin C,Zanella C,Goldberg J,Walsh E,Barchowsky A,Driscoll K

更新日期：1997-09-01 00:00:00

abstract：:Techniques are available to minimize the concentration of asbestos fibers in drinking water. Filtration research conducted at locations on Lake Superior and in the Cascade Mountains in Washington has shown that amphibole and chrysotile fibers can be removed by granular media filtration. Removal percentages can exceed ...

journal_title：Environmental health perspectives

authors： Logsdon GS

更新日期：1983-11-01 00:00:00