Prostaglandin synthase-mediated metabolism of carcinogens and a potential role for peroxyl radicals as reactive intermediates.

abstract：:Short-term increases in ambient air pollution have been associated with an increased incidence of acute cardiac events. We assessed the effect of inhalation exposure to concentrated ambient particles (CAPs) on myocardial ischemia in a canine model of coronary artery occlusion. Six mongrel dogs underwent thoracotomy fo...

journal_title：Environmental health perspectives

authors： Wellenius GA,Coull BA,Godleski JJ,Koutrakis P,Okabe K,Savage ST,Lawrence JE,Murthy GG,Verrier RL

更新日期：2003-04-01 00:00:00

abstract：:Biomarkers are desirable for quantitating human exposure to environmental tobacco smoke (ETS) and for predicting potential health risks for exposed individuals. A number of biomarkers of ETS have been proposed. At present cotinine, measured in blood, saliva, or urine, appears to be the most specific and the most sensi...

journal_title：Environmental health perspectives

authors： Benowitz NL

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Lead (Pb) exposure may influence the plasma concentration of homocysteine, a one-carbon metabolite associated with cardiovascular and neurodegenerative diseases. Little is known about the associations between Pb and homocysteine over time, or the potential influence of dietary factors. OBJECTIVES:We examine...

journal_title：Environmental health perspectives

authors： Bakulski KM,Park SK,Weisskopf MG,Tucker KL,Sparrow D,Spiro A 3rd,Vokonas PS,Nie LH,Hu H,Weuve J

更新日期：2014-10-01 00:00:00

abstract：:Pregnant rats were exposed by inhalation to vapor concentrations of 100, 200, 400 or 800 ppm of ethylene glycol monopropyl ether acetate on days 6 through 15 of gestation. Concentrations of 400 and 800 ppm reduced the feed intake, mean body weight and red blood cell counts. Mean corpuscular volume and mean corpuscular...

journal_title：Environmental health perspectives

authors： Krasavage WJ,Katz GV

更新日期：1984-08-01 00:00:00

abstract：:There is concern about the human health effects of inhalation of acid compounds found in urban air pollution. It was the purpose of this study to investigate three of these acid compounds, sulfur dioxide (SO2), sulfuric acid (H2SO4), and nitric acid (HNO3) in a group of allergic adolescent subjects. Subjects were expo...

journal_title：Environmental health perspectives

authors： Koenig JQ,Covert DS,Pierson WE

更新日期：1989-02-01 00:00:00

abstract：:Neonatal treatment of female mice with diethystilbestrol (DES) is known to induce ovary-independent persistent proliferation and cornification of vaginal epithelium. This irreversibly changed vaginal epithelium persistently expressed higher levels of c-jun and c-fos mRNAs, which was not altered by postpubertal estroge...

journal_title：Environmental health perspectives

authors： Iguchi T,Fukazawa Y,Bern HA

更新日期：1995-10-01 00:00:00

abstract：:In numerous in vivo systems it has been shown that diets high in menhaden oil (a fish oil high in omega-3 fatty acids) can inhibit the carcinogenic process. In the present study, we have assessed the effects of a diet containing menhaden oil on 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-DNA adduct formation in targe...

journal_title：Environmental health perspectives

authors： Schut HA

更新日期：1994-10-01 00:00:00

abstract：:Chronic exposure to oxidants is associated with an increased incidence of malignancy; however, the mechanism(s) by which oxidants contribute to carcinogenesis is unknown. Since oncogene activation plays an important role in carcinogenesis, we hypothesized that hydroxyl radical-induced DNA damage might contribute to ca...

journal_title：Environmental health perspectives

authors： Jackson JH

更新日期：1994-12-01 00:00:00

abstract：:Research conducted in recent years has increased public health concern about the toxicity of lead at low dose and has supported a reappraisal of the levels of lead exposure that may be safely tolerated in the workplace. In this article, which appears as part of a mini-monograph on adult lead exposure, we summarize a b...

journal_title：Environmental health perspectives

authors： Kosnett MJ,Wedeen RP,Rothenberg SJ,Hipkins KL,Materna BL,Schwartz BS,Hu H,Woolf A

更新日期：2007-03-01 00:00:00

abstract：:Gene expression is a unique way of characterizing how cells and organisms adapt to changes in the external environment. The measurements of gene expression levels upon exposure to a chemical can be used both to provide information about the mechanism of action of the toxicant and to form a sort of "genetic signature" ...

journal_title：Environmental health perspectives

authors： Lettieri T

更新日期：2006-01-01 00:00:00

abstract：:Studies were performed to investigate the effects of FireMaster FF-1, a chemical fire retardant consisting of a mixture of polybrominated biphenyls (PBB), on immune functions in mice and rats. Animals received 22 daily treatments of 0.03, 0.3, 3.0, or 30 mg PBB/kg body weight in a period covering 30 days. PBB exposure...

journal_title：Environmental health perspectives

authors： Luster MI,Faith RE,Moore JA

更新日期：1978-04-01 00:00:00

abstract：:We used an improved method for trapping carbon-centered radicals (.R) from the gas-phase to compare radical suites trapped from various tobacco smoke and model smoke systems. Using a nitroxide trap, 3-amino-2,2,5,5-tetramethyl-1-pyrrolidinyloxy (3AP), on solid support, we trapped radicals directly from the gas phase, ...

journal_title：Environmental health perspectives

authors： Flicker TM,Green SA

更新日期：2001-08-01 00:00:00

abstract：:The three modern "faces" of mercury are our perceptions of risk from the exposure of billions of people to methyl mercury in fish, mercury vapor from amalgam tooth fillings, and ethyl mercury in the form of thimerosal added as an antiseptic to widely used vaccines. In this article I review human exposure to and the to...

journal_title：Environmental health perspectives

authors： Clarkson TW

更新日期：2002-02-01 00:00:00

abstract：:The occurrence of high cadmium levels in the digestive gland (hepatopancreas) of the crab Cancer pagurus is reviewed and its possible significance to human health is discussed. Previous attempts to isolate this cadmium in its native form are briefly reviewed and the present method used in this laboratory to isolate cr...

journal_title：Environmental health perspectives

authors： Overnell J

更新日期：1986-03-01 00:00:00

abstract：:The fundamental problems in population monitoring for genetic effects are twofold: the binomialized nature of the data and the lower power due to small risk of finding positive results. The binomial character is artificial, even forced, and can with advantage be replaced by more refined analysis, and by a focus on all...

journal_title：Environmental health perspectives

authors： Murphy EA

更新日期：1981-12-01 00:00:00

abstract：BACKGROUND:The Marcellus Shale is a vast natural gas field underlying parts of Pennsylvania, New York, West Virginia, Virginia, and Maryland. Rapid development of this field has been enabled by advances in hydrofracking techniques that include injection of chemical and physical agents deep underground. Response to publ...

journal_title：Environmental health perspectives

authors： Goldstein BD,Kriesky J,Pavliakova B

更新日期：2012-04-01 00:00:00

abstract：:Forty percent of hazardous waste sites in the United States are co-contaminated with organic and metal pollutants. Data from both aerobic and anaerobic systems demonstrate that biodegradation of the organic component can be reduced by metal toxicity. Metal bioavailability, determined primarily by medium composition/so...

journal_title：Environmental health perspectives

authors： Sandrin TR,Maier RM

更新日期：2003-06-01 00:00:00

abstract：:Consideration of needs for public health interventions and new research requires comparative assessments of the health benefits that are likely to result from alternative uses of limited regulatory and technical resources. This paper briefly examines regulatory and research priorities in the light of recent informatio...

journal_title：Environmental health perspectives

authors： Hattis D

更新日期：1981-10-01 00:00:00

abstract：:This article provides an overview of methods for reliability assessment of quantitative structure-activity relationship (QSAR) models in the context of regulatory acceptance of human health and environmental QSARs. Useful diagnostic tools and data analytical approaches are highlighted and exemplified. Particular empha...

journal_title：Environmental health perspectives

authors： Eriksson L,Jaworska J,Worth AP,Cronin MT,McDowell RM,Gramatica P

更新日期：2003-08-01 00:00:00

abstract：:The types of biological response to an environmental agent can depend on dose, thus in this case a family of widely different dose-response relationships would be expected. For those situations where the magnitude of the effect may be determined on probabilistic grounds as a function of dose ("stochastic" model), no p...

journal_title：Environmental health perspectives

authors： Radford EP

更新日期：1981-12-01 00:00:00

abstract：:Often a compound's biological activity is determined by complex relationships between its structural components. Such a relationship often can only be adequately described and exploited by multivariate structure-activity relationship (SAR) studies that can deal with many variables simultaneously. Pattern recognition (...

journal_title：Environmental health perspectives

authors： Stouch TR,Jurs PC

更新日期：1985-09-01 00:00:00

abstract：:Rats were used to study the general activity and the isoenzyme spectrum of lactate dehydrogenase (LDH) during single-instance and long-term introduction of polychlorocamphene. Total lactate dehydrogenase activity decreases in the liver during the single-instance introduction of half the LD50 (120 mg/kg). The isoenzyme...

journal_title：Environmental health perspectives

authors： Kuz'minskaya UA,Alekhina SM

更新日期：1976-02-01 00:00:00

abstract：:We investigated the metabolic fate of a low dose (25 micro g/kg) of bisphenol A [2,2-bis(4-hydroxy-phenyl)propane] (BPA) injected subcutaneously in CD1 pregnant mice using a tritium-labeled molecule. Analytic methods were developed to allow a radio-chromatographic profiling of BPA residues in excreta and tissues, as w...

journal_title：Environmental health perspectives

authors： Zalko D,Soto AM,Dolo L,Dorio C,Rathahao E,Debrauwer L,Faure R,Cravedi JP

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Previous literature suggests that higher ambient temperature may play a role in increasing the risk of suicide. However, no multi-country study has explored the shape of the association and the role of moderate and extreme heat across different locations. OBJECTIVES:We examined the short-term temperature-su...

journal_title：Environmental health perspectives

authors： Kim Y,Kim H,Gasparrini A,Armstrong B,Honda Y,Chung Y,Ng CFS,Tobias A,Íñiguez C,Lavigne E,Sera F,Vicedo-Cabrera AM,Ragettli MS,Scovronick N,Acquaotta F,Chen BY,Guo YL,Seposo X,Dang TN,de Sousa Zanotti Stagliorio Coel

更新日期：2019-11-01 00:00:00

abstract：:Between 1966 and 1986, the childhood leukemia rate in Woburn, Massachusetts, was 4-fold higher than the national average. A multidisciplinary research team from MIT, which is being supported by the NIEHS Superfund Basic Research Program, has explored the possible importance of a temporal correlation between the period...

journal_title：Environmental health perspectives

authors： Durant JL,Chen J,Hemond HF,Thilly WG

更新日期：1995-09-01 00:00:00

abstract：:The neurochemical basis of memory has been approached experimentally in four different ways: the bioassay; the interventive approach; the interventive-correlative approach; and the correlative approach. These approaches are fundamentally similar to those used for the study of the chemistry of any behavior. Each of the...

journal_title：Environmental health perspectives

authors： Dunn AJ

更新日期：1978-10-01 00:00:00

abstract：:In this study, the cohort consisted of 18,135 distribution employees with potential exposure to gasoline for at least one year at land-based terminals (n = 9,026) or on marine vessels (n = 9,109) between 1946 and 1985. The primary objective of the study was to determine the relationship, if any, between exposure to ga...

journal_title：Environmental health perspectives

authors： Wong O,Harris F,Smith TJ

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Modern toxicology is shifting from an observational to a mechanistic science. As part of this shift, high-throughput toxicity assays are being developed using alternative, nonmammalian species to prioritize chemicals and develop prediction models of human toxicity. METHODS:The nematode Caenorhabditis elegan...

journal_title：Environmental health perspectives

authors： Boyd WA,Smith MV,Co CA,Pirone JR,Rice JR,Shockley KR,Freedman JH

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Epidemiologic studies have demonstrated that occupational noise exposure is associated with hypertension, but the related mechanism in vascular structural changes is unclear. OBJECTIVE:This panel study aimed to investigate effects of occupational noise exposure on ambulatory vascular structural properties i...

journal_title：Environmental health perspectives

authors： Chang TY,Su TC,Lin SY,Jain RM,Chan CC

更新日期：2007-11-01 00:00:00

abstract：:Uterine leiomyomas (fibroids, myomas) are the most common tumors occurring in the genital tract of women over 30 years of age. These benign uterine smooth-muscle tumors are estimated to be clinically significant in at least 25% of the American female population during their reproductive years. Furthermore, when thorou...

journal_title：Environmental health perspectives

authors： Newbold RR,DiAugustine RP,Risinger JI,Everitt JI,Walmer DK,Parrott EC,Dixon D

更新日期：2000-10-01 00:00:00